Parameters for proton minibeam radiotherapy using a clinical scanning beam system

References

• Amendola B, Perez NC, Mayr N, et al. Spatially fractionated radiation therapy with lattice radiation in far-advanced bulky cervical cancer: a clinical and molecular imaging outcome study. Radiat Res. 2020;194:724–736.
   PubMed Web of Science ®Google Scholar
• Choi JI, Daniels J, Cohen D, et al. Clinical outcomes of spatially fractionated GRID radiotherapy in the treatment of bulky tumors of the head and neck. Cureus. 2019;11(5):e4637. doi: 10.7759/cureus.4637.
   PubMed Web of Science ®Google Scholar
• Martí Nez-Rovira I, Fois G, Prezado Y. Dosimetric evaluation of new approaches in GRID therapy using nonconventional radiation sources: dosimetric evaluation of new approaches in GRID therapy. Med Phys. 2015;42(2):685–693. doi: 10.1118/1.4905042.
   PubMed Web of Science ®Google Scholar
• Snider J, Molitoris J, Shyu S, et al. Spatially fractionated radiotherapy (GRID) prior to standard neoadjuvant conventionally fractionated radiotherapy for bulky, High-Risk soft tissue and osteosarcomas: feasibility, safety, and promising pathologic response rates. Radiat Res. 2020;194:707–714.
   PubMed Web of Science ®Google Scholar
• Yan W, Khan MK, Wu X, et al. Spatially fractionated radiation therapy: history, present and the future. Clin Transl Radiat Oncol. 2020;20:30–38. doi: 10.1016/j.ctro.2019.10.004.
   PubMed Web of Science ®Google Scholar
• Prezado Y, Jouvion G, Patriarca A, et al. Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas. Sci Rep. 2018;8(1):16479–16410. doi: 10.1038/s41598-018-34796-8.
   PubMedGoogle Scholar
• Prezado Y, Jouvion G, Guardiola C, et al. Tumor control in RG2 Glioma-Bearing rats: a comparison between proton minibeam therapy and standard proton therapy. Int J Radiat Oncol Biol Phys. 2019;104(2):266–271. doi: 10.1016/j.ijrobp.2019.01.080.
   PubMed Web of Science ®Google Scholar
• Mohiuddin M, Lynch C, Gao M, et al. Early clinical results of proton spatially fractionated GRID radiation therapy (SFGRT). Br J Radiol. 2020;93(1107):20190572. doi: 10.1259/bjr.20190572.
   PubMed Web of Science ®Google Scholar
• Girst S, Greubel C, Reindl J, et al. Proton minibeam radiation therapy reduces side effects in an in vivo mouse ear model. Int J Radiat Oncol Biol Phys. 2016;95(1):234–241. doi: 10.1016/j.ijrobp.2015.10.020.
   PubMed Web of Science ®Google Scholar
• Prezado Y. Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors. C R Biol. 2021;344(4):409–420. doi: 10.5802/crbiol.71.
   PubMed Web of Science ®Google Scholar
• Lamirault C, Doyère V, Juchaux M, et al. Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions. Sci Rep. 2020;10(1):13511. doi: 10.1038/s41598-020-70371-w.
   PubMed Web of Science ®Google Scholar
• Overgaard CB, Reaz F, Sitarz M, et al. An experimental setup for proton irradiation of a murine leg model for radiobiological studies. Acta Oncol. 2023;0:1–8. doi: 10.1080/0284186X.2023.2246641.
   Google Scholar
• De Marzi L, Patriarca A, Nauraye C, et al. Implementation of planar proton minibeam radiation therapy using a pencil beam scanning system: a proof of concept study. Med Phys. 2018;45(11):5305–5316. doi: 10.1002/mp.13209.
   PubMed Web of Science ®Google Scholar
• Guardiola C, Peucelle C, Prezado Y. Optimization of the mechanical collimation for minibeam generation in proton minibeam radiation therapy. Med Phys. 2017;44(4):1470–1478. doi: 10.1002/mp.12131.
   PubMed Web of Science ®Google Scholar
• Sotiropoulos M, Prezado Y. A scanning dynamic collimator for spot-scanning proton minibeam production. Sci Rep. 2021;11(1):18321. doi: 10.1038/s41598-021-97941-w.
   PubMed Web of Science ®Google Scholar
• Schneider T, De Marzi L, Patriarca A, et al. Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical Centre. Sci Rep. 2020;10(1):1384. doi: 10.1038/s41598-020-58052-0.
   PubMed Web of Science ®Google Scholar
• Ortiz R, De Marzi L, Prezado Y. Preclinical dosimetry in proton minibeam radiation therapy: robustness analysis and guidelines. Med Phys. 2022;49(8):5551–5561. doi: 10.1002/mp.15780.
   PubMed Web of Science ®Google Scholar
• Kim M, Hwang UJ, Park K, et al. Dose profile modulation of proton minibeam for clinical application. Cancers (Basel). 2022;14(12):2888. doi: 10.3390/cancers14122888.
   PubMed Web of Science ®Google Scholar
• Allison J, Amako K, Apostolakis J, et al. Geant4 developments and applications. IEEE Trans Nucl Sci. 2006;53(1):270–278. doi: 10.1109/TNS.2006.869826.
   Web of Science ®Google Scholar
• DCPT beam model. GitHub. Available from: https://github.com/APTG/2022_DCPT_LET/tree/main/data/resources/dcpt_beam_model
   Google Scholar
• Lægdsmand PMT. Monte Carlo model for scanning proton beam at the Danish Center for Proton Therapy [Master thesis]. Denmark: Aarhus University; 2020.
   Google Scholar
• Sørensen BS, Bassler N, Nielsen S, et al. Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo. Acta Oncol. 2017;56(11):1387–1391. doi: 10.1080/0284186X.2017.1351621.
   PubMed Web of Science ®Google Scholar
• Sørensen BS, Horsman MR, Alsner J, et al. Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model. Acta Oncol. 2015;54(9):1623–1630. doi: 10.3109/0284186X.2015.1069890.
   PubMed Web of Science ®Google Scholar
• Grevillot L, Frisson T, Zahra N, et al. Optimization of GEANT4 settings for proton pencil beam scanning simulations using GATE. Nucl Instrum Methods Phys Res Sect B Beam Interact Mater At. 2010;268(20):3295–3305. doi: 10.1016/j.nimb.2010.07.011.
   Web of Science ®Google Scholar
• Cirrone P, Cuttone G, Mazzaglia S, et al. Hadrontherapy: a geant4-based tool for proton/ion-therapy studies. Prog Nucl Sci Technol. 2011;2:207–212.
   Google Scholar
• Winterhalter C, Taylor M, Boersma D, et al. Evaluation of GATE-RTion (GATE/Geant4) monte Carlo simulation settings for proton pencil beam scanning quality assurance. Med Phys. 2020;47(11):5817–5828. doi: 10.1002/mp.14481.
   PubMed Web of Science ®Google Scholar
• Volz L, Reidel CA, Durante M, et al. Investigating slit-collimator-produced carbon ion minibeams with high-resolution CMOS sensors. Instruments. 2023;7(2):18. doi: 10.3390/instruments7020018.
   Google Scholar