The potential benefits from respiratory gating for breast cancer patients regarding target coverage and dose to organs at risk when applying strict dose limits to the heart: results from the DBCG HYPO trial

References

• Overgaard M, Jensen M-B, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999;353:1641–1648.
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet. 2011;378:771–784.
   PubMed Web of Science ®Google Scholar
• Bodilsen A, Offersen BV, Christiansen P, et al. Pattern of relapse after breast conserving therapy, a study of 1519 early breast cancer patients treated in the Central Region of Denmark 2000–2009. Acta Oncol. 2016;55:964–969.
   PubMed Web of Science ®Google Scholar
• Taylor C, Candace C, Duane FK, et al. Estimating the risks of breast cancer radiotherapy: evidence from modern radiation doses to the lungs and heart and from previous randomized trials. JCO. 2017;35:1641–1649.
   PubMed Web of Science ®Google Scholar
• Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987–998.
   PubMed Web of Science ®Google Scholar
• Rehammar JC, Jensen M-B, McGale P, et al. Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977–2005. Radiother Oncol. 2017;123:229–305.
   Web of Science ®Google Scholar
• Taylor CW, Wang Z, Macaulay E, et al. Exposure of the heart in breast cancer radiation therapy: a systematic review of heart doses published during 2003 to 2013. Int J Radiat Oncol Biol Phys. 2015;93:845–853.
   PubMed Web of Science ®Google Scholar
• Thorsen LBJ, Thomsen MS, Berg M, et al. CT-planned internal mammary node radiotherapy in the DBCG-IMN study: benefit versus potentially harmful effects. Acta Oncol. 2014;53:1027–1034.
   PubMed Web of Science ®Google Scholar
• Thorsen LBJ, Thomsen MS, Overgaard M, et al. Quality assurance of conventional non-CT-based internal mammary lymph node irradiation in a prospective Danish Breast Cancer Cooperative Group trial: the DBCG-IMN study. Acta Oncol. 2013;52:1526–1534.
   PubMed Web of Science ®Google Scholar
• Thorsen LBJ, Offersen BV, Danø H, et al. DBCG-IMN: a population-based cohort study on the effect of internal mammary node irradiation in early node-positive breast cancer. J Clin Oncol. 2016;34:314–321.
   PubMed Web of Science ®Google Scholar
• Whelan TJ, Olivotto IA, Parulekar WR, et al. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373:307–316.
   PubMed Web of Science ®Google Scholar
• Poortmans PM, Collette S, Kirkove C, et al. Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med. 2015;373:317–327.
   PubMed Web of Science ®Google Scholar
• Nilsson G, Holmberg L, Garmo H, et al. Distribution of coronary artery stenosis after radiation for breast cancer. JCO. 2012;30:380–386.
   PubMed Web of Science ®Google Scholar
• Correa CR, Litt HI, Hwang W-T, et al. Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. JCO. 2007;25:3031–3037.
   PubMed Web of Science ®Google Scholar
• Nilsson G, Witt Nyström P, Isacsson U, et al. Radiation dose distribution in coronary arteries in breast cancer radiotherapy. Acta Oncol. 2017;55:959–963.
   Google Scholar
• Nissen HN, Appelt A. Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients. Radiother Oncol. 2013;106:28–32.
   PubMed Web of Science ®Google Scholar
• Korreman SS, Pedersen AN, Nøttrup TJ, et al. Breathing adapted radiotherapy for breast cancer: Comparison of free breathing gating with the breath-hold technique. Radiother Oncol. 2005;76:311–318.
   PubMed Web of Science ®Google Scholar
• Rice L, Goldsmith C, Green MLM, et al. An effective deep-inspiration breath-hold radiotherapy technique for left-breast cancer: impact of post-mastectomy treatment, nodal coverage, and dose schedule on organs at risk. BCTT. 2017;9:437–446.
   Google Scholar
• Damkjaer SM, Aznar MC, Pedersen AN, et al. Reduced lung dose and improved inspiration level reproducibility in visually guided DIBH compared to audio coached EIG radiotherapy for breast cancer patients. Acta Oncol. 2013;52:1458–1463.
   PubMed Web of Science ®Google Scholar
• Jensen M-B, Laenkholm A-V, Offersen BV, et al. The clinical database and implementation of treatment guidelines by the Danish Breast Cancer Cooperative Group in 2007–2016. Acta Oncol. Forthcoming. Available from: https://doi.org/10.1080/0284186X.2017.1404638
   Web of Science ®Google Scholar
• Westberg J, Krogh S, Brink C, et al. A DICOM based radiotherapy plan database for research collaboration and reporting. J Phys: Conf Ser. 2014;489:012100.
   Google Scholar
• Nielsen MH, Berg M, Pedersen AN, et al. Delineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: national guidelines and contouring atlas by the Danish Breast Cancer Cooperative Group. Acta Oncol. 2013;52:703–710.
   PubMed Web of Science ®Google Scholar
• Lorenzen EL, Taylow CW, Maraldo M, et al. Inter-observer variation in delineation of the heart and left anterior descending coronary artery in radiotherapy for breast cancer: a multi-centre study from Denmark and the UK. Radiother Oncol. 2013;108:254–258.
   PubMed Web of Science ®Google Scholar
• Essers M, Poortmans PM, Verschueren K, et al. Should breathing adapted radiotherapy also be applied for right-sided breast irradiation?. Acta Oncol. 2016;55:460–465.
   PubMed Web of Science ®Google Scholar
• Lorenzen EL, Brink C, Taylor CW, et al. Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy. Radiother Oncol. 2016;119:71–76.
   PubMed Web of Science ®Google Scholar
• Schönecker S, Walter F, Freislederer P, et al. Treatment planning and evaluation of gated radiotherapy in left-sided breast cancer patients using the CatalystTM/SentinelTM system for deep inspiration breath-hold (DIBH). Radiat Oncol. 2016;11:143.
   PubMed Web of Science ®Google Scholar