Interim analysis of patient-reported outcome compliance and dosimetry in a phase 3 randomized clinical trial of oesophagus-sparing spinal radiotherapy

References

• Cole JS, Patchell RA. Metastatic epidural spinal cord compression. Lancet Neurol. 2008;7(5):459–466. doi: 10.1016/S1474-4422(08)70089-9.
   PubMed Web of Science ®Google Scholar
• Oldenburger E, Brown S, Willmann J, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases. Radiother Oncol. 2022;173:240–253. doi: 10.1016/j.radonc.2022.06.002.
   PubMed Web of Science ®Google Scholar
• Rades D, Šegedin B, Conde-Moreno AJ, et al. Radiotherapy with 4 Gy × 5 versus 3 Gy × 10 for metastatic epidural spinal cord compression: final results of the SCORE-2 trial (ARO 2009/01). J Clin Oncol. 2016;34(6):597–602. doi: 10.1200/JCO.2015.64.0862.
   PubMed Web of Science ®Google Scholar
• Maranzano E, Bellavita R, Rossi R, et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol. 2005;23(15):3358–3365. doi: 10.1200/JCO.2005.08.193.
   PubMed Web of Science ®Google Scholar
• Maranzano E, Trippa F, Casale M, et al. 8 Gy single-dose radiotherapy is effective in metastatic spinal cord compression: results of a phase III randomized multicentre Italian trial. Radiother Oncol. 2009;93(2):174–179. doi: 10.1016/j.radonc.2009.05.012.
   PubMed Web of Science ®Google Scholar
• Hoskin PJ, Hopkins K, Misra V, et al. Effect of single-fraction vs multifraction radiotherapy on ambulatory status among patients with spinal canal compression from metastatic cancer: the SCORAD randomized clinical trial. JAMA. 2019;322(21):2084–2094. doi: 10.1001/jama.2019.17913.
   PubMed Web of Science ®Google Scholar
• Thirion PG, Dunne MT, Kelly PJ, et al. Non-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression. Br J Cancer. 2020;122(9):1315–1323. doi: 10.1038/s41416-020-0768-z.
   PubMed Web of Science ®Google Scholar
• Gram V, Fog LS, Hemer M, et al. Patient reported upper gastro-intestinal symptoms associated with fractionated image-guided conformal radiotherapy for metastatic spinal cord compression. Tech Innov Patient Support Radiat Oncol. 2020;13:1–5. doi: 10.1016/j.tipsro.2019.11.008.
   PubMedGoogle Scholar
• Gram VR, Gram D, Persson GF, et al. Reduction of oesophageal toxicity with VMAT dose-sparing radiotherapy in thoracic metastatic spinal cord compression: a feasibility study. Tech Innov Patient Support Radiat Oncol. 2022;23:8–14. doi: 10.1016/j.tipsro.2022.07.001.
   PubMedGoogle Scholar
• Stevens R, Macbeth F, Toy E, et al. Palliative radiotherapy regimens for patients with thoracic symptoms from non‐small cell lung cancer. Cochrane Database Syst Rev. 2015;1:CD002143.
   PubMedGoogle Scholar
• Louie AV, Granton PV, Fairchild A, et al. Palliative radiation for advanced Central lung tumors with intentional avoidance of the esophagus (PROACTIVE): a phase 3 randomized clinical trial. JAMA Oncol. 2022;8(4):1–7. doi: 10.1001/jamaoncol.2021.7664.
   PubMed Web of Science ®Google Scholar
• Kamran SC, Yeap BY, Ulysse CA, et al. Assessment of a contralateral esophagus-sparing technique in locally advanced lung cancer treated with high-dose chemoradiation. A phase 1 nonrandomized trial. JAMA Oncol. 2021;7(6):910–914. doi: 10.1001/jamaoncol.2021.0281.
   PubMed Web of Science ®Google Scholar
• Abu-Hegazy M, Wahba HA. Single-versus multi-fraction radiation treatment for metastatic spinal cord compression: functional outcome study. Chin Ger J Clin Oncol. 2011;10(9):535–540. doi: 10.1007/s10330-011-0832-5.
   Google Scholar
• Lee KA, Dunne M, Small C, et al. ICORG 05-03: prospective randomized non-inferiority phase III trial comparing two radiation schedules in malignant spinal cord compression (not proceeding with surgical decompression); the quality-of-life analysis. Acta Oncol. 2018;57(7):965–972. doi: 10.1080/0284186X.2018.1433320.
   PubMed Web of Science ®Google Scholar
• Rades D, Šegedin B, Conde-Moreno AJ, et al. Patient-reported outcomes-secondary analysis of the SCORE-2 trial comparing 4 Gy × 5 to 3 Gy × 10 for metastatic epidural spinal cord compression. Int J Radiat Oncol Biol Phys. 2019;105(4):760–764. doi: 10.1016/j.ijrobp.2019.08.002.
   PubMed Web of Science ®Google Scholar
• Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Ann Intern Med. 2010;152(11):726–732. doi: 10.7326/0003-4819-152-11-201006010-00232.
   PubMed Web of Science ®Google Scholar
• Tokuhashi Y, Uei H, Oshima M, et al. Scoring system for prediction of metastatic spine tumor prognosis. World J Orthop. 2014;5(3):262–271. doi: 10.5312/wjo.v5.i3.262.
   PubMedGoogle Scholar
• Rades D, Hueppe M, Schild SE. A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care. Cancer. 2013;119(4):897–903. doi: 10.1002/cncr.27849.
   PubMed Web of Science ®Google Scholar
• Rades D, Rudat V, Veninga T, et al. A score predicting posttreatment ambulatory status in patients irradiated for metastatic spinal cord compression. Int J Radiat Oncol Biol Phys. 2008;72(3):905–908. doi: 10.1016/j.ijrobp.2008.02.018.
   PubMed Web of Science ®Google Scholar
• Bartels RHMA, Feuth T, Van Der Maazen R, et al. Development of a model with which to predict the life expectancy of patients with spinal epidural metastasis. Cancer. 2007;110(9):2042–2049. doi: 10.1002/cncr.23002.
   PubMed Web of Science ®Google Scholar
• Donovan EK, Sienna J, Mitera G, et al. Systematic review single versus multifraction radiotherapy for spinal cord compression: a systematic review and meta-analysis. Radiother Oncol. 2019;134:55–66. doi: 10.1016/j.radonc.2019.01.019.
   PubMed Web of Science ®Google Scholar