Anaerobic digestion of livestock and poultry manures spiked with tetracycline antibiotics

References

• Halling-Sørensen, G.; Sengel, B. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria. Arch. Environ. Contam. Toxicol. 2002, 42, 263–271. DOI: 10.1007/s00244-001-0017-2.
   PubMed Web of Science ®Google Scholar
• Jeong, J.; Song, W.; Cooper, W. J.; Jung, J.; Greaves, J. Degradation of Tetracycline Antibiotics: Mechanisms and Kinetic Studies for Advanced Oxidation/Reduction Processes. Chemosphere 2010, 78, 533–540. DOI: 10.1016/j.chemosphere.2009.11.024.
   PubMed Web of Science ®Google Scholar
• López-Peñalver, J. J.; Sánchez-Polo, M.; Gómez-Pacheco, C. V.; Rivera-Utrilla, J. Photodegradation of Tetracyclines in Aqueous Solution by Using UV and UV/H2O2 Oxidation Processes. J. Chem. Technol. Biotechnol. 2010, 85, 1325–1333. DOI: 10.1002/jctb.2435.
   Web of Science ®Google Scholar
• Daghrir, R.; Drogui, P. Tetracycline Antibiotics in the Environment: A Review. Environ. Chem. Lett. 2013, 11, 209–227. DOI: 10.1007/s10311-013-0404-8.
   Web of Science ®Google Scholar
• Granados-Chinchilla, F.; Rodríguez, C. Tetracyclines in Food and Feedingstuffs: From Regulation to Analytical Methods, Bacterial Resistance, and Environmental and Health Implications. J. Anal. Methods Chem. 2017, 2017, 1–24. DOI: 10.1155/2017/1315497.
   Web of Science ®Google Scholar
• DuPont, H. L.; Steele, J. H. Use of Antimicrobial Agents in Animal Feeds: Implications for Human Health. Clin. Infect. Dis. 1987, 9, 447–460. DOI: 10.1093/clinids/9.3.447.
   Google Scholar
• Diarra, M. S.; Malouin, F.; Jacques, M. Postantibiotic and Physiological Effects of Tilmicosin, Tylosin, and Apramycin at Subminimal and Suprainhibitory Concentrations on Some Swine and Bovine Respiratory Tract Pathogens. Int. J. Antimicrob. Agents 1999, 12, 229–237. DOI: 10.1016/S0924-8579(99)00069-2.
   PubMed Web of Science ®Google Scholar
• Aga, D. S.; O'Connor, S.; Ensley, S.; Payero, J. O.; Snow, D.; Tarkalson, D. Determination of the Persistence of Tetracycline Antibiotics and Their Degradates in Manure-Amended Soil Using Enzyme-Linked Immunosorbent Assay and Liquid Chromatography-Mass Spectrometry. J. Agric. Food Chem. 2005, 53, 7165–7171. DOI: 10.1021/jf050415+.
   PubMed Web of Science ®Google Scholar
• Loftin, K. A.; Henny, C.; Adams, C. D.; Surampali, R.; Mormile, M. R. Inhibition of Microbial Metabolism in Anaerobic Lagoons by Selected Sulfonamides, Tetracyclines, Lincomycin, and Tylosin Tartrate. Environ. Toxicol. Chem. 2005, 24, 782. DOI: 10.1897/04-093R.1.
   PubMed Web of Science ®Google Scholar
• US FDA. New Animal Drugs and New Animal Drug Combination Products Administered in or on Medicated Feed or Drinking Water of Food Producing Animals: Recommendations for Drug Sponsors for Voluntarily Aligning Product Use Conditions with GFI #209. 2013.
   Google Scholar
• Koluman, A.; Dikici, A. Antimicrobial Resistance of Emerging Foodborne Pathogens: Status Quo and Global Trends. Crit. Rev. Microbiol. 2013, 39, 57–69. DOI: 10.3109/1040841X.2012.691458.
   PubMed Web of Science ®Google Scholar
• Jjemba, P. K. The Potential Impact of Veterinary and Human Therapeutic Agents in Manure and Biosolids on Plants Grown on Arable Land: A Review. Agriculture. Ecosyst. Environ. 2002, 93, 267–278. DOI: 10.1016/S0167-8809(01)00350-4.
   Web of Science ®Google Scholar
• Álvarez, J. A.; Otero, L.; Lema, J. M.; Omil, F. The Effect and Fate of Antibiotics during the Anaerobic Digestion of Pig Manure. Bioresour. Technol. 2010, 101, 8581–8586. DOI: 10.1016/j.biortech.2010.06.075.
   PubMed Web of Science ®Google Scholar
• Karthikeyan, K. G.; Meyer, M. T. Occurrence of Antibiotics in Wastewater Treatment Facilities in Wisconsin, USA. Sci. Total Environ. 2006, 361, 196–207. DOI: 10.1016/j.scitotenv.2005.06.030.
   PubMed Web of Science ®Google Scholar
• Campagnolo, E. R.; Johnson, K. R.; Karpati, A.; Rubin, C. S.; Kolpin, D. W.; Meyer, M. T.; Esteban, J. E.; Currier, R. W.; Smith, K.; Thu, K. M.; McGeehin, M. Antimicrobial Residues in Animal Waste and Water Resources Proximal to Large-Scale Swine and Poultry Feeding Operations. Sci. Total Environ. 2002, 299, 89–95. DOI: 10.1016/S0048-9697(02)00233-4.
   PubMed Web of Science ®Google Scholar
• Bautitz, I. R.; Nogueira, R. F. P. Degradation of Tetracycline by photo-Fenton Process—Solar Irradiation and Matrix Effects. J. Photochem. Photobiol. A: Chem. 2007, 187, 33–39. DOI: 10.1016/j.jphotochem.2006.09.009.
   Web of Science ®Google Scholar
• Wei, R.; Ge, F.; Huang, S.; Chen, M.; Wang, R. Occurrence of Veterinary Antibiotics in Animal Wastewater and Surface Water around Farms in Jiangsu Province, China. Chemosphere 2011, 82, 1408–1414. DOI: 10.1016/j.chemosphere.2010.11.067.
   PubMed Web of Science ®Google Scholar
• He, L.-Y.; Ying, G.-G.; Liu, Y.-S.; Su, H.-C.; Chen, J.; Liu, S.-S.; Zhao, J.-L. Discharge of Swine Wastes Risks Water Quality and Food Safety: Antibiotics and Antibiotic Resistance Genes from Swine Sources to the Receiving Environments. Environ. Int. 2016, 92–93, 210–219. DOI: 10.1016/j.envint.2016.03.023.
   PubMed Web of Science ®Google Scholar
• Chee-Sanford, J. C.; Aminov, R. I.; Krapac, I. J.; Garrigues-Jeanjean, N.; Mackie, R. I. Occurrence and Diversity of Tetracycline Resistance Genes in Lagoons and Groundwater Underlying Two Swine Production Facilities. Appl. Environ. Microbiol. 2001, 67, 1494–1502. DOI: 10.1128/AEM.67.4.1494-1502.2001.
   PubMed Web of Science ®Google Scholar
• Koike, S.; Krapac, I. G.; Oliver, H. D.; Yannarell, A. C.; Chee-Sanford, J. C.; Aminov, R. I.; Mackie, R. I. Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period. Appl. Environ. Microbiol. 2007, 73, 4813–4823. DOI: 10.1128/AEM.00665-07.
   PubMed Web of Science ®Google Scholar
• Gao, P.; Munir, M.; Xagoraraki, I. Correlation of Tetracycline and Sulfonamide Antibiotics with Corresponding Resistance Genes and Resistant Bacteria in a Conventional Municipal Wastewater Treatment Plant. Sci. Total Environ. 2012, 421–422, 173–183. DOI: 10.1016/j.scitotenv.2012.01.061.
   PubMed Web of Science ®Google Scholar
• Agga, G. E.; Arthur, T. M.; Durso, L. M.; Harhay, D. M.; Schmidt, J. W. Antimicrobial-Resistant Bacterial Populations and Antimicrobial Resistance Genes Obtained from Environments Impacted by Livestock and Municipal Waste. PLoS One 2015, 10, e0132586. DOI: 10.1371/journal.pone.0132586.
   PubMed Web of Science ®Google Scholar
• Agga, G. E.; Cook, K. L.; Netthisinghe, A. M. P.; Gilfillen, R. A.; Woosley, P. B.; Sistani, K. R. Persistence of Antibiotic Resistance Genes in Beef Cattle Backgrounding Environment over Two Years after Cessation of Operation. PLoS One 2019, 14, e0212510. DOI: 10.1371/journal.pone.0212510.
   PubMed Web of Science ®Google Scholar
• Xu, W.; Zhang, G.; Li, X.; Zou, S.; Li, P.; Hu, Z.; Li, J. Occurrence and Elimination of Antibiotics at Four Sewage Treatment Plants in the Pearl River Delta (PRD), South China. Water Res. 2007, 41, 4526–4534. DOI: 10.1016/j.watres.2007.06.023.
   PubMed Web of Science ®Google Scholar
• Sarmah, A. K.; Meyer, M. T.; Boxall, A. B. A. A Global Perspective on the Use, Sales, Exposure Pathways, Occurrence, Fate and Effects of Veterinary Antibiotics (VAs) in the Environment. Chemosphere 2006, 65, 725–759. DOI: 10.1016/j.chemosphere.2006.03.026.
   PubMed Web of Science ®Google Scholar
• Kemper, N. Veterinary Antibiotics in the Aquatic and Terrestrial Environment. Ecol. Indic. 2008, 8, 1–13. DOI: 10.1016/j.ecolind.2007.06.002.
   Web of Science ®Google Scholar
• Wu, N.; Qiao, M.; Zhang, B.; Cheng, W.-D.; Zhu, Y.-G. Abundance and Diversity of Tetracycline Resistance Genes in Soils Adjacent to Representative Swine Feedlots in China. Environ. Sci. Technol. 2010, 44, 6933–6939. DOI: 10.1021/es1007802.
   PubMed Web of Science ®Google Scholar
• Bagge, E.; Sahlström, L.; Albihn, A. The Effect of Hygienic Treatment on the Microbial Flora of Biowaste at Biogas Plants. Water Res. 2005, 39, 4879–4886. DOI: 10.1016/j.watres.2005.03.016.
   PubMed Web of Science ®Google Scholar
• Saunders, O.; Harrison, J.; Fortuna, A. M.; Whitefield, E.; Bary, A. Effect of Anaerobic Digestion and Application Method on the Presence and Survivability of E. coli and Fecal Coliforms in Dairy Waste Applied to Soil. Water. Water. Air. Soil Pollut. 2012, 223, 1055–1063. DOI: 10.1007/s11270-011-0923-5.
   Web of Science ®Google Scholar
• Resende, J. A.; Silva, V. L.; Oliveira, T. L. R. d.; Oliveira Fortunato, S. d.; Costa Carneiro, J. D.; Otenio, M. H.; Diniz, C. G. Prevalence and Persistence of Potentially Pathogenic and Antibiotic Resistant Bacteria during Anaerobic Digestion Treatment of Cattle Manure. Bioresour. Technol. 2014, 153, 284–291. DOI: 10.1016/j.biortech.2013.12.007.
   PubMed Web of Science ®Google Scholar
• Miller, J. H.; Novak, J. T.; Knocke, W. R.; Pruden, A. Survival of Antibiotic Resistant Bacteria and Horizontal Gene Transfer Control Antibiotic Resistance Gene Content in Anaerobic Digesters. Front. Microbiol. 2016, 7, 263 DOI: 10.3389/fmicb.2016.00263.
   PubMed Web of Science ®Google Scholar
• Sui, Q.; Zhang, J.; Chen, M.; Tong, J.; Wang, R.; Wei, Y. Distribution of Antibiotic Resistance Genes (ARGs) in Anaerobic Digestion and Land Application of Swine Wastewater. Environ. Poll. 2016, 213, 751–759. DOI: 10.1016/j.envpol.2016.03.038.
   PubMed Web of Science ®Google Scholar
• Couch, M.; Agga, G. E.; Kasumba, J.; Parekh, R. R.; Loughrin, J. H.; Conte, E. D. Abundances of Tetracycline Resistance Genes and Tetracycline Antibiotics during Anaerobic Digestion of Swine Waste. J. Environ. Quality 2019, 48, 171. DOI: 10.2134/jeq2018.09.0331.
   PubMed Web of Science ®Google Scholar
• Amarakoon, I. D.; Zvomuya, F.; Sura, S.; Larney, F. J.; Cessna, A. J.; Xu, S.; McAllister, T. A. Dissipation of Antimicrobials in Feedlot Manure Compost after Oral Administration versus Fortification after Excretion. J. Environ. Quality 2016, 45, 503. DOI: 10.2134/jeq2015.07.0408.
   PubMed Web of Science ®Google Scholar
• Arikan, O. A. Degradation and Metabolization of Chlortetracycline during the Anaerobic Digestion of Manure from Medicated Calves. J. Hazard. Mater. 2008, 158, 485–490. DOI: 10.1016/j.jhazmat.2008.01.096.
   PubMed Web of Science ®Google Scholar
• Arikan, O. A.; Sikora, L. J.; Mulbry, W.; Khan, S. U.; Rice, C.; Foster, G. D. The Fate and Effect of Oxytetracycline during the Anaerobic Digestion of Manure from Therapeutically Treated Calves. Process Biochem. 2006, 41, 1637–1643. DOI: 10.1016/j.procbio.2006.03.010.
   Web of Science ®Google Scholar
• Wilkie, A. In Anaerobic digestion of dairy manure: design and process considerations, Proceedings of the Dairy Manure Management, Cornell University, Ithaca, NY, 2005.
   Google Scholar
• Marti, R.; Scott, A.; Tien, Y.-C.; Murray, R.; Sabourin, L.; Zhang, Y.; Topp, E. Impact of Manure Fertilization on the Abundance of Antibiotic-Resistant Bacteria and Frequency of Detection of Antibiotic Resistance Genes in Soil and on Vegetables at Harvest. Appl. Environ. Microbiol. 2013, 79, 5701–5709. DOI: 10.1128/AEM.01682-13.
   PubMed Web of Science ®Google Scholar
• Navarro, A. F.; Cegarra, J.; Roig, A.; Garcia, D. Relationships between Organic Matter and Carbon Contents of Organic Wastes. Bioresour. Technol. 1993, 44, 203–207. DOI: 10.1016/0960-8524(93)90153-3.
   Web of Science ®Google Scholar
• Moral, R.; Moreno-Caselles, J.; Perez-Murcia, M. D.; Perez-Espinosa, A.; Rufete, B.; Paredes, C. Characterisation of the Organic Matter Pool in Manures. Bioresour. Technol. 2005, 96, 153–158. DOI: 10.1016/j.biortech.2004.05.003.
   PubMed Web of Science ®Google Scholar
• Peters, J.; Combs, S.; Hoskins, B.; Jarman, J.; Kovar, J.; Watson, M.; Wolf, A.; Wolf, N. Recommended Methods of Manure Analysis. 2003, 30–38. Available at https://soils.wisc.edu/extension/pubs/A3769.pdf (accessed Sep 17, 2019)
   Google Scholar
• Capone, D. G.; Weston, D. P.; Miller, V.; Shoemaker, C. Antibacterial Residues in Marine Sediments and Invertebrates following Chemotherapy in Aquaculture. Aquaculture 1996, 145, 55–75. DOI: 10.1016/S0044-8486(96)01330-0.
   Web of Science ®Google Scholar
• Marchaim, U.; Krause, C. Propionic to Acetic Acid Ratios in Overloaded Anaerobic Digestion. Bioresour. Technol. 1993, 43, 195–203. DOI: 10.1016/0960-8524(93)90031-6.
   Web of Science ®Google Scholar
• Yen, H.; Brune, D. Anaerobic co-Digestion of Algal Sludge and Waste Paper to Produce Methane. Bioresour. Technol. 2007, 98, 130–134. DOI: 10.1016/j.biortech.2005.11.010.
   PubMed Web of Science ®Google Scholar
• Wang, X.; Lu, X.; Li, F.; Yang, G. Effects of Temperature and Carbon-Nitrogen (C/N) Ratio on the Performance of Anaerobic Co-Digestion of Dairy Manure, Chicken Manure and Rice Straw: Focusing on Ammonia Inhibition. PLoS One 2014, 9, e97265. DOI: 10.1371/journal.pone.0097265.
   PubMed Web of Science ®Google Scholar
• Hamilton, D. Organic Matter Content of Wastewater and Manure 2016. Available at http://pods.dasnr.okstate.edu/docushare/dsweb/Get/v_Document-8265/BAE-1760web.pdf (accessed 17 Sep, 2019).
   Google Scholar
• Bolan, N.; Adriano, D.; Mahimairaja, S. Distribution and Bioavailability of Trace Elements in Livestock and Poultry Manure by-Products. Crit. Rev. Environ. Sci. Technol. 2004, 34, 291–338. DOI: 10.1080/10643380490434128.
   Web of Science ®Google Scholar
• Zhang, F.; Li, Y.; Yang, M.; Li, W. Content of Heavy Metals in Animal Feeds and Manures from Farms of Different Scales in Northeast China. Int. J. Environ. Res. Public Health. 2012, 9, 2658–2668. DOI: 10.3390/ijerph9082658.
   PubMed Web of Science ®Google Scholar
• Wang, H.; Dong, Y.; Yang, Y.; Toor, G. S.; Zhang, X. Changes in Heavy Metal Contents in Animal Feeds and Manures in an Intensive Animal Production Region of China. J. Environ. Sci. 2013, 25, 2435–2442. DOI: 10.1016/S1001-0742(13)60473-8.
   Web of Science ®Google Scholar
• Varel, V. H.; Wells, J. E.; Shelver, W. L.; Rice, C. P.; Armstrong, D. L.; Parker, D. B. Effect of Anaerobic Digestion Temperature on Odour, Coliforms and Chlortetracycline in Swine Manure or Monensin in Cattle Manure*: Effect of Anaerobic Digestion on Chlortetracycline and Monensin. J. Appl. Microbiol. 2012, 112, 705–715. DOI: 10.1111/j.1365-2672.2012.05250.x.
   PubMed Web of Science ®Google Scholar
• Weiland, P. Biogas Production: current State and Perspectives. Appl. Microbiol. Biotechnol. 2010, 85, 849–860. DOI: 10.1007/s00253-009-2246-7.
   PubMed Web of Science ®Google Scholar
• Calli, B.; Mertoglu, B.; Inanc, B.; Yenigun, O. Effects of High Free Ammonia Concentrations on the Performances of Anaerobic Bioreactors. Process Biochem. 2005, 40, 1285–1292. DOI: 10.1016/j.procbio.2004.05.008.
   Web of Science ®Google Scholar
• Procházka, J.; Dolejš, P.; Máca, J.; Dohányos, M. Stability and Inhibition of Anaerobic Processes Caused by Insufficiency or Excess of Ammonia Nitrogen. Appl. Microbiol. Biotechnol. 2012, 93, 439–447. DOI: 10.1007/s00253-011-3625-4.
   PubMed Web of Science ®Google Scholar
• Stone, J. J.; Clay, S. A.; Zhu, Z.; Wong, K. L.; Porath, L. R.; Spellman, G. M. Effect of Antimicrobial Compounds Tylosin and Chlortetracycline during Batch Anaerobic Swine Manure Digestion. Water Res. 2009, 43, 4740–4750. DOI: 10.1016/j.watres.2009.08.005.
   PubMed Web of Science ®Google Scholar
• Kuhne, M.; Ihnen, D.; Moller, G.; Agthe, O. Stability of Tetracycline in Water and Liquid Manure. J. Vet. Med. Series A 2000, 47, 379–384. DOI: 10.1046/j.1439-0442.2000.00300.x.
   Google Scholar
• Wu, X.; Wei, Y.; Zheng, J.; Zhao, X.; Zhong, W. The Behavior of Tetracyclines and Their Degradation Products during Swine Manure Composting. Bioresour. Technol. 2011, 102, 5924–5931. DOI: 10.1016/j.biortech.2011.03.007.
   PubMed Web of Science ®Google Scholar
• Thiele-Bruhn, S. Pharmaceutical Antibiotic Compounds in Soils – A Review. J. Plant Nutr. Soil Sci. 2003, 166, 145–167. DOI: 10.1002/jpln.200390023.
   Web of Science ®Google Scholar
• Wang, Q.; Yates, S. R. Laboratory Study of Oxytetracycline Degradation Kinetics in Animal Manure and Soil. J. Agric. Food Chem. 2008, 56, 1683–1688. DOI: 10.1021/jf072927p.
   PubMed Web of Science ®Google Scholar
• Loke, M.-L.; Tjørnelund, J.; Halling-Sørensen, B. Halling-Sørensen, B. Determination of the Distribution Coefficient (logKd) of Oxytetracycline, Tylosin A, Olaquindox and Metronidazole in Manure. Chemosphere 2002, 48, 351–361. DOI: 10.1016/S0045-6535(02)00078-4.
   PubMed Web of Science ®Google Scholar
• Pils, J. R. V.; Laird, D. A. Sorption of Tetracycline and Chlortetracycline on K- and Ca-Saturated Soil Clays, Humic Substances, and Clay − Humic Complexes. Environ. Sci. Technol. 2007, 41, 1928–1933. DOI: 10.1021/es062316y.
   PubMed Web of Science ®Google Scholar
• Li, L.-L.; Huang, L.-D.; Chung, R.-S.; Fok, K.-H.; Zhang, Y.-S. Sorption and Dissipation of Tetracyclines in Soils and Compost. Pedosphere 2010, 20, 807–816. DOI: 10.1016/S1002-0160(10)60071-9.
   Web of Science ®Google Scholar
• Karcı, A.; Balcıoğlu, I. A. Investigation of the Tetracycline, Sulfonamide, and Fluoroquinolone Antimicrobial Compounds in Animal Manure and Agricultural Soils in Turkey. Science of the Total Environment 2009, 407, 4652–4664. DOI: 10.1016/j.scitotenv.2009.04.047.
   PubMed Web of Science ®Google Scholar
• Zhang, G.; Liu, X.; Sun, K.; Zhao, Y.; Lin, C. Sorption of Tetracycline to Sediments and Soils: assessing the Roles of pH, the Presence of Cadmium and Properties of Sediments and Soils. Front. Environ. Sci. Eng. China 2010, 4, 421–429. DOI: 10.1007/s11783-010-0265-3.
   Web of Science ®Google Scholar
• Wang, Z.; Jiang, Q.; Wang, R.; Yuan, X.; Yang, S.; Wang, W.; Zhao, Y. Effects of Dissolved Organic Matter on Sorption of Oxytetracycline to Sediments. Geofluids 2018, 2018, 1–12. DOI: 10.1155/2018/1254529.
   Web of Science ®Google Scholar
• Pollard, A. T.; Morra, M. J. Fate of Tetracycline Antibiotics in Dairy Manure-Amended Soils. Environ. Rev. 2018, 26, 102–112. DOI: 10.1139/er-2017-0041.
   Google Scholar
• MacKay, A. A.; Canterbury, B. Oxytetracycline Sorption to Organic Matter by Metal-Bridging. J. Environ. Quality 2005, 34, 1964. DOI: 10.2134/jeq2005.0014.
   PubMed Web of Science ®Google Scholar
• Jiang, W.-T.; Chang, P.-H.; Wang, Y.-S.; Tsai, Y.; Jean, J.-S.; Li, Z. Sorption and Desorption of Tetracycline on Layered Manganese Dioxide Birnessite. Int. J. Environ. Sci. Technol. 2015, 12, 1695–1704. DOI: 10.1007/s13762-014-0547-6.
   Web of Science ®Google Scholar
• Cowley, C. A.; Brorsen, B. W.; Hamilton, D. W. Economic Feasibility of Anaerobic Digestion with Swine Operations. J. Agric. Appl. Econ. 2019, 51, 49–68. DOI: 10.1017/aae.2018.20.
   Web of Science ®Google Scholar
• Schmidt, T.; Harris, P.; Lee, S.; McCabe, B. K. Investigating the Impact of Seasonal Temperature Variation on Biogas Production from Covered Anaerobic Lagoons Treating Slaughterhouse Wastewater Using Lab Scale Studies. J. Environ. Chem. Eng. 2019, 7, 103077. DOI: 10.1016/j.jece.2019.103077.
   Web of Science ®Google Scholar
• Senés‐Guerrero, C.; Colón‐Contreras, F. A.; Reynoso‐Lobo, J. F.; Tinoco‐Pérez, B.; Siller‐Cepeda, J. H.; Pacheco, A. Biogas‐Producing Microbial Composition of an Anaerobic Digester and Associated Bovine Residues. MicrobiologyOpen 2019,8(9) e854. DOI: 10.1002/mbo3.854.
   Web of Science ®Google Scholar
• Winckler, C.; Grafe, A. Use of Veterinary Drugs in Intensive Animal Production: Evidence for Persistence of Tetracycline in Pig Slurry. J. Soils Sediments 2001, 1, 66–70. DOI: 10.1007/BF02987711.
   Google Scholar