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Treatment

Protective effects of N-acetylcysteine on a chemical-induced murine model of asthma

, PhD, , PhD, , PhD, , MD & , MD
Pages 1208-1215 | Received 19 Feb 2020, Accepted 07 Jun 2020, Published online: 26 Jun 2020

References

  • Trivedi V, Apala DR, Iyer VN. Occupational asthma: diagnostic challenges and management dilemmas. Curr Opin Pulm Med. 2017;23(2):177–183. doi:10.1097/MCP.0000000000000352.
  • Johnson VJ, Matheson JM, Luster MI. Animal models for diisocyanate asthma: answers for lingering questions. Curr Opin Allergy Clin Immunol. 2004;4(2):105–110. doi:10.1097/00130832-200404000-00006.
  • Chen R, Zhang Q, Chen S, Tang H, Huang P, Wei S, Liang Z, Chen X, Tao A, Yao L. IL-17F, rather than IL-17A, underlies airway inflammation in a steroid-insensitive toluene diisocyanate-induced asthma model. Eur Respir J. 2019;53(4):1801510. doi:10.1183/13993003.01510-2018.
  • Tse HN, Raiteri L, Wong KY, Ng LY, Yee KS, Tseng C. Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD. Chest. 2014;146(3):611–623. doi:10.1378/chest.13-2784.
  • Fowdar K, Chen H, He Z, Zhang J, Zhong X, Zhang J, Li M, Bai J. The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: a meta-analysis and systematic review. Heart Lung. 2017;46(2):120–128. doi:10.1016/j.hrtlng.2016.12.004.
  • Zhang L, He YL, Li QZ, Hao XH, Zhang ZF, Yuan JX, Bai YP, Jin YL, Liu N, Chen G, et al. N-acetylcysteine alleviated silica-induced lung fibrosis in rats by down-regulation of ROS and mitochondrial apoptosis signaling. Toxicol Mech Methods. 2014;24(3):212–219. doi:10.3109/15376516.2013.879974.
  • Hwang HW, Jung H, Hyeon J, Park YH, Ahn JS, Im YH, Nam SJ, Kim SW, Lee JE, Yu JH, et al. A nomogram to predict pathologic complete response (pCR) and the value of tumor-infiltrating lymphocytes (TILs) for prediction of response to neoadjuvant chemotherapy (NAC) in breast cancer patients. Breast Cancer Res Treat. 2019;173(2):255–266. doi:10.1007/s10549-018-4981-x.
  • Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E, Butterfield DA, Morley JE. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003;84(5):1173–1183. doi:10.1046/j.1471-4159.2003.01580.x.
  • Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-acetylcysteine as an antioxidant and disulphide breaking agent: the reasons. Free Radic Res. 2018;52(7):751–762. doi:10.1080/10715762.2018.1468564.
  • Wisnewski AV, Hettick JM, Siegel PD. Toluene diisocyanate reactivity with glutathione across a vapor/liquid interface and subsequent transcarbamoylation of human albumin. Chem Res Toxicol. 2011;24(10):1686–1693. doi:10.1021/tx2002433.
  • Valstar DL, Schijf MA, Nijkamp FP, Bloksma N, Henricks PA. Glutathione-conjugated toluene diisocyanate causes airway inflammation in sensitised mice. Arch Toxicol. 2004;78(9):533–539. doi:10.1007/s00204-004-0571-2.
  • Lange RW, Day BW, Lemus R, Tyurin VA, Kagan VE, Karol MH. Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanatotoluene. Chem Res Toxicol. 1999;12(10):931–936. doi:10.1021/tx990045h.
  • Lantz RC, Lemus R, Lange RW, Karol MH. Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanate. Toxicol Sci. 2001;60(2):348–355. doi:10.1093/toxsci/60.2.348.
  • Bullone M, Lavoie JP. The contribution of oxidative stress and inflamm-aging in human and equine asthma. Int J Mol Sci. 2017;18(12):2612. doi:10.3390/ijms18122612.
  • van der Vliet A, Janssen-Heininger Y, Anathy V. Oxidative stress in chronic lung disease: from mitochondrial dysfunction to dysregulated redox signaling. Mol Aspects Med. 2018;63:59–69. doi:10.1016/j.mam.2018.08.001.
  • Lim HF, Nair P. Airway inflammation and inflammatory biomarkers. Semin Respir Crit Care Med. 2018;39(1):56–63. doi:10.1055/s-0037-1606217.
  • Silveira JS, Antunes GL, Kaiber DB, Da Costa MS, Marques EP, Ferreira FS, Gassen RB, Breda RV, Wyse ATS, Pitrez P, et al. Reactive oxygen species are involved in eosinophil extracellular traps release and in airway inflammation in asthma. J Cell Physiol. 2019;234(12):23633–23646. doi:10.1002/jcp.28931.
  • Kim H, Lee S, Jeong S, Hong S. Protease-activated receptors 2-antagonist suppresses asthma by inhibiting reactive oxygen species-thymic stromal lymphopoietin inflammation and epithelial tight junction degradation. Allergy Asthma Immunol Res. 2019;11(4):560–571. doi:10.4168/aair.2019.11.4.560.
  • Lee PH, Hong J, Jang AS. N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression. Korean J Intern Med. 2020. doi:10.3904/kjim.2019.105.
  • Yao L, Zhao H, Tang H, Liang J, Liu L, Dong H, Zou F, Cai S. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016;173(17):2600–2613. doi:10.1111/bph.13539.
  • Yao L, Zhao H, Tang H, Xiong J, Zhao W, Liu L, Dong H, Zou F, Cai S. Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma. Allergy. 2017;72(4):579–589. doi:10.1111/all.13045.
  • Huang P, Wei S, Huang W, Wu P, Chen S, Tao A, Wang H, Liang Z, Chen R, Yan J, et al. Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model. Int Immunopharmacol. 2019;74:105646. doi:10.1016/j.intimp.2019.05.031.
  • Daniels RD. Occupational asthma risk from exposures to toluene diisocyanate: a review and risk assessment. Am J Ind Med. 2018;61(4):282–292. doi:10.1002/ajim.22815.
  • Vanoirbeek JA, De Vooght V, Synhaeve N, Nemery B, Hoet PH. Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate? Toxicol Sci. 2009;109(2):256–264. doi:10.1093/toxsci/kfp065.
  • Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014;141(2):150–159. doi:10.1016/j.pharmthera.2013.09.006.
  • Carlsten C, Macnutt MJ, Zhang Z, Sava F, Pui MM. Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity. Toxicol Sci. 2014;139(2):479–487. doi:10.1093/toxsci/kfu040.
  • Reiprich M, Rudzok S, Schutze N, Simon JC, Lehmann I, Trump S, Polte T. Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. Allergy. 2013;68(4):481–489. doi:10.1111/all.12121.
  • He M, Ichinose T, Yoshida S, Nishikawa M, Sun G, Shibamoto T. Role of iron and oxidative stress in the exacerbation of allergic inflammation in murine lungs caused by urban particulate matter <2.5 mum and desert dust. J Appl Toxicol. 2019;39(6):855–867. doi:10.1002/jat.3773.
  • Song J, Zhao H, Dong H, Zhang D, Zou M, Tang H, Liu L, Liang Z, Lv Y, Zou F, et al. Mechanism of E-cadherin redistribution in bronchial airway epithelial cells in a TDI-induced asthma model. Toxicol Lett. 2013;220(1):8–14. doi:10.1016/j.toxlet.2013.03.033.
  • Froidure A, Mouthuy J, Durham SR, Chanez P, Sibille Y, Pilette C. Asthma phenotypes and IgE responses. Eur Respir J. 2016;47(1):304–319. doi:10.1183/13993003.01824-2014.
  • Choi G, Trinh HKT, Yang E, Ye Y, Shin YS, Kim S, Park H. Role of clusterin/progranulin in toluene diisocyanate-inducedoccupational asthma. Exp Mol Med. 2018;50(5):1–10. doi:10.1038/s12276-018-0085-2.
  • Mishra V, Banga J, Silveyra P. Oxidative stress and cellular pathways of asthma and inflammation: therapeutic strategies and pharmacological targets. Pharmacol Ther. 2018;181:169–182. doi:10.1016/j.pharmthera.2017.08.011.
  • Thomson NC. Novel approaches to the management of noneosinophilic asthma. Ther Adv Respir Dis. 2016;10(3):211–234. doi:10.1177/1753465816632638.
  • Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. Eur Respir J. 2018;52(1):1352020. doi:10.1183/09031936.00202013.
  • Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159–175. doi:10.1038/nri3399.
  • Kim SH, Uuganbayar U, Trinh H, Pham DL, Kim N, Kim M, Sohn H, Park HS. Evaluation of neutrophil activation status according to the phenotypes of adult asthma. Allergy Asthma Immunol Res. 2019;11(3):381–393. doi:10.4168/aair.2019.11.3.381.
  • Millar TM, Phan V, Tibbles LA. ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment. Free Radic Biol Med. 2007;42(8):1165–1177. doi:10.1016/j.freeradbiomed.2007.01.015.
  • Rogliani P, Matera MG, Page C, Puxeddu E, Cazzola M, Calzetta L. Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respir Res. 2019;20(1):104. doi:10.1186/s12931-019-1078-y.
  • Rahman I, Macnee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J. 2000;16(3):534–554. doi:10.1034/j.1399-3003.2000.016003534.x.
  • Vanoirbeek JA, Tarkowski M, De Vooght V, Nemery B, Hoet PH. Immunological determinants in a mouse model of chemical-induced asthma after multiple exposures. Scand J Immunol. 2009;70(1):25–33. doi:10.1111/j.1365-3083.2009.02263.x.
  • Zhuang J, Cui H, Zhuang L, Zhai Z, Yang F, Luo G, He J, Zhao H, Zhao W, He Y, et al. Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomed Pharmacother. 2020;125:109925. doi:10.1016/j.biopha.2020.109925.
  • Liang X, Zhang D, Liu W, Yan Y, Zhou F, Wu W, Yan Z. Reactive oxygen species trigger NF-κB-mediated NLRP3 inflammasome activation induced by zinc oxide nanoparticles in A549 cells. Toxicol Ind Health. 2017;33(10):737–745. doi:10.1177/0748233717712409.
  • Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B. Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med. 2019;8(10):1613. doi:10.3390/jcm8101613.

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