Ketoprofen Spray-dried Microspheres Based on Eudragit® RS and RL: Study of the Manufacturing Parameters

REFERENCES

• I. Caruso, E. Frigerio, M. Fumagalli, C. Liverta, L. Moro, and V. Tamassia. 1982. Bioavailability study on a new slow-release formulation of ketoprofen. J. Int. Med. Res. 10:229–233.
   PubMed Web of Science ®Google Scholar
• F. Castelli, B. Conti, D. E. Maccarrone, U. Conte, and G. Puglisi. 1998. Comparative study of ‘in vitro’ release of anti-inflammatory drugs from polylactide-co-glycolide microspheres. Int. J. Pharm. 176:85–98.
   Web of Science ®Google Scholar
• F. Castelli, C. Messina, M. G. Sarpietro, R. Pignatello, and G. Puglisi. 2002. Flurbiprofen release from Eudragit RS and RL aqueous nanosus-pensions: A kinetic study by DSC and dialysis experiments. AAPS PharmSciTech 3:1–8.
   Google Scholar
• H-K. Chan, and N. Y. K. Chew. 2003. Novel alternative methods for the delivery of drugs for the treatment of asthma. Adv. Drug Deliv. Rev. 55:793–805.
   PubMed Web of Science ®Google Scholar
• I. El-Gibaly. 2002. Oral delayed-release system based on Zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int. J. Pharm. 232:199–211.
   PubMed Web of Science ®Google Scholar
• A. H. El-Kamel, M. S. Sokar, S. S. Al Gamal, and V. F. Naggar. 2001. Preparation and evaluation of ketoprofen floating oral delivery system. Int. J. Pharm. 220:13–21.
   PubMed Web of Science ®Google Scholar
• E. Esposito, R. Roncarati, R. Cortesi, F. Cervellati, and C. Nastruzzi. 2000. Production of eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics. Pharm. Dev. Technol. 5:267–278.
   PubMed Web of Science ®Google Scholar
• F. Gabor, B. Ertl, M. Wirth, and R. Mallinger. 1999. Ketoprofen-poly(D, L-lactic-co-glicolic acid) microspheres: Influence of manufacturing parameters and type of polymer on the release characteristics. J. Microencapsul. 16:1–12.
   PubMed Web of Science ®Google Scholar
• E. Gavini, V. Sanna, C. Juliano, and P. Giunchedi. 2003. Compressed biodegradable matrices of spray-dried PLGA microspheres for the modified release of ketoprofen. J. Microencapsul. 20:193–201.
   PubMed Web of Science ®Google Scholar
• I. Genta, P. Perugini, B. Conti, and F. Pavanetto. 1997. A multiple emulsion method to entrap a lipophilic compound into chitosan microspheres. Int. J. Pharm. 152:237–246.
   Web of Science ®Google Scholar
• P. Giunchedi, and U. Conte. 1995. Spray-drying as a preparation method of microparticulate drug delivery systems: An overview. S.T.P. Pharm. Sci. 5:276–290.
   Web of Science ®Google Scholar
• P. Giunchedi, U. Conte, P. Chetoni, and M. F. Saettone. 1999. Pectin microspheres as ophthalmic carriers for piroxicam: Evaluation in vitro and in vivo in albino rabbits. Eur. J. Pharm. Sci. 9:1–7.
   PubMed Web of Science ®Google Scholar
• P. Giunchedi, B. Conti, L. Maggi, and U. Conte. 1994. Cellulose acetate butyrate and polycaprolactone for ketoprofen spray-dried microsphere preparation. J. Microencapsul. 11:381–393.
   PubMed Web of Science ®Google Scholar
• P. Giunchedi, E. Gavini, G. Bonacucina, and G. F. Palmieri. 2000. Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method. J. Microencapsul. 17:711–720.
   PubMed Web of Science ®Google Scholar
• P. Giunchedi, L. Maggi, U. Conte, and C. Caramella. 1991. Ketoprofen pulsatile absorption from ‘multiple unit’ hydrophilic matrices. Int. J. Pharm. 77:177–181.
   Web of Science ®Google Scholar
• S. Goto, M. Kawata, M. Nakamura, K. Maekauwa, and T. Ayoama. 1986. Eudragit RS and RL (acrylic resins) micro-capsules as pH insensitive and sustained release prepara-tions of ketoprofen. J. Microencapsul. 3:293–304.
   PubMedGoogle Scholar
• M. J. Habib, and R. Meuse. 1995. Development of controlled release formulations of ketorpofen for oral use. Drug. Dev. Ind. Pharm. 21:1463–1472.
   Web of Science ®Google Scholar
• S. Haznedar, and B. Dortunç. 2004. Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide. Int. J. Pharm. 269:131–140.
   PubMed Web of Science ®Google Scholar
• G. W. Houghton, M. J. Dennis, E. D. Rigler, and R. L. Parsons. 1984. Comparative pharmacokinetics of ketoprofen derived from single oral doses of ketoprofen capsules or a novel sustained-release pellet formulation. Biopharm. Drug Dispos. 5:203–209.
   PubMed Web of Science ®Google Scholar
• G. W. Houghton, M. J. Dennis, R. Templelon, R. M. Calvert, and D. G. Cresswell. 1984. A pharmacokinetic study of repeated doses of a new controlled release of ketoprofen. Int. J. Clin. Pharmacol. Ther. 23:131–133.
   Google Scholar
• Y. Kawashima, T. Niwa, T. Handa, H. Takeuchi, and Y. Ito. 1991. Preparation and characterization of a new controlled re-lease ibuprofen suspension for improving suspendability. Int. J. Pharm. 75:25–36.
   Web of Science ®Google Scholar
• Y. Kawashima, T. Niwa, T. Handa, H. Takeuchi, T. Iwamoto, and Y. Ito. 1989. Preparation of prolonged-release spheri-cal micromatrix of ibuprofen with acrylic polymer by the emulsion solvent diffusion method for improving bioavailability. Chem. Pharm. Bull. 37:425–429.
   PubMed Web of Science ®Google Scholar
• Y. Kawashima, H. Toshiyuki, H. Takeuchi, T. Hino, and Y. Ito. 1992. Control of prolonged drug release and compression properties of ibuprofen microsponges with acrylic poly-mer; Eudragit RS, changing their intrapartical porosity. Chem. Pharm. Bull. 40:196–201.
   PubMed Web of Science ®Google Scholar
• M. Kawata, M. Nakamura, T. Goto, and T. Ayoama. 1968. Preparation and dissolution pattern of Eudragit RS microcapsules containing Ketoprofen. Chem. Pharm. Bull. 34:2618–2623.
   Google Scholar
• E. Khalil, and A. Sallam. 1999. Interaction of two Diclofenac acid salts with copolymers of ammoniomethacrylate: Effect of additives and release profiles. Drug. Dev. Ind. Pharm. 25:419–427.
   PubMed Web of Science ®Google Scholar
• M. A. Khan, J. Dib, and I. K. Reedy. 1996. Statistical optimization of ketoprofen Eudragit S100 coprecipitates to obtain controlled release tablets. Drug. Dev. Ind. Pharm. 22:135–141.
   Web of Science ®Google Scholar
• A. Le Liboux, M. Teule, A. Frydman, B. Osterhuis, and J. H. G. Jonkman. 1994. Effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen. Eur. J. Clin. Pharmacol. 47:361–366.
   PubMed Web of Science ®Google Scholar
• R. Marcolongo, M. Rubegni, D. Provvedi, N. Giordano, E. Frati, and G. Bruni. 1984. A double-blind, interpatient comparison of plain and slow-release ketoprofen in osteoarthritis. Int. J. Clin. Pharmacol. Ther. 22:377–381.
   Web of Science ®Google Scholar
• K. Masters. 1991. The spray drying handbook. New York, USA: Longman Scientific and Technical.
   Google Scholar
• T. Mateovic-Rojnik, R. Frlan, M. Bogataj, P. Bukovec, and A. Mrhar. 2005. Effect of preparation temperature in solvent evaporation process on Eudragit RS microsphere properties. Chem. Pharm. Bull. 53:143–146.
   PubMed Web of Science ®Google Scholar
• C. Meier. 2005, April. Phisico chemical properties of Eudragit® polymers and their influences on film properties. Conference paper presented at 47th Eudragit International Workshop, Darmstadt, Germany.
   Google Scholar
• M. D. L. Moretti, E. Gavini, C. Juliano, G. Pirisino, and P. Giunchedi. 2001. Spray-dried microspheres containing ketoprofen formulated into capsules and tablets. J. Microencapsul. 18:111–121.
   PubMed Web of Science ®Google Scholar
• K. D. Morley, R. M. Bernstein, G. R. V. Hughes, C. M. Black, C. A. N. Rajapakse, and L. Wilson. 1984. A comparative trial of a controlled-release formulation of ketoprofen (‘oruvail’) and a conventional capsule formulation of ketoprofen (‘orudis’) in patients with osteoarthritis of the hip. Curr. Med. Res. Opin. 9:28–34.
   PubMed Web of Science ®Google Scholar
• D. M. Omari, A. Sallam, A. Abd-Elbary, and M. El-Samaligy. 2004. Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions. Int. J. Pharm. 274:85–96.
   PubMed Web of Science ®Google Scholar
• G. F. Palmieri, G. Bonacucina, P. Di Martino, and S. Martelli. 2002a. Gastro-resistant microspheres containing ketoprofen. J. Microencapsul. 19:111–119.
   PubMed Web of Science ®Google Scholar
• G. F. Palmieri, G. Bonacucina, P. Di Martino, and S. Martelli. 2002b. Microencapsulation of semisolid ketoprofen/polymer microspheres. Int. J. Pharm. 242:175–178.
   PubMed Web of Science ®Google Scholar
• G. F. Palmieri(Chair), I. Elisei, P. Di Martino, and S. Martelli. 2000, April Formulation of microparticulate systems for modified release containing ketoprofen. Conference paper presented at the 19th Pharmaceutical Technology Conference. Baveno-Stresa, Italy.
   Google Scholar
• G. F. Palmieri, S. Martelli, D. Lauri, and P. Wehrle. 1996. Gelatin-acacia complex coacervation as a method for ketoprofen microencapsulation. Drug Dev. Ind. Pharm. 22:951–957.
   Web of Science ®Google Scholar
• C. Parejo, A. Gallardo, and J. San Roman. 1998. Controlled release of NSAIDs bound to polyacrylic carrier systems. J. Mater. Sci. Mater. Med. 9:803–809.
   PubMed Web of Science ®Google Scholar
• R. Pignatello, M. A. Vandelli, P. Giunchedi, and G. Puglisi. 1997. Properties of Tolmetin-loaded Eudragit RL100 and RS100 microparticles prepared by different techniques. STP Pharm. Sci. 7:148–157.
   Google Scholar
• M. I. Ré, and B. Biscans. 1999. Preparation of microspheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method. Powder Technol. 101:120–133.
   Web of Science ®Google Scholar
• M. Ricci, P. Blasi, S. Giovagnoli, C. Rossi, G. Macchiarulo, G. Luca, G. Basta, and R. Calafiore. 2005. Ketoprofen controlled release from composite microcapsules for cell encapsulation: Effect on post-transplant acute inflammation. J. Control. Release 107:395–407.
   PubMed Web of Science ®Google Scholar
• A. Roda, L. Sabatini, M. Mirasoli, M. Baraldini, and E. Roda. 2002. Biovailability of a new ketoprofen formulation for once-daily oral administration. Int. J. Pharm. 241:165–172.
   PubMed Web of Science ®Google Scholar
• G. J. Vergote, C. Vervaet, I. Van Driessche, S. Hoste, S. De Smedt, J. Demeester, R. A. Jain, S. Ruddy, and J. P. Remon. 2001. An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen. Int. J. Pharm. 219:81–87.
   PubMed Web of Science ®Google Scholar
• M. L. Vueba, L. A. E. Batista de Carvalho, F. Veiga, J. J. Sousa, and M. E. Pina. 2004. Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets. Eur. J. Pharm. Biopharm. 58:51–59.
   PubMed Web of Science ®Google Scholar