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Original Articles

Methadone Death, Dosage and Torsade de Pointes: Risk-Benefit Policy Implications

Pages 513-519 | Published online: 08 Sep 2011

REFERENCES

  • Anglin , M. D. and McGlothlin , E. H. 1984 . “ Outcome of narcotic addict treatment in California. ” . In Drug Abuse Treatment Evaluation: Strategies, Progress and Prospects. Edited by: Tims , F. M. and Ludford , J. P. Rockville, MD : NIDA. . NIDA Research Monograph 51.
  • Baden , M. M. 1970 . Methadone related deaths in New York City . International Journal of the Addictions , 5 : 489 – 98 .
  • Bale , R. N. , Van Stone , W. W. , Kulau , J. M. , Engelsing , T. M.J. and Elashoft , R. M. 1980 . Therapeutic communities vs. methadone maintenance. A prospective controlled study of narcotic addiction treatment: Design and one year follow up . Archives of General Psychiatry , 37 : 179 – 93 .
  • Ball , J. C. and Ross , A. 1991 . The Effectiveness of Methadone Maintenance. New York : Springer-Verlag. .
  • Ball , J. C. , Myers , C. P. and Friedman , S. R. 1988 . Reducing the risk of AIDS through Methadone Maintenance Treatment . Journal of Health and Social Behavior , 29 : 214 – 26 .
  • Ballesteros , M. F. , Sanford , C. P. , Gilchrist , J. , Agyekem , G. A. and Butts , J. 2003 . Increase in deaths due to methadone in North Carolina . Journal of the American Medical Association , 290 ( 1 ) : 40
  • Barrett , D. H. , Luk , A. J. , Parrish , R. G. and Jones , T. S. 1996 . An investigation of medical examiner cases in which methadone was detected. Harris County, Texas, 1987–1992 . Journal of Forensic Science , 41 : 442 – 48 .
  • Bednar , M. M. , Harringan , E. P. and Ruskin , J. N. 2002 . Torsade de pointes associated with non-antiarrhythmic drugs and observations on gender and QTc . American Journal of Cardiology , 89 : 1316 – 19 .
  • Bell , J. , Bowron , P. , Lewis , J. and Bately , R. 1990 . Serumlevels of methadone in maintenance clients who persist in illicit drug use . British Journal of Addiction , 85 : 1599 – 1602 .
  • Bentley , A. J. and Busuttil , A. 1996 . Deaths among drug abusers in south-east Scotland, 1989–1994 . Meicine, Science and the Law , 36 : 231 – 36 .
  • Bond , C. 1998 . Single nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction . Proceedings of the National Academy of Sciences , 95 : 9608 – 13 .
  • Blix , O. and Gronbladh , L. 1991 . “ The impact of methadone maintenance treatment on the spread of HIV among IV heroin addicts in Sweden. ” . In Drug Addiction and AJDS. Edited by: Loimer , N. , Schmid , R. and Springer , A. Vienna : Springer-Verlag. .
  • Bryant , W. K. , Galea , S. , Tracey , M. , Markham Piper , T. and Tardiff , K. J. 2004 . Overdose deaths attributed to methadone and heroin in New york City, 1990–1998 . Addiction , 99 ( 7 ) : 846 – 54 .
  • Buster , M. C. , Van Brussel , G. H. and Van Den Brin , W. 2002 . An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam . Addiction , 97 ( 8 ) : 993 – 1001 .
  • Cairns , A. , Roberts , I. S. and Benbow , E. W. 1996 . Characteristics of fatal methadone overdose in Manchester, 1985–94 . British Medical Journal , 313 ( 7052 ) : 264 – 5 .
  • Caplehorn , J. R. 1998 . Deaths in the first two weeks of maintenance treatment in NSW in 1994: Identifying cases of iatrogenic methadone toxicity . Drug and Alcohol Review , 17 : 9 – 17 .
  • capelhorn , J. R. and Drummer , O. H. 2002 . Fatal methadone toxicity: Signs, circumstances, and the role of benzodiazepines . Australia and New Zealand Journal of Public Health , 26 ( 4 ) : 358 – 63 .
  • Capelhorn , J. R. and Drummer , O. H. 1999 . Mortality associated with New South Wales methadone programs in 1994: Lives lost and saved . Medical Journal of Australia , 170 ( 3 ) : 104 – 9 .
  • Capelhorn , J. R. and Bell , J. 1991 . Methadone dosage and retention of patients in maintenance treatment . Medical Journal of Australia , 54 ( 3 ) : 195 – 9 .
  • Caplehorn , J. R. , Dalton , M. S. , Haldar , F. , Petrenas , A. M. and Nisbet , J. G. 1996 . Methadone maintenance and addicts risk of fatal heroin overdose . Substance Use and Misuse , 31 ( 2 ) : 177 – 96 .
  • Cooper , J. R. 1989 . Methadone and AIDS . Journal of the American Medical Association , 262 : 1664 – 8 .
  • Cooper , J. R. , Altman , F. , Brown , B. S. and Czechowitz , M. 1983 . Research on the Treatment of Narcotic Addiction. Washington, D.C. : US GPO. .
  • Cooper , G. A. , Seymour , A. , Cassidy , M. T. and Oliver , J. S. 1999 . A study of methadone in fatalities in the strathclyde region, 1991–1996 . Medicine, Science and the Law , 39 : 233 – 42 .
  • Craig , R. J. 1980 . Effectiveness of low dose methadone maintenance for the treatment of inner city heroin addicts . International Journal of the Addictions , 15 : 701 – 10 .
  • D'Aunno , T. and Vaughn , T. F. 1992 . Variations in methadone treatment practices: Results from a national study . Journal of the American Medical Association , 267 : 253 – 58 .
  • Davoli , M. , Perucci , C. A. , Forastire , F. , Doyle , P. and Rapiti , E. 1993 . Risk factors for overdose mortality: A case-control study within a cohort of intravenous drug users . International Journal of Epidemiology , 22 : 273 – 77 .
  • De Bels , D. , Staroukine , M. and Devrienndt , J. 2003 . Torsade de pointes due to methadone . Annals of Internal Med , 139 ( 2 ) : E 156
  • Decerf , J. A. , Gressens , B. , Brohet , C. , Liolios , A. and Hantson , P. 2004 . Can methadone prolong the QT interval? . Intensive Care Medicine , 30 : 1690 – 91 .
  • Deponti , F. , Poluzzi , E. and Montanaro , N. 2001 . Organizing evidence on QT prolongation and occurrence of torsade de pointes with non-arrhythmic drugs: A call for consensus . European Journal of Clinical Pharmacology , 57 : 185 – 209 .
  • Dole , V. P. and Nyswander , M. 1967 . Heroin addiction: A metabolic disease . Archives of Internal Medicine , 120 : 19 – 24 .
  • Dole , V. P. and Nyswander , M. 1965 . A medical treatment for diacetylmorphine (heroin) addiction . Journal of the American Medical Association , 193 : 80 – 84 .
  • Dole , V. P. , Robinson , J. W. , Oraaca , J. , Towns , E. and Searcy , P. 1969 . Methadone treatment of randomly selected criminal addicts . New England Journal of Medicine , 280 : 1372 – 75 .
  • Drummer , O. H. and Opeskin , K. 1992 . Methadone toxicity causing death in ten subjects starting on a methadone maintenance program . American Journal of Forensic Medicine and Pathology , 13 ( 4 ) : 346 – 50 .
  • Dyer , K. R. and White , J. M. 1997 . Patterns of symptom complaints in methadone maintenance patients . Addiction , 92 ( 11 ) : 1445 – 55 .
  • Dyer , K. R. , Foster , D. J.R. , White , J. M. , Somogyi , A. A. and Menelaou , A. 1999 . Steady state pharmacokinetics and pharmacodynamics in methadone maintained patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships . Clinical Pharmacology and Therapeutics , 65 : 685 – 94 .
  • Dyer , K. R. , White , J. , Foster , D. J.R. , Bochner , F. and Menelaou , A. 2001 . The relationship between mood state and plasma methadone concentration in maintenance patients . Journal of Clinical Psychopharmacology , 21 ( 1 ) : 78 – 84 .
  • Eap , C. B. , Bourquin , M. , Martin , J. , Spagnoli , J. and Powell , K. 2000 . Plasma concentration of the enantomers of methadone and therapeutic response in methadone maintenance treatment . Drug and Alcohol Dependence , 61 ( 1 ) : 47 – 54 .
  • Eap , C. B. , Bertschy , G. , Finkbeiner , T. , Gastpar , M. , Scherbaum , N. and Baumann , P. 1998 . High interindividual variability of methadone enantomer blood levels to dose ratios . Archives of General Psychiatry , 55 : 89 – 90 .
  • Eap , C. B. , Finkheiner , T. , Gastpar , M. , Scherbaum , N. and Powell , K. 1996 . Replacement of R-Methadone by a double dose of R/S-Methadone in addicts: iInterindividual variability of the R/S ratios and evidence of adaptive changes in methadone pharmacokinetics . European Journal of Clinical Pharmacology , 50 : 385 – 89 .
  • Faggiano , F. , Vigna-Taglianti , F. , Veersino , E. and Lemma , P. 2003 . Methadone maintenance at different dosages for opioid dependence . Cochrane Database of Systematic Reviews , 3 : CD002208
  • Foster , D. J.R. , Somogyi , A. , Dyer , K. R. , White , J. M. and Bochner , F. 2000 . Steady state pharmacokinetics of R and S-Methadone in methadone maintenance patients . British Journal of Clinical Pharmacology , 50 : 427 – 40 .
  • Frank , B. 2000 . An overview of heroin trends in New York City: Past, present and future . Journal of Medicine , 67 ( 5–6 ) : 340 – 46 .
  • Fugelstad , A. , Rajs , J. , Bottiger , M. and Gerhardsson de Verrdeir , M. 1995 . Mortality among HIV infected intravenous drug addicts in Stockholm in relation to methadone treatment . Addiction , 90 : 711 – 16 .
  • Gagajewski , A. and Apple , F. S. 2003 . Methadone related deaths in Hennepin County, Minnesota: 1992–2002 . Journal of Forensic Science , 48 ( 3 ) : 668 – 71 .
  • Gardner , R. 1970 . Methadone misuse and death by overdose . British Journal of Addiction , 65 : 113 – 18 .
  • Gearing , F. R. and Schweitzer , M. D. 1974 . An epidemiologic evaluation of long term methadone maintenance treatment for heroin addiction . American Journal of Epidemiology , 100 : 101 – 12 .
  • Ghodse , H. , Schifano , F. , Oyefeso , A. , Jambert-Gray , R. , Cobain , K. and Cockery , J. 2003 . “ Drug related deaths as reported by participating procurators fiscal ad coroners in England, Wales, Northern Ireland, Scotland, Isle of Man, Grumsy, Jersey. ” . In Annual Review 2002 and NP-SAD Surveillance Report No. II. London : Centre for Addiction Studies, St George Hospital Medical School. .
  • Gil , M. , Sala , M. , Anguera , I. , Chapinal , O. and Cervantes , M. 2003 . QT prolongation and torsade de pointes in patient infected with HIV and treated with methadone . American Journal of Cardiology , 92 : 995 – 97 .
  • Goldstein , A. , Hansteen , R. W. and Horns , W. H. 1975 . Control of methadone dosage by patients . Journal of the American Medical Association , 234 ( 7 ) : 734 – 37 .
  • Goodnick , P. J. , Jerry , J. and Parra , F. 2002 . Psychotropic drugs and the ECG: Focus on the QT interval . Expert Opinion in Pharmacotherapy , 3 ( 5 ) : 479 – 98 .
  • Grab , H. , Behnsen , S. , Kimont , H. G. , Staak , M. and Kaferstein , H. 2003 . Methadone and its role in drug related fatalities in Cologne, 1989–2000 . Forensic Science International , 132 : 195 – 200 .
  • Grabowski , J. G. , Rhoades , H. , Elk , J. S. and Creson , D. 1993 . “ Clinicwide and individualized behavioral interventions in drug dependence treatment. ” . In Behavioral Treatments for Drug Abuse and Dependence. Edited by: Onken , L. S. , Blaine , J. D. and Boren , J. J. Rockville, MD : U.S. Depart of Health and Human Services. . NIDA Research Monograph # 137
  • Griffith , C. 2004 . Deaths related to drug poisoning: England and Wales, 1998–2002 . Health Statistics Quarterly , 21 : 59 – 66 .
  • Griffith , C. , Brock , A. and Mickleburgh , M. 2002 . Deaths related to drug poisoning: Results for England and Wales, 1993–2000 . Health Statistics Quarterly , 13 : 76 – 82 .
  • Gronbladh , L. , Ohlund , L. S. and Gunne , L. M. 1990 . Mortality in heroin addiction: Impact of methadone treatment . Acta Psychiatrica Scandinavica , 82 : 223 – 7 .
  • Gunne , L. M. and Gronbladh , L. 1981 . The Swedish methadone maintenance program: A controlled study . Drug and Alcohol Dependence , 7 : 249 – 56 .
  • Havassy , B. and Tschann , J. M. 1983 . Client initiative, inertia, and demographics: More powerful than treatment interventions in methadone maintenance . International Journal of the Addictions , 18 : 617 – 31 .
  • Havassy , B. , Hargreaves , W. and De Barros , L. 1979 . Self regulation of dose in methadone maintenance with contingent privileges . Addictive Behaviors , 4 : 31 – 38 .
  • Haverkamp , W. , Breithardt , G. , Camm , A. J. , Janse , M. J. , Rosen , M. R. , Antzelevitch , C. , Escande , D. , Franz , M. , Malik , M. , Moss , A. and Shah , R. 2000 . The potential for QT prolongation and pro-arrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology . Cardiovascular Research , 47 : 219 – 33 .
  • Hickman , M. , Madden , P. , Baker , A. , Wallace , C. and Wakefield , J. 2003 . Trends in drug overdose deaths in England and Wales, 1993–98: Methadone does not kill more people than heroin . Addiction , 9 : 1325 – 6 .
  • Hiltunen , A. J. , Beck , O. , Hjemdahl , P. , Liljeberg , U. and Almstrom , U. 1999 . Rated well being in relation to plasma concentrations of L and D-Methadone in satisfied and dissatisfied patients on methadone maintenance treatment . Psychopharmacology , 143 : 385 – 93 .
  • Holmstrand , J. , Anggard , E. and Gunne , L. M. 1978 . Methadone maintenance: plasma levels and therapeutic outcome . Clinical Pharmacology and Therapeutics , 23 : 175 – 80 .
  • Homes , W. H. , Rado , M. and Goldstein , A. 1975 . Plasma levels and symptom complaints in patients maintained on daily dose of methadone hydrochloride . Clinical Pharmacology and Therapeutics , 17 : 636 – 49 .
  • Hubbard , R. L. and Marsden , M. E. 1989 . Drug Abuse Treatment: A National Study of Effectiveness. Chapel Hill : University of North Carolina Press. .
  • Iguchi , M. , Stitzer , M. L. , Bigelow , G. E. and Leibson , I. A. 1988 . Contingency management in methadone maintenance: Effects of reinforcing and aversive consequences on illicit polydrug use . Journal of Drug and Alcohol Dependence , 22 : 1 – 7 .
  • Kidorf , M. and Steizer , M. L. 1996 . Contingent use of take homes and split dosing to reduce illicit drug use of methadone patients . Behavior Therapy , 27 : 41 – 51 .
  • Kornick , C. A. , Kilborne , M. J. , Santiango-Palma , J. , Shulman , G. and Pezzullo , J. C. 2003 . QTc interval prolongation associated with intravenous methadone . Pain , 105 : 499 – 506 .
  • Krantz , M. J. and Mehler , P. S. 2004 . Methadone and QT prolongation: A dose dependent effect? . American Journal of Cardiology , 93 ( 7 ) : 952
  • Krantz , M. J. , Rowan , S. B. and Mehler , P. S. 2005 . Cocaine related torsade de pointes in a methadone maintenance patient . Journal of Addictive Disease , 24 ( 1 ) : 53 – 60 .
  • Krantz , M. J. , Kutinsky , I. B. , Robertson , A. D. and Mehler , P. S. 2003 . Dose related effects of methadone on QT prolongation in a series of patients with torsade de pointes . Pharmacotherapy , 23 ( 6 ) : 802 – 5 .
  • Krantz , M. J. , Lewkowicz , L. , Hays , H. , Woodroffe , M. A. , Robertson , A. D. and Mehler , P. S. 2002 . Torsade de pointes associated with very-high dose methadone . Annals of Internal medicine , 137 ( 6 ) : 501 – 4 .
  • Kreek , M. J. 2000 . Methadone related opioid agonist pharmacotherapy for heroin addiction . Annals of the New York Academy of Sciences , 99 : 186 – 216 .
  • Kreek , M. J. 1973 . Plasma and urine levels of methadone . New York State Journal of Medicine , 73 : 2773 – 77 .
  • La Harpe , R. and Frye , G. 1995 . Todesfalle im Zusammenhang mit methadone — Eiahme im Kanton Genf (1987–1993) . Archiv für Kriminologie , 196 : 24 – 29 .
  • Leavitt , S. B. , Shinderman , M. , Maxwell , S. , Eap , C. B. and Paris , P. 2000 . When enough is not enough: New perspectives on optimal methadone maintenance dose . Mount Sinai Journal of Medicine , 67 ( 5–6 ) : 404 – 11 .
  • Lorimer , N. and Schmid , R. 1992 . The use of plasma levels to optimize methadone maintenance treatment . Drug and Alcohol Dependence , 30 : 241 – 46 .
  • Magura , S. , Casriel , R. , Goldsmith , D. S. , Strug , D. L. and Lipton , D. S. 1998 . Contingency contracting with polydrug abusing methadone patients . Addictive Behaviors , 13 : 113 – 18 .
  • Man , L. M. , Best , M. , Gossop , M. , Stillwell , G. and Strang , J. 2004 . Relationship between prescribing and risk of opiate overdose among drug users in and out of maintenance treatment . European Addiction Research , 10 ( 1 ) : 35 – 40 .
  • Marks , J. 1999 . Deaths from methadone and heroin . Lancet , 343 : 976
  • Marmor , M. , Des Jarlais , D. C. and Cohen , H. 1987 . Risk factors for infection of human immunodeficiency virus among intravenous drug abusers in New York City . AIDS , I : 39 – 44 .
  • Martell , B. A. , Amsten , J. H. , Ray , B. and Gourevitch , M. N. 2003 . The impact of methadone induction on cardiac conduction in opiate users . Annals of Internal Medicine , 139 ( 2 ) : 154 – 55 .
  • Maxwell , S. and Shinderman , M. S. 2002 . Optimizing long term response to Methadone Maintenance Treatment: A 152 week follow up using higher dose methadone . Journal of Addictive Disease , 21 : 1 – 12 .
  • McGlothlin , W. H. and Anglin , M. D. 1981 . Long term follow up of clients of high and low dose methadone programs . Archives of General Psychiatry , 38 : 1055 – 63 .
  • Milby , J. B. , Carrell , C. , English , C. , Fritschi , O. and Clarke , D. 1978 . Take home methadone: Contingency effects on drug seeking and productivity of narcotic addicts . Addictive Behaviors , 3 : 215 – 20 .
  • Muraskin , W. 1988 . The silent epidemic: The social, ethical, and medical problems surrounding the fight against hepatitis . British Journal of Social History , 22 : 277 – 98 .
  • Neeleman , J. and Ferrell , M. 1997 . Fatal methadone and heroin overdose time trends in England and Wales . Journal of Epidemiology and Community Health , 51 : 435 – 37 .
  • Newcombe , R. 1999 . Live and let die: Is methadone more likely to kill you than heroin? . Druglink , 11 : 9 – 12 .
  • Newcome , R. 1996 . A reply to Ward . Addiction , 91 ( 11 ) : 1727 – 29 .
  • Newman , R. G. and Whitehell , E. B. 1979 . Double blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong . Lancet , 8 : 485 – 88 .
  • Pani , P. P. , Pirastu , R. , Ricci , A. and Gessa , G. L. 1996 . Prohibition of take home dosages: negative consequences on methadone maintenance treatment . Drug and Alcohol Dependence , 41 : 81 – 84 .
  • Parret , G. , Deglon , J. J. , Kreek , M. J. , Ho , A. and La Harpe , R. 2000 . Lethal methadone intoxications in Geneva, Switzerland from 1994–1998 . Addiction , 95 : 1647 – 53 .
  • Patti , A. M. , Santi , A. , Pompa , M. , Giustini , C. and Vescia , N. 1993 . Viral hepatitis and drugs: A continuing problem . International Journal of Epidemiology , 22 : 135 – 39 .
  • Piguet , V. , Desmeules , J. , Ehret , G. , Stoller , R. and Dayer , P. 2004 . QT interval prolongation in patients on methadone with concomitant drugs . Journal of Clinical Psychopharmacology , 24 ( 4 ) : 446 – 48 .
  • Pirnay , S. , Borron , S. W. , Giudicelli , C. P. , Tourneau , J. and Baud , F. J. 2004 . A critical review of the causes of death among post-mortem toxicological investigations: analysis of 34 buprenorphine-associated and 35 methadone-associated deaths . Addiction , 99 : 978 – 88 .
  • Resnick , R. B. 1977 . Problems of methadone diversion and implications for control . International Journal of the Addictions , 12 : 803 – 06 .
  • Resnick , R. B. , Butler , P. and Washton , A. M. 1981 . “ Patient self adjustment of methadone maintenance dose. ” . In Problems of Drug Dependence 1981. Edited by: Harris , L. Rockville, MD : US Dept of Health and Human Services. . NIDA Research Monograph #41.
  • Rhodes , H. M. , Creson , D. , Elk , R. , Schmitz , J. and Grabowski , J. 1998 . Retention, HIV risk, and illicit drug use during treatment: Methadone dose and visit frequency . American Journal of Public Health , 88 : 34 – 39 .
  • Sala , M. , Anguera , I. and Cervantes , M. 2003 . Torsade de pointes due to methadone . Annals of Internal Medicine , 139 ( 4 ) : W64
  • Schmitz , J. M. , Rhoades , R. E. , Creson , D. , Hussein , I. and Grabowski , J. 1998 . Medication take home doses and contingency management . Experimental and Clinical Psychopharmacology , 6 ( 2 ) : 162 – 68 .
  • Schmoldt , A. , lwersen-Bergmann , S. , Stein , S. , Franzelius , C. and Heinemann , A. 1999 . Methadon-Todesfalle und lntoxikationen im Umfeld der Substituierten und bei Drogenkonsimenten . Hamburger Arzteblatt , 43 : 835 – 44 .
  • Schoenbaum , E. E. , Hartel , D. , Selwyn , P. A. , Klein , R. S. and Davenny , K. 1989 . Risk factors for human immunodeficiency virus infection in intravenous drug users . New England Journal of Medicine , 321 : 874 – 79 .
  • Seitzer , M. L. , Iguchi , M. Y. and Felch , L. J. 1992 . Contingent take home incentive: Effects on drug use of methadone maintenance patients . Journal of Applied Behavior Analysis , 15 : 493 – 503 .
  • Seitzer , M. L. , Iguchi , M. Y. , Kidorf , M. and Bigelow , G. E. 1993 . “ Contingency management in methadone treatment: The case for positive incentives. ” . In Behavioral Treatment for Drug Abuse and Dependence. Edited by: Onken , L. S. , Blaine , J. D. and Boren , J. J. Washington, D.C. : US Dept of Health and Human Services. . NIH Pub no. 93–3684: 19–36.
  • Senay , E. C. 1985 . Methadone maintenance treatment . International Journal of the Addictions , 20 : 803 – 21 .
  • Seymour , A. , Black , M. , Jay , J. , Cooper , G. and Weir , C. 2003 . The role of methadone in drug related deaths in the west of Scotland . Addiction , 98 : 995 – 1002 .
  • Strain , E. C. , Biegelow , G. E. , Liebson , I. A. and Steizer , M. 1999 . Moderate vs high-dose methadone in the treatment of opioid dependence: A randomized trial . Journal of the American Medical Association , 281 ( II ) : 1000 – 5 .
  • Strain , E. C. , Steitzer , M. L. , Liebson , I. A. and Bigelow , G. E. 1993 . Dose response effects of methadone in the treatment of opioid dependence . Annals of Internal Medicine , 119 : 23 – 27 .
  • Tennent , F. S. , Rawson , R. A. , Cohen , A. , Tasrver , A. and Clabough , D. 1984 . “ Methadone plasma levels and persistent drug abuse in high dose maintenance patients. ” . In Problems of Drug Dependence,1983. Edited by: Harris , L. Rockville, MD : NIDA. . NIDA Research Monograph #49.
  • Tims , F. M. and Ludford , J. P. 1984 . Drug Abuse Treatment Evaluation: Strategies, Process and Prospects. Rockville, MD : NIDA. .
  • Vanichseni , S. , Wongsuwan , B. , Choopanya , K. and Wongpanich , K. A. 1991 . Controlled trial of methadone maintenance in a population of intravenous drug users in Bangkok: implications for prevention of HIV . lnternativnal Journal of the Addictions , 26 : 1313 – 20 . Staff of the BMA Narcotics Clinic no. 6
  • Vieweg , W. V.R. and Wood , M. A. 2004 . Tricyclic antidepressants, QT interval and torsade de pointes . Psychosomatics , 45 ( 5 ) : 371 – 77 .
  • Vincent , G. M. 2000 . Long QT Syndrome . Cardiology Clinics , 16 : 309 – 25 .
  • Vormfelde , S. V. and Poser , W. 2001 . Deaths attributed to methadone . Pharmacopsychiatry , 34 : 217 – 22 .
  • Walker , P. W. , Klein , D. and Kasza , L. 2003 . High dose methadone and ventricular arrhythmias: A report of three cases . Pain , 103 ( 3 ) : 321 – 24 .
  • Ward , J. , Mattick , R. P. , Hall , W. and Darke , S. 1996 . The effectiveness and safety of methadone maintenance . Addiction , 91 ( 11 ) : 1727 – 29 .
  • Wolff , K. , Sanderson , M. , Hay , A. W.M. and Raistrick , D. 1991 . Methadone concentration in plasma and their relationship to drug dosage . Clinical Chemistry , 37 : 205 – 09 .
  • Yankovitz , S. R. , Des Jarlais , D. C. , Peyser , N. P. , Drew , E. and Friedmann , P . 1991 . A randomized trial of an interim methadone maintenance clinic . American Journal of Public Health , 81 : 1185 – 91 .
  • Zador , D. and Sunjic , S. 2000 . Deaths in methadone maintenance treatment in New South Wales Australia, 1990–1995 . Addiction , 95 ( 1 ) : 77 – 84 .
  • Zanis , D. A. and Woody , G. E. 1998 . One-year mortality rates following methadone treatment discharge . Drug and Alcohol Dependence , 52 ( 3 ) : 257 – 60 .

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