Advanced search
Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 31, 2007 - Issue 4
Submit an article Journal homepage
199
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Plasma and Urine Hydroxyurea Levels Might be Useful in the Management of Adult Sickle Cell Disease

Dora Bachir Treatment Center of Sickle Cell Anemia, AP-HP, Hôpital Henri Mondor, Créteil, France
,
Anne Hulin Laboratory of Pharmacology and Toxicology, AP-HP, Hôpital Henri Mondor, Créteil, FranceCorrespondence[email protected]
,
Estelle Huet Laboratory of Pharmacology and Toxicology, AP-HP, Hôpital Henri Mondor, Créteil, France
,
Anoosha Habibi Treatment Center of Sickle Cell Anemia, AP-HP, Hôpital Henri Mondor, Créteil, France
,
Ruben Nzouakou Treatment Center of Sickle Cell Anemia, AP-HP, Hôpital Henri Mondor, Créteil, France
,
Madjeline El Mahrab Laboratory of Pharmacology and Toxicology, AP-HP, Hôpital Henri Mondor, Créteil, France
,
Alain Astier Laboratory of Pharmacology and Toxicology, AP-HP, Hôpital Henri Mondor, Créteil, France
&
Frédéric Galacteros Treatment Center of Sickle Cell Anemia, AP-HP, Hôpital Henri Mondor, Créteil, France; Université Paris 12, Faculté de Médecine, AP-HP, Hôpital Henri Mondor, Créteil, France
 show all
Pages 417-425 | Received 13 Oct 2006, Accepted 12 Mar 2007, Published online: 07 Jul 2009

REFERENCES

  • Elford HL. Effect of hydroxyurea on ribonucleotide reductase. Biochem Biophys Res Commun 1968; 33(1)129–135
  • Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005; 353(1)33–45
  • Lori F, Malykh A, Cara A, Sun D, Weinstein JN, Lisziewicz J, Gallo RC. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 1994; 266(5184)801–805
  • Rodgers GP, Dover GJ, Uyesaka N, Noguchi CT, Schechter AN, Nienhuis AW. Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. N Engl J Med 1993; 328(2)73–80
  • Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, McMahon RP, Bonds DR. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 1995; 332(20)1317–1322
  • Steinberg MH, Voskaridou E, Kutlar A, Loukopoulos D, Koshy M, Ballas SK, Castro O, Barton F. Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. Am J Hematol 2003; 72(2)121–126
  • Tracewell WG, Trump DL, Vaughan WP, Smith DC, Gwilt PR. Population pharmacokinetics of hydroxyurea in cancer patients. Cancer Chemother Pharmacol 1995; 35(5)417–422
  • Dalton RN, Turner C, Dick M, Height SE, Awogbade M, Inusa B, Okpala I, O'Driscoll S, Thein SL, Rees DC. The measurement of urinary hydroxyurea in sickle cell anaemia. Br J Haematol 2005; 130(1)138–144
  • Yan JH, Ataga K, Kaul S, Olson JS, Grasela DM, Gothelf S, Kutlar A, Orringer E. The influence of renal function on hydroxyurea pharmacokinetics in adults with sickle cell disease. J Clin Pharmacol 2005; 45(4)434–445
  • Davidson JD, Winter TS. A method of analyzing for hydroxyurea in biological fluids. Cancer Chemother Rep 1963; 27: 97–110
  • Fabricius E, Rajewsky F. Determination of hydroxyurea in mammalian tissues and blood. Rev Eur Etud Clin Biol 1971; 16(7)679–683
  • Iyamu EW, Roa PD, Kopsombut P, Aguinaga MD, Turner EA. New isocratic high-performance liquid chromatographic procedure to assay the anti-sickling compound hydroxyurea in plasma with ultraviolet detection. J Chromatogr B Biomed Sci Appl 1998; 709(1)119–126
  • Manouilov KK, McGuire TR, Gwilt PR. Colorimetric determination of hydroxyurea in human serum using high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1998; 708(1–2)321–324
  • Gwilt PR, Tracewell WG. Pharmacokinetics and pharmacodynamics of hydroxyurea. Clin Pharmacokinet 1998; 34(5)347–358
  • Gwilt PR, Manouilov KK, McNabb J, Swindells SS. Pharmacokinetics of hydroxyurea in plasma and cerebrospinal fluid of HIV-1-infected patients. J Clin Pharmacol 2003; 43(9)1003–1007
  • Villani P, Maserati R, Regazzi MB, Giacchino R, Lori F. Pharmacokinetics of hydroxyurea in patients infected with human immunodeficiency virus type I. J Clin Pharmacol 1996; 36(2)117–121
  • de Montalembert M, Bachir D, Hulin A, Gimeno L, Mogenet A, Bresson JL, Macquin-Mavier I, Roudot-Thoraval F, Astier A, Galacteros F. A phase 1 pharmacokinetics study of hydroxurea 1,000 mg coated breakable tablets and 500 mg capsules in pediatric and adult patients with sickle cell disease. Haematologica 2006; 91(12)1685–1658
  • Ferguson RP, Arun A, Carter C, Walker SD, Castro O. Hydroxyurea treatment of sickle cell anemia in hospital-based practices. Am J Hematol 2002; 70(4)326–328

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.