Enhanced bioavailability and antihypertensive activity of nisoldipine loaded nanoemulsion: optimization, cytotoxicity and uptake across Caco-2 cell line, pharmacokinetic and pharmacodynamic studies

References

• Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev. 1997;25(1):47–58.
   Web of Science ®Google Scholar
• Akhtar N, Ahad A, Khar RK, et al. The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review. Expert Opin Ther Pat. 2011;21(4):561–576.
   PubMed Web of Science ®Google Scholar
• Agrawal S, Giri TK, Tripathi DK, et al. A review on novel therapeutic strategies for the enhancement of solubility for hydrophobic drugs through lipid and surfactant based self micro emulsifying drug delivery system: a novel approach. Am J Drug Discov Dev. 2012;2(4):143–183.
   Google Scholar
• Khachane PV, Jain AS, Dhawan VV, et al. Cationic nanoemulsions as potential carriers for intracellular delivery. Saudi Pharm J. 2015;23(2):188–194.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wang J, Wang Y, et al. Self-emulsifying drug delivery system improves preventive effect of curcuminoids on chronic heart failure in rats. Saudi Pharm J. 2018;26(4):528–534.
   PubMed Web of Science ®Google Scholar
• Pouton CW. Lipid formulations for oral administration of drugs: nonemulsifying,self-emulsifying and ‘self-microemulsifying’ drug deliverysystems. Eur J Pharm Sci. 2000;11(Suppl 2):S93–S98.
   PubMed Web of Science ®Google Scholar
• Singh Y, Meher JG, Raval K, et al. Nanoemulsion: concepts, development and applications in drug delivery. J Control Release. 2017;252:28–49.
   PubMed Web of Science ®Google Scholar
• Li YJ, Hu XB, Lu XL, et al. Nanoemulsion-based delivery system for enhanced oral bioavailability and caco-2 cell monolayers permeability of berberine hydrochloride. Drug Deliv. 2017;24(1):1868–1873.
   PubMed Web of Science ®Google Scholar
• Nagi A, Iqbal B, Kumar S, et al. Quality by design based silymarin nanoemulsion for enhancement of oral bioavailability. J Drug Deliv Sci Tech. 2017;40:35–44.
   Web of Science ®Google Scholar
• Thakkar HP, Khunt A, Dhande RD, et al. Formulation and evaluation of Itraconazole nanoemulsion for enhanced oral bioavailability. J Microencapsul. 2015;32(6):559–569.
   PubMed Web of Science ®Google Scholar
• Wilkinson GR. The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans. Adv Drug Deliv Rev. 1997;27(2–3):129–159.
   PubMed Web of Science ®Google Scholar
• Dudhipala N, Veerabrahma K. Pharmacokinetic and pharmacodynamic studies of nisoldipine loaded solid lipid nanoparticles by central composite design. Drug Dev Ind Pharm. 2015;41(12):1968–1977.
   PubMed Web of Science ®Google Scholar
• Dudhipala N, Janga KY, Gorre T. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation. Artif Cells Nanomed Biotechnol. 2018;46(sup2):616–625.
   PubMed Web of Science ®Google Scholar
• Nekkanti V, Rueda J, Wang Z, et al. Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine. Int J Pharm. 2016;505(1–2):79–88.
   PubMedGoogle Scholar
• Laxmi M, Bhardwaj A, Mehta S, et al. Development and characterization of nanoemulsion as carrier for the enhancement of bioavailability of artemether. Artif Cells Nanomed Biotechnol. 2015;43(5):334–344.
   PubMed Web of Science ®Google Scholar
• Sawant KK, Mundada VP, Patel VJ. Development and optimization of w/o/w multiple emulsion of lisinopril dihydrate using Plackett Burman and Box-Behnken designs. J Nanomed Nanotechnol. 2017;8:1–11.
   Google Scholar
• Patel MR, Patel MH, Patel RB. Preparation and in vitro/ex vivo evaluation of nanoemulsion for transnasal delivery of paliperidone. Appl Nanosci. 2016;6(8):1095–1104.
   Web of Science ®Google Scholar
• Gupta S, Chavhan S, Sawant KK. Self-nanoemulsifying drug delivery system for adefovir dipivoxil: design, characterization, in vitro and ex vivo evaluation. Colloids Surf A. 2011;392(1):145–155.
   Google Scholar
• Acharya SP, Pundarikakshudu K, Panchal A, et al. Preparation and evaluation of transnasal microemulsion of carbamazepine. Asian J Pharm Sci. 2013;8(1):64–70.
   Google Scholar
• Bandivadeka MM, Pancholi SS, Kaul-Ghanekar R, et al. Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. Drug Dev Ind Pharm. 2012;38(7):883–892.
   PubMed Web of Science ®Google Scholar
• Ge L, He X, Zhang Y, et al. A dabigatran etexilate phospholipid complex nanoemulsion system for further oral bioavailability by reducing drug-leakage in the gastrointestinal tract. Nanomedicine. 2018;14(4):1455–1464.
   Web of Science ®Google Scholar
• Meirelles GC, Mendes C, Caon T, et al. Intestinal permeability enhancement of benzopyran HP1-loaded nanoemulsions. Eur J Pharm Sci. 2019;127:115–120.
   PubMed Web of Science ®Google Scholar
• Patel MH, Mundada VP, Sawant KK. Novel drug delivery approach via self-microemulsifying drug delivery system for enhancing oral bioavailability of asenapine maleate: optimization, characterization, cell uptake, and in vivo pharmacokinetic studies. AAPS PharmSciTech. 2019;20(2):1–8.
   Web of Science ®Google Scholar
• Beg S, Sharma G, Thanki K, et al. Positively charged self-nanoemulsifying oily formulations of olmesartanmedoxomil: systematic development, in vitro, ex vivo and in vivo evaluation. Int J Pharm. 2015;493(1–2):466–482.
   PubMedGoogle Scholar
• Teixeira MC, Severino P, Andreani T, et al. d-α-tocopherol nanoemulsions: size properties, rheological behavior, surface tension, osmolarity and cytotoxicity. Saudi Pharm J. 2017;25(2):231–235.
   PubMed Web of Science ®Google Scholar
• Negi LM, Tariq M, Talegaonkar S. Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-Glycoprotein modulation. Colloids Surf. 2013;111:346–353.
   Google Scholar
• Joshi G, Kumar A, Sawant K. Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur J Pharm Sci. 2014;60:80–89.
   PubMed Web of Science ®Google Scholar
• Patel MH, Mundada VP, Sawant KK. Fabrication of solid lipid nanoparticles of lurasidone HCl for oral delivery: optimization, in vitro characterization, cell line studies and in vivo efficacy in schizophrenia. Drug Dev Ind Pharm. 2019;45(8):1242–1257.
   PubMed Web of Science ®Google Scholar
• Marinkovic VD, Agbaba D, Karljikovic-Rajic K, et al. Photochemical degradation of solid-state nisoldipine monitored by HPLC. J Pharm Biomed Anal. 2003;32(4-5):929–935.
   PubMed Web of Science ®Google Scholar
• Reaven GM, Ho H, Hoffman BB. Attenuation of fructose-induced hypertension in rats by exercise training. Hypertension. 1988;12(2):129–132.
   PubMed Web of Science ®Google Scholar
• Elnaggar YS, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharm. 2009;380(1-2):133–141.
   PubMed Web of Science ®Google Scholar
• Jafari SM, He Y, Bhandari B. Nano-emulsion production by sonication and microfluidization—a comparison. Int J Food Prop. 2006;9:475–485.
   Web of Science ®Google Scholar
• Shahavi MH, Hosseini M, Jahanshahi M, et al. Evaluation of critical parameters for preparation of stable clove oil nanoemulsion. Arab J Chem. 2019;12:3225–3230.
   Web of Science ®Google Scholar
• Tang SY, Shridharan P, Sivakumar M. Impact of process parameters in the generation of novel aspirin nanoemulsions–comparative studies between ultrasound cavitation and microfluidizer. UltrasonSonochem. 2013;20(1):485–497.
   Web of Science ®Google Scholar
• Tang SY, Manickam S, Wei TK, et al. Formulation development and optimization of a novel Cremophore EL-based nanoemulsion using ultrasound cavitation. Ultrason Sonochem. 2012;19(2):330–345.
   PubMed Web of Science ®Google Scholar
• Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.
   PubMed Web of Science ®Google Scholar
• Priya S, Koland M, Kumari S. Nanoemulsion components screening of quetiapine fumarate: effect of surfactant and Co surfactant. Asian J Pharm Clin Res. 2015;8:136–140.
   Google Scholar
• Devarajan V, Ravichandran V. Nanoemulsions: as modified drug delivery tool. Int J Comprehen Pharm. 2011;4:1–6.
   Google Scholar
• Chhabra G, Chuttani K, Mishra AK, et al. Design and development of nanoemulsion drug delivery system of amlodipine besilate for improvement of oral bioavailability. Drug Dev Ind Pharm. 2011;37(8):907–916.
   PubMed Web of Science ®Google Scholar
• Trevaskis NL, Charman WN, Porter CJ. Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv Drug Deliv Rev. 2008;60(6):702–716.
   PubMed Web of Science ®Google Scholar
• Gao F, Zhang Z, Bu H, et al. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J Control Release. 2011;149(2):168–174.
   PubMed Web of Science ®Google Scholar
• Ranpise NS, Korabu SS, Ghodake VN. Second generation lipid nanoparticles (NLC) as an oral drug carrier for delivery of lercanidipine hydrochloride. Colloid Surf B. 2014;116:81–87.
   PubMed Web of Science ®Google Scholar