Calcium phosphate-based nanosystems for advanced targeted nanomedicine

References

• Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 2005;19:311–330.
   PubMed Web of Science ®Google Scholar
• Wagner V, Dullaart A, Bock A-K. The emerging nanomedicine landscape. Nat Biotechnol. 2006; 24:1211–1217.
   PubMed Web of Science ®Google Scholar
• Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol. 2010;7:653–664.
   PubMed Web of Science ®Google Scholar
• Doane TL, Burda C. The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy. Chem Soc Rev. 2012;41:2885–2911.
   PubMed Web of Science ®Google Scholar
• Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol Rev 2001;53:283–318.
   PubMed Web of Science ®Google Scholar
• Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev. 2001;47:65–81.
   PubMed Web of Science ®Google Scholar
• Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer. 2005;5:161–171.
   PubMed Web of Science ®Google Scholar
• Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3:16–20.
   PubMed Web of Science ®Google Scholar
• Pietronave S, Iafisco M, Locarno D, et al. Functionalized nanomaterials for diagnosis and therapy of cancer. J Appl Biomater Biomech 2009;7:77–89.
   PubMedGoogle Scholar
• Peer D, Karp JM, Hong S, et al. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2007;2:751–760.
   PubMed Web of Science ®Google Scholar
• Davis ME, Chen Z, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7:771–782.
   PubMed Web of Science ®Google Scholar
• Singal PK, Iliskovic N. Doxorubicin-induced cardiomyopathy. N Engl J Med. 1998;339:900–905.
   PubMed Web of Science ®Google Scholar
• Zhang Y-W, Shi J, Li Y-J, et al. Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Arch Immunol Ther Exp. 2009;57:435–445.
   PubMed Web of Science ®Google Scholar
• Arany I, Safirstein RL. Cisplatin nephrotoxicity. Semin Nephrol. 2003;23:460–464.
   Google Scholar
• Yao X, Panichpisal K, Kurtzman N, et al. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2007;334:115–124.
   PubMed Web of Science ®Google Scholar
• Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008;73:994–1007.
   PubMed Web of Science ®Google Scholar
• West SG. Methotrexate hepatotoxicity. Rheum Dis Clin North Am. 1997;23:883–915.
   PubMed Web of Science ®Google Scholar
• McCarthy JR. Multifunctional agents for concurrent imaging and therapy in cardiovascular disease. Adv Drug Deliv Rev. 2010;62:1023–1030.
   PubMed Web of Science ®Google Scholar
• Agulla J, Brea D, Campos F, et al. In vivo theranostics at the peri-infarct region in cerebral ischemia. Theranostics 2013;4:90–105.
   PubMed Web of Science ®Google Scholar
• Godin B, Sakamoto JH, Serda RE, et al. Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases. Trends Pharmacol Sci. 2010;31:199–205.
   PubMed Web of Science ®Google Scholar
• Miragoli M, Ceriotti P, Iafisco M, et al. Inhalation of peptide-loaded nanoparticles improves heart failure. Sci Transl Med 2018;10:eaan6205.
   PubMed Web of Science ®Google Scholar
• Zhang L, Gu FX, Chan JM, et al. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008;83:761–769.
   PubMed Web of Science ®Google Scholar
• Torchilin VP. Multifunctional nanocarriers. Adv Drug Deliv Rev. 2006;58:1532–1555.
   PubMed Web of Science ®Google Scholar
• Xie J, Lee S, Chen X. Nanoparticle-based theranostic agents. Adv Drug Deliv Rev. 2010;62:1064–1079.
   PubMed Web of Science ®Google Scholar
• von Maltzahn G, Park J-H, Agrawal A, et al. Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res. 2009;69:3892–3900.
   PubMed Web of Science ®Google Scholar
• Norman RS, Stone JW, Gole A, et al. Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods. Nano Lett. 2008;8:302–306.
   PubMed Web of Science ®Google Scholar
• Bañobre-López M, Teijeiro A, Rivas J. Magnetic nanoparticle-based hyperthermia for cancer treatment. Rep Pract Oncol Radiother. 2013;18:397–400.
   PubMedGoogle Scholar
• Zarepour A, Zarrabi A. Khosravi A. SPIONs as nano-theranostics agents. In: Zarepour A, Zarrabi A, Khosravi A, editors. SPIONs as Nano-Theranostics Agents. Singapore: Springer; 2017. p. 1–44.
   Google Scholar
• Chen W-H, Luo G-F, Qiu W-X, et al. Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemotherapy. Biomaterials 2017;117:54–65.
   PubMed Web of Science ®Google Scholar
• Satterlee AB, Yuan H, Huang L. A radio-theranostic nanoparticle with high specific drug loading for cancer therapy and imaging. J Control Release. 2015;217:170–182.
   PubMed Web of Science ®Google Scholar
• Mi P, Dewi N, Yanagie H, et al. Hybrid calcium phosphate-polymeric micelles incorporating gadolinium chelates for imaging-guided gadolinium neutron capture tumor therapy. ACS Nano. 2015;9:5913–5921.
   PubMed Web of Science ®Google Scholar
• Chapman S, Dobrovolskaia M, Farahani K, et al. Nanoparticles for cancer imaging: the good, the bad, and the promise. Nano Today. 2013;8:454–460.
   PubMed Web of Science ®Google Scholar
• Neuberger T, Schöpf B, Hofmann H, et al. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J Magn Magn Mater. 2005;293:483–496.
   Web of Science ®Google Scholar
• de Rosales RTM. Potential clinical applications of bimodal PET-MRI or SPECT-MRI agents. J Label Compd Radiopharm. 2014;57:298–303.
   PubMed Web of Science ®Google Scholar
• Pansare VJ, Hejazi S, Faenza WJ, et al. Review of long-wavelength optical and NIR imaging materials: contrast agents, fluorophores, and multifunctional nano carriers. Chem Mater. 2012;24:812–827.
   PubMed Web of Science ®Google Scholar
• Xie J, Chen K, Huang J, et al. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 2010;31:3016–3022.
   PubMed Web of Science ®Google Scholar
• Kelkar SS, Reineke TM. Theranostics: combining imaging and therapy. Bioconjugate Chem. 2011;22:1879–1903.
   PubMed Web of Science ®Google Scholar
• Del Vecchio S, Zannetti A, Fonti R, et al. Nuclear imaging in cancer theranostics. Q J Nucl Med Mol Imaging 2007;51:152.
   PubMed Web of Science ®Google Scholar
• Degli Esposti L, Carella F, Iafisco M. Inorganic nanoparticles for theranostic use. In: Guarino V, Ambrosio L, editors. Electrofluidodynamic technologies (EFDTs) for biomaterials and medical devices. Sawston: Woodhead-Elsevier; 2017.
   Google Scholar
• Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med. 2010;363:301–304.
   PubMed Web of Science ®Google Scholar
• Ginsburg GS, McCarthy JJ. Personalized medicine: revolutionizing drug discovery and patient care. Trends Biotechnol. 2001;19:491–496.
   PubMed Web of Science ®Google Scholar
• Singh N, Jenkins GJS, Asadi R, et al. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev. 2010;1:5358.
   PubMedGoogle Scholar
• Stroh A, Zimmer C, Gutzeit C, et al. Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages. Free Radic Biol Med. 2004;36:976–984.
   PubMed Web of Science ®Google Scholar
• Doshi N, Mitragotri S. Designer biomaterials for nanomedicine. Adv Funct Mater. 2009;19:3843–3854.
   Web of Science ®Google Scholar
• Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev. 2013;65:71–79.
   PubMed Web of Science ®Google Scholar
• Nichols JW, Bae YH. EPR: evidence and fallacy. J Control Release. 2014;190:451–464.
   PubMed Web of Science ®Google Scholar
• Danhier F. To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine? J Control Release 2016;244:108–121.
   PubMed Web of Science ®Google Scholar
• Steichen SD, Caldorera-Moore M, Peppas NA. A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics. Eur J Pharm Sci. 2013;48:416–427.
   PubMed Web of Science ®Google Scholar
• Torchilin VP. Passive and active drug targeting: drug delivery to tumors as an example. In: Schäfer-Korting M, editor. Drug delivery. Berlin, Heidelberg: Springer; 2010. p. 3–53.
   Google Scholar
• Toporkiewicz M, Meissner J, Matusewicz L, et al. Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges. Int J Nanomed 2015;10:1399–1414.
   PubMed Web of Science ®Google Scholar
• Stewart B, Wild CP. World cancer report 2014. Health. 2017. Available from: http://www.thehealthwell.info/node/725845
   Google Scholar
• Ferlay J, Soerjomataram I, Ervik M., et al. GLOBOCAN 2012 V1.0, Estimated cancer incidence, mortality and prevalence worldwide: IARC CancerBase No. 11 [Internet]. 2012. Available from: http://globocan.iarc.fr
   Google Scholar
• Bertrand N, Wu J, Xu X, et al. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Del Rev. 2014;66:2–25.
   PubMed Web of Science ®Google Scholar
• Danhier F, Feron O, Preat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release. 2010;148:135–146.
   PubMed Web of Science ®Google Scholar
• Yu MK, Park J, Jon S. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics 2012;2:3.
   PubMed Web of Science ®Google Scholar
• Tapeinos C, Battaglini M, Ciofani G. Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. J Control Release. 2017;264:306–332.
   PubMed Web of Science ®Google Scholar
• Dang L, Liu J, Li F, et al. Targeted delivery systems for molecular therapy in skeletal disorders. IJMS. 2016;17:428.
   Google Scholar
• Wang X, Yang Y, Jia H, et al. Peptide decoration of nanovehicles to achieve active targeting and pathology-responsive cellular uptake for bone metastasis chemotherapy. Biomater Sci. 2014;2:961–971.
   PubMed Web of Science ®Google Scholar
• Wang M, Thanou M. Targeting nanoparticles to cancer. Pharmacol Res. 2010;62:90–99.
   PubMed Web of Science ®Google Scholar
• Dehaini D, Fang RH, Zhang L. Biomimetic strategies for targeted nanoparticle delivery. Bioeng Transl Med. 2016;1:30–46.
   PubMed Web of Science ®Google Scholar
• Ramzy L, Nasr M, Metwally AA, et al. Cancer nanotheranostics: a review of the role of conjugated ligands for overexpressed receptors. Eur J Pharm Sci. 2017;104:273–292.
   PubMed Web of Science ®Google Scholar
• Shaughnessy AF. Monoclonal antibodies: magic bullets with a hefty price tag. BMJ. 2012;345:e8346.
   PubMed Web of Science ®Google Scholar
• Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol. 2005;23:1126.
   PubMed Web of Science ®Google Scholar
• Zhang X-X, Eden HS, Chen X. Peptides in cancer nanomedicine: drug carriers, targeting ligands and protease substrates. J Control Release. 2012;159:2–13.
   PubMed Web of Science ®Google Scholar
• Laakkonen P, Vuorinen K. Homing peptides as targeted delivery vehicles. Integr Biol. 2010;2:326–337.
   Google Scholar
• Dua P, Kim S, Lee D-K. Nucleic acid aptamers targeting cell-surface proteins. Methods. 2011;54:215–225.
   PubMed Web of Science ®Google Scholar
• Qian ZM. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev. 2002;54:561–587.
   PubMed Web of Science ®Google Scholar
• Daniels TR, Delgado T, Helguera G, et al. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol. 2006;121:159–176.
   PubMed Web of Science ®Google Scholar
• Daniels TR, Bernabeu E, Rodríguez JA, et al. The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochim Biophys Acta. 2012;1820:291–317.
   PubMed Web of Science ®Google Scholar
• Irache JM, Salman HH, Gamazo C, et al. Mannose-targeted systems for the delivery of therapeutics. Expert Opin Drug Deliv. 2008;5:703–724.
   PubMed Web of Science ®Google Scholar
• Campbell IG, Jones TA, Foulkes WD, et al. Folate-binding protein is a marker for ovarian cancer. Cancer Res 1991;51:5329–5338.
   PubMed Web of Science ®Google Scholar
• Chen C, Ke J, Zhou XE, et al. Structural basis for molecular recognition of folic acid by folate receptors. Nature 2013;500:486.
   PubMed Web of Science ®Google Scholar
• Johnston APR, Kamphuis MMJ, Such GK, et al. Targeting cancer cells: controlling the binding and internalization of antibody-functionalized capsules. ACS Nano. 2012;6:6667–6674.
   PubMed Web of Science ®Google Scholar
• Brissette R, Prendergast J, Goldstein N. Identification of cancer targets and therapeutics using phage display. Curr Opin Drug Discov Devel 2006;9:363–369.
   PubMed Web of Science ®Google Scholar
• Beck A, Wurch T, Bailly C, et al. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol. 2010;10:345–352.
   PubMed Web of Science ®Google Scholar
• Koivunen E, Arap W, Rajotte D, et al. Identification of receptor ligands with phage display peptide libraries. J Nucl Med 1999;40:883.
   PubMed Web of Science ®Google Scholar
• Marasco D, Perretta G, Sabatella M, et al. Past and future perspectives of synthetic peptide libraries. CPPS. Curr Cpps. 2008;9:447–467.
   Google Scholar
• Smith GP, Petrenko VA. Phage display. Chem Rev. 1997;97:391–410.
   PubMed Web of Science ®Google Scholar
• Janas T, Janas T. The selection of aptamers specific for membrane molecular targets. Cell Mol Biol Lett 2010;16:25.
   PubMed Web of Science ®Google Scholar
• Stoltenburg R, Reinemann C, Strehlitz B. SELEX—a (r) evolutionary method to generate high-affinity nucleic acid ligands. Biomol Eng. 2007;24:381–403.
   PubMedGoogle Scholar
• Gu FX, Karnik R, Wang AZ, et al. Targeted nanoparticles for cancer therapy. Nano Today. 2007;2:14–21.
   Web of Science ®Google Scholar
• Wilson DS, Szostak JW. In vitro selection of functional nucleic acids. Annu Rev Biochem. 1999;68:611–647.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Levy-Nissenbaum E, Alexis F, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano. 2012;6:696–704.
   PubMed Web of Science ®Google Scholar
• Zhang K, Sefah K, Tang L, et al. A novel aptamer developed for breast cancer cell internalization. ChemMedChem 2012;7:79–84.
   PubMed Web of Science ®Google Scholar
• Zhou J, Rossi JJ. The therapeutic potential of cell-internalizing aptamers. Ctmc Curr Ctmc. 2009;9:1144–1157.
   Web of Science ®Google Scholar
• Bouchard P, Hutabarat R, Thompson K. Discovery and development of therapeutic aptamers. Annu Rev Pharmacol Toxicol. 2010;50:237–257.
   PubMed Web of Science ®Google Scholar
• Keefe AD, Cload ST. SELEX with modified nucleotides. Curr Opin Chem Biol. 2008;12:448–456.
   PubMed Web of Science ®Google Scholar
• Brown KC. New approaches for cell-specific targeting: identification of cell-selective peptides from combinatorial libraries. Curr Opin Chem Biol. 2000;4:16–21.
   PubMed Web of Science ®Google Scholar
• Danhier F, Le Breton A, Préat V. RGD-based strategies to target alpha (v) beta (3) integrin in cancer therapy and diagnosis. Mol Pharmaceutics. 2012;9:2961–2973.
   PubMed Web of Science ®Google Scholar
• Tortorella S, Karagiannis TC. Transferrin receptor-mediated endocytosis: a useful target for cancer therapy. J Membrane Biol. 2014;247:291–307.
   PubMed Web of Science ®Google Scholar
• McCarthy JR, Bhaumik J, Karver MR, et al. Targeted nanoagents for the detection of cancers. Mol Oncol. 2010;4:511–528.
   PubMed Web of Science ®Google Scholar
• Garcia-Bennett A, Nees M, Fadeel B. In search of the holy grail: folate-targeted nanoparticles for cancer therapy. Biochem Pharmacol. 2011;81:976–984.
   PubMed Web of Science ®Google Scholar
• Zhao X, Li H, Lee RJ. Targeted drug delivery via folate receptors. Expert Opin Drug Deliv. 2008;5:309–319.
   PubMed Web of Science ®Google Scholar
• Thorstensen K, Romslo I. The role of transferrin in the mechanism of cellular iron uptake. Biochem J. 1990;271:1
   PubMed Web of Science ®Google Scholar
• Ponka P, Lok CN. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999;31:1111–1137.
   PubMed Web of Science ®Google Scholar
• Thorstensen K, Romslo I. The transferrin receptor: its diagnostic value and its potential as therapeutic target. Scand J Clin Lab Invest. 1993;53:113–120.
   Web of Science ®Google Scholar
• Hashida M. Cell-specific delivery of genes with glycosylated carriers. Adv Drug Deliv Rev. 2001;52:187–196.
   PubMed Web of Science ®Google Scholar
• Rensen PCN, Sliedregt LAJM, Ferns M, et al. Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo. J Biol Chem. 2001;276:37577–37584.
   PubMed Web of Science ®Google Scholar
• Platt VM, Szoka FC Jr. Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharmaceutics. 2008;5:474–486.
   PubMed Web of Science ®Google Scholar
• Mattheolabakis G, Milane L, Singh A, et al. Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine. J Drug Target. 2015;23:605–618.
   PubMed Web of Science ®Google Scholar
• Saravanakumar G, Deepagan VG, Jayakumar R, et al. Hyaluronic acid-based conjugates for tumor-targeted drug delivery and imaging. J Biomed Nanotechnol. 2014;10:17–31.
   PubMed Web of Science ®Google Scholar
• Arpicco S, Milla P, Stella B, et al. Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment. Molecules. 2014;19:3193–3230.
   PubMed Web of Science ®Google Scholar
• Ogawa M, Kosaka N, Choyke PL, et al. In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. Cancer Res. 2009;69:1268–1272.
   PubMed Web of Science ®Google Scholar
• Hu C-MJ, Kaushal S, Cao HST, et al. Half-antibody functionalized lipid − polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells. Mol Pharmaceutics. 2010;7:914–920.
   PubMed Web of Science ®Google Scholar
• Shen C, Lan X, Lu X, et al. Site-specific surface functionalization of gold nanorods using DNA origami clamps. J Am Chem Soc. 2016;138:1764–1767.
   PubMed Web of Science ®Google Scholar
• Polito L, Monti D, Caneva E, et al. One-step bioengineering of magnetic nanoparticles via a surface diazo transfer/azide–alkyne click reaction sequence. ChemComm 2008;621–623.
   Google Scholar
• Brennan JL, Hatzakis NS, Tshikhudo TR, et al. Bionanoconjugation via click chemistry: the creation of functional hybrids of lipases and gold nanoparticles. Bioconjugate Chem. 2006;17:1373–1375.
   PubMed Web of Science ®Google Scholar
• Kamphuis MMJ, Johnston APR, Such GK, et al. Targeting of cancer cells using click-functionalized polymer capsules. J Am Chem Soc. 2010;132:15881–15883.
   PubMed Web of Science ®Google Scholar
• von Maltzahn G, Ren Y, Park J-H, et al. In vivo tumor cell targeting with “click” nanoparticles. Bioconjug Chem. 2008;19:1570–1578.
   PubMed Web of Science ®Google Scholar
• Deshayes S, Maurizot V, Clochard M-C, et al. “Click’ conjugation of peptide on the surface of polymeric nanoparticles for targeting tumor angiogenesis. Pharm Res. 2011;28:1631–1642.
   PubMed Web of Science ®Google Scholar
• Thorek DL, Elias eR, Tsourkas A. Comparative analysis of nanoparticle-antibody conjugations: carbodiimide versus click chemistry. Mol Imaging. 2009;8:221–229.
   PubMed Web of Science ®Google Scholar
• Bolley J, Guenin E, Lievre N, et al. Carbodiimide versus click chemistry for nanoparticle surface functionalization: a comparative study for the elaboration of multimodal superparamagnetic nanoparticles targeting αvβ3 integrins. Langmuir 2013;29:14639–14647.
   PubMed Web of Science ®Google Scholar
• Sivaram AJ, Wardiana A, Howard CB, et al. Recent advances in the generation of antibody–nanomaterial conjugates. Adv Healthcare Mater. 2018;7:1700607.
   Web of Science ®Google Scholar
• Niemeyer CM. Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angew Chem Int Ed. 2001;40:4128–4158.
   PubMed Web of Science ®Google Scholar
• Hazarika P, Ceyhan B, Niemeyer CM. Sensitive detection of proteins using difunctional DNA–gold nanoparticles. Small 2005;1:844–848.
   PubMed Web of Science ®Google Scholar
• Niemeyer CM, Ceyhan B. DNA‐directed functionalization of colloidal gold with proteins. Angew Chem Int Ed. 2001;40:3685–3688.
   PubMed Web of Science ®Google Scholar
• Kukolka F, Müller BK, Paternoster S, et al. A single‐molecule Förster resonance energy transfer analysis of fluorescent DNA–protein conjugates for nanobiotechnology. Small. 2006;2:1083–1089.
   PubMed Web of Science ®Google Scholar
• Degli Esposti L, Tampieri A, Iafisco M. Nanostructured calcium phosphates in theranostic nanomedicine. In: Uskoković V, Editor. Nanotechnologies in preventive and regenerative medicine. Amsterdam: Elsevier; 2017.
   Google Scholar
• Gómez-Morales J, Iafisco M, Delgado-López JM, et al. Progress on the preparation of nanocrystalline apatites and surface characterization: overview of fundamental and applied aspects. Prog Cryst Growth Charact Mater. 2013;59:1–46.
   Web of Science ®Google Scholar
• Iafisco M, Delgado-López JM. Apatite: synthesis, structural characterization, and biomedical applications. Hauppauge: Nova Science Publishers, Incorporated; 2014.
   Google Scholar
• Iafisco M, Varoni E, Di Foggia M, et al. Conjugation of hydroxyapatite nanocrystals with human immunoglobulin G for nanomedical applications. Colloids Surf B Biointerfaces. 2012;90:1–7.
   PubMed Web of Science ®Google Scholar
• Dorozhkin SV. Bioceramics of calcium orthophosphates. Biomaterials. 2010;31:1465–1485.
   PubMed Web of Science ®Google Scholar
• Dorozhkin SV. Nanosized and nanocrystalline calcium orthophosphates. Acta Biomater. 2010;6:715–734.
   PubMed Web of Science ®Google Scholar
• Iafisco M, Catalucci D. Nano-apatites with designed chemistry and crystallinity for bone regeneration and nanomedical applications. In: Sprio S, Tampieri A, editors. Bio-inspired regenerative medicine: materials, processes, and clinical applications. Singapore: Pan Stanford Publishing; 2016. p. 47–83.
   Google Scholar
• Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res. 1998;13:94–117.
   Web of Science ®Google Scholar
• LeGeros RZ. Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res. 2002;395:81–98.
   PubMed Web of Science ®Google Scholar
• Dorozhkin SV, Epple M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed. 2002;41:3130–3146.
   PubMed Web of Science ®Google Scholar
• Doremus RH. Bioceramics. J Mater Sci. 1992;27:285–297.
   Web of Science ®Google Scholar
• Orlovskii VP, Komlev VS, Barinov SM. Hydroxyapatite and hydroxyapatite-based ceramics. Inorg Mater. 2002;38:973–984.
   Web of Science ®Google Scholar
• Ferraz M, Monteiro F, Manuel C. Hydroxyapatite nanoparticles: a review of preparation methodologies. J Appl Biomater Biomech. 2004;2:74–80.
   PubMedGoogle Scholar
• Norton J, Malik KR, Darr JA, et al. Recent developments in processing and surface modification of hydroxyapatite. Adv Appl Ceram. 2006;105:113–139.
   Web of Science ®Google Scholar
• Murugan R, Ramakrishna S. Development of cell-responsive nanophase hydroxyapatite for tissue engineering. Am J Biochem Biotechnol. 2007;3:118–124.
   Google Scholar
• Wang L, Nancollas GH. Calcium orthophosphates: crystallization and dissolution. Chem Rev. 2008;108:4628–4669.
   PubMed Web of Science ®Google Scholar
• Lin K, Wu C, Chang J. Advances in synthesis of calcium phosphate crystals with controlled size and shape. Acta Biomater. 2014;10:4071–4102.
   PubMed Web of Science ®Google Scholar
• Sadat-Shojai M, Khorasani M-T, Dinpanah-Khoshdargi E, et al. Synthesis methods for nanosized hydroxyapatite with diverse structures. Acta Biomater. 2013;9:7591–7621.
   PubMed Web of Science ®Google Scholar
• Zhou L, Chen Z, Dong K, et al. DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery. Biomaterials 2014;35:8694–8702.
   PubMed Web of Science ®Google Scholar
• Navarro M, Michiardi A, Castaño O, et al. Biomaterials in orthopaedics. J R Soc Interface. 2008;5:1137–1158.
   PubMed Web of Science ®Google Scholar
• Roveri N, Iafisco M. Evolving application of biomimetic nanostructured hydroxyapatite. Nanotechnol Sci Appl. 2010;3:107–125.
   Google Scholar
• Iafisco M, Palazzo B, Martra G, et al. Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates. Nanoscale 2012;4:206–217.
   PubMed Web of Science ®Google Scholar
• Roveri N, Palazzo B, Iafisco M. The role of biomimetism in developing nanostructured inorganic matrices for drug delivery. Expert Opin Drug Deliv. 2008;5:861–877.
   PubMed Web of Science ®Google Scholar
• Delgado-López JM, Iafisco M, Rodríguez I, et al. Crystallization of bioinspired citrate-functionalized nanoapatite with tailored carbonate content. Acta Biomater. 2012;8:3491–3499.
   PubMed Web of Science ®Google Scholar
• Sandhofer B, Meckel M, Delgado-López JM, et al. Synthesis and preliminary in vivo evaluation of well-dispersed biomimetic nanocrystalline apatites labeled with positron emission tomographic imaging agents. ACS Appl Mater Interfaces. 2015;7:10623–10633.
   PubMed Web of Science ®Google Scholar
• Chatzipanagis K, Iafisco M, Roncal-Herrero T, et al. Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation. CrystEngComm 2016;18:3170–3173.
   Web of Science ®Google Scholar
• Iafisco M, Ramírez-Rodríguez GB, Sakhno Y, et al. The growth mechanism of apatite nanocrystals assisted by citrate: relevance to bone biomineralization. CrystEngComm 2015;17:507–511.
   Web of Science ®Google Scholar
• Di Mauro V, Iafisco M, Salvarani N, et al. Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs. Nanomedicine 2016;11:891–906.
   PubMed Web of Science ®Google Scholar
• McCarthy JR, Weissleder R. Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev. 2008;60:1241–1251.
   PubMed Web of Science ®Google Scholar
• Halas N. Playing with plasmons: tuning the optical resonant properties of metallic nanoshells. MRS Bull. 2005;30:362–367.
   Web of Science ®Google Scholar
• Murphy CJ, Sau TK, Gole AM, et al. Anisotropic Metal Nanoparticles: synthesis, Assembly, and Optical Applications. J Phys Chem B. 2005;109:13857–13870.
   Google Scholar
• Cobley CM, Chen J, Cho EC, et al. Gold nanostructures: a class of multifunctional materials for biomedical applications. Chem Soc Rev. 2011;40:44–56.
   PubMed Web of Science ®Google Scholar
• Arriagada F, Osseo-Asare K. Phase and dispersion stability effects in the synthesis of silica nanoparticles in a non-ionic reverse microemulsion. Colloids Surf. 1992;69:105–115.
   Google Scholar
• Stöber W, Fink A, Bohn E. Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Interface Sci. 1968;26:62–69.
   Web of Science ®Google Scholar
• Cai Q, Luo Z-S, Pang W-Q, et al. Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium. Chem Mater. 2001;13:258–263.
   Web of Science ®Google Scholar
• Huo Q, Margolese DI, Stucky GD. Surfactant control of phases in the synthesis of mesoporous silica-based materials. Chem Mater. 1996;8:1147–1160.
   Web of Science ®Google Scholar
• Discher DE, Eisenberg A. Polymer vesicles. Science. 2002;297:967–973.
   PubMed Web of Science ®Google Scholar
• Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B. 2010;75:1–18.
   PubMed Web of Science ®Google Scholar
• Soppimath KS, Aminabhavi TM, Kulkarni AR, et al. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70:1–20.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Ruiz I, Delgado-López JM, Durán-Olivencia MA, et al. pH-Responsive delivery of doxorubicin from citrate–apatite nanocrystals with tailored carbonate content. Langmuir. 2013;29:8213–8221.
   PubMed Web of Science ®Google Scholar
• Uskoković V, Uskoković DP. Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents. J Biomed Mater Res B. 2011;96B:152–191.
   Web of Science ®Google Scholar
• Lee H, Choi HW, Kim K, et al. Modification of hydroxyapatite nanosurfaces for enhanced colloidal stability and improved interfacial adhesion in nanocomposites. Chem Mater. 2006;18:5111–5118.
   Web of Science ®Google Scholar
• Boanini E, Gazzano M, Bigi A. Ionic substitutions in calcium phosphates synthesized at low temperature. Acta Biomater. 2010;6:1882–1894.
   PubMed Web of Science ®Google Scholar
• Šupová M. Substituted hydroxyapatites for biomedical applications: a review. Ceram Int. 2015;41:9203–9231.
   Web of Science ®Google Scholar
• Marycz K, Pazik R, Zawisza K, et al. Multifunctional nanocrystalline calcium phosphates loaded with Tetracycline antibiotic combined with human adipose derived mesenchymal stromal stem cells (hASCs). Mater Sci Eng. 2016;69:17–26.
   Google Scholar
• Wang Y, Wang J, Hao H, et al. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles. ACS Nano. 2016;10:9927–9937.
   PubMed Web of Science ®Google Scholar
• Iafisco M, Sandri M, Panseri S, et al. Magnetic bioactive and biodegradable hollow Fe-doped hydroxyapatite coated poly (l-lactic) acid micro-nanospheres. Chem Mater. 2013;25:2610–2617.
   Web of Science ®Google Scholar
• Iannotti V, Adamiano A, Ausanio G, et al. Fe-doping-induced magnetism in nano-hydroxyapatites. Inorg Chem. 2017;56:4446–4458.
   Web of Science ®Google Scholar
• Morgan TT, Muddana HS, Altinoǧlu E, et al. Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery. Nano Lett. 2008;8:4108–4115.
   PubMed Web of Science ®Google Scholar
• Perera TSH, Han Y, Lu X, et al. Rare earth doped apatite nanomaterials for biological application. J Nanomater. 2015;2015:705390.
   PubMedGoogle Scholar
• Hu Y-Y, Rawal A, Schmidt-Rohr K. Strongly bound citrate stabilizes the apatite nanocrystals in bone. Proc Natl Acad Sci. 2010;107:22425–22429.
   PubMed Web of Science ®Google Scholar
• Klesing J, Wiehe A, Gitter B, et al. Positively charged calcium phosphate/polymer nanoparticles for photodynamic therapy. J Mater Sci: Mater Med. 2010;21:887–892.
   PubMed Web of Science ®Google Scholar
• Liu T, Chen S, Liu D, et al. On the study of BSA-loaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery. J Control Release. 2005;107:112–121.
   PubMed Web of Science ®Google Scholar
• Yang P, Quan Z, Li C, et al. Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier. Biomaterials. 2008;29:4341–4347.
   PubMed Web of Science ®Google Scholar
• Victor SP, Kumar TSS. Tailoring calcium-deficient hydroxyapatite nanocarriers for enhanced release of antibiotics. J Biomed Nanotechnol. 2008;4:203–209.
   Web of Science ®Google Scholar
• Rohanizadeh R, Chung K. Hydroxyapatite as a carrier for bone morphogenetic protein. J Oral Implantol. 2011;37:659–672.
   PubMed Web of Science ®Google Scholar
• Victor SP, Paul W, Jayabalan M, et al. Supramolecular hydroxyapatite complexes as theranostic near-infrared luminescent drug carriers. CrystEngComm. 2014;16:9033–9042.
   Web of Science ®Google Scholar
• Victor SP, Paul W, Jayabalan M, et al. Cucurbituril/hydroxyapatite based nanoparticles for potential use in theranostic applications. CrystEngComm. 2014;16:6929–6936.
   Web of Science ®Google Scholar
• Iafisco M, Drouet C, Adamiano A, et al. Superparamagnetic iron-doped nanocrystalline apatite as a delivery system for doxorubicin. J Mater Chem B. 2016;4:57–70.
   Web of Science ®Google Scholar
• Iafisco M, Delgado-Lopez JM, Varoni EM, et al. Cell surface receptor targeted biomimetic apatite nanocrystals for cancer therapy. Small. 2013;9:3834–3844.
   PubMed Web of Science ®Google Scholar
• Cheng X, Kuhn L. Chemotherapy drug delivery from calcium phosphate nanoparticles. Int J Nanomed. 2007;2:667.
   PubMed Web of Science ®Google Scholar
• Iafisco M, Palazzo B, Marchetti M, et al. Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals. J Mater Chem. 2009;19:8385–8392.
   Web of Science ®Google Scholar
• Iafisco M, Margiotta N. Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: a mini-review. J Inorg Biochem. 2012;117:237–247.
   PubMed Web of Science ®Google Scholar
• Barroug A, Kuhn LT, Gerstenfeld LC, et al. Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release. J Orthop Res. 2004;22:703–708.
   PubMed Web of Science ®Google Scholar
• Palazzo B, Iafisco M, Laforgia M, et al. Biomimetic hydroxyapatite–drug nanocrystals as potential bone substitutes with antitumor drug delivery properties. Adv Funct Mater. 2007;17:2180–2188.
   Web of Science ®Google Scholar
• Mukesh U, Kulkarni V, Tushar R, et al. Methotrexate loaded self-stabilized calcium phosphate nanoparticles: a novel inorganic carrier for intracellular drug delivery. J Biomed Nanotechnol. 2009;5:99–105.
   PubMed Web of Science ®Google Scholar
• Dai CF, Li SP, Li XD. Synthesis of nanostructured methotrexate/hydroxyapatite: Morphology control, growth mechanism, and bioassay explore. Colloids Surf B Biointerfaces. 2015;136:262–271.
   PubMed Web of Science ®Google Scholar
• Rodan GA, Fleisch HA. Bisphosphonates: mechanisms of action. J Clin Invest. 1996;97:2692
   PubMed Web of Science ®Google Scholar
• Russell R, Rogers M. Bisphosphonates: from the laboratory to the clinic and back again. Bone. 1999;25:97–106.
   PubMed Web of Science ®Google Scholar
• Iafisco M, Palazzo B, Falini G, et al. Adsorption and conformational change of myoglobin on biomimetic hydroxyapatite nanocrystals functionalized with alendronate. Langmuir. 2008;24:4924–4930.
   PubMed Web of Science ®Google Scholar
• Pascaud P, Gras P, Coppel Y, et al. Interaction between a bisphosphonate, tiludronate, and biomimetic nanocrystalline apatites. Langmuir. 2013;29:2224–2232.
   PubMed Web of Science ®Google Scholar
• Grossmann G, Grossmann A, Ohms G, et al. Solid‐state NMR of bisphosphonates adsorbed on hydroxyapatite. Magn Reson Chem. 2000;38:11–16.
   Web of Science ®Google Scholar
• Pascaud P, Errassifi F, Brouillet F, et al. Adsorption on apatitic calcium phosphates for drug delivery: interaction with bisphosphonate molecules. J Mater Sci Mater Med. 2014;25:2373–2381.
   PubMed Web of Science ®Google Scholar
• Josse S, Faucheux C, Soueidan A, et al. Novel biomaterials for bisphosphonate delivery. Biomaterials. 2005;26:2073–2080.
   PubMed Web of Science ®Google Scholar
• Bosco R, Iafisco M, van den Beucken J, et al. Adsorption of alendronate onto biomimetic apatite nanocrystals to develop drug carrier coating for bone implants. In: Ishikawa K, Iwamoto Y, editors. Key Engineering Materials. Zürich: Trans Tech Publ; 2013.
   Google Scholar
• Hoffman A, Stepensky D, Ezra A, et al. Mode of administration-dependent pharmacokinetics of bisphosphonates and bioavailability determination. Int J Pharm. 2001;220:1–11.
   PubMed Web of Science ®Google Scholar
• Bessa PC, Casal M, Reis R. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med. 2008;2:1–96.
   PubMed Web of Science ®Google Scholar
• Burg KJL, Porter S, Kellam JF. Biomaterial developments for bone tissue engineering. Biomaterials. 2000;21:2347–2359.
   PubMed Web of Science ®Google Scholar
• Lutolf MP, Weber FE, Schmoekel HG, et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol. 2003;21:513–518.
   PubMed Web of Science ®Google Scholar
• Lee K, Silva EA, Mooney DJ. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J Royal Soc Interface. 2011;8:153–170.
   PubMed Web of Science ®Google Scholar
• Sheikh Z, Javaid M, Hamdan N, et al. Bone regeneration using bone morphogenetic proteins and various biomaterial carriers. Materials 2015;8:1778–1816.
   PubMed Web of Science ®Google Scholar
• Bessa PC, Casal M, Reis R. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J Tissue Eng Regen Med. 2008;2:1–13.
   PubMed Web of Science ®Google Scholar
• Wang Q, Wang M, Lu X, et al. Effects of atomic-level nano-structured hydroxyapatite on adsorption of bone morphogenetic protein-7 and its derived peptide by computer simulation. Sci Rep. 2017;7:15152.
   PubMed Web of Science ®Google Scholar
• Dong X-L, Qi W, Tao W, et al. The dynamic behaviours of protein BMP-2 on hydroxyapatite nanoparticles. Molecular Simulation. 2011;37:1097–1104.
   Web of Science ®Google Scholar
• Xie G, Sun J, Zhong G, et al. Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro. J Mater Sci Mater Med. 2010;21:1875–1880.
   PubMed Web of Science ®Google Scholar
• Epple M, Ganesan K, Heumann R, et al. Application of calcium phosphate nanoparticles in biomedicine. J Mater Chem. 2010;20:18–23.
   Web of Science ®Google Scholar
• Graham FL, van der Eb AJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 1973;52:456–467.
   PubMed Web of Science ®Google Scholar
• James RF, Grosveld FG. DNA-mediated gene transfer into mammalian cells. In: Walker JM, Gaastra W, editors. Techniques in molecular biology. Boston: Springer; 1987. p. 187–202.
   Google Scholar
• Mostaghaci B, Loretz B, Lehr CM. Calcium phosphate system for gene delivery: historical background and emerging opportunities. Cpd. 2016;22:1529–1533.
   Google Scholar
• Roy I, Mitra S, Maitra A, et al. Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm. 2003;250:25–33.
   PubMed Web of Science ®Google Scholar
• Xie Y, Chen Y, Sun M, et al. A mini review of biodegradable calcium phosphate nanoparticles for gene delivery. Cpb. 2013;14:918–925.
   Google Scholar
• Bisht S, Bhakta G, Mitra S, et al. pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. Int J Pharm. 2005;288:157–168.
   PubMed Web of Science ®Google Scholar
• Sokolova VV, Radtke I, Heumann R, et al. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials. 2006;27:3147–3153.
   PubMed Web of Science ®Google Scholar
• Maitra A. Calcium phosphate nanoparticles: second-generation nonviral vectors in gene therapy. Expert Rev Mol Diagn. 2005;5:893–905.
   PubMed Web of Science ®Google Scholar
• Kingston RE, Chen CA, Rose JK. Calcium phosphate transfection. Curr Protoc Mol Biol. 2003;20:20.3.1–20.3.8.
   Google Scholar
• Al-Kattan A, Girod-Fullana S, Charvillat C, et al. Biomimetic nanocrystalline apatites: emerging perspectives in cancer diagnosis and treatment. Int J Pharm. 2012;423:26–36.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Kennell C, Lee J-Y, et al. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomed Nanotechnol Biol Med. 2017;13:403–410.
   PubMed Web of Science ®Google Scholar
• Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6:688–701.
   PubMed Web of Science ®Google Scholar
• Mirkin CA, Niemeyer CM. Nanobiotechnology II: more Concepts and Applications. Hoboken: John Wiley & Sons; 2007.
   Google Scholar
• Al-Kattan A, Errassifi F, Sautereau A-M, et al. Medical potentialities of biomimetic apatites through adsorption, ionic substitution, and mineral/organic associations: three illustrative examples. Adv Eng Mater. 2010;12:B224–B233.
   Web of Science ®Google Scholar
• Nadar RA, Margiotta N, Iafisco M, et al. Bisphosphonate‐functionalized imaging agents, anti‐tumor agents and nanocarriers for treatment of bone cancer. Adv Healthc Mater 2017;6:1601119.
   Web of Science ®Google Scholar
• Papapoulos SE. Bisphosphonate actions: physical chemistry revisited. Bone 2006;38:613–616.
   PubMed Web of Science ®Google Scholar
• Cole LE, Vargo-Gogola T, Roeder RK. Targeted delivery to bone and mineral deposits using bisphosphonate ligands. Adv Drug Deliv Rev. 2016;99:12–27.
   PubMed Web of Science ®Google Scholar
• Russo L, Taraballi F, Lupo C, et al. Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation. Interface Focus. 2014;4:20130040.
   PubMed Web of Science ®Google Scholar
• Liu Q, de Wijn JR, de Groot K, et al. Surface modification of nano-apatite by grafting organic polymer. Biomaterials. 1998;19:1067–1072.
   PubMed Web of Science ®Google Scholar
• Hong Z, Qiu X, Sun J, et al. Grafting polymerization of L-lactide on the surface of hydroxyapatite nano-crystals. Polymer. 2004;45:6699–6706.
   Web of Science ®Google Scholar
• Nwe K, Brechbiel MW. Growing applications of ‘click chemistry’ for bioconjugation in contemporary biomedical research. Cancer Biother Radiopharm. 2009;24:289–302.
   PubMed Web of Science ®Google Scholar
• Hein CD, Liu X-M, Wang D. Click chemistry, a powerful tool for pharmaceutical sciences. Pharm Res. 2008;25:2216–2230.
   PubMed Web of Science ®Google Scholar
• Katz E, Willner I. Integrated nanoparticle–biomolecule hybrid systems: synthesis, properties, and applications. Angew Chem Int Ed. 2004;43:6042–6108.
   PubMed Web of Science ®Google Scholar
• Hirsch JD, Eslamizar L, Filanoski BJ, et al. Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation. Anal Biochem. 2002;308:343–357.
   PubMed Web of Science ®Google Scholar
• Wilchek M, Bayer EA. [3] Applications of avidin-biotin technology: literature survey. Methods Enzymol 1990;184:14–45.
   PubMed Web of Science ®Google Scholar
• Diamandis EP, Christopoulos TK. The biotin-(strept) avidin system: principles and applications in biotechnology. Clin Chem. 1991;37:625–636.
   PubMed Web of Science ®Google Scholar
• Haugland RP, Spence MT, Johnson I. Handbook of fluorescent probes and research chemicals. In: Haugland RP, Spence MT, Johnson I, editors. Molecular probes; Carlsbad: Life Technologies; 1996.
   Google Scholar
• Liu T, Zhang G, Chen Y-H, et al. Tissue specific expression of suicide genes delivered by nanoparticles inhibits gastric carcinoma growth. Cancer Biol Ther. 2006;5:1683–1690.
   PubMed Web of Science ®Google Scholar
• Zhang G, Liu T, Chen Y-H, et al. Tissue specific cytotoxicity of colon cancer cells mediated by nanoparticle-delivered suicide gene in vitro and in vivo. Clin Cancer Res. 2009;15:201–207.
   PubMed Web of Science ®Google Scholar
• Ashokan A, Menon D, Nair S, et al. A molecular receptor targeted, hydroxyapatite nanocrystal based multi-modal contrast agent. Biomaterials. 2010;31:2606–2616.
   PubMed Web of Science ®Google Scholar
• Li J, Chen Y-C, Tseng Y-C, et al. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J Control Release. 2010;142:416–421.
   PubMed Web of Science ®Google Scholar
• Barth BM, Sharma R, Altınoğlu Eİ, et al. Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo. ACS Nano. 2010;4:1279–1287.
   PubMed Web of Science ®Google Scholar
• Barth BM, I. Altinoğlu E, Shanmugavelandy SS, et al. Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia. ACS Nano. 2011;5:5325–5337.
   PubMed Web of Science ®Google Scholar
• Kozlova D, Chernousova S, Knuschke T, et al. Cell targeting by antibody-functionalized calcium phosphate nanoparticles. J Mater Chem. 2012;22:396–404.
   Web of Science ®Google Scholar
• Yang Y, Li J, Liu F, et al. Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol Ther. 2012;20:609–615.
   PubMed Web of Science ®Google Scholar
• Rout SR, Behera B, Maiti TK, et al. Multifunctional magnetic calcium phosphate nanoparticles for targeted platin delivery. Dalton Trans. 2012;41:10777–10783.
   PubMed Web of Science ®Google Scholar
• Yang Y, Hu Y, Wang Y, et al. Nanoparticle delivery of pooled siRNA for effective treatment of non-small cell lung caner. Mol Pharmaceutics. 2012;9:2280.
   PubMed Web of Science ®Google Scholar
• Hu Y, Haynes MT, Wang Y, et al. A highly efficient synthetic vector: non-hydrodynamic delivery of DNA to hepatocyte nuclei in vivo. ACS Nano. 2013;7:5376.
   PubMed Web of Science ®Google Scholar
• Temchura VV, Kozlova D, Sokolova V, et al. Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles loaded with protein antigen. Biomaterials. 2014;35:6098–6105.
   PubMed Web of Science ®Google Scholar
• Al-Kattan A, Santran V, Dufour P, et al. Novel contributions on luminescent apatite-based colloids intended for medical imaging. J Biomater Appl. 2014;28:697–707.
   PubMed Web of Science ®Google Scholar
• Lee MS, Lee JE, Byun E, et al. Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa–hyaluronic acid conjugate. J Control Release. 2014;192:122–130.
   PubMed Web of Science ®Google Scholar
• Haedicke K, Kozlova D, Gräfe S, et al. Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy. Acta Biomater. 2015;14:197–207.
   PubMed Web of Science ®Google Scholar
• Kong L, Mu Z, Yu Y, et al. Polyethyleneimine-stabilized hydroxyapatite nanoparticles modified with hyaluronic acid for targeted drug delivery. RSC Adv. 2016;6:101790–101799.
   Web of Science ®Google Scholar
• Chu W, Huang Y, Yang C, et al. Calcium phosphate nanoparticles functionalized with alendronate-conjugated polyethylene glycol (PEG) for the treatment of bone metastasis. Int J Pharm. 2017;516:352–363.
   PubMed Web of Science ®Google Scholar
• Suh MS, Shen J, Kuhn LT, et al. Layer-by-layer nanoparticle platform for cancer active targeting. Int J Pharm. 2017;517:58–66.
   PubMedGoogle Scholar
• Zilker C, Kozlova D, Sokolova V, et al. Nanoparticle-based B-cell targeting vaccines: tailoring of humoral immune responses by functionalization with different TLR-ligands. Nanomedicine. 2017;13:173–182.
   PubMed Web of Science ®Google Scholar
• Wu VM, Mickens J, Uskokovic V. Bisphosphonate-functionalized hydroxyapatite nanoparticles for the delivery of the bromodomain inhibitor JQ1 in the treatment of osteosarcoma. ACS Appl Mater Interfaces. 2017;9:25887–25904.
   PubMed Web of Science ®Google Scholar
• Cipreste MF, Gonzalez I, da Mata MartinsTM, et al. Attaching folic acid on hydroxyapatite nanorod surfaces: an investigation of the HA–FA interaction. RSC Adv. 2016;6:76390–76400.
   Web of Science ®Google Scholar
• Dasargyri A, Kümin CD, Leroux JC. Targeting nanocarriers with anisamide: fact or artifact? Adv Mater. 2017;29:160351.
   PubMed Web of Science ®Google Scholar
• Cheng Z, Al Zaki A, Hui JZ, et al. Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science. 2012; 338:903–910.
   PubMed Web of Science ®Google Scholar
• Tampieri A, D'Alessandro T, Sandri M, et al. Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite. Acta Biomater. 2012;8:843–851.
   PubMed Web of Science ®Google Scholar
• Chang K-C, Li C-Y, Hsu C-K, et al. Synthesis and properties of Fe-modified calcium-deficient hydroxyapatite nanocrystal for mri contrast agent. Biomed Eng Appl Basis Commun. 2011;23:393–401.
   Web of Science ®Google Scholar
• Panseri S, Montesi M, Sandri M, et al. Magnetic labelling of mesenchymal stem cells with iron-doped hydroxyapatite nanoparticles as tool for cell therapy. J Biomed Nanotechnol. 2016;12:909–921.
   PubMed Web of Science ®Google Scholar
• Kaygili O, Dorozhkin SV, Ates T, et al. Dielectric properties of Fe doped hydroxyapatite prepared by sol–gel method. Ceram Int. 2014;40:9395–9402.
   Google Scholar
• Gou M, Li S, Zhang L, et al. Facile one-pot synthesis of carbon/calcium phosphate/Fe 3 O 4 composite nanoparticles for simultaneous imaging and pH/NIR-responsive drug delivery. Chem Commun. 2016;52:11068–11071.
   PubMed Web of Science ®Google Scholar
• Pareta RA, Taylor E, Webster TJ. Increased osteoblast density in the presence of novel calcium phosphate coated magnetic nanoparticles. Nanotechnology 2008;19:265101.
   PubMed Web of Science ®Google Scholar
• Ventura M, Sun Y, Cremers S, et al. A theranostic agent to enhance osteogenic and magnetic resonance imaging properties of calcium phosphate cements. Biomaterials 2014;35:2227–2233.
   PubMed Web of Science ®Google Scholar
• Syamchand SS, Sony G. Multifunctional hydroxyapatite nanoparticles for drug delivery and multimodal molecular imaging. Microchim Acta. 2015;182:1567–1589.
   Web of Science ®Google Scholar
• Petchsang N, Pon-On W, Hodak JH, et al. Magnetic properties of Co-ferrite-doped hydroxyapatite nanoparticles having a core/shell structure. J Magnet Magnet Mater. 2009; 321:1990–1995.
   Google Scholar
• Gopi D, Ansari MT, Shinyjoy E, et al. Synthesis and spectroscopic characterization of magnetic hydroxyapatite nanocomposite using ultrasonic irradiation. Spectrochim Acta A Mol Biomol Spectrosc. 2012;87:245–250.
   PubMed Web of Science ®Google Scholar
• Pankhurst QA, Connolly J, Jones SK, et al. Applications of magnetic nanoparticles in biomedicine. J Phys D: Appl Phys. 2003;36:R167.
   Web of Science ®Google Scholar
• Dobson J. Magnetic nanoparticles for drug delivery. Drug Dev Res. 2006;67:55–60.
   Web of Science ®Google Scholar
• Clime L, Drogoff B, Zhao S, et al. Magnetic nanocarriers: from material design to magnetic manipulation. IJNT. 2008;5:1268–1305.
   Google Scholar