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Original Articles: BiGART 2023 Issue

HPV testing versus p16 immunohistochemistry in oropharyngeal squamous cell carcinoma: results from the DAHANCA 19 study

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Pages 1384-1388 | Received 14 Aug 2023, Accepted 28 Sep 2023, Published online: 14 Oct 2023

References

  • Lassen P. The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother Oncol. 2010;95(3):371–380. doi: 10.1016/j.radonc.2010.04.022.
  • Lassen P, Eriksen JG, Hamilton-Dutoit S, et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 2009;27(12):1992–1998. doi: 10.1200/JCO.2008.20.2853.
  • Lassen P, Huang SH, Su J, et al. Treatment outcomes and survival following definitive (chemo)radiotherapy in HPV-positive oropharynx cancer: large-scale comparison of DAHANCA vs PMH cohorts. Int J Cancer. 2022;150(8):1329–1340. doi: 10.1002/ijc.33876.
  • Lilja-Fischer JK, Ulhøi BP, Alsner J, et al. Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts. Acta Oncol. 2019;58(10):1489–1494. doi: 10.1080/0284186X.2019.1660802.
  • Lassen P, Overgaard J. Scoring and classification of oropharyngeal carcinoma based on HPV-related p16-expression. Radiother Oncol. 2012;105(2):269–270. doi: 10.1016/j.radonc.2012.09.017.
  • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human papillomaviruses. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 90. Lyon, France: IARC; 2007. p. 1–636.
  • Eriksen JG, Maare C, Johansen J, et al. 5-Y update of the randomized phase III trial DAHANCA19: primary (chemo) RT +/- zalutumumab in HNSCC. Radiother. Oncol. 2018;127: S137–S138. doi: 10.1016/S0167-8140(18)30581-4.
  • Jensen K, Friborg J, Hansen CR, et al. The danish head and neck cancer group (DAHANCA) 2020 radiotherapy guidelines. Radiother Oncol. 2020;151:149–151. doi: 10.1016/j.radonc.2020.07.037.
  • Andersen K, Holm K, Tranberg M, et al. Targeted next generation sequencing for human papillomavirus genotyping in cervical Liquid-Based cytology samples. Cancers (Basel). 2022;14(3):652. doi: 10.3390/cancers14030652.
  • El-Naggar AK, Westra WH. p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency. Head Neck. 2012;34(4):459–461. doi: 10.1002/hed.21974.
  • Mehanna H, Taberna M, von Buchwald C, et al. Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis. Lancet Oncol. 2023;24(3):239–251. doi: 10.1016/S1470-2045(23)00013-X.
  • Larsen CG, Jensen DH, Carlander A-LF, et al. Novel nomograms for survival and progression in HPV + and HPV- oropharyngeal cancer: a population-based study of 1,542 consecutive patients. Oncotarget. 2016;7(44):71761–71772. doi: 10.18632/oncotarget.12335.
  • Bentzen J, Toustrup K, Eriksen JG, et al. Locally advanced head and neck cancer treated with accelerated radiotherapy, the hypoxic modifier nimorazole and weekly cisplatin. Results from the DAHANCA 18 phase II study. Acta Oncol. 2015;54(7):1001–1007. doi: 10.3109/0284186X.2014.992547.
  • Lassen P, Alsner J, Andrup Kristensen C, et al. OC-0105: Incidence and survival after HPV + and HPV- oropharynx cancer in Denmark 1986-2020 - A DAHANCA study. Radiother Oncol. 2023;182: S66–S67. doi: 10.1016/S0167-8140(23)08519-5.
  • Mehanna H, Robinson M, Hartley A, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet. 2019;393(10166):51–60. doi: 10.1016/S0140-6736(18)32752-1.
  • Gillison ML, Trotti AM, Harris J, et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet. 2019;393(10166):40–50. doi: 10.1016/S0140-6736(18)32779-X.

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