Acta Oncologica, Volume 57, Issue 1 (2018)

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Acta Oncologica, Volume 57, Issue 1 (2018)

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Papers at the occasion of the 40-years anniversary of DBCG – the Danish Breast Cancer Cooperative Group and the 16th Acta Oncologica Symposium, Aarhus, Denmark - January 18-19, 2018

EDITORIAL

Editorial
Is DBCG abreast of new developments?
Birgitte V. Offersen, Bent Ejlertsen, Eva Balslev, Henrik Flyger, Anne-Marie Gerdes, Mads K. Hansen, Lisbet R. Hølmich, Maj-Britt Jensen, Bent Kristensen, Anne-Vibeke Laenkholm, Henning T. Mouridsen, Mette H. Nielsen, Jens Overgaard, Malgorzata Tuxen, Ilse Vejborg & Peer Christiansen
Pages: 1-2
Published online: 03 Jan 2018
CitationforIs DBCG abreast of new developments? | Full Text | PDF (337.4 KB)
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ORIGINAL ARTICLES

Article
Forty years of landmark trials undertaken by the Danish Breast Cancer Cooperative Group (DBCG) nationwide or in international collaboration
Bent Ejlertsen, Birgitte Vrou Offersen, Jens Overgaard, Peer Christiansen, Maj-Britt Jensen, Niels Kroman, Ann Søgaard Knoop & Henning Mouridsen
Pages: 3-12
Published online: 05 Dec 2017
AbstractforForty years of landmark trials undertaken by the Danish Breast Cancer Cooperative Group (DBCG) nationwide or in international collaboration | Full Text | References | PDF (1 MB)
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Article
The clinical database and implementation of treatment guidelines by the Danish Breast Cancer Cooperative Group in 2007–2016
Maj-Britt Jensen, Anne-Vibeke Laenkholm, Birgitte V. Offersen, Peer Christiansen, Niels Kroman, Henning T. Mouridsen & Bent Ejlertsen
Pages: 13-18
Published online: 05 Dec 2017
AbstractforThe clinical database and implementation of treatment guidelines by the Danish Breast Cancer Cooperative Group in 2007–2016 | Full Text | References | PDF (780.7 KB) | Supplemental
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Article
Breast conserving surgery versus mastectomy: overall and relative survival—a population based study by the Danish Breast Cancer Cooperative Group (DBCG)
Peer Christiansen, Stina Lyck Carstensen, Bent Ejlertsen, Niels Kroman, Birgitte Offersen, Anne Bodilsen & Maj-Britt Jensen
Pages: 19-25
Published online: 23 Nov 2017
AbstractforBreast conserving surgery versus mastectomy: overall and relative survival—a population based study by the Danish Breast Cancer Cooperative Group (DBCG) | Full Text | References | PDF (901 KB) | Supplemental
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Article
Two years of tamoxifen or no adjuvant systemic therapy for patients with high-risk breast cancer: long-term follow-up of the Copenhagen breast cancer trial
Maj-Britt Jensen, Jens Fabricius Krarup, Torben Palshof, Henning T. Mouridsen & Bent Ejlertsen
Pages: 26-30
Published online: 22 Nov 2017
AbstractforTwo years of tamoxifen or no adjuvant systemic therapy for patients with high-risk breast cancer: long-term follow-up of the Copenhagen breast cancer trial | Full Text | References | PDF (578.9 KB)
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Article
Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG)
Signe Korsgaard Skriver, Anne-Vibeke Laenkholm, Birgitte Bruun Rasmussen, Jürgen Handler, Bo Grundtmann, Tove Filtenborg Tvedskov, Peer Christiansen, Ann S. Knoop, Maj-Britt Jensen & Bent Ejlertsen
Pages: 31-37
Published online: 23 Nov 2017
AbstractforNeoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG) | Full Text | References | PDF (858.3 KB) | Supplemental
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Article
Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy – results from two independent randomized trials
Tinne Laurberg, Trine Tramm, Torsten Nielsen, Jan Alsner, Silje Nord, Simen Myhre, Therese Sørlie, Samuel Leung, Cheng Fan, Charles Perou, Karen Gelmon, Jens Overgaard, David Voduc, Aleix Prat & Maggie Chon U. Cheang
Pages: 38-43
Published online: 25 Nov 2017
AbstractforIntrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy – results from two independent randomized trials | Full Text | References | PDF (739 KB) | Supplemental
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Article
The ability of PAM50 risk of recurrence score to predict 10-year distant recurrence in hormone receptor-positive postmenopausal women with special histological subtypes
Anne-Vibeke Laenkholm, Maj-Britt Jensen, Jens Ole Eriksen, Wesley Buckingham, Sean Ferree, Torsten O. Nielsen & Bent Ejlertsen
Pages: 44-50
Published online: 04 Dec 2017
AbstractforThe ability of PAM50 risk of recurrence score to predict 10-year distant recurrence in hormone receptor-positive postmenopausal women with special histological subtypes | Full Text | References | PDF (907.5 KB) | Supplemental
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Article
Characterization of basal-like subtype in a Danish consecutive primary breast cancer cohort
Savvas Kinalis, Finn Cilius Nielsen, Maj-Lis Talman, Bent Ejlertsen & Maria Rossing
Pages: 51-57
Published online: 22 Nov 2017
AbstractforCharacterization of basal-like subtype in a Danish consecutive primary breast cancer cohort | Full Text | References | PDF (2 MB)
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Article
Molecular subtyping of breast cancer improves identification of both high and low risk patients
Maria Rossing, Olga Østrup, Wiktor W. Majewski, Savvas Kinalis, Maj-Britt Jensen, Ann Knoop, Niels Kroman, Maj-Lis Talman, Thomas V. O. Hansen, Bent Ejlertsen & Finn C. Nielsen
Pages: 58-66
Published online: 22 Nov 2017
AbstractforMolecular subtyping of breast cancer improves identification of both high and low risk patients | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer
Anne E. Lykkesfeldt, Benedikte R. Iversen, Maj-Britt Jensen, Bent Ejlertsen, Anita Giobbie-Hurder, Birgit E. Reiter, Tove Kirkegaard & Birgitte B. Rasmussen
Pages: 67-73
Published online: 04 Dec 2017
AbstractforAurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer | Full Text | References | PDF (836.3 KB)
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REVIEW

Review
Triple negative breast cancer – prognostic role of immune-related factors: a systematic review
Elisabeth Specht Stovgaard, Dorte Nielsen, Estrid Hogdall & Eva Balslev
Pages: 74-82
Published online: 23 Nov 2017
AbstractforTriple negative breast cancer – prognostic role of immune-related factors: a systematic review | Full Text | References | PDF (810.8 KB)
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ORIGINAL ARTICLES

Article
An inter-observer Ki67 reproducibility study applying two different assessment methods: on behalf of the Danish Scientific Committee of Pathology, Danish breast cancer cooperative group (DBCG)
Anne-Vibeke Laenkholm, Dorthe Grabau, Maj-Lis Møller Talman, Eva Balslev, Anne Marie Bak Jylling, Tomasz Piotr Tabor, Morten Johansen, Anja Brügmann, Giedrius Lelkaitis, Tina Di Caterino, Henrik Mygind, Thomas Poulsen, Henrik Mertz, Gorm Søndergaard & Birgitte Bruun Rasmussen
Pages: 83-89
Published online: 05 Dec 2017
AbstractforAn inter-observer Ki67 reproducibility study applying two different assessment methods: on behalf of the Danish Scientific Committee of Pathology, Danish breast cancer cooperative group (DBCG) | Full Text | References | PDF (1,021.6 KB)
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Article
Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists
Trine Tramm, Tina Di Caterino, Anne-Marie B. Jylling, Giedrius Lelkaitis, Anne-Vibeke Lænkholm, Péter Ragó, Tomasz P. Tabor, Maj-Lis M. Talman, Emmanouela Vouza & On behalf of the Scientific Committee of Pathology, Danish Breast Cancer Group (DBCG)
Pages: 90-94
Published online: 23 Nov 2017
AbstractforStandardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists | Full Text | References | PDF (826.6 KB) | Supplemental
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Article
Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG
I. M. H. Soenderstrup, A. V. Laenkholm, M. B. Jensen, J. O. Eriksen, A. M. Gerdes, T. V. O. Hansen, T. A. Kruse, M. J. Larsen, I. S. Pedersen, M. Rossing, M. Thomassen & B. Ejlertsen
Pages: 95-101
Published online: 22 Nov 2017
AbstractforClinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG | Full Text | References | PDF (770.6 KB)
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Article
Influence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer
Trine Tramm, Marianne Kyndi, Flemming B. Sørensen, Jens Overgaard & Jan Alsner
Pages: 102-106
Published online: 04 Dec 2017
AbstractforInfluence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer | Full Text | References | PDF (681.1 KB) | Supplemental
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Article
DBCG hypo trial validation of radiotherapy parameters from a national data bank versus manual reporting
Carsten Brink, Ebbe L. Lorenzen, Simon Long Krogh, Jonas Westberg, Martin Berg, Ingelise Jensen, Mette Skovhus Thomsen, Esben Svitzer Yates & Birgitte Vrou Offersen
Pages: 107-112
Published online: 05 Dec 2017
AbstractforDBCG hypo trial validation of radiotherapy parameters from a national data bank versus manual reporting | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
The potential benefits from respiratory gating for breast cancer patients regarding target coverage and dose to organs at risk when applying strict dose limits to the heart: results from the DBCG HYPO trial
Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mette S. Thomsen, Christina Maria Lutz, Lasse Refsgaard, Henrik D. Nissen & Birgitte V. Offersen
Pages: 113-119
Published online: 05 Dec 2017
AbstractforThe potential benefits from respiratory gating for breast cancer patients regarding target coverage and dose to organs at risk when applying strict dose limits to the heart: results from the DBCG HYPO trial | Full Text | References | PDF (951.2 KB)
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Article
Concurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database
Deirdre Cronin-Fenton, Timothy L. Lash, Thomas P. Ahern, Per Damkier, Peer Christiansen, Bent Ejlertsen & Henrik T. Sørensen
Pages: 120-128
Published online: 05 Dec 2017
AbstractforConcurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database | Full Text | References | PDF (957.5 KB)
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Article
Influence of specific comorbidities on survival after early-stage breast cancer
Marianne Ewertz, Lotte Holm Land, Susanne Oksbjerg Dalton, Deirdre Cronin-Fenton & Maj-Britt Jensen
Pages: 129-134
Published online: 05 Dec 2017
AbstractforInfluence of specific comorbidities on survival after early-stage breast cancer | Full Text | References | PDF (607.8 KB) | Supplemental
  • 2959 Views
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Article
Mortality and recurrence rates among systemically untreated high risk breast cancer patients included in the DBCG 77 trials
Maj-Britt Jensen, Torsten O. Nielsen, Ann S. Knoop, Anne-Vibeke Laenkholm, Eva Balslev & Bent Ejlertsen
Pages: 135-140
Published online: 23 Nov 2017
AbstractforMortality and recurrence rates among systemically untreated high risk breast cancer patients included in the DBCG 77 trials | Full Text | References | PDF (1 MB) | Supplemental
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Article
The occurrence of fractures after adjuvant treatment of breast cancer: a DBCG register study
Bent Kristensen, Bent Ejlertsen, Maj-Britt Jensen, Henning T. Mouridsen & for the Danish Breast Cancer Cooperative Group
Pages: 141-145
Published online: 23 Nov 2017
AbstractforThe occurrence of fractures after adjuvant treatment of breast cancer: a DBCG register study | Full Text | References | PDF (656.5 KB)
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Article
Quality of life and care needs in women with estrogen positive metastatic breast cancer: a qualitative study
Gitte Lee Mortensen, Ivan Bredbjerg Madsen, Randi Krogsgaard & Bent Ejlertsen
Pages: 146-151
Published online: 05 Dec 2017
AbstractforQuality of life and care needs in women with estrogen positive metastatic breast cancer: a qualitative study | Full Text | References | PDF (696.8 KB) | Supplemental
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LETTERS TO THE EDITOR

Letter
Breast cancer patient advocacy in Denmark
Eva Bundesen
Pages: 152-153
Published online: 05 Dec 2017
CitationforBreast cancer patient advocacy in Denmark | Full Text | PDF (251.7 KB)
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Letter
Provision of data from the clinical database and of biological material from the tumor bank of the Danish Breast Cancer Cooperative Group 2008–2017
Henning Mouridsen, Peer Christiansen, Maj-Britt Jensen, Anne-Vibeke Laenkholm, Henrik Flyger, Birgitte Offersen, Ilse Vejborg & Bent Ejlertsen
Pages: 154-156
Published online: 05 Dec 2017
First Page PreviewforProvision of data from the clinical database and of biological material from the tumor bank of the Danish Breast Cancer Cooperative Group 2008–2017 | Full Text | References | PDF (577.7 KB) | Supplemental
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Letter
Palliative treatment with carboplatin as late line therapy to patients with metastatic breast cancer
Lena H. Rosvig, Sven T. Langkjer, Ann Knoop & Anders B. Jensen
Pages: 156-159
Published online: 05 Dec 2017
First Page PreviewforPalliative treatment with carboplatin as late line therapy to patients with metastatic breast cancer | Full Text | References | PDF (538.1 KB) | Supplemental
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Letter
A Danish national effort of BRCA1/2 variant classification
Inge Søkilde Pedersen, Ane Y. Schmidt, Birgitte Bertelsen, Anja Ernst, Christian Liebst Toft Andersen, Torben Kruse, Maria Rossing & Mads Thomassen
Pages: 159-162
Published online: 23 Nov 2017
First Page PreviewforA Danish national effort of BRCA1/2 variant classification | Full Text | References | PDF (929.8 KB) | Supplemental
  • 1944 Views
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Letter
The accuracy of preoperative staging of the axilla in primary breast cancer: a national register based study on behalf of Danish Breast Cancer Group (DBCG)
Kristine Hamran, Linnea Langhans, Ilse Vejborg, Tove Filtenborg Tvedskov & Niels Kroman
Pages: 162-166
Published online: 05 Dec 2017
First Page PreviewforThe accuracy of preoperative staging of the axilla in primary breast cancer: a national register based study on behalf of Danish Breast Cancer Group (DBCG) | Full Text | References | PDF (855.1 KB)
  • 771 Views
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Letter
Axillary lymph node dissection in breast cancer patients after sentinel node biopsy
Christina Jessing, Linnea Langhans, Maj-Britt Jensen, Maj-Lis Talman, Tove Filtenborg Tvedskov & Niels Kroman
Pages: 166-169
Published online: 23 Nov 2017
First Page PreviewforAxillary lymph node dissection in breast cancer patients after sentinel node biopsy | Full Text | References | PDF (514.9 KB) | Supplemental
  • 1574 Views
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Letter
Occult breast cancer in breast reduction specimens
Lotte Meyer, Camilla Bille, Thomas Foged & Anne Marie Bak Jylling
Pages: 170-173
Published online: 04 Dec 2017
First Page PreviewforOccult breast cancer in breast reduction specimens | Full Text | References | PDF (525.3 KB) | Supplemental
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