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Research Article

Enhancement of oral bioavailability of anti-HIV drug rilpivirine HCl through nanosponge formulation*

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Pages 2076-2084 | Received 02 Feb 2017, Accepted 12 Aug 2017, Published online: 13 Sep 2017

References

  • Gupta U, Jain NK. Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting. Adv Drug Deliv Rev. 2010;62:478–490.
  • Look M, Bandyopadhyay A, Blum JS, et al. Application of nanotechnologies for improved immune response against infectious diseases in the developing world. Adv Drug Deliv Rev. 2010;62:378–393.
  • Wong HL, Chattopadhyay N, Wu XY, et al. Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Deliv Rev. 2010;62:503–517.
  • Das NJ, Amiji MM, Bahia MF, et al. Nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Adv Drug Deliv Rev. 2010;62:458–477.
  • Clercq ED. Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009;33:307–320.
  • UNAIDS. UNAIDS – Global Report – 2013. Available from: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013
  • Venkatesh DN, Baskaran M, Satyanarayana VV, et al. Fabrication and in vivo evaluation of nelfinavir loaded PLGA nanoparticles for enhancing oral bioavailability and therapeutic effect. Saudi Pharm J. 2015;23: 667–674.
  • Alcaro S, Alteri C, Artese A, et al. Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase. Drug Resist Updat. 2011;14:141–149.
  • Sosnik A, Chiappetta DA, Carcaboso AM. Drug delivery systems in HIV pharmacotherapy: what has been done and the challenges standing ahead. J Control Release. 2009;138:2–15.
  • Hammer SM, Saag MS, Schechter M, et al. International AIDS Society-USA panel. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society – USA panel. J Am Med Assoc 2006;296:827–843.
  • Vicente Fernandez-Montero J, Vispo ME, et al. Rilpivirine: a next-generation non-nucleoside analogue for the treatment of HIV infection. Expert Opin Pharmacother. 2012;13:1007–1014.
  • Garvey L, Winston A. Rilpivirine: A novel non-nucleoside reverse transcriptase inhibitor. Expert Opin Investig Drugs. 2009;18:1035–1041.
  • Ford N, Lee J, Andrieux-Meyer I, et al. Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings. HIV/AIDS – Res Palliat Care 2011;3:35–44.
  • Kommavarapu S, Maruthapillai A, Palanisamy K, et al. Preparation and characterization of rilpivirine solid dispersions with the application of enhanced solubility and dissolution rate. Beni-Suef Univ J Appl Sci. 2015;4:71–79.
  • Tshweu L, Katata L, Kalombo L, et al. Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method. Nanomedicine (Lond). 2013;9: 1821–1833.
  • Kesisoglou F, Panmai S, Wu Y. Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev. 2007;59:631–644.
  • Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12:1068–1075.
  • Kovarova M, Council OD, Date AA, et al. Nanoformulations of rilpivirine for topical pericoital and systemic coitus-independent administration efficiently prevent HIV transmission. PLoS Pathog. 2015;1:e1005075.
  • Ahmed R, Patil G. Zaheer Nanosponges – a completely new Nano-Horizon: pharmaceutical applications and recent advances. Drug Dev Ind Pharm. 2012;39: 1263–1272.
  • Trotta F, Zanetti M, Cavalli R. Cyclodextrin-based nanosponges as drug carriers. Beilstein J Org Chem. 2012;8:2091–2099.
  • Lembo D, Swaminathan S, Donalisio M, et al. Encapsulation of acyclovir in new carboxylated cyclodextrin-based nanosponges improves the agent’s antiviral efficacy. Int J Pharm. 2013;443:262–272.
  • Trotta F, Caldera F, Cavalli R, et al. Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease. Expert Opin Drug Deliv. 2016;13:1671–1680.
  • Swaminathan S, Vavia PR, Trotta F, et al. Formulation of betacyclodextrin based nanosponges of itraconazole. J Incl Phenom Macrocycl Chem. 2007;57:89–94.
  • Swaminathan S, Pastero L, Serpe L, et al. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm. 2010;74:193–201.
  • Sherje AP, Dravyakar BR, Kadam D, et al. Cyclodextrin-based nanosponges: A critical review. Carbohydr Polym. 2017;173:37–49.
  • Caldera F, Tannous M, Cavalli R, et al. Evolution of cyclodextrin nanosponges. Int J Pharm. Forthcoming. [cited 2017 Jun 20]. DOI:10.1016/j.ijpharm.2017.06.072
  • Singireddy A, Subramanian S. Optimization of microwave-assisted synthesis of cyclodextrin nanosponges using response surface methodology. J Porous Mater. 2014;21:1015–1023.
  • Ansari KA, Vavia PR, Trotta F, et al. Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study. AAPS Pharm Sci Tech. 2011;12:279–286.
  • Higuchi T, Connors KA. Phase solubility techniques. Anal. Chem. Instrum 1965;4:117–212.
  • Shende PK, Deshmukh K, Trotta F, et al. Novel cyclodextrin nanosponges for delivery of calcium in hyperphosphatemia. Int J Pharm. 2013;456:95–100.
  • Shende PK, Gaud RS, Bakal R, et al. Effect of inclusion complexation of meloxicam with β-cyclodextrin and β-cyclodextrin based nanosponges on solubility, in vitro release and stability studies. Colloids Surf B: Biointerfaces. 2015;36:105–110.
  • Addepalli VR, Appala RN. Development and validation of a LC-MS/MS method for the determination of rilpivirine in sprague dawley rat serum and its application to pharmacokinetic study. Asian J Biomed Pharm Sci 2013;3:23–29.
  • Sharma R, Walker R, Pathak K. Evaluation of the Kinetics and Mechanism of Drug Release from econazole nitrate nanosponge loaded carbapol hydrogel. Indian J Pharm Res Edu 2011;45:25–31.
  • Torne SJ, Ansari KA, Vavia PR, et al. Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded nanosponges. Drug Deliv. 2010;17: 419–425.
  • Rao M, Bajaj A, Khole I, et al. In vitro and in vivo evaluation of b-cyclodextrin-based nanosponges of telmisartan. J Incl Phenom Macrocycl Chem 2012;77:1–4.
  • European medicine agency, Assesment report of Edurant, 2011.
  • Therapeutic goods administration, Australian public assessment report for Rilpivirine, March 2012.
  • Cavalli R, Trotta F, Tumiatti W. Cyclodextrin-based Nanosponges for Drug Delivery. J Incl Phenom Macrocycl Chem. 2006;56:209–213.
  • Dora CP, Trotta F, Kushwah V, et al. Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability. Carbohydr Polym. 2016;137:339–349.

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