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Hemoglobin
international journal for hemoglobin research
Volume 31, 2007 - Issue 4
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Original Article

Hb Kenya among Luo Adults and Young Children in Malaria Holoendemic Western Kenya: Screened by High Performance Liquid Chromatography and Confirmed By Polymerase Chain Reaction

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Pages 401-408 | Received 03 Jan 2007, Accepted 15 Jun 2007, Published online: 07 Jul 2009

REFERENCES

  • Huisman THJ, Schroeder WA, Charache S, Bethlenfalvay NC, Bouver NC, Bouver N, Shelton JR, Shelton JB, Apell G. Hereditary persistence of fetal hemoglobin. Heterogeneity of fetal hemolobin in homozygotes and in conjunction with β-thalassemia. N Engl J Med 1871; 285(13)711–716
  • Wood WG. Hereditary persistence of fetal hemoglobin and δβ thalassemia. Disorders of Hemoglobin: Genetics, Pathophysiology and Clinical Management, MH Steinberg, BG Forget, DR Higgs, RL Nagel. Cambridge University Press, Cambridge 2001; 356–388
  • Huisman THJ, Wrightstone RN, Wilson JB, Schroeder WA, Kendall AG. Hemoglobin Kenya, the product of γ and β polypeptide chains. Arch Biochem Biophys 1972; 153(2)850–855
  • Kendall AG, Ojwang PJ, Schroeder WA, Huisman THJ. Hemoglobin Kenya, the product of a γβ fusion gene: studies of the family. Am J Hum Genet 1973; 25(5)548–563
  • Nute PE, Wood WG, Stamatoyannopolous G, Olweny C, Failkow PJ. The Kenya form of hereditary persistence of foetal haemoglobin: structural studies and evidence of homogeneous distribution of Haemoglobin F using fluorescent anti-Haemoglobin F antibodies. Br J Haematol 1976; 32(1)55–63
  • Ojwang PJ, Ogada T, Bakioglu I, Headlee MG, Reese AL, Huisman THJ. Abnormal haemoglobins in Western Kenya. East Afr Med J 1984; 61(12)886–891
  • Rai DK, Alvelius G, Landin B. Identification of Hb Kenya (Aγ81Leu-β86Ala) by electrospray mass spectrometry. Hemoglobin 2002; 26(1)71–75
  • Landin B, Jeppsson JO. Rare β chain hemoglobin variants found in Swedish patients during Hb A1canalysis. Hemoglobin 1993; 17(4)303–318
  • Huisman THJ. Compound heterozygosity for Hb S and the hybrid Hbs Lepore, P-Nilotic, P-Nilotic, and Kenya; comparition of hematological and hemoglobin composition data. Hemoglobin 1997; 21(3)249–257
  • Hardison RC, Chui DHK, Giardine B, Riemer C, Patrinos GP, Anagnou N, Miller W, Wajcman H. HbVar: a relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mut 2002; 19(3)225–233,
  • Traeger-Synodinos J, Old JM, Petrou M, Galanello R. Best practice guidelines for carrier identification and prenatal diagosis of haemoglobinopathies. Clinical Molecular Genetics Society (CMGS) and European Molecular Genetics Quality Networt (EMQN) 2002
  • Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory. Clin Chem 2004; 50(10)1736–1747
  • Fucharoen S, Winichagoon P, Wisedpanichkij R, Sae-Ngow B, Sriphanich R, Oncoung W, Muangsapaya W, Chowthaworn J, Kanokpongsakdi S, Bunyaratvej A, Piankijagum A, Dewaele C. Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC. Clin Chem 1998; 44(4)740–748
  • Kwiatkowski DP. How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 2005; 77(2)171–192
  • Weatherall DJ. The thalassemias. The Molecular Basis of Blood Diseases, G Stamatoyannopoulos, PW Majerus, RM Perlmutter, H Varmus. W.B. Saunders Company, Philadelphia 2001; 3: 157–205

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