740
Views
4
CrossRef citations to date
0
Altmetric
Vaccines

Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality-of-life and other patient-reported outcomes in adults receiving add-on therapy

&
Pages 1245-1251 | Received 24 Jul 2017, Accepted 08 Dec 2017, Published online: 18 Jan 2018

References

  • Geldmacher H, Biller H, Herbst A, et al. Die Prävalenz der chronisch obstruktiven Lungenerkrankung (COPD) in Deutschland. [The prevalence of chronic obstructive pulmonary disease (COPD) in Germany. Results of the BOLD study]. Dtsch Med Wochenschr 2008;133:2609-14 [German]
  • Gibson GJ, Loddenkemper R, Lundbäck B, et al. Respiratory health and disease in Europe: the new European Lung White Book. Eur Respir J 2013;42:559-63
  • Brunton S, Carmichael BP, Colgan R, et al. Acute exacerbation of chronic bronchitis: a primary care consensus guideline. Am J Manag Care 2004;10:689-96
  • Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Updated 2009. Executive Summary. Available at: https://hmsa.com/portal/provider/GOLD_Report_08_WM1.pdf. [Last accessed 10 January 2018]
  • Cazzola M, MacNee W, Martinez FJ, et al., on behalf of the American Thoracic Society/European Respiratory Society Task Force on outcomes of COPD. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J 2008;31:416-68
  • Gillissen A, Buhl R, Kardos P, et al. Studienendpunkte bei der chronisch-obstruktiven Lungenerkrankung (COPD): “Minimal clinically important difference” [Trial end-point in chronic obstructive pulmonary disease (COPD): minimal clinically important difference]. Pneumologie 2008;62:149-57 [German]
  • Lin XJ, Lin IM, Fan SY. Methodological issues in measuring health-related quality of life. Tzu Chi Med J 2013;25:8-12
  • Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference, New York, June, 19–22, 1946
  • Weldring T, Smith SMS. Patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs). Health Serv Insights 2013;6:61-8
  • Bullinger M. Das Konzept der Lebensqualität in der Medizin - Entwicklung und heutiger Stellenwert [The concept of quality of life in medicine – development and current importance]. Z Evid Fortbild Qual Gesundh wesen 2014;108:97-103 [German]
  • Bullinger M, Siegrist J, Ravens-Sieberer U, editors. Jahrbuch der Medizinischen Psychologie, Band 18, Lebensqualitätsforschung aus medizinpsychologischer und -soziologischer Perspektive [Quality of life research from a medical-psychological and sociological perspective]. Göttingen: Hogrefe; 2000 [German]
  • Marks GB, Dunn SM, Wollcock AJ. A scale for the measurement of quality of life in adults with asthma. J Clin Epidemiol 1992;45:461-72
  • Domingo-Salvany A, Lamarca R, Ferrer M, et al. Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:680-5
  • Schöffski O, Graf von der Schulenburg JM, editors. Gesundheitsökonomische Evaluationen [Health-economic evaluations]. Heidelberg: Springer; 2007 [German]
  • Rutishauser C, Sawyer SM, Bowes G. Quality of life assessment in children and adolescents with asthma. Eur Respir J 1998;12:486-94
  • Schmier JK, Halpern MT, Higashi MK, et al. The quality of life impact of acute exacerbations of chronic bronchitis (AECB): a literature review. Qual Life Res 2005;14:329-47
  • Menn P, Weber N, Holle R. Health-related quality of life in patients with severe COPD hospitalized for exacerbations – comparing EQ-5D, SF-12 and SGRQ. Health Qual Life Outcomes 2010;8:39
  • Matthys H, Pliskevich DA, Bondarchuk OM, et al. Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. Respir Med 2013;107:691-701
  • Matthys H, Malek FA. Antibiotic use in patients with COPD receiving EPs 7630 as an add-on treatment. Atemwegs- und Lungenkrankheiten 2015;1:27-34
  • Matthys H, Lehmacher W, Zimmermann A, et al. EPs 7630 in acute respiratory tract infections – a systematic review and meta-analysis of randomized clinical trials. J Lung Pulm Respir Res 2016;3(1):00068
  • Agbabiaka TB, Guo R, Ernst E. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Phytomedicine 2008;15:378-85
  • Agbabiaka TB, Guo R, Ernst E. Erratum to “Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis” [Phytomedicine 15 (2008) 378–85]. Phytomedicine 2009;16:798-9
  • Timmer A, Günther J, Motschall E, et al. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev 2013;10:CD006323
  • Matthys H, Köhler S, Kamin W. Safety and tolerability of EPs 7630 in clinical trials. Adv Pharmacoepidemiol Drug Saf 2013;2:142
  • Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles of Pelargonium sidoides DC. Phytother Res 2001;15:122-6
  • Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo®. Phytomedicine 2007;14(Suppl6):9-17
  • Kolodziej H, Kayser O, Radtke OA, et al. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine 2003;10(Suppl4):18-24
  • Kolodziej H, Kiderlen AF. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630. Phytomedicine 2007;14(Suppl4):18-26
  • Witte K, Koch E, Volk HD, et al. The Pelargonium sidoides extract EPs 7630 drives the innate immune defense by activating selected MAP kinase pathways in human monocytes. PLoS One 2015;10:e0138075
  • Conrad A, Hansmann C, Engels I, et al. Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine 2007;14(Suppl6):46-51
  • Conrad A, Jung I, Tioua D, et al. Extract of Pelargonium sidoides (EPs 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. Phytomedicine 2007;14(Suppl6):52-9
  • Rezaizadehnajafi L, Wink M. EPs7630® from Pelargonium sidoides increases stress resistance in Caenorhabditis elegans probably via the DAF-16/FOXO pathway. Phytomedicine 2014;21:547-50
  • Michaelis M, Doerr HW, Cinatl J Jr. Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine 2011;18:384-6
  • Neugebauer P, Mickenhagen A, Siefer O, et al. A new approach to pharmacological effects on ciliary beat frequency in cell cultures—exemplary measurements under Pelargonium sidoides extract (EPs 7630). Phytomedicine 2005;12(1–2):46-51
  • Bao Y, Gao Y, Koch E, et al. Evaluation of pharmacodynamic activities of EPs® 7630, a special extract from roots of Pelargonium sidoides, in animals models of cough, secretolytic activity and acute bronchitis. Phytomedicine 2015;22:504-9
  • Matthys H, Lizogub VG, Funk P, et al. Pelargonium sidoides bei akuter Bronchitis – Gesundheitsbezogene Lebensqualität und Therapiebeurteilung aus Patientensicht unter Behandlung mit EPs 7630. [Pelargonium sidoides in acute bronchitis – Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment]. Wien Med Wochenschr 2010;160:564-570 [German]
  • Kind P. Chapter 22. The EuroQoL instrument: an index of health-related quality of life. In: Spilker B, editor. Quality of Life and Pharmacoeconomics in Clinical Trials. 2. Philadelphia: Lippincott-Raven Publishers; 1996. pp. 191-201
  • Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation: the St. George’s Respiratory Questionnaire. Am Rev Respir Dis 1992;145:1321-7
  • Steinsbekk A, Biolchini J, Heger M, et al. Data collection in homeopathic practice - a proposal for an international standard. HomInt R&D Newsletter 1999;2:3-23
  • Jones PW. St. George’s Respiratory Questionnaire: MCID. COPD 2005;2:75-9
  • Matthys H, Kamin W. Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studies. Curr Med Res Opin 2013;29:1383-90

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.