1,992
Views
49
CrossRef citations to date
0
Altmetric
Review Articles

Systemic drugs with impact on osteoarthritis

, , , , , , , , , , & show all
Pages 498-523 | Received 15 Sep 2019, Accepted 29 Oct 2019, Published online: 15 Nov 2019

References

  • Aitken D, Laslett LL, Cai G, Hill C, March L, Wluka AE, Wang Y, Blizzard L, Cicuttini F, Jones G. 2018. A protocol for a multicentre, randomized, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2. BMC Musculoskelet Disord. 19(1):217.
  • Aitken D, Laslett LL, Pan F, Haugen IK, Otahal P, Bellamy N, Bird P, Jones G. 2018. A randomized double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis – the HUMOR trial. Osteoarth Cartilage. 26(7):880–887.
  • Akkiraju H, Nohe A. 2015. Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration. J Dev Biol. 3(4):177-192.
  • Ali AA, Lewis SM, Badgley HL, Allaben WT, Leakey JE. 2011. Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: implications for human efficacy and toxicity. Arch Biochem Biophys. 510(1):11–18.
  • Altman RD, Manjoo A, Fierlinger A, Niazi F, Nicholls M. 2015. The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskelet Disord. 16(1):321.
  • Anderson LA, Stewart J, Thornton P, Wilson K, Fookes C, Puckey M. 2018. Drugs.com. [accessed 2018 Sep 3]. https://www.drugs.com/.
  • Antoniou J, Wang HT, Hadjab I, Aldebeyan S, Alaqeel MA, Meij BP, Tryfonidou MA, Mwale F. 2015. The effects of naproxen on chondrogenesis of human mesenchymal stem cells. Tissue Eng Part A. 21(13–14):2136–2146.
  • Apostu D, Lucaciu O, Lucaciu GDO, Crisan B, Crisan L, Baciut M, Onisor F, Baciut G, Campian RS, Bran S. 2017. Systemic drugs that influence titanium implant osseointegration. Drug Metab Rev. 49(1):92–104.
  • Apostu D, Lucaciu O, Mester A, Benea H, Oltean-Dan D, Onisor F, Baciut M, Bran S. 2019. Cannabinoids and bone regeneration. Drug Metab Rev. 51(1):65–75.
  • Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, et al. 2016. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomized controlled trial. Osteoarth Cartilage. 24(11):1858–1866.
  • Arti HR, Azemi EA. 2012. Comparing the effect of glucosamine and glucosamine with alendronate in symptomatic relieve of degenerative knee joint disease: a double-blind randomized clinical trial study. Jundishapur J Nat Pharm Prod. 7(3):87–92.
  • Ashraf S, Cha BH, Kim JS, Ahn J, Han I, Park H, Lee SH. 2016. Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. Osteoarth Cartilage. 24(2):196–205.
  • Bagger YZ, Tankó LB, Alexandersen P, Karsdal MA, Olson M, Mindeholm L, Azria M, Christiansen C. 2005. Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis. Bone. 37(3):425–430.
  • Bello AR, Oesser S. 2006. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 22(11):2221–2232.
  • Bhosale AM, Richardson JB. 2008. Articular cartilage: structure, injuries and review of management. Br Med Bull. 87(1):77–95.
  • Bingham COO, III, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Claw DJ, Spector TD, Pelletier JP, Raynauld JP, et al. 2006. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two‐year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum. 54(1):3494–3507.
  • Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F. 2009. Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures. Arthritis Rheum. 60(12):3676–3685.
  • Boe C, Vangsness CT. 2015. Fish oil and osteoarthritis: current evidence. Am J Orthop (Orthop). 44(7):302–305.
  • Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, Wolfe F, Schnitzer TJ, Moreland LW, Manzi S, et al. 2005. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 52(7):2015–2025.
  • Brizuela NY, Montrull HL, Demurtas SL, Meirovich CI. 2007. [Articular cartilage in osteoarthritic patients: effects of diclofenac, celecoxib and glucosamine sulfate on inflammatory markers]. Rev Fac Cien Med Univ Nac Cordoba. 64(2):9–15.
  • Butawan M, Benjamin RL, Bloomer RJ. 2017. Methylsulfonylmethane: applications and safety of a novel dietary supplement. Nutrients 9(3):290.
  • Buttgereit F, Burmester GR, Bijlsma J. 2015. Non-surgical management of knee osteoarthritis: where are we now and where do we need to go? RMD Open. 1(1):e000027.
  • Caamaño MC, Garcia-Padilla S, Duarte-Vásquez MA, González-Romero KE, Rosado JL. 2017. A double-blind, active-controlled clinical trial of sodium bicarbonate and calcium gluconate in the treatment of bilateral osteoarthritis of the knee. Clin Med Insights Arthritis Musculoskelet Disord. 10:1179544116688899.
  • Chang SW, Shefelbine SJ, Buehler MJ. 2012. Structural and mechanical differences between collagen homo- and heterotrimers: relevance for the molecular origin of brittle bone disease. Biophys J. 102(3):640–648.
  • Chang Z, Huo L, Li P, Wu Y, Zhang P. 2015. Ascorbic acid provides protection for human chondrocytes against oxidative stress. Mol Med Rep. 12(5):7086–7092.
  • Chen R, Qi QL, Wang MT, Li QY. 2016. Therapeutic potential of naringin: an overview. Pharma Biol. 54(12):3203–3210.
  • Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. 2013. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 72(10):1732–1736.
  • Chubinskaya S, Hurtig M, Rueger DC. 2007. OP-1/BMP-7 in cartilage repair. Int Orthop (SICO). 31(6):773–781.
  • Cicero AFG, Laghi L. 2007. Activity and potential role of licofelone in the management of osteoarthritis. Clin Interv Aging. 2(1):73–79.
  • Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A. 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 24(5):1485–1496.
  • Cohen SB, Proudman S, Kivitz AJ, Burch FX, Donohue JP, Burstein D, Sun YN, Banfield C, Vincent MS, Ni L, Zack DJ. 2011. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther. 13(4):R125.
  • Coles JM, Zhang L, Blum JJ, Warman ML, Jay GD, Guilak F, Zauscher S. 2010. Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum. 62(6):1666–1674.
  • Crasci L, Panico A. 2013. Protective effects of many citrus flavonoids on cartilage degradation process. J Biomater Nanobiotechnol. 4:279–283.
  • Cunha JP. 2017. Forteo side effects center. [accessed 2018 Sep 3]. https://www.rxlist.com/forteo-side-effects-drug-center.htm#overview.
  • da Costa BR, Nüesch E, Reichenbach S, Jüni P, Rutjes AW. 2012. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 11:CD007323.
  • De Boer TN, Huisman AM, Polak AA, Niehoff AG, van Rinsum AC, Saris D, Bijlsma JW, Lafeber FJ, Mastbergen SC. 2009. The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment. Osteoarth Cartilage. 17(4):482–488.
  • Dearmin MG, Trumble TN, Garcia A, Chambers JN, Budsberg SC. 2014. Chondroprotective effects of zoledronic acid on articular cartilage in dogs with experimentally induced osteoarthritis. Am J Vet Res. 75(4):329–337.
  • Ding C, Jin X, Wang X, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Winzenberg T, Blizzard L, Jones G. 2016. Vitamin D supplementation for the management of knee osteoarthritis: a randomized controlled trial. Osteoarth Cartilage. 24(Suppl 1):S49.
  • Fuggle N, Curtis E, Shaw S, Spooner L, Bruyere O, Ntani G, Parsons C, Conaghan PG, Corp N, Honvo G, et al. 2019. Safety of opioids in osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 16(Suppl 1):129–143.
  • Eckstein F, Winzheimer M, Hohe J, Englmeier KH, Reiser M. 2001. Interindividual variability and correlation among morphological parameters of knee joint cartilage plates: analysis with three-dimensional MR imaging. Osteoarthritis Cartilage. 9(2):101–111.
  • Gallagher B, Tjoumakaris FP, Harwood MI, Good RP, Ciccotti MG, Freedman KB. 2015. Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. Am J Sports Med. 43(3):734–744.
  • Goldring MB. 2012. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Therap Adv Musculoskeletal Dis. 4(4):269–285.
  • Goldring MB. 2017. Cartilage and Chondrocytes. Nguyen Phat JSC [accessed 2018 Sep 3]. https://musculoskeletalkey.com/cartilage-and-chondrocytes/.
  • Groeneboer S, Pastoureau P, Vignon E, Vander Cruyssen B, Elewaut D, Verbruggen G. 2008. Cyclodextrin polysulfate protects articular cartilage in experimental lapine knee osteoarthritis. Osteoarth Cartilage. 16(9):986–993.
  • Gu H, Li K, Li X, Yu X, Wang W, Ding L, Liu L. 2016. Oral resveratrol prevents osteoarthritis progression in C57BL/6J mice fed a high-fat diet. Nutrients. 8(4):233.
  • Hempfling W, Dilger K, Beuers U. 2003. Systematic review: ursodeoxycholic acid–adverse effects and drug interactions. Aliment Pharmacol Ther. 18(10):963–972.
  • Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. 2010. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 18(2):141-149.
  • Herrak P, Görtz B, Hayer S, Redlich K, Reiter E, Gasser J, Bergmeister H, Kollias G, Smolen JS, Schett G. 2004. Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis. Arthritis Rheum. 50(7):2327–2337.
  • Higuchi M, Masuda T, Sasuda K, Ishii S, Abe K. 1980. Ultrastructure of the articular cartilage after systemic administration of hydrocortisone in the rabbit: an electron microscopic study. Clin Orthop Relat Res. 152:296–302.
  • Hill CL, March LM, Aitken D, Lester SE, Battersby R, Hynes K, Fedorova T, Proudman SM, James M, Cleland LG, et al. 2016. Fish oil in knee osteoarthritis: a randomized clinical trial of low dose versus high dose. Ann Rheum Dis. 75(1):23–29.
  • Huang TC, Chang WT, Hu YC, Hsieh BS, Cheng HL, Yen JH, Chiu PR, Chang KL. 2018. Zinc protects articular chondrocytes through changes in Nrf2-mediated antioxidants, cytokines and matrix metalloproteinases. Nutrients. 10(4):471.
  • Huh YH, Lee G, Song WH, Koh JT, Ryu JH. 2015. Crosstalk between FLS and chondrocytes is regulated by HIF-2-mediated cytokines in arthritis. Exp Mol Med. 47:1–10.
  • Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DS. 2010. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway. Rheumatology (Oxford). 49(11):2043–2053.
  • Imada K, Tsuchida A, Ogawa K, Sofat N, Nagase H, Ito A, Sato T. 2016. Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro. Biochem Biophys Res Commun. 476(4):352–358.
  • Jerosch J. 2011. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids. Int J Rheumatol. 2011(3):969012.
  • Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard L, et al. 2016. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 315(10):1005–1013.
  • Jørgensen AEM, Kjaer M, Heinemeier KM. 2017. The effect of aging and mechanical loading on the metabolism of articular cartilage. J Rheumatol. 44(4):410–417.
  • Kadri A, Ea HK, Bazille C, Hannouche D, Lioté F, Cohen-Solal ME. 2008. Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis. Arthritis Rheum. 58(8):2379–2386.
  • Kang SJ, Kim JW, Kim KY, Ku SK, Lee YJ. 2014. Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague–Dawley rats. J Orthop Surg Res. 9(1):14.
  • Karsdal MA, Byrjalsen I, Alexandersen P, Bihlet A, Andersen JR, Riis BJ, Bay-Jensen AC, Christiansen C, CSMC021C2301/2 investigators 2015. Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials. Osteoarth Cartilage. 23(4):532–543.
  • Karsdal MA, Michaelis M, Ladel C, Siebuhr AS, Bihlet AR, Andersen JR, Guehring H, Christiansen C, Bay-Jensen AC, Kraus VB. 2016. Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future. Osteoarthritis Cartilage. 24(12):2013-2021.
  • Karsdal MA, Tanko LB, Riis BJ, Sondergard BC, Henriksen K, Altman RD, Qvist P, Christiansen C. 2006. Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA? Osteoarth Cartilage. 14(7):617–624.
  • Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. 2015. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 17(1):30.
  • Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. 2006. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarth Cartilage. 14(3):286–294.
  • Kimura H, Ng JMY, Curran T. 2008. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell. 13(3):249–260.
  • Knapik JJ, Pope R, Hoedebecke SS, Schram B, Orr R. 2019. Effects of oral chondroitin sulfate on osteoarthritis-related pain and joint structural changes: systematic review and meta-analysis. J Spec Oper Med. 19(1):113–124.
  • Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR. 2005. Role of interleukin-1 and tumor necrosis factor in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 52(1):128–135.
  • Kubo M, Takase T, Matsusue Y, Rauvala H, Imai S. 2002. Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice. Osteoarth Cartilage. 10(12):968–976.
  • Kudur MH, Hulmani M. 2013. Rebamipide: a novel agent in the treatment of recurrent aphthous ulcer and Behcet’s syndrome. Indian J Dermatol. 58(5):352–354.
  • Kumagai K, Kubo M, Imai S, Toyoda F, Maeda T, Okumura N, Matsuura H, Matsusue Y. 2013. The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes. Int J Mol Sci. 14(10):19705–19715.
  • Kurz B, Jost B, Schünke M. 2002. Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice. Osteoarth Cartilage 10(2):119–126.
  • Kwoh CK, Roemer FW, Hannon MJ, Moore CE, Jakicic JM, Guermazi A, Green SM, Evans RW, Boudreau R. 2014. Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial. Arthritis Rheumatol. 66(4):930–939.
  • Laptoiu D, Marinescu R, Balan C, Antoniac I. 2015. Rheologic properties of some current hyaluronic acid products for viscosupplimentation – new trends for amelioration. Mater Plast. 52(4):500–503.
  • Laslett LL, Doré DA, Quinn SJ, Boon P, Ryan E, Winzenberg TM, Jones G. 2012. Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomized controlled trial. Ann Rheum Dis. 71(8):1322–1328.
  • Lee HH, O'Malley MJ, Friel NA, Chu CR. 2013. Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair. Osteoarth Cartilage. 21(2):385–393.
  • Lee S, Nemeño JG, Lee JI. 2016. Repositioning bevacizumab: a promising therapeutic strategy for cartilage regeneration. Tissue Eng Part B Rev. 22(5):341–357.
  • Lee SW, Rho JH, Lee SY, Kim JH, Cheong JH, Kim HY, Jeong NY, Chung WT, Yoo YH. 2015. Leptin protects rat articular chondrocytes from cytotoxicity induced by TNF-α in the presence of cyclohexamide. Osteoarth Cartilage. 23(12):2269–2278.
  • Legendre F, Bogdanowicz P, Boumediene K, Pujol JP. 2005. Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular. J Rheumatol. 32(7):1307–1316.
  • Li R, Cai L, Ding J, Hu CM, Wu TN, Hu XY. 2015. Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis. J Pharm Pharmacol. 67(7):963–971.
  • Li S, Niu G, Wu Y, Du G, Huang C, Yin X, Liu Z, Song C, Leng H. 2016. Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-β1 in ovariectomized rats. Osteoarth Cartilage. 24(2):345–353.
  • Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 52(3):167–175.
  • Liu Y-D, Yang H-X, Liao L-F, Jiao K, Zhang H-Y, Lu L, Zhang M, Zhang J, He J-J, Wu Y-P, et al. 2016. Systemic administration of strontium or NBD peptide ameliorates early stage cartilage degradation of mouse mandibular condyles. Osteoarth Cartilage. 24(1):178–187.
  • Lucaciu O, Apostu D, Mester A, Campian RS, Gheban D, Miron RJ. 2019. Atelo-collagen type I bovine bone substitute and membrane in guided bone regeneration: a series of clinical cases and histopathological assessments. Histol Histopathol. 34(9):1061–1071.
  • Lucaciu O, Crisan B, Crisan L, Baciut M, Soritau O, Bran S, Biris AR, Hurubeanu L, Hedesiu M, Vacaras S, et al. 2015a. In quest of optimal drug-supported and targeted bone regeneration in the cranio facial area: a review of techniques and methods. Drug Metab Rev. 47(4):455–469.
  • Lucaciu O, Crisan B, Hedesiu M, Soritau O, Dirzu N, Crisan L, Campian R, Baciut G, Baciut M, Onisor F, et al. 2018. The role of BMP-2, low level laser therapy and low X ray doses in dental follicle stem cell migration. Part Sci Technol. 36(8):981–988.
  • Lucaciu O, Soriţău O, Gheban D, Ciuca DR, Virtic O, Vulpoi A, Dirzu N, Câmpian R, Băciuţ G, Popa C, et al. 2015b. Dental follicle stem cells in bone regeneration on titanium implants. BMC Biotechnol. 15(1):114.
  • Maheu E, Cadet C, Marty M, Moyse D, Kerloch I, Coste P, Dougados M, Mazieres B, Spector TD, Halhol H, et al. 2014. Randomised, controlled trial of avocado-soyeban unsaponifiable (Piascledine) effect on structure modification on hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 73(2):376–384.
  • Marks R. 2018. Vitamin C and articular integrity. Nov Tech Arthritis Bone Res. 2(5):1–5.
  • McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson-Hughes B. 2013. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 309(2):155–162.
  • McAlindon TE, Nuite M, Krishnan N, Ruthazer R, Price LL, Burstein D, Griffith J, Flechsenhar K. 2011. Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarth Cartilage. 19(4):399–405.
  • Mester A, Apostu D, Ciobanu L, Piciu A, Lucaciu O, Campian RS, Taulescu M, Bran S. 2019a. The impact of proton pump inhibitors on bone regeneration and implant osseointegration. Drug Metab Rev. 51(3):330–339.
  • Mester A, Ciobanu L, Taulescu M, Apostu D, Lucaciu O, Filip GA, Feldrihan V, Licarete E, Ilea A, Piciu A, et al. 2019b. Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats. J Periodontol. 90(8):911–919.
  • Miller RE, Block JA, Malfait AM. 2017. Nerve growth factor (NGF) blocakde for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Curr Opin Rhaumatol. 29(1):110–118.
  • Minashima T, Zhang Y, Lee Y, Kirsch T. 2014. Lithium protects against cartilage degradation in osteoarthritis. Arthritis Rheumatol. 66(5):1228–1236.
  • Moon SJ, Jeong JH, Jhun JY, Yang EJ, Min JK, Choi JY, Cho ML. 2014. Ursodeoxycholic acid ameliorates pain severity and cartilage degeneration in monosodium iodoacetate-induced osteoarthritis in rats. Immune Netw. 14(1):45–53.
  • Moon S-J, Woo Y-J, Jeong J-H, Park M-K, Oh H-J, Park J-S, Kim E-K, Cho M-L, Park S-H, Kim H-Y, et al. 2012. Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. Osteoarth Cartilage. 20(11):1426–1438.
  • Moskowitz RW. 2000. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 30(2):87–99.
  • Nagai T, Sato M, Kobayashi M, Yokoyama M, Tani Y, Mochida J. 2014. Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis. Arthritis Res Ther. 16(5):427.
  • Ng HY, Lee KXA, Shen YF. 2017. Articular cartilage: structure, composition, injuries and repair. JSM Bone Joint Dis. 1(2):1010.
  • Nguyen C, Boutron I, Baron G, Coudeyre E, Berenbaum F, Poiraudeau S, Rannou F. 2017. Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): protocol for a multicentre randomised double-blind placebo-controlled trial. BMC Open. 7(9):e017652.
  • Nielsen RH, Bay-Jensen AC, Byrjalsen I, Karsdal MA. 2011. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarth Cartilage. 19(4):466–473.
  • Nishii T, Tamura S, Shiomi T, Yoshikawa H, Sugano N. 2013. Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial. Clin Rheumatol. 32(12):1759–1766.
  • Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, Koikeda T, Maruya R, Fukui N. 2015. Oral hyaluronan relieves knee pain: a review. Nutr J. 15(1):11.
  • Ogawa H, Kozhemyakina E, Hung HH, Grodzinsky AJ, Lassar AB. 2014. Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev. 28(2):127–139.
  • Okazaki M, Higuchi Y, Kitamura H. 2003. AG-041R stimulates cartilage matrix synthesis without promoting terminal differentiation in rat articular chondrocytes. Osteoarth Cartilage. 11(2):122–132.
  • Orth P, Cucchiarini M, Zurakowski D, Menger MD, Kohn DM, Madry H. 2013. Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo. Osteoarth Cartilage. 21(4):614–624.
  • Osani MC, Bannuru RR. 2019. Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. Korean J Intern Med. 34(5):966–973.
  • Ozbey O, Sahin Z, Ozenci AM, Acar N, Ustunel I. 2010. The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage. Acta Histochem. 112(5):424–431.
  • Ozenci AM. 2013. Protective effect of zoledronic acid on corticosteroid-induced chondrocyte apoptosis in rat articular cartilage. Acta Orthop Traumatol Turc. 47(6):430–435.
  • Pagonis T. 2013. Effect of methyl-sulfonyl-methane on osteoarthritis and cartilage (MSM). [accessed 2018 Sep 3]. https://clinicaltrials.gov/ct2/show/NCT01836757?type=Intr&cond=cartilage&draw=2.
  • Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T, Iezaki T, Kaneda K, Sugiura M, Hinoi E. 2017. Amelioration of the development of osteoarthritis by daily intake of β-cryptoxanthin. Biol Pharm Bull. 40(7):1116–1120.
  • Pathak NN, Lingaraju MC, Balaganur V, Kant V, More AS, Kumar D, Kumar D, Tandan SK. 2015. Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis. Inflamm Res. 64(3–4):161–169.
  • Pavelka K, Coste P, Geher P, Krejci G. 2010. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol. 29(6):659–670.
  • Paz-Filho G, Mastronardi CA, Licinio J. 2015. Leptin treatment: facts and expectations. Metabolism. 64(1):146–156.
  • Pelletier JP, Kapoor M, Fahmi H, Lajeunesse D, Blesius A, Maillet J, Martel-Pelletier J. 2013. Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium. Ann Rheum Dis. 72(2):250–257.
  • Pelletier JP, Raynauld JP, Beaulieu AD, Bessette L, Morin F, de Brum-Fernandes AJ, Delorme P, Dorais M, Paiement P, Abram F, et al. 2016. Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study. Arthritis Res Ther. 18(1):256.
  • Pelletier J-P, Raynauld J-P, Beaulieu AD, Bessette L, Morin F, de Brum-Fernandes AJ, Delorme P, Dorais M, Paiement P, Abram F, et al. 2016. Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study. Arthritis Res Ther. 18(1):256.
  • Permuy M, Guede D, López-Peña M, Muñoz F, González-Cantalapiedra A, Caeiro J-R. 2014. Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis. BMC Vet Res. 10(1):97.
  • Piciu D, Irimie A, Kontogeorgos G, Piciu A, Buiga R. 2013. Highly aggressive pathology of non-functional parathyroid carcinoma. Orphanet J Rare Dis. 3(8):115.
  • Pohlig F, Guell F, Lenze U, Lenze FW, Mühlhofer HML, Schauwecker J, Toepfer A, Mayer-Kuckuk P, von Eisenhart-Rothe R, Burgkart R, et al. 2016. Hyaluronic acid suppresses the expression of metalloproteinases in osteoarthritic cartilage stimulated simultaneously by interleukin 1β and mechanical load. PLoS One. 11(3):e0150020.
  • Polachek H, Leibovitz E, Dagan R. 2011. Joint cartilage lesions caused by quinolones in young animals--can we generalize to children? Harefuah. 150(9):721–724.
  • Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, et al. 2002. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 61(Suppl II):1178–1181.
  • Rasheed N, Alghasham A, Rasheed Z. 2016. Lactoferrin from Camelus dromedarius inhibits nuclear transcription factor-kappa B activation, cyclooxygenase-2 expression and prostaglandin E2 production in stimulated human chondrocytes. Pharmacognosy Res. 8(2):135–141.
  • Rau JV, Antoniac I, Cama G, Komlev VS, Ravaglioli A. 2016. Bioactive materials for bone tissue engineering. BioMed Research Int. 2016;3741428.
  • Raynauld JP, Martel-Pelletier J, Bias P, Laufer S, Haraoui B, Choquette D, Beaulieu AD, Abram F, Dorais M, Vignon E, et al. 2009. Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI. Ann Rheum Dis. 68(6):938–947.
  • Reginster JY, Beaudart C, Neuprez A, Bruyère O. 2013. Strontium ranelate in the treatment of knee osteoarthritis: new insights and emerging clinical evidence. Therap Adv Musculoskeletal Dis. 5(5):268–276.
  • Ricard-Blum S. 2011. The collagen family. Cold Spring Harb Perspect Biol. 3:a004978.
  • Roughley PJ. 2001. Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. Arthritis Res. 3(6):342–347.
  • Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, et al. 2011. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med. 3(101):101ra93.
  • Sanaei M, Banasiri M, Shafiee G, Rostami M, Alizad S, Ebrahimi M, Larijani B, Heshmat R. 2016. Calcium vitamin D3 supplementation on clinical practice: side effect and satisfaction. J Diabetes Metab Disord. 15(1):9.
  • Sanga P, Katz N, Polverejan E, Wang S, Kelly KM, Haeussler J, Thipphawong J. 2017. Long-term safety and efficacy of fulranumab in patients with moderate-to-severe osteoarthritis pain: a phase II randomized, double-blind, placebo-controller extension study. Arthritis Rheumatol. 69(4):763–773.
  • Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN. 2013. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 471(11):3556–3562.
  • Schachter HM, Kourad K, Merali Z, Lumb A, Tran K, Miguelez M. 2005. Effects of omega-3 fatty acids on mental health: summary. In: AHRQ Evidence Report Summaries. Rockville, MD: Agency for Healthcare Research and Quality.
  • Schmitt LC, Quatman CE, Paterno MV, Best TM, Flanigan DC. 2014. Functional outcomes after surgical management of articular cartilage lesions in the knee: a systematic literature review to guide postoperative rehabilitation. J Orthop Sports Phys Ther. 44(8):565–a10.
  • Sharma CV, Mehta V. 2013. Paracetamol: mechanism and updates. Continuing Educ Anaesthesia Crit Care Pain. 14(4):153–158.
  • Shimaya M, Muneta T, Ichinose S, Tsuji K, Sekiya I. 2010. Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins. Osteoarthritis Cartilage. 18(10):1300–1309.
  • Simopoulou T, Malizos KN, Poultsides L, Tsezou A. 2010. Protective effect of atorvastatin in cultured osteoarthritic chondrocytes. J Orthop Res. 28(1):110–115.
  • Snijders GF, van den Ende CH, van Riel PL, van den Hooge FH, den Broeder AA. Noac Study Group 2011. The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial. Ann Rheum Dis. 70(7):1191–1196.
  • Sondergaard B-C, Oestergaard S, Christiansen C, Tankó LB, Karsdal MA. 2007. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum. 56(8):2674–2678.
  • Sophia F, Bedi A, Rodeao SA. 2009. The basic science of articular cartilage: structure, composition, and function. Sports Health. 1(6):461–468.
  • Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J, Vincent TL. 2018. Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ. Ann Rheum Dis. 77(9):1372–1380.
  • Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M. 2012. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs. J Orthop Res. 30(5):673–678.
  • Tanthaisong P. 2016. Effect of lithium chloride and SB216763 on chondrogenic differentiation of human Wharton’s jelly derived mesenchymal stem cells [master’s thesis]. Nakhon Ratchasima, Thailand: Suranaree University of Technology.
  • Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. 2012. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012:167928.
  • Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA, Knight MM. 2015. Lithium chloride prevents interleukin‐1β induced cartilage degradation and loss of mechanical properties. J Orthop Res. 33(10):1552–1559.
  • Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, Reiner A, Poole AR, Laverty S. 2005. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum. 52(4):1118–1128.
  • Titorencu I, Albu MG, Giurginca M, Jinga V, Antoniac I, Trandafir V, Cotrut C, Miculescu F, Simionescu M. 2010. In vitro biocompatibility of human endothelial cells with collagen-doxycycline matrices. Mol Crystals Liquid Crystals. 523(1):82–96.
  • Towheed TE, Maxwell L, Judd MG, Catton M, Hochberg MC, Wells G. 2006. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev. 25(1):CD004257.
  • Turgeman G, Zilberman Y, Zhou S, Kelly P, Moutsatsos IK, Kharode YP, Borella LE, Bex FJ, Komm BS, Bodine PVN, et al. 2002. Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice. J Cell Biochem. 86(3):461–474.
  • Ulivi V, Lenti M, Gentili C, Marcolongo G, Cancedda R, Cancedda FD. 2011. Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. Arthritis Res Ther. 13(3):R92.
  • Uysal M, Ozkoc G, Bolat F, Turker M, Erdem M. 2016. Zoledronic acid effect on chondrocyte apoptosis in degenerative osteoarthritis model. Int Surg. 101(5–6):291–296.
  • Van der Kraan PM, van den Berg WB. 2012. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarth Cartilage. 20(3):223–232.
  • van Helvoort EM, Coeleveld K, de Boer TN, Huisman AM, Polak AA, Bijlsma JWJ, van Laar JM, Lafeber F, Mastbergen SC. 2017. Lack of a clear disease modifying activity of celecoxib treatment of end-stage knee osteoarthritis: a randomized observer blinded clinical trial. JSM Bone Joint Dis. 1(2):1006.
  • Vaysbrot EE, Osani MC, Musetti MC, McAlindon TE, Bannuru RR. 2018. Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarth Cartilage. 26(2):154–164.
  • Wang J, Gao JS, Chen JW, Li F, Tian J. 2012. Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit. Rheumatol Int. 32(6):1541–1548.
  • Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E. 2001. Human notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. J Immunol. 167(1):289–295.
  • Wang SX, Abramson SB, Attur M, Karsdal MA, Preston RA, Lozada CJ, Kosloski MP, Hong F, Jiang P, Saltarelli MJ, et al. 2017. Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. Osteoarth Cartilage. 25(12):1952–1961.
  • Wang Y, Prentice LF, Vitetta L, Wluka AW, Cicuttini FM. 2004. The effect of nutritional supplements on osteoarthritis. Altern Med Rev. 9(3):275–296.
  • Wang Y, Tonkin A, Jones G, Hill C, Ding C, Wluka AE, Forbes A, Cicuttini FM. 2015. Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial. Trials. 16(1):584.
  • Wluka AE, Ding C, Wang Y, Jones G, Urquhart DM, Cicuttini FM. 2015. Aspirin is associated with reduced cartilage loss in knee osteoarthritis: data from a cohort study. Maturitas. 81(3):394–397.
  • Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE. 2007. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 5:20.
  • Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA, Ba K, Wang J, Lin Y, et al. 2017. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insights. 2(1):e88553.
  • Xu Q, Zhang Z-F, Sun W-X. 2017. Effect of naringin on monosodium iodoacetate-induced osteoarthritis pain in rats. Med Sci Monit. 23:3746–3751.
  • Yan JY, Tian FM, Wang WY, Cheng Y, Song HP, Zhang YZ, Zhang L. 2014. Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis. Osteoarth Cartilage. 22(11):1869–1877.
  • Yang CY, Chanalaris A, Troeberg L. 2017. ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects. Osteoarth Cartilage. 25(7):1000–1009.
  • Yoon JB, Kim SJ, Hwang SG, Chang S, Kang SS, Chun JS. 2003. Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity. J Biol Chem. 278(17):15319–15325.
  • You WC, Li W, Zhuang Z, Tang Y, Lu HC, Ji XJ, Shen W, Shi JX, Zhou ML. 2012. Biphasic activation of nuclear factor-kappa B in experimental models of subarachnoid hemorrhage in vivo and in vitro. Mediators Inflamm. 2012(2012):1–10.
  • Zhang D, Zhou Y. 2014. The protective effects of donepezil (DP) against cartilage matrix destruction induced by TNF-α. Biochem Biophys Res Commun. 454(1):115–118.
  • Zhang P, Wu C, Huang XH, Shen CL, Li L, Zhang W, Yao CZ. 2017. Aspirin suppresses TNF-α-induced MMP-9 expression via NF-κB and MAPK signaling pathways in RAW264.7 cells. Exp Ther Med. 14(6):5597–5604.
  • Zhang ZH, Li HX, Qi YP, Du LJ, Zhu SY, Wu MY, Lu HL, Yu Y, Han W. 2010. Recombinant human midkine stimulates proliferation of articular chondrocytes. Cell Prolif. 43(2):184–194.
  • Zhao W, Zhang S, Wang B, Huang J, Lu WW, Chen D. 2016. Runx2 and microRNA regulation in bone and cartilage diseases. Ann NY Acad Sci. 1383(1):80–87.
  • Zhao Y, Li Z, Wang W, Zhang H, Chen J, Su P, Liu L, Li W. 2016. Naringin protects against cartilage destruction in osteoarthritis through repression of NF-κB signaling pathway. Inflammation. 39(1):385–392.
  • Zhu S, Chen K, Lan Y, Zhang N, Jiang R, Hu J. 2013. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 53(2):340–349.
  • Zhu Z, Li J, Ruan G, Wang G, Huang C, Ding C. 2018. Investigational drugs for the treatment of osteoarthritis, an update on recent developments. Expert Opin Invest Drugs. 27(11):881–900.
  • Zuscik M, Carmody E, Ritchlin C. 2017. Teriparatide as a chondroregenerative therapy in OA. [accessed 2018 Sep 3]. https://clinicaltrials.gov/ct2/show/NCT03072147?type=Intr&cond=cartilage&draw=3&rank=143.
  • Zweers MC, de Boer TN, van Roon J, Bijlsma JW, Lafeber FP, Mastbergen SC. 2011. Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis. Arthritis Res Ther. 13(5):239.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.