Non-Celiac Gluten Sensitivity: Literature Review

REFERENCES

• Shewry , P R . 2009 . Wheat . J Exp Bot , 60 : 1537 – 1553 .
   PubMed Web of Science ®Google Scholar
• Losowsky , M S . 2008 . A history of coeliac disease . Dig Dis , 26 : 112 – 120 .
   PubMed Web of Science ®Google Scholar
• Martin , S . 2008 . Against the grain: an overview of celiac disease . J Am Acad Nurse Pract , 20 : 243 – 250 .
   PubMedGoogle Scholar
• Reilly , N R and Green , P H . 2012 . Epidemiology and clinical presentations of celiac disease . Semin Immunopathol , 34 : 473 – 478 .
   PubMed Web of Science ®Google Scholar
• Rewers , M . 2005 . Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? . Gastroenterology , 128 ( 4 Suppl 1 ) : S47 – S51 .
   PubMed Web of Science ®Google Scholar
• Mustalahti , K , Catassi , C , Reunanen , A , Fabiani , E , Heier , M , McMillan , S , Murray , L , Metzger , M H , Gasparin , M , Bravi , E , Mäki , M and the Coeliac EU Cluster, Project Epidemiology . 2010 . The prevalence of celiac disease in Europe: results of a centralized, international mass screening project . Ann Med , 42 : 587 – 595 .
   PubMed Web of Science ®Google Scholar
• Riddle , M S , Murray , J A and Porter , C K . 2012 . The incidence and risk of celiac disease in a healthy US adult population . Am J Gastroenterol , 107 : 1248 – 1255 .
   PubMed Web of Science ®Google Scholar
• Rubio-Tapia , A , Ludvigsson , J F , Brantner , T L , Murray , J A and Everhart , J E . 2012 . The prevalence of celiac disease in the United States . Am J Gastroenterol , 107 : 1538 – 1544 .
   PubMed Web of Science ®Google Scholar
• Volta , U and De Giorgio , R . 2012 . New understanding of gluten sensitivity . Nat Rev Gastroenterol Hepatol , 9 : 295 – 299 .
   PubMed Web of Science ®Google Scholar
• Aziz , I and Sanders , D S . 2012 . Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity . Proc Nutr Soc , 71 : 576 – 580 .
   PubMedGoogle Scholar
• Bizzaro , N , Tozzoli , R , Villalta , D , Fabris , M and Tonutti , E . 2012 . Cutting-edge issues in celiac disease and in gluten intolerance . Clin Rev Allergy Immunol , 42 : 279 – 287 .
   PubMed Web of Science ®Google Scholar
• Di Sabatino , A and Corazza , G R . 2012 . Nonceliac gluten sensitivity: sense or sensibility? . Ann Intern Med , 156 : 309 – 311 .
   PubMed Web of Science ®Google Scholar
• Lyndsey , L . 3 years after deadline, FDA still hasn't defined ‘gluten-free’. The Washington Post April 29, 2011. Accessed at: http://www.washingtonpost.com/politics/3-years-after-deadline-fda-still-hasnt-defined-gluten-free/2011/04/22/AFRq6i8E_story.html
   Google Scholar
• Verdu , E F , Armstrong , D and Murray , J A . 2009 . Between celiac disease and irritable bowel syndrome: the “no man's land” of gluten sensitivity . Am J Gastroenterol , 104 : 1587 – 1594 .
   PubMed Web of Science ®Google Scholar
• Ball , A J , Hadjivassiliou , M and Sanders , D S . 2010 . Is gluten sensitivity a “no man's land” or a “fertile crescent” for research? . Am J Gastroenterol , 105 : 222 – 223 .
   PubMed Web of Science ®Google Scholar
• Battais , F , Richard , C , Jacquenet , S , Denery-Papini , S and Moneret-Vautrin , D A . 2008 . Wheat grain allergies: an update on wheat allergens . Eur Ann Allergy Clin Immunol , 40 : 67 – 76 .
   PubMedGoogle Scholar
• Wieser , H . 2007 . Chemistry of gluten proteins . Food Microbiol , 24 : 115 – 119 .
   PubMed Web of Science ®Google Scholar
• Howdle , P D . 2006 . Gliadin, glutenin or both? The search for the Holy Grail in coeliac disease . Eur J Gastroenterol Hepatol , 18 : 703 – 706 .
   PubMedGoogle Scholar
• Black , J L and Orfila , C . 2011 . Impact of coeliac disease on dietary habits and quality of life . J Hum Nutr Diet , 24 : 582 – 587 .
   PubMed Web of Science ®Google Scholar
• Hyams , J S . 2002 . Diet and gastrointestinal disease . Curr Opin Pediatr , 14 : 567 – 569 .
   PubMedGoogle Scholar
• Scanlon , S A and Murray , J A . 2011 . Update on celiac disease—etiology, differential diagnosis, drug targets, and management advances . Clin Exp Gastroenterol , 4 : 297 – 311 .
   PubMedGoogle Scholar
• Diaz-Amigo , C and Popping , B . 2012 . Gluten and gluten-free: issues and considerations of labeling regulations, detection methods, and assay validation . J AOAC Int , 95 : 337 – 348 .
   PubMed Web of Science ®Google Scholar
• Sapone , A , Bai , J C , Ciacci , C , Dolinsek , J , Green , P H , Hadjivassiliou , M , Kaukinen , K , Rostami , K , Sanders , D S , Schumann , M , Ullrich , R , Villalta , D , Volta , U , Catassi , C and Fasano , A . 2012 . Spectrum of gluten-related disorders: consensus on new nomenclature and classification . BMC Med , 10 : 13
   PubMed Web of Science ®Google Scholar
• Troncone , R and Jabri , B . 2011 . Coeliac disease and gluten sensitivity . J Intern Med , 269 : 582 – 590 .
   PubMed Web of Science ®Google Scholar
• Volta , U , Tovoli , F , Cicola , R , Parisi , C , Fabbri , A , Piscaglia , M , Fiorini , E and Caio , G . 2012 . Serological tests in gluten sensitivity (nonceliac gluten intolerance) . J Clin Gastroenterol , 46 : 680 – 685 .
   PubMed Web of Science ®Google Scholar
• Ludvigsson , J F , Leffler , D A , Bai , J C , Biagi , F , Fasano , A , Green , P H , Hadjivassiliou , M , Kaukinen , K , Kelly , C P , Leonard , J N , Lundin , K E , Murray , J A , Sanders , D S , Walker , M M , Zingone , F and Ciacci , C . 2013 . The Oslo definitions for coeliac disease and related terms . Gut , 62 : 43 – 52 .
   PubMed Web of Science ®Google Scholar
• Giersiepen , K , Lelgemann , M , Stuhldreher , N , Ronfani , L , Husby , S , Koletzko , S , Korponay-Szabó , I R and the ESPGHAN Working Group on Coeliac Disease Diagnosis . 2012 . Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report . J Pediatr Gastroenterol Nutr , 54 : 229 – 241 .
   PubMed Web of Science ®Google Scholar
• Kaukinen , K , Turjanmaa , K , Mäki , M , Partanen , J , Venäläinen , R , Reunala , T and Collin , P . 2000 . Intolerance to cereals is not specific for coeliac disease . Scand J Gastroenterol , 35 : 942 – 946 .
   PubMed Web of Science ®Google Scholar
• Cooper , B T , Holmes , G K , Ferguson , R , Thompson , R A , Allan , R N and Cooke , W T . 1980 . Gluten-sensitive diarrhea without evidence of celiac disease . Gastroenterology , 79 : 801 – 806 .
   PubMed Web of Science ®Google Scholar
• Ribes-Koninckx , C , Mearin , M L , Korponay-Szabó , I R , Shamir , R , Husby , S , Ventura , A , Branski , D , Catassi , C , Koletzko , S , Mäki , M , Troncone , R , Zimmer , K P and the ESPGHAN Working Group on Coeliac Disease Diagnosis: Coeliac disease diagnosis . 2012 . ESPGHAN 1990 criteria or need for a change? Results of a questionnaire . J Pediatr Gastroenterol Nutr , 54 : 15 – 19 .
   PubMed Web of Science ®Google Scholar
• Cianci , R , Pagliari , D , Landolfi , R , Frosali , S , Colagiovanni , A , Cammarota , G and Pandolfi , F . 2012 . New insights on the role of T cells in the pathogenesis of celiac disease . J Biol Regul Homeost Agents , 26 : 171 – 179 .
   PubMedGoogle Scholar
• Qiao , S W , Iversen , R , Ráki , M and Sollid , L M . 2012 . The adaptive immune response in celiac disease . Semin Immunopathol , 34 : 523 – 540 .
   PubMed Web of Science ®Google Scholar
• Di Sabatino , A , Vanoli , A , Giuffrida , P , Luinetti , O , Solcia , E and Corazza , G R . 2012 . The function of tissue transglutaminase in celiac disease . Autoimmun Rev , 11 : 746 – 753 .
   PubMed Web of Science ®Google Scholar
• Inomata , N . 2009 . Wheat allergy . Curr Opin Allergy Clin Immunol , 9 : 238 – 243 .
   PubMed Web of Science ®Google Scholar
• Keet , C A , Matsui , E C , Dhillon , G , Lenehan , P , Paterakis , M and Wood , R A . 2009 . The natural history of wheat allergy . Ann Allergy Asthma Immunol , 102 : 410 – 415 .
   PubMed Web of Science ®Google Scholar
• Fraser , J S , Engel , W , Ellis , H J , Moodie , S J , Pollock , E L , Wieser , H and Ciclitira , P J . 2003 . Coeliac disease: in vivo toxicity of the putative immunodominant epitope . Gut , 52 : 1698 – 1702 .
   PubMed Web of Science ®Google Scholar
• Moron , B , Bethune , M T , Comino , I , Manyani , H , Ferragud , M , Lopez , M C , Cebolla , A , Khosla , C and Sousa , C . 2008 . Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide . PLoS One , 3 : e2294
   PubMed Web of Science ®Google Scholar
• Dolfini , E , Roncoroni , L , Elli , L , Fumagalli , C , Colombo , R , Ramponi , S , Forlani , F and Bardella , M T . 2005 . Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model . World J Gastroenterol , 11 : 7597 – 7601 .
   PubMed Web of Science ®Google Scholar
• Clemente , M G , De Virgiliis , S , Kang , J S , Macatagney , R , Musu , M P , Di Pierro , M R , Drago , S , Congia , M and Fasano , A . 2003 . Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function . Gut , 52 : 218 – 223 .
   PubMed Web of Science ®Google Scholar
• Drago , S , El Asmar , R , Di Pierro , M , Grazia Clemente , M , Tripathi , A , Sapone , A , Thakar , M , Iacono , G , Carroccio , A , D’Agate , C , Not , T , Zampini , L , Catassi , C and Fasano , A . 2006 . Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines . Scand J Gastroenterol , 41 : 408 – 419 .
   PubMed Web of Science ®Google Scholar
• Fasano , A . 2012 . Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications . Clin Gastroenterol Hepatol , 10 : 1096 – 1100 .
   PubMed Web of Science ®Google Scholar
• Elli , L , Dolfini , E and Bardella , M T . 2003 . Gliadin cytotoxicity and in vitro cell cultures . Toxicol Lett , 146 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Reinke , Y , Behrendt , M , Schmidt , S , Zimmer , K P and Naim , H Y . 2011 . Impairment of protein trafficking by direct interaction of gliadin peptides with actin . Exp Cell Res , 317 : 2124 – 2135 .
   PubMed Web of Science ®Google Scholar
• Luciani , A , Villella , V R , Vasaturo , A , Giardino , I , Pettoello-Mantovani , M , Guido , S , Cexus , O N , Peake , N , Londei , M , Quaratino , S and Maiuri , L . 2010 . Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa . Gut , 59 : 311 – 319 .
   PubMedGoogle Scholar
• Ertekin , V , Selimoğlu , M A , Türkan , Y and Akçay , F . 2005 . Serum nitric oxide levels in children with celiac disease . J Clin Gastroenterol , 39 : 782 – 785 .
   PubMedGoogle Scholar
• Mazzarella , G , Stefanile , R , Camarca , A , Giliberti , P , Cosentini , E , Marano , C , Iaquinto , G , Giardullo , N , Auricchio , S , Sette , A , Troncone , R and Gianfrani , C . 2008 . Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis . Gastroenterology , 134 : 1017 – 1027 .
   PubMed Web of Science ®Google Scholar
• Verdu , E F , Huang , X , Natividad , J , Lu , J , Blennerhassett , P A , David , C S , McKay , D M and Murray , J A . 2008 . Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice . Am J Physiol Gastrointest Liver Physiol , 294 : G217 – G225 .
   PubMed Web of Science ®Google Scholar
• Choi , S , DiSilvio , B , Fernstrom , M H and Fernstrom , J D . 2011 . The chronic ingestion of diets containing different proteins produces marked variations in brain tryptophan levels and serotonin synthesis in the rat . Neurochem Res , 36 : 559 – 565 .
   PubMed Web of Science ®Google Scholar
• Lavö , B , Knutson , L , Lööf , L , Odlind , B , Venge , P and Hällgren , R . 1989 . Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease . Am J Med , 87 : 655 – 660 .
   PubMed Web of Science ®Google Scholar
• Tursi , A . 2004 . Gastrointestinal motility disturbances in celiac disease . J Clin Gastroenterol , 38 : 642 – 645 .
   PubMed Web of Science ®Google Scholar
• Sanders , D S , Carter , M J , Hurlstone , D P , Pearce , A , Ward , A M , McAlindon , M E and Lobo , A J . 2001 . Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care . Lancet , 358 : 1504 – 1508 .
   PubMed Web of Science ®Google Scholar
• Sanders , D . 2002 . Irritable bowel syndrome and coeliac disease . Lancet , 359 : 1436 – 1437 .
   PubMedGoogle Scholar
• Sanders , D S and Azmy , I A . 2004 . Celiac disease serology and irritable bowel syndrome: does the relationship merit further evaluation? . Mayo Clin Proc , 79 : 1209 – 1210 .
   PubMedGoogle Scholar
• Benini , L , Sembenini , C , Salandini , L , Dall’O , E , Bonfante , F and Vantini , I . 2001 . Gastric emptying of realistic meals with and without gluten in patients with celiac disease. Effect of jejunal mucosal recovery . Scand J Gastroenterol , 36 : 1044 – 1048 .
   PubMed Web of Science ®Google Scholar
• Perri , F , Pastore , M , Zicolella , A , Annese , V , Quitadamo , M and Andriulli , A . 2000 . Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal . Acta Paediatr , 89 : 921 – 925 .
   PubMed Web of Science ®Google Scholar
• Rocco , A , Sarnelli , G , Compare , D , de Colibus , P , Micheli , P , Somma , P , Marotti , B , Cuomo , R and Nardone , G . 2008 . Tissue ghrelin level and gastric emptying rate in adult patients with celiac disease . Neurogastroenterol Motil , 20 : 884 – 890 .
   PubMed Web of Science ®Google Scholar
• Spiller , R C , Lee , Y C , Edge , C , Ralphs , D N , Stewart , J S , Bloom , S R and Silk , D B . 1987 . Delayed mouth–caecum transit of a lactulose labelled liquid test meal in patients with steatorrhoea caused by partially treated coeliac disease . Gut , 28 : 1275 – 1282 .
   PubMed Web of Science ®Google Scholar
• Vazquez-Roque , M I , Camilleri , M , Carlson , P , McKinzie , S , Murray , J A , Brantner , T L , Burton , D D and Zinsmeister , A R . 2011 . HLA-DQ genotype is associated with accelerated small bowel transit in patients with diarrhea-predominant irritable bowel syndrome . Eur J Gastroenterol Hepatol , 23 : 481 – 487 .
   PubMedGoogle Scholar
• Wahnschaffe , U , Ullrich , R , Riecken , E O and Schulzke , J D . 2001 . Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome . Gastroenterology , 121 : 1329 – 1338 .
   PubMed Web of Science ®Google Scholar
• Biesiekierski , J R , Rosella , O , Rose , R , Liels , K , Barrett , J S , Shepherd , S J , Gibson , P R and Muir , J G . 2011 . Quantification of fructans, galacto-oligosaccharides and other short-chain carbohydrates in processed grains and cereals . J Hum Nutr Diet , 24 : 154 – 176 .
   PubMed Web of Science ®Google Scholar
• Barrett , J S and Gibson , P R . 2012 . Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? . Therap Adv Gastroenterol , 5 : 261 – 268 .
   PubMed Web of Science ®Google Scholar
• Natividad , J M , Huang , X , Slack , E , Jury , J , Sanz , Y , David , C , Denou , E , Yang , P , Murray , J , McCoy , K D and Verdú , E F . 2009 . Host responses to intestinal microbial antigens in gluten-sensitive mice . PLoS One , 4 : e6472
   PubMed Web of Science ®Google Scholar
• Sapone , A , Lammers , K M , Casolaro , V , Cammarota , M , Giuliano , M T , De Rosa , M , Stefanile , R , Mazzarella , G , Tolone , C , Russo , M I , Esposito , P , Ferraraccio , F , Cartenì , M , Riegler , G , de Magistris , L and Fasano , A . 2011 . Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity . BMC Med , 9 : 23
   PubMed Web of Science ®Google Scholar
• Sapone , A , Lammers , K M , Mazzarella , G , Mikhailenko , I , Cartenì , M , Casolaro , V and Fasano , A . 2010 . Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease . Int Arch Allergy Immunol , 152 : 75 – 80 .
   PubMed Web of Science ®Google Scholar
• Volta , U , Tovoli , F , Cicola , R , Parisi , C , Fabbri , A , Piscaglia , M , Fiorini , E and Caio , G . 2012 . Serological tests in gluten sensitivity (nonceliac gluten intolerance) . J Clin Gastroenterol , 46 : 680 – 685 .
   PubMed Web of Science ®Google Scholar
• León , F , Sánchez , L , Camarero , C and Roy , G . 2005 . Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease . Dig Dis Sci , 50 : 593 – 600 .
   PubMedGoogle Scholar
• Fernández , S , Molina , I J , Romero , P , González , R , Peña , J , Sánchez , F , Reynoso , F R , Pérez-Navero , J L , Estevez , O , Ortega , C and Santamaría , M . 2011 . Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients . Am J Gastroenterol , 106 : 528 – 538 .
   PubMed Web of Science ®Google Scholar
• Monteleone , I , Sarra , M , Del Vecchio Blanco , G , Paoluzi , O A , Franzè , E , Fina , D , Fabrizi , A , MacDonald , T T , Pallone , F and Monteleone , G . 2010 . Characterization of IL-17A-producing cells in celiac disease mucosa . J Immunol , 184 : 2211 – 2218 .
   PubMed Web of Science ®Google Scholar
• Fina , D , Sarra , M , Caruso , R , Del Vecchio Blanco , G , Pallone , F , MacDonald , T T and Monteleone , G . 2008 . Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease . Gut , 57 : 887 – 892 .
   PubMed Web of Science ®Google Scholar
• Hmida , N B , Ben Ahmed , M , Moussa , A , Rejeb , M B , Said , Y , Kourda , N , Meresse , B , Abdeladhim , M , Louzir , H and Cerf-Bensussan , N . 2012 . Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease? . Am J Gastroenterol , 107 : 604 – 611 .
   PubMed Web of Science ®Google Scholar
• Josefowicz , S Z , Lu , L F and Rudensky , A Y . 2012 . Regulatory T cells: mechanisms of differentiation and function . Annu Rev Immunol , 30 : 531 – 564 .
   PubMed Web of Science ®Google Scholar
• Sakaguchi , S , Wing , K , Onishi , Y , Prieto-Martin , P and Yamaguchi , T . 2009 . Regulatory T cells: how do they suppress immune responses? . Int Immunol , 21 : 1105 – 1111 .
   PubMed Web of Science ®Google Scholar
• Granzotto , M , dal Bo , S , Quaglia , S , Tommasini , A , Piscianz , E , Valencic , E , Ferrara , F , Martelossi , S , Ventura , A and Not , T . 2009 . Regulatory T-cell function is impaired in celiac disease . Dig Dis Sci , 54 : 1513 – 1519 .
   PubMed Web of Science ®Google Scholar
• Zanzi , D , Stefanile , R , Santagata , S , Iaffaldano , L , Iaquinto , G , Giardullo , N , Lania , G , Vigliano , I , Vera , A R , Ferrara , K , Auricchio , S , Troncone , R and Mazzarella , G . 2011 . IL-15 interferes with suppressive activity of intestinal regulatory T cells expanded in Celiac disease . Am J Gastroenterol , 106 : 1308 – 1317 .
   PubMed Web of Science ®Google Scholar
• Vorobjova , T , Uibo , O , Heilman , K , Rägo , T , Honkanen , J , Vaarala , O , Tillmann , V , Ojakivi , I and Uibo , R . 2009 . Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus . Scand J Gastroenterol , 44 : 422 – 430 .
   PubMed Web of Science ®Google Scholar
• Hansson , T , Ulfgren , A K , Lindroos , E , DannAEus , A , Dahlbom , I and Klareskog , L . 2002 . Transforming growth factor–beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease . Scand J Immunol , 56 : 530 – 537 .
   PubMed Web of Science ®Google Scholar
• Eiró , N , González-Reyes , S , González , L , González , L O , Altadill , A , Andicoechea , A , Fresno-Forcelledo , M F , Rodrigo-Sáez , L and Vizoso , F J . 2012 . Duodenal expression of toll-like receptors and interleukins are increased in both children and adult celiac patients . Dig Dis Sci , 57 : 2278 – 2285 .
   PubMed Web of Science ®Google Scholar
• Szebeni , B , Veres , G , Dezsofi , A , Rusai , K , Vannay , A , Bokodi , G , Vásárhelyi , B , Korponay-Szabó , I R , Tulassay , T and Arató , A . 2007 . Increased mucosal expression of toll-like receptor (TLR)2 and TLR4 in coeliac disease . J Pediatr Gastroenterol Nutr , 45 : 187 – 193 .
   PubMed Web of Science ®Google Scholar
• Kalliomäki , M , Satokari , R , Lähteenoja , H , Vähämiko , S , Grönlund , J , Routi , T and Salminen , S . 2012 . Expression of microbiota, toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease . J Pediatr Gastroenterol Nutr , 54 : 727 – 732 .
   PubMed Web of Science ®Google Scholar
• Camilleri , M , Madsen , K , Spiller , R , Van Meerveld , B G and Verne , G N . 2012 . Intestinal barrier function in health and gastrointestinal disease . Neurogastroenterol Motil , 24 : 503 – 512 .
   PubMed Web of Science ®Google Scholar
• Bertolazzi , S , Lanzarotto , F , Zanini , B , Ricci , C , Villanacci , V and Lanzini , A . 2011 . Bio-physical characteristics of gastrointestinal mucosa of celiac patients: comparison with control subjects and effect of gluten free diet . BMC Gastroenterol , 11 : 119
   PubMedGoogle Scholar
• Visser , J , Rozing , J , Sapone , A , Lammers , K and Fasano , A . 2009 . Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms . Ann N Y Acad Sci , 1165 : 195 – 205 .
   PubMed Web of Science ®Google Scholar
• Biesiekierski , J R , Newnham , E D , Irving , P M , Barrett , J S , Haines , M , Doecke , J D , Shepherd , S J , Muir , J G and Gibson , P R . 2011 . Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial . Am J Gastroenterol , 106 : 508 – 514 .
   PubMed Web of Science ®Google Scholar
• Sander , G R , Cummins , A G , Henshall , T and Powell , B C . 2005 . Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins . FEBS Lett , 579 : 4851 – 4855 .
   PubMed Web of Science ®Google Scholar
• Ciccocioppo , R , Finamore , A , Ara , C , Di Sabatino , A , Mengheri , E and Corazza , G R . 2006 . Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease . Am J Clin Pathol , 125 : 502 – 511 .
   PubMedGoogle Scholar
• Assimakopoulos , S F , Papageorgiou , I and Charonis , A . 2011 . Enterocytes’ tight junctions: from molecules to diseases . World J Gastrointest Pathophysiol , 2 : 123 – 137 .
   PubMedGoogle Scholar
• Carroccio , A , Mansueto , P , Iacono , G , Soresi , M , D’Alcamo , A , Cavataio , F , Brusca , I , Florena , A M , Ambrosiano , G , Seidita , A , Pirrone , G and Rini , G B . 2012 . Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity . Am J Gastroenterol , 107 : 1898 – 1906 .
   PubMed Web of Science ®Google Scholar
• Kokkonen , J , Holm , K , Karttunen , T J and Mäki , M . 2000 . Children with untreated food allergy express a relative increment in the density of duodenal gammadelta+ T cells . Scand J Gastroenterol , 35 : 1137 – 1142 .
   PubMed Web of Science ®Google Scholar
• Augustin , M T , Kokkonen , J and Karttunen , T J . 2005 . Duodenal cytotoxic lymphocytes in cow's milk protein sensitive enteropathy and coeliac disease . Scand J Gastroenterol , 40 : 1398 – 1406 .
   PubMed Web of Science ®Google Scholar
• Kokkonen , T S , Augustin , M T , Kokkonen , J , Karttunen , R and Karttunen , T J . 2012 . Serum and tissue CD23, IL-15, and FasL in cow's-milk protein-sensitive enteropathy and in coeliac disease . J Pediatr Gastroenterol Nutr , 54 : 525 – 531 .
   PubMedGoogle Scholar
• Knippels , L M , van Wijk , F and Penninks , A H . 2004 . Food allergy: what do we learn from animal models? . Curr Opin Allergy Clin Immunol , 4 : 205 – 209 .
   PubMedGoogle Scholar
• Perrier , C , Thierry , A C , Mercenier , A and Corthésy , B . 2010 . Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice . Clin Exp Allergy , 40 : 153 – 162 .
   PubMedGoogle Scholar
• Oboki , K , Ohno , T , Saito , H and Nakae , S . 2008 . Th17 and allergy . Allergol Int , 57 : 121 – 134 .
   PubMedGoogle Scholar
• Herberth , G , Daegelmann , C , Röder , S , Behrendt , H , Krämer , U , Borte , M , Heinrich , J , Herbarth , O , Lehmann , I and the LISAplus Study Group . 2010 . IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study . Pediatr Allergy Immunol , 21 : 1086 – 1090 .
   PubMed Web of Science ®Google Scholar
• Krogulska , A , Borowiec , M , Polakowska , E , Dynowski , J , Młynarski , W and Wasowska-Królikowska , K . 2011 . FOXP3, IL-10, and TGF-β genes expression in children with IgE-dependent food allergy . J Clin Immunol , 31 : 205 – 215 .
   PubMed Web of Science ®Google Scholar
• Westerholm-Ormio , M , Vaarala , O , Tiittanen , M and Savilahti , E . 2010 . Infiltration of Foxp3- and toll-like receptor-4-positive cells in the intestines of children with food allergy . J Pediatr Gastroenterol Nutr , 50 : 367 – 376 .
   PubMed Web of Science ®Google Scholar
• Brazowski , E , Cohen , S , Yaron , A , Filip , I and Eisenthal , A . 2010 . FOXP3 expression in duodenal mucosa in pediatric patients with celiac disease . Pathobiology , 77 : 328 – 334 .
   PubMedGoogle Scholar
• Sicherer , S H , Wood , R A , Stablein , D , Burks , A W , Liu , A H , Jones , S M , Fleischer , D M , Leung , D Y , Grishin , A , Mayer , L , Shreffler , W , Lindblad , R and Sampson , H A . 2010 . Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy . J Allergy Clin Immunol , 125 : 1077 – 1083 .
   PubMed Web of Science ®Google Scholar
• Galli , E , Ciucci , A , Cersosimo , S , Pagnini , C , Avitabile , S , Mancino , G , Delle Fave , G and Corleto , V D . 2010 . Eczema and food allergy in an Italian pediatric cohort: no association with TLR-2 and TLR-4 polymorphisms . Int J Immunopathol Pharmacol , 23 : 671 – 675 .
   PubMed Web of Science ®Google Scholar
• Prescott , S L , Noakes , P , Chow , B W , Breckler , L , Thornton , C A , Hollams , E M , Ali , M , van den Biggelaar , A H and Tulic , M K . 2008 . Presymptomatic differences in toll-like receptor function in infants who have allergy . J Allergy Clin Immunol , 122 : 391 – 399 .
   PubMedGoogle Scholar
• Bashir , M E , Louie , S , Shi , H N and Nagler-Anderson , C . 2004 . Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy . J Immunol , 172 : 6978 – 6987 .
   PubMed Web of Science ®Google Scholar
• Ventura , M T , Polimeno , L , Amoruso , A C , Gatti , F , Annoscia , E , Marinaro , M , Di Leo , E , Matino , M G , Buquicchio , R , Bonini , S , Tursi , A and Francavilla , A . 2006 . Intestinal permeability in patients with adverse reactions to food . Dig Liver Dis , 38 : 732 – 736 .
   PubMedGoogle Scholar
• Laudat , A , Arnaud , P , Napoly , A and Brion , F . 1994 . The intestinal permeability test applied to the diagnosis of food allergy in paediatrics . West Indian Med J , 43 : 87 – 88 .
   PubMed Web of Science ®Google Scholar
• Troncone , R , Caputo , N , Florio , G and Finelli , E . 1994 . Increased intestinal sugar permeability after challenge in children with cow's milk allergy or intolerance . Allergy , 49 : 142 – 146 .
   PubMed Web of Science ®Google Scholar
• Staiano , A , Troncone , R , Simeone , D , Mayer , M , Finelli , E , Cella , A and Auricchio , S . 1995 . Differentiation of cows’ milk intolerance and gastro-oesophageal reflux . Arch Dis Child , 73 : 439 – 442 .
   PubMed Web of Science ®Google Scholar
• Pizzuti , D , Senzolo , M , Buda , A , Chiarelli , S , Giacomelli , L , Mazzon , E , Curioni , A , Faggian , D and De Lazzari , F . 2011 . In vitro model for IgE mediated food allergy . Scand J Gastroenterol , 46 : 177 – 187 .
   PubMed Web of Science ®Google Scholar
• Digiacomo , D V , Tennyson , C A , Green , P H and Demmer , R T . 2013 . Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009–2010 . Scand J Gastroenterol , 48 : 921 – 925 .
   PubMed Web of Science ®Google Scholar
• Brottveit , M , Vandvik , P O , Wojniusz , S , Løvik , A , Lundin , K E and Boye , B . 2012 . Absence of somatization in non-coeliac gluten sensitivity . Scand J Gastroenterol , 47 : 770 – 777 .
   PubMed Web of Science ®Google Scholar
• Jackson , J R , Eaton , W W , Cascella , N G , Fasano , A and Kelly , D L . 2012 . Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity . Psychiatr Q , 83 : 91 – 102 .
   PubMed Web of Science ®Google Scholar
• Carroccio , A , Iacono , G , Di Prima , L , Pirrone , G , Cavataio , F , Ambrosiano , G , Sciumè , C , Geraci , G , Florena , A , Teresi , S , Barbaria , F , Pepe , I , Campisi , G , Mansueto , P , Soresi , M and Di Fede , G . 2011 . Antiendomysium antibodies assay in the culture medium of intestinal mucosa: an accurate method for celiac disease diagnosis . Eur J Gastroenterol Hepatol , 23 : 1018 – 1023 .
   PubMed Web of Science ®Google Scholar
• Carroccio , A , Iacono , G , D’Amico , D , Cavataio , F , Teresi , S , Caruso , C , Di , P L , Colombo , A , D’Arpa , F , Florena , A , Notarbartolo , A and Montalto , G . 2002 . Production of anti-endomysial antibodies in cultured duodenal mucosa: usefulness in celiac disease diagnosis . Scand J Gastroenterol , 37 : 32 – 38 .
   PubMed Web of Science ®Google Scholar
• Dezi , R , Niveloni , S , Sugai , E , Pedreira , S , Smecuol , E , Vazquez , H , Doldan , I , Cabanne , A , Boerr , L , Valero , J , Kogan , Z , Mauriño , E and Bai , J C . 1992 . Gluten sensitivity in the rectal mucosa of first-degree relatives of celiac disease patients . Am J Gastroenterol , 92 : 1326 – 1330 .
   Google Scholar
• Troncone , R , Mazzarella , G , Leone , N , Mayer , M , De Vincenzi , M , Greco , L and Auricchio , S . 1998 . Gliadin activates mucosal cell mediated immunity in cultured rectal mucosa from coeliac patients and a subset of their siblings . Gut , 43 : 484 – 489 .
   PubMed Web of Science ®Google Scholar
• Rostami , K , Kerckhaert , JP6 , Tiemessen , R , Meijer , J W and Mulder , C J . 1999 . The relationship between anti-endomysium antibodies and villous atrophy in coeliac disease using both monkey and human substrate . Eur J Gastroenterol Hepatol , 11 : 439 – 442 .
   PubMed Web of Science ®Google Scholar
• Kurppa , K , Collin , P , Viljamaa , M , Haimila , K , Saavalainen , P , Partanen , J , Laurila , K , Huhtala , H , Paasikivi , K , Mäki , M and Kaukinen , K . 2009 . Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study . Gastroenterology , 136 : 816 – 823 .
   PubMed Web of Science ®Google Scholar
• Wahnschaffe , U , Schulzke , J D , Zeitz , M and Ullrich , R . 2007 . Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome . Clin Gastroenterol Hepatol , 5 : 844 – 850 .
   PubMed Web of Science ®Google Scholar
• Marie , I , Lecomte , F , Hachulla , E , Antonietti , M , François , A , Levesque , H and Courtois , H . 2001 . An uncommon association: celiac disease and dermatomyositis in adults . Clin Exp Rheumatol , 19 : 201 – 203 .
   PubMed Web of Science ®Google Scholar
• Pellegrini , G , Scotta , M S , Soardo , S , Avanzini , M A , Ravelli , A , Burgio , G R and Martini , A . 1991 . Elevated IgA anti-gliadin antibodies in juvenile chronic arthritis . Clin Exp Rheumatol , 9 : 653 – 656 .
   PubMedGoogle Scholar
• Sima , H , Hekmatdoost , A , Ghaziani , T , Alavian , S M , Mashayekh , A and Zali , M R . 2010 . The prevalence of celiac autoantibodies in hepatitis patients . Iran J Allergy Asthma Immunol , 9 : 157 – 162 .
   PubMedGoogle Scholar
• Czaja , A J . 1998 . Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis . Dig Dis Sci , 43 : 2190 – 2195 .
   PubMedGoogle Scholar
• Volta , U , Bellentani , S , Bianchi , F B , Brandi , G , De Franceschi , L , Miglioli , L , Granito , A , Balli , F and Tiribelli , C . 2001 . High prevalence of celiac disease in Italian general population . Dig Dis Sci , 46 : 1500 – 1505 .
   PubMed Web of Science ®Google Scholar
• Hadjivassiliou , M , Gibson , A , Davies-Jones , G A , Lobo , A J , Stephenson , T J and Milford-Ward , A . 1996 . Does cryptic gluten sensitivity play a part in neurological illness? . Lancet , 347 : 369 – 371 .
   PubMed Web of Science ®Google Scholar
• Carroccio , A , Brusca , I , Mansueto , P , Pirrone , G , Barrale , M , Di Prima , L , Ambrosiano , G , Iacono , G , Lospalluti , M L , La Chiusa , S M and Di Fede , G . 2010 . A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome . Clin Gastroenterol Hepatol , 8 : 254 – 260 .
   PubMed Web of Science ®Google Scholar
• Brown , I , Mino-Kenudson , M , Deshpande , V and Lauwers , G Y . 2006 . Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis . Arch Pathol Lab Med , 130 : 1020 – 1025 .
   PubMedGoogle Scholar
• Chang , F , Mahadeva , U and Deere , H . 2005 . Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa . APMIS , 113 : 385 – 399 .
   PubMed Web of Science ®Google Scholar
• Robert , M E . 2005 . Gluten sensitive enteropathy and other causes of small intestinal lymphocytosis . Semin Diagn Pathol , 22 : 284 – 294 .
   PubMedGoogle Scholar
• Inomata , N . 2009 . Wheat allergy: Curr Opin Allergy . Clin Immunol , 9 : 238 – 243 .
   Google Scholar
• Pourpak , Z , Mansouri , M , Mesdaghi , M , Kazemnejad , A and Farhoudi , A . 2004 . Wheat allergy: clinical and laboratory findings . Int Arch Allergy Immunol , 133 : 168 – 173 .
   PubMedGoogle Scholar