Linear energy transfer-inclusive brainstem necrosis risk models applied to an independent paediatric proton therapy cohort

References

• Yock TI, Constine LS, Mahajan A. Protons, the brainstem, and toxicity: ingredients for an emerging dialectic. Acta Oncol. 2014;53(10):1279–1282. doi: 10.3109/0284186X.2014.957415.
   PubMed Web of Science ®Google Scholar
• Indelicato DJ, Flampouri S, Rotondo RL, et al. Incidence and dosimetric parameters of pediatric brainstem toxicity following proton therapy. Acta Oncol. 2014;53(10):1298–1304. doi: 10.3109/0284186X.2014.957414.
   PubMed Web of Science ®Google Scholar
• Stokkevag CH, Indelicato DJ, Herfarth K, et al. Normal tissue complication probability models in plan evaluation of children with brain tumors referred to proton therapy. Acta Oncol. 2019;58(10):1416–1422. doi: 10.1080/0284186X.2019.1643496.
   PubMed Web of Science ®Google Scholar
• Paganetti H, Niemierko A, Ancukiewicz M, et al. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002;53(2):407–421. doi: 10.1016/s0360-3016(02)02754-2.
   PubMed Web of Science ®Google Scholar
• Underwood TSA, McNamara AL, Appelt A, et al. A systematic review of clinical studies on variable proton relative biological effectiveness (RBE). Radiother Oncol. 2022;175:79–92. doi: 10.1016/j.radonc.2022.08.014.
   PubMed Web of Science ®Google Scholar
• Handeland AH, Indelicato DJ, Fjæra LF, et al. Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma. Phys Imaging Radiat Oncol. 2023;27:100466. doi: 10.1016/j.phro.2023.100466.
   PubMedGoogle Scholar
• Fjæra LF, Indelicato DJ, Handeland AH, et al. A case-control study of linear energy transfer and relative biological effectiveness related to symptomatic brainstem toxicity following pediatric proton therapy. Radiother Oncol. 2022;175:47–55. doi: 10.1016/j.radonc.2022.07.022.
   PubMed Web of Science ®Google Scholar
• Engeseth GM, Stokkevåg C, Muren LP. Achievements and challenges in normal tissue response modelling for proton therapy. Phys Imaging Radiat Oncol. 2022;24:118–120. doi: 10.1016/j.phro.2022.11.004.
   PubMedGoogle Scholar
• Bentzen SM, Constine LS, Deasy JO, et al. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S3–S9. doi: 10.1016/j.ijrobp.2009.09.040.
   PubMed Web of Science ®Google Scholar
• Gentile MS, Yeap BY, Paganetti H, et al. Brainstem injury in pediatric patients with posterior fossa tumors treated with proton beam therapy and associated dosimetric factors. Int J Radiat Oncol Biol Phys. 2018;100(3):719–729. doi: 10.1016/j.ijrobp.2017.11.026.
   PubMed Web of Science ®Google Scholar
• Haas-Kogan D, Indelicato D, Paganetti H, et al. National cancer institute workshop on proton therapy for children: considerations regarding brainstem injury. Int J Radiat Oncol Biol Phys. 2018;101(1):152–168. doi: 10.1016/j.ijrobp.2018.01.013.
   PubMed Web of Science ®Google Scholar
• Indelicato DJ, Bradley JA, Rotondo RL, et al. Outcomes following proton therapy for pediatric ependymoma. Acta Oncol. 2018;57(5):644–648. doi: 10.1080/0284186X.2017.1413248.
   PubMed Web of Science ®Google Scholar
• Hahn C, Heuchel L, Ödén J, et al. Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges. Radiat Oncol. 2022;17(1):169. doi: 10.1186/s13014-022-02143-x.
   PubMed Web of Science ®Google Scholar
• Liu C, Patel SH, Shan J, et al. Robust optimization for intensity modulated proton therapy to redistribute high linear energy transfer from nearby critical organs to tumors in head and neck cancer. Int J Radiat Oncol Biol Phys. 2020;107(1):181–193. doi: 10.1016/j.ijrobp.2020.01.013.
   PubMed Web of Science ®Google Scholar
• Rana S, Traneus E, Jackson M, et al. Quantitative analysis of dose-averaged linear energy transfer (LETd) robustness in pencil beam scanning proton lung plans. Med Phys. 2022;49(5):3444–3456. doi: 10.1002/mp.15569.
   PubMed Web of Science ®Google Scholar
• Hahn C, Eulitz J, Peters N, et al. Impact of range uncertainty on clinical distributions of linear energy transfer and biological effectiveness in proton therapy. Med Phys. 2020;47(12):6151–6162. doi: 10.1002/mp.14560.
   PubMed Web of Science ®Google Scholar
• Toma-Dasu I, Dasu A, Vestergaard A, et al. RBE for proton radiation therapy – a Nordic view in the international perspective. Acta Oncol. 2020;59(10):1151–1156. doi: 10.1080/0284186X.2020.1826573.
   PubMed Web of Science ®Google Scholar
• Mayo C, Yorke E, Merchant TE. Radiation associated brainstem injury. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S36–S41. doi: 10.1016/j.ijrobp.2009.08.078.
   PubMed Web of Science ®Google Scholar
• Grassberger C, Trofimov A, Lomax A, et al. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011;80(5):1559–1566. doi: 10.1016/j.ijrobp.2010.10.027.
   PubMed Web of Science ®Google Scholar