2,619
Views
93
CrossRef citations to date
0
Altmetric
Pharmacovigilance

Ongoing strategies to improve the management of upper respiratory tract infections and reduce inappropriate antibiotic use particularly among lower and middle-income countries: findings and implications for the future

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , , , , , , , , , , ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , , , ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon, , , ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 301-327 | Received 07 Aug 2019, Accepted 01 Dec 2019, Published online: 30 Dec 2019

References

  • Founou RC, Founou LL, Essack SY. Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis. PLoS One. 2017;12(12):e0189621.
  • Taylor JH, Yerushalmi E, Smith R, et al. Estimating the economic costs of antimicrobial resistance: model and results. 2014. Available from: http://www.rand.org/content/dam/rand/pubs/research_reports/RR900/RR911/RAND_RR911.pdf.
  • O'Neill J. Securing new drugs for future generations: the pipeline of antibiotics. The review of antimicrobial resistance. Available from: https://amr-review.org/sites/default/files/SECURING%20NEW%20DRUGS%20FOR%20FUTURE%20GENERATIONS%20FINAL%20WEB_0.pdf.
  • Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13(12):1057–1098.
  • World Bank Group – Drug-resistant infections – a threat to our economic future. Available from: http://documents.worldbank.org/curated/en/323311493396993758/pdf/114679-REVISED-v2-Drug-Resistant-Infections-Final-Report.pdf.
  • Shallcross LJ, Howard SJ, Fowler T, et al. Tackling the threat of antimicrobial resistance: from policy to sustainable action. Phil Trans R Soc B. 2015;370(1670):20140082.
  • Michael CA, Dominey-Howes D, Labbate M. The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health. 2014;2(145).
  • Centers for Disease Prevention and Control. Antibiotic resistance threats in the United States. 2013. Available from: https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf.
  • Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014;6:25–64.
  • World Health Organisation. Antimicrobial resistance. 2018. Available from: http://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.
  • Antonanzas F, Goossens H. The economics of antibiotic resistance: a claim for personalised treatments. Eur J Health Econ. 2019;20(4):483–485.
  • Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci USA. 2018;115(15):E3463–e70.
  • Reardon S. Antibiotic resistance sweeping developing world. Nature. 2014;509(7499):141–142.
  • Aslam B, Wang W, Arshad MI, et al. Antibiotic resistance: a rundown of a global crisis. IDR. 2018;11:1645–1658.
  • Hofer U. The cost of antimicrobial resistance. Nat Rev Microbiol. 2019;17(1):3.
  • Cassini A, Hogberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66.
  • Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeut Adv Drug Safe. 2014;5(6):229–241.
  • Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309–318.
  • Laxminarayan R, Sridhar D, Blaser M, et al. Achieving global targets for antimicrobial resistance. Science. 2016;353(6302):874–875.
  • Aly SM. Risk of antimicrobial misuse. IJHS. 2013;7(1):V–VII.
  • Shaikhan F, Rawaf S, Majeed A, et al. Knowledge, attitude, perception and practice regarding antimicrobial use in upper respiratory tract infections in Qatar: a systematic review. JRSM Open. 2018;9(9):205427041877497.
  • Goossens H. Antibiotic consumption and link to resistance. Clinical microbiology and infection. 2009;15(3):12–15.
  • Bell BG, Schellevis F, Stobberingh E, et al. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis. 2014;14(1):13.
  • Goossens H, Ferech M, Vander Stichele R, et al. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet. 2005;365(9459):579–587.
  • Tyrstrup M, Melander E, Hedin K, et al. Children with respiratory tract infections in Swedish primary care; prevalence of antibiotic resistance in common respiratory tract pathogens and relation to antibiotic consumption. BMC Infect Dis. 2017;17(1):603.
  • Nasrin D, Collignon PJ, Roberts L, et al. Effect of beta lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study. BMJ. 2002;324(7328):28–30.
  • Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clinic Proceedings. 2011;86(2):156–167.
  • Costelloe C, Metcalfe C, Lovering A, et al. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340(may18 2):c2096.
  • Wilkinson A, Ebata A, MacGregor H. Interventions to reduce antibiotic prescribing in LMICs: a scoping review of evidence from human and animal health systems. Antibiotics. 2018;8(1):2.
  • Marston HD, Dixon DM, Knisely JM, et al. Antimicrobial resistance. JAMA. 2016;316(11):1193–1204.
  • Alvarez-Uria G, Gandra S, Mandal S, et al. Global forecast of antimicrobial resistance in invasive isolates of Escherichia coli and Klebsiella pneumoniae. Int J Infect Dis. 2018;68:50–53.
  • WHO. Antimicrobial resistance. Fact Sheet. 2018. Available from: http://www.who.int/mediacentre/factsheets/fs194/en/.
  • Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(10):1791–1798.
  • Fernandes MR, Moura Q, Sartori L, et al. Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene. Euro Surveillance. 2016;21(17).
  • Scully C, Robinson AN, Wiesenfeld D. Antimicrobial resistance: dangerous abuse. Br Dent J. 2016;220(4):154–155.
  • Mendelson M, Brink A, Gouws J, et al. The One Health stewardship of colistin as an antibiotic of last resort for human health in South Africa. Lancet Infect Dis. 2018;18(9):e288–e94.
  • Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med. 2004;10(S12):S122–S1229.
  • Wojkowska-Mach J, Godman B, Glassman A, et al. Antibiotic consumption and antimicrobial resistance in Poland; findings and implications. Antimicrob Resist Infect Control. 2018;7(1):136.
  • Labuschagne QS, Gous A, Bronkhorst E, et al. COLISTIN: adult and paediatric guideline for South Africa, 2016. South Africa J Infect Dis. 2016;31(1):3–7.
  • Furst J, Cizman M, Mrak J, et al. The influence of a sustained multifaceted approach to improve antibiotic prescribing in Slovenia during the past decade: findings and implications. Exp Rev Anti-Infect Ther. 2015;13(2):279–289.
  • Roope LSJ, Smith RD, Pouwels KB, et al. The challenge of antimicrobial resistance: what economics can contribute. Science. 2019;364(6435):eaau4679.
  • Padget M, Guillemot D, Delarocque-Astagneau E. Measuring antibiotic consumption in low-income countries: a systematic review and integrative approach. Int J Antimicrob Agent. 2016;48(1):27–32.
  • Auta A, Hadi MA, Oga E, et al. Global access to antibiotics without prescription in community pharmacies: a systematic review and meta-analysis. J Infect. 2019;78(1):8–18.
  • Ramani VK, Pattankar J, Puttahonnappa SK. Acute respiratory infections among under-five age group children at urban slums of Gulbarga city: a longitudinal study. JCDR. 2016;10(5):LC08–LC13.
  • Le Doare K, Barker CI, Irwin A, et al. Improving antibiotic prescribing for children in the resource-poor setting. Br J Clin Pharmacol. 2015;79(3):446–455.
  • Nga DTT, Chuc NTK, Hoa NP, et al. Antibiotic sales in rural and urban pharmacies in northern Vietnam: an observational study. BMC Pharmacol Toxicoly. 2014;15:6.
  • Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrob Resist Infect Control. 2017;6(1):47.
  • Faizullah M, Nisar-Ur-Rahman Umar M, Anwar M, et al. A cross-sectional study on knowledge, attitude and practices of medical doctors towards antibiotic prescribing patterns and resistance in Khyber Pakhtun Khawah, Pakistan. J Appl Pharma Sci. 2017;7(12):38–46.
  • Sakeena MHF, Bennett AA, McLachlan AJ. Non-prescription sales of antimicrobial agents at community pharmacies in developing countries: a systematic review. Int J Antimicrob Agent. 2018;52(6):771–782.
  • Farley E, Stewart A, Davies MA, et al. Antibiotic use and resistance: Knowledge, attitudes and perceptions among primary care prescribers in South Africa. S Afr Med J. 2018;108(9):763–771.
  • Nguyen QH, Nguyen TK, Ho D, et al. Unnecessary antibiotic use for mild acute respiratory infections during 28-day follow-up of 823 children under five in rural Vietnam. Trans R Soc Trop Med Hyg. 2011;105(11):628–636.
  • Chang J, Xu S, Zhu S, et al. Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study. Lancet Infect Dis. 2019;19(12):1345.
  • Dye C. After 2015: infectious diseases in a new era of health and development. Phil Trans R Soc B. 2014;369(1645):20130426.
  • Walson JL, Berkley JA. The impact of malnutrition on childhood infections. Curr Opin Infect Dis. 2018;31(3):231–236.
  • Checkley W, Pollard SL, Siddharthan T, et al. Managing threats to respiratory health in urban slums. Lancet Resp Med. 2016;4(11):852–854.
  • Godman B, Fadare J, Kibuule D, et al. Initiatives across countries to reduce antibiotic utilisation and resistance patterns: impact and implications. In: Arora G, Sajid A, Kalia VC, editors. Drug resistance in bacteria, fungi, malaria, and cancer. Cham: Springer International Publishing; 2017. p. 539–576.
  • Md Rezal RS, Hassali MA, Alrasheedy AA, et al. Physicians' knowledge, perceptions and behaviour towards antibiotic prescribing: a systematic review of the literature. Exp Rev Anti-InfectTher. 2015;13(5):665–680.
  • Schwartländer B. World health Organization. Antibiotics changed modern medicine, but we must act to protect them. 2015. Available from: http://www.wpro.who.int/china/mediacentre/releases/2015/20151119/en/.
  • Atif M, Asghar S, Mushtaq I, et al. What drives inappropriate use of antibiotics? A mixed methods study from Bahawalpur, Pakistan. IDR. 2019;12:687–699.
  • Huttner B, Goossens H, Verheij T, et al. Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries. Lancet Infect Dis. 2010;10(1):17–31
  • Dar OA, Hasan R, Schlundt J, et al. Exploring the evidence base for national and regional policy interventions to combat resistance. Lancet. 2016;387(10015):285–295.
  • Bao L, Peng R, Wang Y, et al. Significant reduction of antibiotic consumption and patients' costs after an action plan in China, 2010–2014. PLoS One. 2015;10(3):e0118868.
  • WHO. Antimicrobial resistance. Global report on surveillance. Available from: http://www.euro.who.int/en/health-topics/disease-prevention/antimicrobial-resistance/news/news/2014/04/new-report-antibiotic-resistance-a-global-health-threat.
  • Jinks T, Lee N, Sharland M, et al. A time for action: antimicrobial resistance needs global response. Bull World Health Organ. 2016;94(8):558–558a.
  • European Commission. A European One Health action plan against antimicrobial resistance (AMR). 2017. Available from: https://ec.europa.eu/health/amr/sites/amr/files/amr_action_plan_2017_en.pdf.
  • Seale AC, Gordon NC, Islam J, et al. AMR Surveillance in low and middle-income settings – a roadmap for participation in the global antimicrobial surveillance system (GLASS). Wellcome Open Res. 2017;2:92.
  • CDC. Antibiotic prescribing and use in doctor’s offices. For healthcare professionals. 2018. Available from: https://www.cdc.gov/antibiotic-use/community/for-hcp/index.html.
  • Schellack N, Benjamin D, Brink A, et al. A situational analysis of current antimicrobial governance, regulation, and utilization in South Africa. Int J Infect Dis. 2017;64:100–106.
  • Rezal RS, Hassali MA, Alrasheedy AA, et al. Prescribing patterns for upper respiratory tract infections: a prescription-review of primary care practice in Kedah, Malaysia, and the implications. Exp Rev Anti-Infect Ther. 2015;13(12):1547–1556.
  • Abilova V, Kurdi A, Godman B. Ongoing initiatives in Azerbaijan to improve the use of antibiotics; findings and implications. Exp Rev Anti-Infect Ther. 2018;16(1):77–84.
  • Bojanic L, Markovic-Pekovic V, Skrbic R, et al. Recent initiatives in the Republic of Srpska to enhance appropriate use of antibiotics in ambulatory care; their influence and implications. Front Pharmacol. 2018;9(442).
  • Raka L, Kurti A, Jakupi A, et al. Kosovo's national action plan for antimicrobial resistance. Lancet Infect Dis. 2019;19(3):244.
  • Newitt S, Oloyede O, Puleston R, et al. Demographic, knowledge and impact analysis of 57,627 antibiotic guardians who have pledged to contribute to tackling antimicrobial resistance. Antibiotics. 2019;8(1):21.
  • Jacobs TG, Robertson J, van den Ham HA, et al. Assessing the impact of law enforcement to reduce over-the-counter (OTC) sales of antibiotics in low- and middle-income countries; a systematic literature review. BMC Health Serv Res. 2019;19(1):536.
  • Petersen I, Hayward AC. Antibacterial prescribing in primary care. J Antimicrob Chemother. 2007;60(suppl_1):i43–i47.
  • Little P, Stuart B, Francis N, et al. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet. 2013;382(9899):1175–1182.
  • Francis NA, Butler CC, Hood K, et al. Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial. BMJ. 2009;339(jul29 2):b2885.
  • Cosby JL, Francis N, Butler CC. The role of evidence in the decline of antibiotic use for common respiratory infections in primary care. Lancet Infect Dis. 2007;7(11):749–756.
  • Tyrstrup M, Beckman A, Molstad S, et al. Reduction in antibiotic prescribing for respiratory tract infections in Swedish primary care–a retrospective study of electronic patient records. BMC Infect Dis. 2016;16(1):709.
  • Lee ML, Cho CY, Hsu CL, et al. Recent trends in antibiotic prescriptions for acute respiratory tract infections in pediatric ambulatory care in Taiwan, 2000–2009: a nationwide population-based study. J Microbiol Immunol Infect. 2016;49(4):554–560.
  • Steinman MA, Gonzales R, Linder JA, et al. Changing use of antibiotics in community-based outpatient practice, 1991–1999. Ann Intern Med. 2003;138(7):525–533.
  • Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA. 2009;302(7):758–766.
  • Havers FP, Hicks LA, Chung JR, et al. Outpatient antibiotic prescribing for acute respiratory infections during influenza seasons. JAMA Netw Open. 2018;1(2):e180243.
  • Dasaraju PV, Liu C. Infections of the respiratory system. In: Baron S, editor. Medical microbiology. Galveston (TX): University of Texas Medical Branch at Galveston; 1996.
  • Dyar OJ, Beovic B, Vlahovic-Palcevski V, et al. How can we improve antibiotic prescribing in primary care? Exp Rev Anti-Infect Ther. 2016;14(4):403–413.
  • van der Meer J. The infectious disease challenges of our time. Front Public Health. 2013;1:7.
  • Vaz LE, Kleinman KP, Raebel MA, et al. Recent trends in outpatient antibiotic use in children. Pediatrics. 2014;133(3):375–385.
  • Wei X, Zhang Z, Hicks JP, et al. Long-term outcomes of an educational intervention to reduce antibiotic prescribing for childhood upper respiratory tract infections in rural China: follow-up of a cluster-randomised controlled trial. PLoS Med. 2019;16(2):e1002733.
  • Barnett ML, Linder JA. Antibiotic prescribing for adults with acute bronchitis in the United States, 1996–2010. JAMA. 2014;311(19):2020–2022.
  • Fleming-Dutra KE, Hersh AL, Shapiro DJ, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA. 2016;315(17):1864–1873.
  • Kalungia AC, Burger J, Godman B, et al. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Exp Rev Anti-Infect Ther. 2016;14(12):1215–1223.
  • Kibuule D, Kagoya HR, Godman B. Antibiotic use in acute respiratory infections in under-fives in Uganda: findings and implications. Exp Rev Anti-Infect Ther. 2016;14(9):863–872.
  • Ebell MH, Radke T. Antibiotic use for viral acute respiratory tract infections remains common. Am J Manag Care. 2015;21(10):e567–e575.
  • Simasek M, Blandino DA. Treatment of the common cold. Am Fam Physician. 2007;75(4):515–520.
  • Butler CC, Hood K, Verheij T, et al. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ. 2009;338:b2242.
  • Lee TH, Wong JG, Lye DC, et al. Medical and psychosocial factors associated with antibiotic prescribing in primary care: survey questionnaire and factor analysis. Br J Gen Pract. 2017;67(656):e168–e177.
  • Holloway KA, Ivanovska V, Wagner AK, et al. Prescribing for acute childhood infections in developing and transitional countries, 1990–2009. Paediat Int Child Health. 2015;35(1):5–13.
  • Hassali MA, Kamil TK, Md Yusof FA, et al. General practitioners' knowledge, attitude and prescribing of antibiotics for upper respiratory tract infections in Selangor, Malaysia: findings and implications. Exp Rev Anti-Infect Ther. 2015;13(4):511–520.
  • Spellberg B, Gilbert DN. The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett. Clinic Infect Dis. 2014;59 (Suppl 2):S71–S75.
  • Batura N, Cuevas C, Khan M, et al. How effective and cost-effective are behaviour change interventions in improving the prescription and use of antibiotics in low-income and middle-income countries? A protocol for a systematic review. BMJ Open. 2018;8(5):e021517.
  • Thornton HV, Hay AD, Redmond NM, et al. Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing. Fam Pract. 2017;34(4):407–415.
  • Collignon P, Athukorala PC, Senanayake S, et al. Antimicrobial resistance: the major contribution of poor governance and corruption to this growing problem. PLoS One. 2015;10(3):e0116746.
  • Alhomoud F, Aljamea Z, Almahasnah R, et al. Self-medication and self-prescription with antibiotics in the Middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. Int J Infect Dis. 2017;57:3–12.
  • Rather IA, Kim BC, Bajpai VK, et al. Self-medication and antibiotic resistance: crisis, current challenges, and prevention. Saudi J Biol Sci. 2017;24(4):808–812.
  • Hersh AL, Shapiro DJ, Pavia AT, et al. Antibiotic prescribing in ambulatory pediatrics in the United States. Pediatrics. 2011;128(6):1053–1061.
  • Vazquez-Lago JM, Lopez-Vazquez P, Lopez-Duran A, et al. Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. Fam Pract. 2012;29(3):352–360.
  • Aly M, Balkhy HH. The prevalence of antimicrobial resistance in clinical isolates from Gulf Corporation Council countries. Antimicrob Resist Infect Control. 2012;1(1):26.
  • Teixeira Rodrigues A, Roque F, Falcao A, et al. Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies. Int J Antimicrob Agent. 2013;41(3):203–212.
  • Torres NF, Chibi B, Middleton LE, et al. Evidence of factors influencing self-medication with antibiotics in low and middle-income countries: a systematic scoping review. Public Health. 2019;168:92–101.
  • Murray CJ, Ortblad KF, Guinovart C, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):1005–1070.
  • Kibuule D, Verbeeck RK, Nunurai R, et al. Predictors of tuberculosis treatment success under the DOTS program in Namibia. Exp Rev Respirat Med. 2018;12((11):979–987.
  • Davis JL, Fei M, Huang L. Respiratory infection complicating HIV infection. Curr Opin Infect Dis. 2008;21(2):184–190.
  • Satyanarayana S, Kwan A, Daniels B, et al. Use of standardised patients to assess antibiotic dispensing for tuberculosis by pharmacies in urban India: a cross-sectional study. Lancet Infect Dis. 2016;16(11):1261–1268.
  • Miller R, Goodman C. Do chain pharmacies perform better than independent pharmacies? Evidence from a standardised patient study of the management of childhood diarrhoea and suspected tuberculosis in urban India. BMJ Glob Health. 2017;2(3):e000457.
  • Nyazema N, Viberg N, Khoza S, et al. Low sale of antibiotics without prescription: a cross-sectional study in Zimbabwean private pharmacies. J Antimicrob Chemother. 2007;59(4):718–726.
  • Erku DA, Mekuria AB, Belachew SA. Inappropriate use of antibiotics among communities of Gondar town, Ethiopia: a threat to the development of antimicrobial resistance. Antimicrob Resist Infect Control. 2017;6(1):112.
  • Haeseker MB, Dukers-Muijrers N, Hoebe C, et al. Trends in antibiotic prescribing in adults in Dutch general practice. PLoS One. 2012;7(12):e51860.
  • Gasson J, Blockman M, Willems B. Antibiotic prescribing practice and adherence to guidelines in primary care in the Cape Town Metro District, South Africa. S Afr Med J. 2018;108(4):304–310.
  • Holloway KA, Rosella L, Henry D. The impact of WHO essential medicines policies on inappropriate use of antibiotics. PLoS One. 2016;11(3):e0152020.
  • Ocan M, Obuku EA, Bwanga F, et al. Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health. 2015;15(1):742.
  • Morgan DJ, Okeke IN, Laxminarayan R, et al. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692–701.
  • Torrone EA, Morrison CS, Chen P-L, Kwok C, et al. Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: an individual participant data meta-analysis of 18 HIV prevention studies. PLoS Med. 2018;15(2):e1002511.
  • Nepal G, Bhatta S. Self-medication with antibiotics in WHO Southeast Asian region: a systematic review. Cureus. 2018;10(4):e2428.
  • Nakajima R, Takano T, Urnaa V, et al. Antimicrobial use in a country with insufficient enforcement of pharmaceutical regulations: A survey of consumption and retail sales in Ulaanbaatar, Mongolia. Southern Med Review. 2010;3(1):19–23.
  • Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. Lancet. 2016;387(10014):168–175.
  • Laxminarayan R, Chaudhury RR. Antibiotic resistance in India: drivers and opportunities for action. PLoS Med. 2016;13(3):e1001974.
  • Van Boeckel TP, Gandra S, Ashok A, Caudron Q, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–750.
  • Miller R, Goodman C. Performance of retail pharmacies in low- and middle-income Asian settings: a systematic review. Health Policy Plan. 2016;31(7):940–953.
  • Haak H. Pharmaceuticals in two Brazilian villages: lay practices and perceptions. Soc Sci Med. 1988;27(12):1415–1427
  • Saradamma RD, Higginbotham N, Nichter M. Social factors influencing the acquisition of antibiotics without prescription in Kerala State, south India. Soc Sci Med. 2000;50(6):891–903.
  • Seeberg J. Connecting pills and people: an ethnography of the pharmaceutical nexus in Odisha, India. Med Anthropol Quarter. 2012;26(2):182–200.
  • Jasim AL, Fadhil TA, Taher SS. Self-medication practice among Iraqi patients in Baghdad city. Am J Pharmacol Sci. 2014;2:18–23.
  • Mwita S, Jande M, Marwa K, et al. Medicines dispensers’ knowledge on the implementation of an artemisinin-based combination therapy policy for the treatment of uncomplicated malaria in Tanzania. J Pharm Health Serv Res. 2017;8(4):227–233.
  • Akinyandenu O, Akinyandenu A. Irrational use and non-prescription sale of antibiotics in Nigeria: a need for change. J Sci Innovat Res. 2014;3(2):251–257.
  • Abdulraheem I, Adegboye A, Fatiregun A. Self-medication with antibiotics: empirical evidence from a Nigerian rural population. BJPR. 2016;11(5):1–13.
  • Farah R, Lahoud N, Salameh P, et al. Antibiotic dispensation by Lebanese pharmacists: a comparison of higher and lower socio-economic levels. J Infect Public Health. 2015;8(1):37–46.
  • Barker AK, Brown K, Ahsan M, et al. Social determinants of antibiotic misuse: a qualitative study of community members in Haryana, India. BMC Public Health. 2017;17(1):333.
  • Al-Faham Z, Habboub G, Takriti F. The sale of antibiotics without prescription in pharmacies in Damascus, Syria. J Infect Dev Ctries. 2011;5(05):396–399.
  • Mbonye AK, Buregyeya E, Rutebemberwa E, et al. Prescription for antibiotics at drug shops and strategies to improve quality of care and patient safety: a cross-sectional survey in the private sector in Uganda. BMJ Open. 2016;6(3):e010632.
  • Apisarnthanarak A, Tunpornchai J, Tanawitt K, et al. Nonjudicious dispensing of antibiotics by drug stores in Pratumthani, Thailand. Infect Control Hosp Epidemiol. 2008;29(6):572–575.
  • Servia-Dopazo M, Figueiras A. Determinants of antibiotic dispensing without prescription: a systematic review. J Antimicrob Chemother. 2018;73(12):3244–3253.
  • Kalungia A, Godman B. Implications of non-prescription antibiotic sales in China. Lancet Infect Dis. 2019;19(12):1272.
  • Erku DA, Aberra SY. Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods study. Antimicrob Resist Infect Control. 2018;7(1):92.
  • Rudolf PM, Bernstein IB. Counterfeit drugs. N Engl J Med. 2004;350(14):1384–1386.
  • Mendelson M, Rottingen JA, Gopinathan U, et al. Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries. Lancet. 2016;387(10014):188–198.
  • Pincock S. WHO tries to tackle problem of counterfeit medicines in Asia. BMJ (Clinical research ed). 2003;327(7424):1126.
  • Fadare JO, Adeoti AO, Desalu OO, et al. The prescribing of generic medicines in Nigeria: knowledge, perceptions and attitudes of physicians. Exp Rev Pharm Out Res. 2016;16(5):639–650.
  • Khan B, Godman B, Babar A, et al. Assessment of active pharmaceutical ingredients in the registration procedures in Pakistan: implications for the future. GaBI J. 2016;5(4):156–163.
  • Acosta A, Vanegas EP, Rovira J, et al. Medicine shortages: Gaps between countries and global perspectives. Front Pharmacol. 2019;10:763.
  • Malan L, Labuschagne Q, Brechtelsbauer E, et al. Sustainable access to antimicrobials; a missing component to antimicrobial stewardship-A Tale of Two Countries. Front Public Health. 2018;6:324.
  • McDonagh MS, Peterson K, Winthrop K, et al. Interventions to reduce inappropriate prescribing of antibiotics for acute respiratory tract infections: summary and update of a systematic review. J Int Med Res. 2018;46(8):3337–3357.
  • Köchling A, Löffler C, Reinsch S, et al. Reduction of antibiotic prescriptions for acute respiratory tract infections in primary care: a systematic review. Implementation Sci. 2018;13(1):47.
  • McKay R, Mah A, Law MR, et al. Systematic review of factors associated with antibiotic prescribing for respiratory tract infections. Antimicrob Agents Chemother. 2016;60(7):4106–4118.
  • Roque F, Herdeiro MT, Soares S, et al. Educational interventions to improve prescription and dispensing of antibiotics: a systematic review. BMC Public Health. 2014;14(1):1276.
  • Lescure D, Paget J, Schellevis F, et al. Determinants of self-medication with antibiotics in European and Anglo-Saxon Countries: a systematic review of the literature. Front Public Health. 2018;6(370)
  • Zanichelli V, Tebano G, Gyssens IC, et al. Patient-related determinants of antibiotic use: a systematic review. Clin Microbiol Infect. 2019;25(1):48–53.
  • Cross EL, Tolfree R, Kipping R. Systematic review of public-targeted communication interventions to improve antibiotic use. J Antimicrob Chemother. 2017;72(4):975–987.
  • Global Respiratory Infection Partnership – GRIP. The global respiratory infection partnership declaration. 2014. Available from: http://www.grip-initiative.org/about-the-partnership/partnerships-mission/the-grip-declaration.
  • Essack S, Bell J, Shephard A. Community pharmacists-leaders for antibiotic stewardship in respiratory tract infection. J Clin Pharm Ther. 2018;43(2):302–307.
  • WHO Collaborating Centre on Patient Safety. The University of Geneva Hospitals and Faculty of Medicine. Evaluation of antibiotic awareness campaigns. 2017. Available from: https://www.who.int/selection_medicines/committees/expert/21/applications/s6_antibiotic_awareness_campaigns.pdf.
  • Haque M, McKimm J, Godman B, et al. Initiatives to reduce postoperative surgical site infections of the head and neck cancer surgery with a special emphasis on developing countries. Exp Rev Anticancer Ther. 2019;19(1):81–92.
  • Godman B, Wettermark B, van Woerkom M, et al. Multiple policies to enhance prescribing efficiency for established medicines in Europe with a particular focus on demand-side measures: findings and future implications. Front Pharmacol. 2014;5:106.
  • Godman B, Malmstrom RE, Diogene E, et al. Are new models needed to optimize the utilization of new medicines to sustain healthcare systems? Exp Rev Clin Pharmacol. 2015;8(1):77–94.
  • Godman B, Bucsics A, Vella Bonanno P, et al. Barriers for access to new medicines: searching for the balance between rising costs and limited budgets. Front Public Health. 2018;6:328.
  • Godman B, Malmström RE, Diogene E, et al. Dabigatran – a continuing exemplar case history demonstrating the need for comprehensive models to optimize the utilization of new drugs. Front Pharmacol. 2014;5:109.
  • Ermisch M, Bucsics A, Vella Bonanno P, et al. Payers' views of the changes arising through the possible adoption of adaptive pathways. Front Pharmacol. 2016;7:305.
  • Campbell SM, Godman B, Diogene E, et al. Quality indicators as a tool in improving the introduction of new medicines. Basic Clin Pharmacol Toxicol. 2015;116(2):146–157.
  • Godman B, Shrank W, Andersen M, et al. Policies to enhance prescribing efficiency in europe: findings and future implications. Front Pharmacol. 2010;1:141.
  • Moorkens E, Vulto AG, Huys I, et al. Policies for biosimilar uptake in Europe: an overview. PLoS One. 2017;12(12):e0190147.
  • Bochenek T, Abilova V, Alkan A, et al. Systemic measures and legislative and organizational frameworks aimed at preventing or mitigating drug shortages in 28 European and Western Asian countries. Front Pharmacol. 2018;8:942.
  • Godman B, Grobler C, Van-De-Lisle M, et al. Pharmacotherapeutic interventions for bipolar disorder type II: addressing multiple symptoms and approaches with a particular emphasis on strategies in lower and middle-income countries. Exp Opin Pharmacother. 2019;20(18):2237–2255.
  • World Bank. World Bank country and lending groups – country classifictions. 2018. Available from: https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups.
  • Cameron A, Ewen M, Ross-Degnan D, et al. Medicine prices, availability, and affordability in 36 developing and middle-income countries: a secondary analysis. Lancet. 2009;373(9659):240–249.
  • Ofori-Asenso R, Agyeman AA. Irrational use of medicines—a summary of key concepts. Pharmacy. 2016;4(4):35.
  • Aregbeshola BS, Khan SM. Out-of-pocket payments, catastrophic health expenditure and poverty among households in Nigeria 2010. Int J Health Policy Manag. 2018;7(9):798–806.
  • OECD. Pharmaceutical spending % of health spending, 2018 or latest available. 2018. Available from: https://data.oecd.org/healthres/pharmaceutical-spending.htm.
  • Godman B, Oortwijn W, de Waure C, et al. Links between pharmaceutical R&D models and access to affordable medicines. A study for the Envi Committee. Available from: http://www.europarl.europa.eu/RegData/etudes/STUD/2016/587321/IPOL_STU(2016)587321_EN.pdf.
  • Nashilongo MM, Singu B, Kalemeera F, et al. Assessing adherence to antihypertensive therapy in primary health care in Namibia: findings and implications. Cardiovasc Drugs Ther. 2017;31(5–6):565–578.
  • Soleymani F, Godman B, Dehghan M, et al. Prescribing patterns of physicians working in both the direct and indirect treatment sectors in Iran; findings and implications. JPHSR. 2019; ISSN 1759-8885.
  • Tiroyakgosi C, Matome M, Summers E, et al. Ongoing initiatives to improve the use of antibiotics in Botswana: University of Botswana symposium meeting report. Exp Rev Anti-Infect Ther. 2018;16(5):381–384.
  • Kotwani A, Wattal C, Joshi PC, et al. Irrational use of antibiotics and role of the pharmacist: an insight from a qualitative study in New Delhi, India. J Clin Pharm Therap. 2012;37(3):308–312.
  • Kamati M, Godman B, Dan Kibuule D. Prevalence of self-medication for acute respiratory infections in Namibia; findings and implications. J Res Pharm Pract. 2019 (In Press).
  • Fink G, D'Acremont V, Leslie H, et al. Antibiotic exposure among children under age five: a cross-sectional analysis of nationally representative facility and household surveys in 8 low- and middle-income countries. Lancet Infect Dis. 2019. doi:10.1016/S1473-3099(19)30572-9
  • Cotton M, Innes S, Jaspan H, et al. Management of upper respiratory tract infections in children. South Africa Fam Pract. 2008;50(2):6–12.
  • Kumar P, Medigeshi GR, Mishra VS, et al. Etiology of acute respiratory infections in infants: a prospective birth cohort study. Pediatr Infect Dis J. 2017;36(1):25–30.
  • Tregoning JS, Schwarze J. Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev. 2010;23(1):74–98.
  • He Y, Lin GY, Wang Q, et al. A 3-year prospective study of the epidemiology of acute respiratory viral infections in hospitalized children in Shenzhen, China. Influenza Other Resp Virus. 2014;8(4):443–451.
  • Selwyn BJ. The epidemiology of acute respiratory tract infection in young children: comparison of findings from several developing countries. Coordinated Data Group of BOSTID Researchers. Reviews of infectious diseases. 1990;12(8):S870–S88.
  • Heikkinen T, Jarvinen A. The common cold. Lancet. 2003;361(9351):51–59.
  • Stover CS, Litwin CM. The epidemiology of upper respiratory infections at a Tertiary Care Center: prevalence, seasonality, and clinical symptoms. J Respir Med. 2014;2014:1. Available from: https://www.hindawi.com/journals/jrm/2014/469393/cta/
  • Poole MD. Acute bacterial rhinosinusitis: clinical impact of resistance and susceptibility. Am J Med. 2004;117(3A):29s–38s.
  • Zoorob R, Sidani MA, Fremont RD, et al. Antibiotic use in acute upper respiratory tract infections. Am Fam Physician. 2012;86(9):817–822.
  • Klein JO. Is acute otitis media a treatable disease? N Engl J Med. 2011;364(2):168–169.
  • Mayo Clinic. Common cold. Patient care and health information. 2018. Available from: https://www.mayoclinic.org/diseases-conditions/common-cold/symptoms-causes/syc-20351605.
  • Turner RB. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allerg, Asthma Immunol. 1997;78(6):531–539
  • Meneghetti A. Upper respiratory tract infection. Pulmonology, Medscape. 2018. Available from: https://emedicine.medscape.com/article/302460-overview. #showall.
  • Petersen I, Johnson AM, Islam A, et al. Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ. 2007;335(7627):982.
  • Asner SA, Petrich A, Hamid JS, et al. Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children. Influenza Other Respir Viruses. 2014;8(4):436–442.
  • Tan CE, Mohd Roozi AH, Wong WHR, et al. Intention to seek medical consultation for symptoms of upper respiratory tract infection–a cross-sectional survey. Int Med J Malay. 2015;14(2):9–15. Available from: http://iiumedic.net/imjm/v1/download/Volume%2014%20No%202/original_articles/Pages-from-IMJM-Dec-2015-Final-V1-p09-15.pdf.
  • Lee MHM, Pan DST, Huang JH, et al. Results from a patient-based health education intervention in reducing antibiotic use for acute upper respiratory tract infections in the private sector primary care setting in Singapore. Antimicrob Agents Chemother. 2017;61(5):e02257–16.
  • Ng C-J, Chia Y-C, Teng C-L, et al. Nik-Sherina H. Factors influencing parental decision to consult for children with upper respiratory tract infection. J Paediatr Child Health. 2008;44(4):208–213.
  • Biezen R, Brijnath B, Grando D, et al. Management of respiratory tract infections in young children-A qualitative study of primary care providers' perspectives. NPJ Prim Care Resp Med. 2017;27(1):15.
  • Abu Hammour K, Abu Farha R, Alsous M, et al. Evaluation of risk factors affecting parental knowledge and attitude toward antibiotic use in children with upper respiratory tract infections. Eur J Integr Med. 2018;17:107–111.
  • Pan DS, Huang JH, Lee MH, et al. Knowledge, attitudes and practices towards antibiotic use in upper respiratory tract infections among patients seeking primary health care in Singapore. BMC Fam Pract. 2016;17(1):148.
  • Teng CL. Antibiotic prescribing for upper respiratory tract infections in the Asia-Pacific region: a brief review. Malaysian Fam Phys. 2014;9(2):18–25.
  • Easton G, Saxena S. Antibiotic prescribing for upper respiratory tract infections in children: how can we improve? London J PrimCare. 2010;3(1):37–41.
  • Renati S, Linder JA. Necessity of office visits for acute respiratory infections in primary care. FAMPRJ. 2016;33(3):312–317.
  • McNulty CA, Nichols T, French DP, et al. Expectations for consultations and antibiotics for respiratory tract infection in primary care: the RTI clinical iceberg. Br J Gen Pract. 2013;63(612):e429–36.
  • Fletcher-Lartey S, Yee M, Gaarslev C, et al. Why do general practitioners prescribe antibiotics for upper respiratory tract infections to meet patient expectations: a mixed methods study. BMJ Open. 2016;6(10):e012244.
  • Braun BL, Fowles JB. Characteristics and experiences of parents and adults who want antibiotics for cold symptoms. Arch Fam Med. 2000;9(7):589–595.
  • Waitumbi JN, Kuypers J, Anyona SB, et al. Outpatient upper respiratory tract viral infections in children with malaria symptoms in Western Kenya. Am J Trop Med Hyg. 2010;83(5):1010–1013.
  • Holloway K, Mathai E, Gray A. Surveillance of community antimicrobial use in resource-constrained settings–experience from five pilot projects. Trop Med Int Health. 2011;16(2):152–161.
  • Hak E, Rovers MM, Kuyvenhoven MM, et al. Incidence of GP-diagnosed respiratory tract infections according to age, gender and high-risk co-morbidity: the Second Dutch National Survey of General Practice. Fam Pract. 2006;23(3):291–294.
  • Masavkar SP, Naikwadi AM. Study of incidence of upper respiratory tract infections in urban and rural population. SJAMS. 2016;4(6C):2023–2026. Available from: https://pdfs.semanticscholar.org/13c3/d448bfa38ed3edc4de7ac49cb3bb98ca12ff.pdf.
  • Koch A, Sorensen P, Homoe P, et al. Population-based study of acute respiratory infections in children, Greenland. Emerg Infect Dis. 2002;8(6):586–593.
  • Harsten G, Prellner K, Heldrup J, et al. Acute respiratory tract infections in children. A three-year follow-up from birth. Acta PaediatrScand. 1990;79(4):402–409.
  • Rovers MM, Balemans WA, Sanders EA, et al. Persistence of upper respiratory tract infections in a cohort followed from childhood to adulthood. Fam Pract. 2006;23(3):286–290.
  • Kvaerner KJ, Nafstad P, Jaakkola JJ. Upper respiratory morbidity in preschool children: a cross-sectional study. Arch Otolaryngol Head Neck Surg. 2000;126(10):1201–1206.
  • Benediktsdottir B. Upper airway infections in preschool children–frequency and risk factors. Scand J Prim Health Care. 1993;11(3):197–201.
  • Leung AK, Newman R, Kumar A, et al. Rapid antigen detection testing in diagnosing group A beta-hemolytic streptococcal pharyngitis. Exp Rev Mol Diag. 2006;6(5):761–766.
  • Pichichero ME. Group A beta-hemolytic streptococcal infections. Pediatr Rev. 1998;19(9):291–302.
  • Cohen JF, Bertille N, Cohen R, et al. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016;7:Cd010502.
  • National Institute for Health and Care Excellence Guideline. Sore throat (acute): antimicrobial prescribing. 2017. Available from: https://www.nice.org.uk/guidance/ng84/documents/draft-guidance.
  • Kim NN, Marikar D. Antibiotic prescribing for upper respiratory tract infections: NICE guidelines. Arch Dis Child Educ Pract Ed. 2019. EPrint. DOI:10.1136/archdischild-2018-316159
  • Arroll B. Antibiotics for upper respiratory tract infections: an overview of Cochrane reviews. Respir Med. 2005;99(3):255–261.
  • Wong DM, Blumberg DA, Lowe LG. Guidelines for the use of antibiotics in acute upper respiratory tract infections. Am Fam Physician. 2006;74(6):956–966.
  • NICE Guidance. Respiratory tract infections (selflimiting): prescribing antibiotics (CG69). 2008. Available from: https://www.nice.org.uk/guidance/cg69/resources/respiratory-tract-infections-selflimiting-prescribing-antibiotics-pdf-975576354757.
  • Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;(6):Cd000247.
  • de Bie S, Kaguelidou F, Verhamme KM, et al. Using prescription patterns in primary care to derive new quality indicators for childhood community antibiotic prescribing. Pediatr Infect Dis J. 2016;35(12):1317–1323.
  • Butt AA, Navasero CS, Thomas B, et al. Antibiotic prescription patterns for upper respiratory tract infections in the outpatient Qatari population in the private sector. Int J Infect Dis. 2017;55:20–23.
  • Ahiabu MA, Tersbol BP, Biritwum R, et al. A retrospective audit of antibiotic prescriptions in primary health-care facilities in Eastern Region, Ghana. Health Policy Plan. 2016;31(2):250–258.
  • Matome M, Kgatlwane J, Massele A, et al. Antibiotic prescribing patterns for URTIs among private practitioners in Botswana; findings and implications. MURIA. 2018;4:18.
  • Kotwani A, Holloway K. Antibiotic prescribing practice for acute, uncomplicated respiratory tract infections in primary care settings in New Delhi, India. Trop Med Int Health. 2014;19(7):761–768.
  • Bhanwra S. A study of non-prescription usage of antibiotics in the upper respiratory tract infections in the urban population. J Pharmacol Pharmacother. 2013;4(1):62–64.
  • Kunda M, Haoses-Gorases L, Goraseb M. An investigation of antibiotic prescribing in patients with upper respiratory tract infections (Urtis) at Katutura Health Centre, Windhoek, Namibia. Single Cell Biol. 2015;04(04):122.
  • Kibuule D, Mubita M, Naikaku E, et al. An analysis of policies for cotrimoxazole, amoxicillin and azithromycin use in Namibia's public sector: findings and therapeutic implications. Int J Clin Pract. 2017;71(2):e12918.
  • Sadoh WE, Akinsete AM. Physicians management of sore throat in children in Benin City, Nigeria. Niger J Clin Pract. 2009;12(4):407–411.
  • Ekwochi U, Chinawa JM, Osuorah CD, et al. The use of unprescribed antibiotics in management of upper respiratory tract infection in children in Enugu, South East Nigeria. J Trop Pediatr. 2014;60(3):249–252.
  • Ab Rahman N, Teng CL, Sivasampu S. Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. BMC Infect Dis. 2016;16(1):208.
  • Zimbabwe Antimicrobial Resistance Core Group. Situation analysis of antimicrobial use and resistance in humans and animals in Zimbabwe. 2017. Available from: https://cddep.org/publications/garp-zimbabwe-situation-analysis/
  • Saengcharoen W, Lerkiatbundit S, Kaewmang K. Knowledge, attitudes, and behaviors regarding antibiotic use for upper respiratory tract infections: a survey of Thai students. Southeast Asian J Trop Med Public Health. 2012;43(5):1233–1244.
  • Tsiko S. Zimbabwe: AMR study reveals shocking misuse of antibiotics in Zim. The Herald 2017. Available from: https://allafrica.com/stories/201701170471.html.
  • Lorencatto F, Charani E, Sevdalis N, et al. Driving sustainable change in antimicrobial prescribing practice: how can social and behavioural sciences help?. J Antimicr Chemother. 2018;73(10):2613–2624.
  • Birgand G, Castro-Sánchez E, Hansen S, et al. Comparison of governance approaches for the control of antimicrobial resistance: analysis of three European countries. Antimicrob Resist Infect Control. 2018;7:28.
  • AAFP. 2018–2019 Influenza vaccine is effective, says CDC. 2019. Available from: https://www.aafp.org/news/health-of-the-public/20190220fluvaccine.html.
  • Costantino C, Vitale F. Influenza vaccination in high-risk groups: a revision of existing guidelines and rationale for an evidence-based preventive strategy. J Prev Med Hyg. 2016;57(1):E13–E18.
  • Lundgren F, Maranhao B, Martins R, et al. Vaccination in the prevention of infectious respiratory diseases in adults. Rev Assoc Med Bras. 2014;60(1):4–15.
  • McCullough AR, Parekh S, Rathbone J, et al. A systematic review of the public's knowledge and beliefs about antibiotic resistance. J Antimicrob Chemother. 2016;71(1):27–33.
  • Essack SY, Desta AT, Abotsi RE, et al. Antimicrobial resistance in the WHO African region: current status and roadmap for action. J Public Health (Oxf). 2017;39(1):8–13.
  • Meyer JC, Schellack N, Stokes J, et al. Ongoing Initiatives to Improve the Quality and Efficiency of Medicine Use within the Public Healthcare System in South Africa; A Preliminary Study. Front Pharmacol. 2017;8:751.
  • Wesangula E, Guntai A, Oluka M. Kenyan national action plan on antimicrobials. 3rd MURIA Training Workshops and Symposium. Available from: file:///C:/Users/mail/Downloads/Kenyan-NAP-Antimicrobials-EWesangula%252c-AGuantai%252c-MOluka.pdf.
  • Yevutsey SK, Buabeng KO, Aikins M, et al. Situational analysis of antibiotic use and resistance in Ghana: policy and regulation. BMC Public Health. 2017;17(1):896.
  • Ronnerstrand B, Lapuente V. Corruption and use of antibiotics in regions of Europe. Health Policy. 2017;121(3):250–256.
  • Saleem Z, Hassali MA, Hashmi FK. Pakistan's national action plan for antimicrobial resistance: translating ideas into reality. Lancet Infect Dis. 2018;18(10):1066–1067.
  • Massele A, Tiroyakgosi C, Matome M, et al. Research activities to improve the utilization of antibiotics in Africa. Exp Rev Pharm Out Res. 2017;17(1):1–4.
  • Shongwe K, S-C W. Development of Swaziland’s National Antimicrobial Resistance Containment Strategic Plan. Submitted to the US Agency for international development by the systems for improved access to pharmaceuticals and services (SIAPS) program. Arlington, VA: Management Sciences for Health; 2018. Available from: http://siapsprogram.org/publication/altview/development-of-swazilands-national-antimicrobial-resistance-containment-strategic-plan/english/.
  • Republic of Kenya. National policy for the prevention and containment of antimicrobial resistance. Nairobi, Kenya: Government of Kenya; 2017. Available from: http://www.health.go.ke/wp-content/uploads/2017/04/Kenya-AMR-Containment-Policy-_Final_April.pdf.
  • Ministry of Health Malaysia. National Antibiotic Guidelines. 2014. Available from: https://www.pharmacy.gov.my/v2/sites/default/files/document-upload/national-antibiotic-guideline-2014-full-versionjun2015_1.pdf.
  • Ministry of Health Malaysia. Protocol of antimicrobial stewardship (AMS) program in healthcare facilities. 2014. Available from: https://www.bing.com/search?q=Malaysia%2C+Protocol+of++Antimicrobial+Stewardship+&form=EDGSPH&mkt=en-gb&httpsmsn=1&refig=213332efe39442b8c24d3012ea336a59&sp=-1&pq=malaysia%2C+protocol+of+antimicrobial+stewardship+&sc=0-48&qs=n&sk=&cvid=213332efe39442b8c24. d3012ea336a59.
  • Sing DYF, Boo YL, Mukhlis R, et al. Antimicrobial stewardship program in a Malaysian district hospital: First year experience. Pak J Med Sci. 2016;32(4):999–1004.
  • Bich HNT, Ministry of Health of Vietnam. The national action plan on antimicrobial resistance in Vietnam period from 2013 to 2020. Available from: file:///C:/Users/mail/Desktop/My%20documents/Ongoing%20papers/Haque%20URTIs/Vietnam%20AMR%20PLan.pdf.
  • Chuc NT, Larsson M, Do NT, et al. Improving private pharmacy practice: a multi-intervention experiment in Hanoi, Vietnam. J Clin Epidemiol. 2002;55(11):1148–1155.
  • Vietnam Ministry of Health. Project to increase control prescription and selling of prescription drugs period 2017–2020. 2017. Available from: http://emoh.moh.gov.vn/publish/home.
  • Vietnam Mistry of Health. Planning for applying information technology to connect drugs suppliers nationwide to control prescription and selling of prescription drugs. 2018. Available from: http://emoh.moh.gov.vn/publish/home.
  • Federal Ministries of Agriculture, Rural Development, Environment and Health, Abuja, Nigeria. National action plan for antimicrobial resistance, 2017–2022. 2017. Available from: https://ncdc.gov.ng/themes/common/docs/protocols/77_1511368219.pdf.
  • Matsebula Z, Rosenkranz B, Reuter H. Establishing and monitoring the introduction of an antimicrobial stewardship programme in Swaziland; findings and implications. MURIA. 2018;4:31.
  • Kalungia AC, Mwambula H, Munkombwe D. Assessment of knowledge and perception on antimicrobial stewardship among physicians and pharmacists at University Teaching Hospitals in Zambia. MURIA. 2018;4:16–17.
  • Kalungia AC, Munkombwe M, Marshall M, et al. Strengthening antimicrobial stewardship using educational strategies: a proposed conceptual framework for professional capacity building in Zambia. MURIA. 2018;4:17.
  • Kapona O. Zambia successfully launches the first multi-sectoral national action plan on antimicrobial resistance (AMR). Health Press Zambia Bull. 2017;1(12):5–7.
  • Mashalla Y, Setlhare V, Massele A, et al. Assessment of prescribing practices at the primary healthcare facilities in Botswana with an emphasis on antibiotics: Findings and implications. Int J Clin Pract. 2017;(12):71.
  • Niaz Q, Godman B, Massele A, et al. Validity of World Health Organisation prescribing indicators in Namibia's primary healthcare: findings and implications. Int J Qual Health Care. 2019;31(5):338–345.
  • Urbiztondo I, de Oliveira SM, Hernandez-Flores N, et al. General practitioners' views on the acceptability and applicability of using quality indicators as an intervention to reduce unnecessary prescription of antibiotics in four South American countries. Antibiotics. 2018;7(3):57.
  • Kamati M, Godman B, Kibuule D. Prevalence self-medication in acute respiratory infections in the informal settlements in Outapi Region, Namibia. MURIA. 2018;4:37.
  • Robertson J, Iwamoto K, Hoxha I, et al. Antimicrobial medicines consumption in Eastern Europe and Central Asia – an updated cross-national study and assessment of quantitative metrics for policy action. Front Pharmacol. 2019;9(1156).
  • Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Leufkens HG, et al. Reply to “decrease in penicillin sales in Brazil after over-the-counter restrictions. Antimicrob Agents Chemother. 2015;59(9):5864.
  • M'ikanatha NM. Antibiotic stewardship in ambulatory care settings and surveillance for enteric pathogens in Pennsylvania. J Lancaster Gen Hosp. 2016;11(3):75–80.
  • Drekonja D, Filice G, Greer N, et al. Antimicrobial stewardship programs in outpatient settings: a systematic review. VA-ESP Project #09-009. 2014. Available from: https://www.hsrd.research.va.gov/publications/esp/antimicrobial-outpatient.pdf.
  • DART. Antibiotics Avoiding Resistance. DART 2020 – third interim report 2018. Available from: https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/3_Downloads/D/DART_2020/BMG_DART2020_3rd-Zwischenbericht_2018_EN.PDF.
  • The Federal Government. DART 2020 – second interim report 2017. Available from: https://www.gesundheitsforschung-bmbf.de/files/DART_2020_%202nd_Interim_Report_2017.pdf.
  • Molstad S, Lofmark S, Carlin K, et al. Lessons learnt during 20 years of the Swedish strategic programme against antibiotic resistance. Bull World Health Organ. 2017;95(11):764–773.
  • ECDC. Quality indicators for antibiotic consumption in the community in Europe. Available from: http://ecdc.europa.eu/en/healthtopics/antimicrobial-resistance-and-consumption/antimicrobial-consumption/esac-net-database/Pages/quality-indicators-primary-care.aspx.
  • Nathwani D, Sneddon J, Patton A, et al. Antimicrobial stewardship in Scotland: impact of a national programme. Antimicrob Resist Infect Control. 2012;1(1):7.
  • NHS Lothian. Antimicrobial prescribing guidelines. 2013. Available from: https://www.nhslothian.scot.nhs.uk/AntimicrobialPrescribingGuidelines/Pages/default.aspx.
  • NHS Fife antibiotic guidance for the treatment of community managed infections. 2014. Available from: file:///C:/Users/mail/Desktop/My%20documents/Ongoing%20papers/Haque%20URTIs/primary-care-antibiotic-guidelines-revised%20NHS%20Fife.pdf.
  • NHS Highland Formulary. 2018. Available from: file:///C:/Users/mail/Desktop/My%20documents/Ongoing%20papers/Haque%20URTIs/highland%20formulary%202018.pdf.
  • Health Protection Scotland. Scottish One Health antimicrobial use and antimicrobial resistance report in 2017. Health Protection Scotland, 2018. Available from: https://www.hps.scot.nhs.uk/resourcedocument.aspx?id=6971.
  • Gilchrist M, Wade P, Ashiru-Oredope D, et al. Antimicrobial stewardship from policy to practice: experiences from UK antimicrobial pharmacists. Infect Dis Ther. 2015;4(S1):51–64.
  • Public Health England. English surveillance programme for antimicrobial utilisation and resistance (ESPAUR). 2018. Report. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/759975/ESPAUR_2018_report.pdf.
  • All Wales Medicine Strategy Group. Primary care antimicrobial guidelines. 2015. Available from: http://www.awmsg.org/docs/awmsg/medman/Primary%20Care%20Antimicrobial%20Guidelines.pdf.
  • Nottinghamshire Area Prescribing Committee. Antimicrobial prescribing guidelines for primary care. 2017. Available from: http://www.nottsapc.nhs.uk/media/1044/antimicrobial-guidelines.pdf.
  • South Central antimicrobial network guidelines for antibiotic prescribing in the community 2018. Available from: http://www.nhsantibioticguidelines.org.uk/downloads/CS47131-NHSNHCCG-Antibiotic-Guidelines-2018-FINAL-WHOLE-WEB-LIVE-v3.pdf.
  • Ashiru-Oredope D, Hopkins S. Antimicrobial resistance: moving from professional engagement to public action. J Antimicrob Chemother. 2015;70(11):2927–2930.
  • HM Government. Tackling antimicrobial resistance 2019–2024 – the UK’s five-year national action plan. 2019. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/773130/uk-amr-5-year-national-action-plan.pdf.
  • Hoxha I, Malaj A, Tako R, et al. Survey on how antibiotics are dispensed in community pharmacies in Albania. Int J Pharm Pharm Sci. 2015;7(7):449–450.
  • Hoxha I, Malaj A, Kraja B, et al. Are pharmacists' good knowledge and awareness on antibiotics taken for granted? The situation in Albania and future implications across countries. J Global Antimicrob Resist. 2018;13:240–245.
  • Ministry of Health and Social Security Albania. Barnat pa recetë, intensifikohen kontrollet në farmaci. October 2018. Available from: http://www.shendetesia.gov.al/barnat-pa-recete-intensifikohen-kontrollet-ne-farmaci/.
  • Ministry of Health and Social Security Albania. Manastirliu ngre “Task Forcë” për kontrollin e barnave. September 2018. Available from: http://www.shendetesia.gov.al/manastirliu-ngre-task-force-per-kontrollin-e-barnave/.
  • Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Dreser A, et al. Impact of over-the-counter restrictions on antibiotic consumption in Brazil and Mexico. PLoS One. 2013;8(10):e75550.
  • Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Leufkens HGM, et al. Seasonal variation in penicillin use in Mexico and Brazil: analysis of the impact of over-the-counter restrictions. Antimicrob Agents Chemother. 2015;59(1):105–110.
  • Wirtz VJ, Herrera-Patino JJ, Santa-Ana-Tellez Y, et al. Analysing policy interventions to prohibit over-the-counter antibiotic sales in four Latin American countries. Trop Med Int Health. 2013;18(6):665–673.
  • Ghana Ministry of Health, Ministry of Food and Agriculture, Ministry of Environment, Science, Technology and Innovation, Ministry of Fisheries and Aquaculture Development. Ghana national action plan for antimicrobial use and resistance, 2017–2021. Available from: http://www.moh.gov.gh/wp-content/uploads/2018/04/NAP_FINAL_PDF_A4_19.03.2018-SIGNED-1.pdf.
  • Fleming Fund – Ghana. Overview of country activity. 2018. Available from: https://www.flemingfund.org/countries/ghana/.
  • Versporten A, Bolokhovets G, Ghazaryan L, et al. Antibiotic use in Eastern Europe: a cross-national database study in coordination with the WHO regional office for Europe. Lancet Infect Dis. 2014;14(5):381–387.
  • Jakupi A, Godman B, Martin A, et al. Utilization and expenditure of anti-cancer medicines in Kosovo: findings and implications. Pharm Open. 2018;2(4):423–432.
  • Markovic-Pekovic V, Grubisa N. Self-medication with antibiotics in the Republic of Srpska community pharmacies: pharmacy staff behavior. Pharmacoepidemiol Drug Saf. 2012;21(10):1130–1133.
  • Markovic-Pekovic V, Grubisa N, Burger J, et al. Initiatives to reduce nonprescription sales and dispensing of antibiotics: findings and implications. J Res Pharm Pract. 2017;6(2):120–125.
  • Meyer J, Sibanda M. Appropriate use of antimicrobials: an ongoing and coordinated effort. S Afr Pharm J. 2016;83(9):41–47.
  • Mendelson M. Matsoso MP. The South African antimicrobial resistance strategy framework. Amr Control. 2015:54–61.
  • SAASP. Mission statement of the South African antibiotic stewardship programme. 2017. Available from: http://www.fidssa.co.za/SAASP.
  • Brink AJ, Messina AP, Feldman C, et al. Antimicrobial stewardship across 47 South African hospitals: an implementation study. Lancet Infect Dis. 2016;16(9):1017–1025.
  • Schellack N, Bronkhorst E, Coetzee R, et al. SASOCP position statement on the pharmacist’s role in antibiotic stewardship 2018. South African J Infect Dis. 2018;33(1):28–35.
  • Ncube NBQ, Solanki GC, Kredo T, et al. Antibiotic prescription patterns of South African general medical practitioners for treatment. MURIA. 2018;4:19.
  • Matsitse TB, Helberg E, Meyer JC, et al. Compliance with the primary health care treatment guidelines and the essential medicines list in the management of sexually transmitted infections in correctional centres in South Africa: findings and implications. Exp Rev Anti-Infect Ther. 2017;15(10):963–972.
  • Burger MF, Lootsa D, Mnisia T, et al. Knowledge and perceptions of antimicrobial stewardship concepts among final year pharmacy students in pharmacy schools across South Africa. Southern Africa J Infect Dis. 2016;1(1):1–7.
  • Wasserman S, Potgieter S, Shoul E, et al. South African medical students' perceptions and knowledge about antibiotic resistance and appropriate prescribing: are we providing adequate training to future prescribers? S Afr Med J. 2017;107(5):405–410.
  • Turkish Medicines And Medical Devices Agency. Pharmaceutical Track And Trace System (İTS). 2019. Available from: https://www.gs1.org/sites/default/files/docs/healthcare/2019.Noordwijk/Presentations-Day3/02.Day3Turkish-pharmaceutical-track-trace-system-ITS.pdf.
  • Meeker D, Linder JA, Fox CR, et al. Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: a randomized clinical trial. JAMA. 2016;315(6):562–570.
  • van der Velden A, Duerden MG, Bell J, et al. Prescriber and patient responsibilities in treatment of acute respiratory tract infections — essential for conservation of antibiotics. Antibiotics. 2013;2(2):316–327.
  • Abera B, Kibret M, Mulu W. Knowledge and beliefs on antimicrobial resistance among physicians and nurses in hospitals in Amhara Region, Ethiopia. BMC Pharmacol Toxicol. 2014;15(1):26.
  • Labi AK, Obeng-Nkrumah N, Bjerrum S, et al. Physicians' knowledge, attitudes, and perceptions concerning antibiotic resistance: a survey in a Ghanaian tertiary care hospital. BMC Health Serv Res. 2018;18(1):126.
  • Mosaddek AS, Islam Z, Rahman F, et al. A pilot study on evaluation of self-medication among undergraduate medical students in Dhaka, Bangladesh. Research J Pharm Tech. 2014;7(11):1240–1245.
  • Mosaddek AS, Haque M, Islam Z, et al. Practice of self-medication among students of a selected medical college of Dhaka City, Bangladesh. Int Med J. 2017;24(2):225–229.
  • Haque M, Rahman NI, Zulkifli Z, et al. Antibiotic prescribing and resistance: knowledge level of medical students of clinical years of University Sultan Zainal Abidin, Malaysia. Therap Clin Risk Manage. 2016;12:413–426.
  • Hoque R, Mostafa A, Haque M. Intern doctors' views on the current and future antibiotic resistance situation of Chattagram Maa O Shishu Hospital Medical College, Bangladesh. Ther Clin Risk Manag. 2015;11:1177–1185.
  • Hoque R, Mostafa A, Haque M. Insight of medical students of clinical years to antimicrobials prescribing and resistance in private medical school, Chittagong, Bangladesh. JYP. 2016;8(4):447–455.
  • Haque M, Rahman NAA, McKimm J, et al. A cross-sectional study evaluating the knowledge and beliefs about, and the use of antibiotics amongst Malaysian university students. Exp Rev Anti-Infect Ther. 2019;17(4):275–284.
  • Saleem Z, Hassali MA, Godman B, et al. Antimicrobial prescribing and determinants of antimicrobial resistance: a qualitative study among physicians in Pakistan. Int J Clin Pharm. 2019;41(5):1348–1358.
  • Lam TP, Lam KF. What are the non-biomedical reasons which make family doctors over-prescribe antibiotics for upper respiratory tract infection in a mixed private/public Asian setting? J Clin Pharm Ther. 2003;28(3):197–201.
  • Moro ML, Marchi M, Gagliotti C, et al. Why do paediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2009;9(1):69.
  • Riaz H, Godman B, Hussain S, et al. Prescribing of bisphosphonates and antibiotics in Pakistan: challenges and opportunities for the future. JPHSR. 2015;6:111–121.
  • Fadare JO, Oshikoya KA, Ogunleye OO, Desalu OO, et al. Drug promotional activities in Nigeria: impact on the prescribing patterns and practices of medical practitioners and the implications. Hosp Pract. 2018;46(2):77–87.
  • Holmes EAF, Harris SD, Hughes A, et al. Cost-effectiveness analysis of the use of point-of-care C-reactive protein testing to reduce antibiotic prescribing in primary care. Antibiotics. 2018;7(4):106.
  • Gonzales R, Anderer T, McCulloch CE, et al. A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. JAMA Intern Med. 2013;173(4):267–273.
  • Hallsworth M, Chadborn T, Sallis A, et al. Provision of social norm feedback to high prescribers of antibiotics in general practice: a pragmatic national randomised controlled trial. Lancet. 2016;387(10029):1743–1752.
  • Fernandez Urrusuno R, Flores Dorado M, Vilches Arenas A, et al. Improving the appropriateness of antimicrobial use in primary care after implementation of a local antimicrobial guide in both levels of care. Eur J Clin Pharmacol. 2014;70(8):1011–1020.
  • Sun Q, Dyar OJ, Zhao L, et al. Overuse of antibiotics for the common cold - attitudes and behaviors among doctors in rural areas of Shandong Province, China. BMC Pharmacol Toxicol. 2015;16(1):6.
  • Esmaily HM, Silver I, Shiva S, et al. Can rational prescribing be improved by an outcome-based educational approach? A randomized trial completed in Iran. J Contin Educ Health Profess. 2010;30(1):11–18.
  • Rambaud-Althaus C, Shao A, Samaka J, et al. Performance of health workers using an electronic algorithm for the management of childhood illness in Tanzania: a pilot implementation study. Am J Trop Med Hyg. 2017;96(1):249–257.
  • Tuon FF, Gasparetto J, Wollmann LC, et al. Mobile health application to assist doctors in antibiotic prescription – an approach for antibiotic stewardship. Brazilian J Infect Dis. 2017;21(6):660–664.
  • Yoon CH, Ritchie SR, Duffy EJ, et al. Impact of a smartphone app on prescriber adherence to antibiotic guidelines in adult patients with community acquired pneumonia or urinary tract infections. PLoS One. 2019;14(1):e0211157.
  • Yip W, Powell-Jackson T, Chen W, et al. Capitation combined with pay-for-performance improves antibiotic prescribing practices in rural China. Health Aff. 2014;33(3):502–510.
  • Shrestha N, Samir KC, Baltussen R, et al. Practical approach to lung health in Nepal: better prescribing and reduction of cost. Trop Med Int Health. 2006;11(5):765–772.
  • Kafle KK, Bhuju GB, Karkee SB, et al. An intervention improving prescribing practices and monitoring drugs availability in a district. NMCJ. 2009;11(4):217–221.
  • Awad AI, Eltayeb IB, Baraka OZ. Changing antibiotics prescribing practices in health centers of Khartoum State, Sudan. Eur J Clin Pharmacol. 2006;62(2):135–142.
  • Adriaenssens N, Coenen S, Tonkin-Crine S, et al. European surveillance of antimicrobial consumption (ESAC): disease-specific quality indicators for outpatient antibiotic prescribing. BMJ Qual Saf. 2011;20(9):764–772.
  • Coenen S, Ferech M, Haaijer-Ruskamp FM, et al. European surveillance of antimicrobial consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Qual Saf Health Care. 2007;16(6):440–445.
  • WHO. Antimicrobial medicines consumption (AMC) network. 2017. Available from: http://www.euro.who.int/en/publications/abstracts/antimicrobial-medicines-consumption-amc-network.-amc-data-20112014-2017
  • Nakwatumbah S, Kibuule D, Godman B, et al. Compliance to guidelines for the prescribing of antibiotics in acute infections at Namibia's national referral hospital: a pilot study and the implications. Exp Rev Anti-Infect Ther. 2017;15(7):713–721.
  • Mashalla YJ, Sepako E, Setlhare V, et al. Availability of guidelines and policy documents for enhancing performance of practitioners at the Primary Health Care (PHC) facilities in Gaborone, Tlokweng and Mogoditshane, Republic of Botswana. J Public Health Epidemiol. 2016;8(8):127–135.
  • Roberts RM, Hicks LA, Bartoces M. Variation in US outpatient antibiotic prescribing quality measures according to health plan and geography. Am J Manag Care. 2016;22(8):519–523.
  • Le Maréchal M, Tebano G, Monnier AA, et al. Quality indicators assessing antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. J Antimicrob Chemother. 2018;73(suppl_6):vi40–vi9.
  • Lind J, Schafheutle E, Hagg AN, et al. General sale of non-prescription medicinal products: comparing legislation in two European countries. Res Social Administr Pharm. 2016;12(1):68–77.
  • Chipwaza B, Mugasa JP, Mayumana I, et al. Self-medication with anti-malarials is a common practice in rural communities of Kilosa district in Tanzania despite the reported decline of malaria. Malar J. 2014;13(1):252.
  • Hadi MA, Karami NA, Al-Muwalid AS, et al. Community pharmacists' knowledge, attitude, and practices towards dispensing antibiotics without prescription (DAwP): a cross-sectional survey in Makkah Province, Saudi Arabia. Int J Infect Dis. 2016;47:95–100.
  • Ramay BM, Lambour P, Cerón A. Comparing antibiotic self-medication in two socio-economic groups in Guatemala City: a descriptive cross-sectional study. BMC Pharmacol Toxicol. 2015;16:11.
  • Hussain A, Ibrahim MIM, Malik M. Assessment of disease management of acute respiratory tract infection at community pharmacies through simulated visits in Pakistan. Lat Am J Pharm. 2012;31:1435–1440.
  • Fleming N, Barbar S, Ashiru-Oredope D. Pharmacists have a critical role in the conservation of effective antibiotics. Pharm J. 2011;287(7675):465.
  • Mukokinya M, Opanga S, Oluka M, et al. Dispensing of antimicrobials in Kenya: a cross-sectional pilot study and its implications. J Res Pharm Pract. 2018;7(2):77–82.
  • Mbui JM, Oluka MN, Guantai EM, et al. Prescription patterns and adequacy of blood pressure control among adult hypertensive patients in Kenya; findings and implications. Exp Rev Clin Pharmacol. 2017;10(11):1263–1271.
  • FIP. FIP statement of policy – control of antimicrobial medicines resistance (AMR). Available from: http://www.fip.org/www/uploads/database_file.php?id=289&table_id.
  • WHO. The role of pharmacist in encouraging prudent use of antibiotics and averting antimicrobial resistance: a review of policy and experience. Available from: http://www.euro.who.int/__data/assets/pdf_file/0006/262815/The-role-of-pharmacist-in-encouraging-prudent-use-of-antibiotics-and-averting-antimicrobial-resistance-a-review-of-policy-and-experience-Eng.pdf?ua=1.
  • Ahmad A, Khan MU, Moorthy J, et al. Comparison of knowledge and attitudes about antibiotics and resistance, and antibiotics self-practicing between Bachelor of Pharmacy and Doctor of Pharmacy students in Southern India. Pharm Pract (Granada). 2015;13(1):523.
  • Chang J, Ye D, Lv B, et al. Sale of antibiotics without a prescription at community pharmacies in urban China: a multicentre cross-sectional survey. J Antimicrob Chemother. 2017;72(4):1235–1242.
  • Eslami N, Eshraghi A, Vaseghi G, et al. Pharmacists' knowledge and attitudes towards upper respiratory infections (URI) in Iran: a cross sectional study. RRCT. 2016;11(4):342–345.
  • Zapata-Cachafeiro M, González-González C, Váquez-Lago JM, et al. Determinants of antibiotic dispensing without a medical prescription: a cross-sectional study in the north of Spain. J Antimicrob Chemother. 2014;69(11):3156–3160.
  • Donkor ES, Tetteh-Quarcoo PB, Nartey P, et al. Self-medication practices with antibiotics among tertiary level students in Accra, Ghana: a cross-sectional study. Int J Environ Res Public Health. 2012;9.
  • Zawahir S, Lekamwasam S, Aslani P. A cross-sectional national survey of community pharmacy staff: knowledge and antibiotic provision. PLoS One. 2019;14(4):e0215484.
  • Saleem Z, Hassali MA, Hashmi FK, et al. Antimicrobial dispensing practices and determinants of antimicrobial resistance: a qualitative study among community pharmacists in Pakistan. Fam Med Com Health. 2019;7:e000138.
  • Almaaytah A, Mukattash TL, Hajaj J. Dispensing of non-prescribed antibiotics in Jordan. Patient Prefer Adherence. 2015;9:1389–1395.
  • Charani E, Smith I, Skodvin B, et al. Investigating the cultural and contextual determinants of antimicrobial stewardship programmes across low-, middle- and high-income countries-a qualitative study. PLoS One. 2019;14(1):e0209847.
  • Al-Mohamadi A, Badr A, Bin Mahfouz L, et al. Dispensing medications without prescription at Saudi community pharmacy: Extent and perception. Saudi Pharm J. 2013;21(1):13–18.
  • Moura ML, Boszczowski I, Mortari N, et al. The impact of restricting over-the-counter sales of antimicrobial drugs: Preliminary analysis of national data. Medicine. 2015;94(38):e1605.
  • Lopes-Junior R, de Sa Del Fiol F, Araujo JL, et al. Decrease in penicillin Sales in Brazil after over-the-counter restrictions. Antimicrob Agents Chemother. 2015;59(9):5862–5863.
  • Roque F, Soares S, Breitenfeld L, et al. Attitudes of community pharmacists to antibiotic dispensing and microbial resistance: a qualitative study in Portugal. Int J Clin Pharm. 2013;35(3):417–424.
  • Lim KK, Teh CC. A cross sectional study of public knowledge and attitude towards antibiotics in Putrajaya, Malaysia. South Med Rev. 2012;5(2):26–33.
  • Monnet DL, Safrany N, Heine N, et al. Comment on: A systematic review of the public's knowledge and beliefs about antibiotic resistance. J Antimicrob Chemother. 2016;71(8):2364–2365.
  • Elong Ekambi G-A, Okalla Ebongue C, Penda IC, et al. Knowledge, practices and attitudes on antibiotics use in Cameroon: self-medication and prescription survey among children, adolescents and adults in private pharmacies. PLoS One. 2019;14(2):e0212875.
  • Pinder RJ, Berry D, Sallis A, et al. Behaviour change for antibiotic prescribing in healthcare settings. Literarure review and behavioural analysis. 2015. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/405031/Behaviour_Change_for_Antibiotic_Prescribing_-_FINAL.pdf.
  • Ivanovska V, Angelovska B, van Dijk L, et al. Change in parental knowledge, attitudes and practice of antibiotic use after a national intervention programme. Eur J Public Health. 2018;28(4):724–729.
  • Cabral C, Ingram J, Lucas PJ, et al. Influence of clinical communication on parents' antibiotic expectations for children with respiratory tract infections. Ann Fam Med. 2016;14(2):141–147.
  • Coenen S, Francis N, Kelly M, et al. Are patient views about antibiotics related to clinician perceptions, management and outcome? A multi-country study in outpatients with acute cough. PLoS One. 2013;8(10):e76691.
  • Doctors and local media: a synergy for public health information?: a controlled trial to evaluate the effects of a multifaceted campaign on antibiotic prescribing (protocol). BMC Public Health. 2011;11:816.
  • Hornik R, Kelly B. Communication and diet: an overview of experience and principles. JNEB. 2007;39(2):S5–S12.
  • Bjorkhem-Bergman L, Andersen-Karlsson E, Laing R, et al. Interface management of pharmacotherapy. Joint hospital and primary care drug recommendations. Eur J Clin Pharmacol. 2013;69(Suppl 1):73–78.
  • Gustafsson LL, Wettermark B, Godman B, et al. The 'wise list'- a comprehensive concept to select, communicate and achieve adherence to recommendations of essential drugs in ambulatory care in Stockholm. Basic Clin Pharmacol Toxicol. 2011;108(4):224–233.
  • Eriksen J, Gustafsson LL, Ateva K, et al. High adherence to the 'Wise List' treatment recommendations in Stockholm: a 15-year retrospective review of a multifaceted approach promoting rational use of medicines. BMJ Open. 2017;7(4):e014345.
  • Sharland M, Pulcini C, Harbarth S, et al. Classifying antibiotics in the WHO essential medicines list for optimal use-be AWaRe. Lancet Infect Dis. 2018;18(1):18–20.
  • Hsia Y, Sharland M, Jackson C, et al. Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries. Lancet Infect Dis. 2019;19(1):67–75.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.