Advanced search
Publication Cover
Scandinavian Journal of Rheumatology Volume 52, 2023 - Issue 1
Submit an article Journal homepage
2,072
Views
4
CrossRef citations to date
0
Altmetric
Articles/Brief Reports

Rheumatoid cachexia in early rheumatoid arthritis: prevalence and associated variables

L Ångström1 Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, SwedenCorrespondence[email protected]
,
K Hörnberg1 Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
,
B Sundström1 Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
&
A Södergren1 Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden;2 Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden
Pages 10-16 | Accepted 25 Aug 2021, Published online: 13 Oct 2021

  • Scott DL, Smith C, Kingsley G. What are the consequences of early rheumatoid arthritis for the individual? Best Pract Res Clin Rheumatol 2005;19:117–36.
  • Michaud KWF. Comorbidities in RA. Best Pract Res Clin Rheumatol 2007;21:885–906.
  • Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, et al. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379–86.
  • Turk SA, van Schaardenburg D, Boers M, De Boer S, Fokker C, Lems WF, et al. An unfavorable body composition is common in early arthritis patients: a case control study. PLoS One 2018;13:e0193377.
  • Rajbhandary R, Khezri A, Panush RS. Rheumatoid cachexia: what is it and why is it important? J Rheumatol 2011;38:406–8.
  • Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med 1988;167:1211–27.
  • Engvall IL, Elkan AC, Tengstrand B, Cederholm T, Brismar K, Hafstrom I. Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 2008;37:321–8.
  • Elkan AC, Håkansson N, Frostegård J, Cederholm T, Hafström I. Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 2009;11:R37.
  • Santo RCE, Fernandes KZ, Lora PS, Filippin LI, Xavier RM. Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2018;9:816–25.
  • Book C, Karlsson MK, Åkesson K, Jacobsson LTH. Early rheumatoid arthritis and body composition. Rheumatology 2009;48:1128–32.
  • da Cunha VR, Brenol CV, Brenol JCT, Fuchs SC, Arlindo EM, Melo IMF, et al. Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity. Scand J Rheumatol 2012;41:186–91.
  • Kremers HM, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE. Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis. Arthritis Rheum 2004;50:3450–7.
  • Lemmey AB, Wilkinson TJ, Clayton RJ, Sheikh F, Whale J, Jones HSJ, et al. Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients. Rheumatology 2016;55:1736–45.
  • Tyrovolas S, Panagiotakos D, Georgousopoulou E, Chrysohoou C, Tousoulis D, Haro JM, et al. Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study. J Epidemiol Community Health 2020;74:26–31.
  • Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569–81.
  • Toombs RJ, Ducher G, Shepherd JA, De Souza MJ. The impact of recent technological advances on the trueness and precision of DXA to assess body composition. Obesity (Silver Spring) 2012;20:30–9.
  • Schutz Y, Kyle UU, Pichard C. Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes Relat Metab Disord 2002;26:953–60.
  • Prevoo ML, van ‘t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, Van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44–8.
  • Fries JF, Spitz P, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis Rheum 1980;23:137–45.
  • Conroy RM, Pyörälä K, Fitzgerald AP, Sans S, Menotti A, De Backer G, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003;24:987–1003.
  • Ciudin A, Salvador R, Budoy A, Spinu C, Diaconu MG, Constantin V, et al. Measurement of waist circumference for retrospective studies - prospective validation of use of CT images to assess abdominal circumference. Endocrinol Nutr 2014;61:147–52.
  • Astrand PO, Ryhming I. A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work. J Appl Physiol 1954;7:218–21.
  • Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand Suppl 1960;49:1–92.
  • Nes BM, Janszky I, Wisløff U, Støylen A, Karlsen T. Age-predicted maximal heart rate in healthy subjects: the HUNT fitness study. Scand J Med Sci Sports 2013;23:697–704.
  • Angstrom L, Hornberg K, Sundstrom B, Jonsson SW, Sodergren A. Aerobic capacity is associated with disease activity and cardiovascular risk factors in early rheumatoid arthritis. Physiother Res Int 2020;25:e1833.
  • Hörnberg K, Pomeroy J, Sandberg C, Södergren A, Ångström L, Sundström B, et al. Physical activity in rheumatoid arthritis: relationship to cardiovascular risk factors, subclinical atherosclerosis, and disease activity. Scand J Rheumatol 2020;49:112–21.
  • Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ 1990;300:230–5.
  • Fransen J, Van Riel PL. The disease activity score and the EULAR response criteria. Rheum Dis Clin North Am 2009;35:745–57, vii–viii.
  • Santo RC, Silva JM, Lora PS, Moro ALD, Freitas EC, Bartikoski BJ, et al. Cachexia in patients with rheumatoid arthritis: a cohort study. Clin Rheumatol 2020;39:3603–13.
  • Baker JF, Von Feldt J, Mostoufi-Moab S, Noaiseh G, Taratuta E, Kim W, et al. Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis. Arthritis Care Res (Hoboken) 2014;66:1612–18.
  • Roubenoff R, Kehayias JJ. The meaning and measurement of lean body mass. Nutr Rev 1991;49:163–75.
  • Marcora SM, Lemmey AB, Maddison PJ. Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot study. J Rheumatol 2005;32:1031–9.
  • Santillán-Díaz C, Ramírez-Sánchez N, Espinosa-Morales R, Orea-Tejeda A, Llorente L, Rodríguez-Guevara G, et al. Prevalence of rheumatoid cachexia assessed by bioelectrical impedance vector analysis and its relation with physical function. Clin Rheumatol 2018;37:607–14.
  • Klein GL. The effect of glucocorticoids on bone and muscle. Osteoporos Sarcopenia 2015;1:39–45.
  • Lemmey AB, Wilkinson TJ, Perkins CM, Nixon LA, Sheikh F, Jones JG, et al. Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis. Eur J Rheumatol 2018;5:160–4.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.