References
- Bouché C, Serdy S, Kahn CR, Goldfine AB. The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev. 2004;25(5):807–30. doi:https://doi.org/10.1210/er.2003-0026.
- Cheng KKY, Lam KSL, Wang B, Phil M, Xu A. Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract Res Clin Endocrinol Metab. 2014;28(1):3–13. doi:https://doi.org/10.1016/j.beem.2013.06.006.
- Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787–94. doi:https://doi.org/10.1172/JCI7231.
- Pari L, Latha M. Antihyperglycaemic effect of Scopariadulcis.: Effect on key metabolic enzymes of carbohydrate metabolism in streptozotocin-induced diabetes. Pharm Biol. 2005;42(8):570–76. doi:https://doi.org/10.1080/13880200490901799.
- Matschinsky FM. Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes. 1996;45(2):223–41. doi:https://doi.org/10.2337/diab.45.2.223.
- Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 2000;49(11):1751–60. doi:https://doi.org/10.2337/diabetes.49.11.1751.
- Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995;333(9):550–54. doi:https://doi.org/10.1056/NEJM199508313330903.
- Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes. 2000;49(12):2063–69. doi:https://doi.org/10.2337/diabetes.49.12.2063.
- Caro JF. Effects of glyburide on carbohydrate metabolism and insulin action in the liver. Am J Med. 1990;89(2A):17S–53S. doi:https://doi.org/10.1016/0002-9343(90)90332-8.
- Da Silva D, Zancan P, Coelho WS, Gomez LS, Sola-Penna M. Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse. Arch Biochem Biophys. 2010;496(1):53–60. doi:https://doi.org/10.1016/j.abb.2010.01.013.
- Da Silva D, Ausina P, Alencar EM, Coelho WS, Zancan P, Sola-Penna M. Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice. IUBMB Life. 2012;64(9):766–74. doi:https://doi.org/10.1002/iub.1063.
- Durazzo A, Lucarini M, Novellino E, Souto EB, Daliu P, Santini A. Abelmoschus esculentus (L.): Bioactive components' beneficial properties-focused on antidiabetic role-for sustainable health applications. Molecules. 2018;24(1):38. doi:https://doi.org/10.3390/molecules24010038.
- Mihretu Y, Wayessa G, Adugna D. Multivariate analysis among okra (Abelmoschus esculentus(L.) Moench) collection in South Western Ethiopia. J Plant Sci. 2014;9:43–50.
- Rahaman Mollick MM, Bhowmick B, Mondal D, Maity D, Rana D, Dash SK, Chattopadhyay S, Roy S, Sarkar J, Acharya K, et al. Anticancer (in vitro) and antimicrobial effect of gold nanoparticles synthesized using Abelmoschus esculentus (L.) pulp extract via a green route. RSC Adv. 2014;4(71):37838–48. doi:https://doi.org/10.1039/C4RA07285E.
- Ortaç D, Cemek M, Karaca T, Büyükokuroğlu ME, Özdemir ZÖ, Kocaman AT, Göneş S. In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions. Pharm Biol. 2018;56(1):165–75. doi:https://doi.org/10.1080/13880209.2018.1442481.
- Zhang T, Xiang J, Zheng G, Yan R, Min X. Preliminary characterization and anti-hyperglycemic activity of a pectic polysaccharide from okra (Abelmoschus esculentus (L.) Moench). J Funct Foods. 2018;41:19–24. doi:https://doi.org/10.1016/j.jff.2017.12.028.
- Majd NE, Tabandeh MR, Shahriari A, Soleimani Z. Okra (Abelmoscus esculentus) improved islets structure, and down-regulated PPARs gene expression in pancreas of high-fat diet and streptozotocin-induced diabetic rats. Cell J. 2018;20(1):31–40.
- Anjani PP, Damayanthi E, Rimbawan R, Handharyani E. Antidiabetic potential of purple okra (Abelmoschus esculentus L.) extract in streptozotocin-induced diabetic rats. IOP Conf Ser Earth Environ Sci. 2018;196:012038. doi:https://doi.org/10.1088/1755-1315/196/1/012038.
- Amadi JAC, Asinobi CO, Okechukwu-Ezike NC, Aloy-Amadi O, Ihemeje A. Glycemic index and load responses of indigenous vegetable sauces among healthy young female adults. FFHD. 2019;9(9):576–92. doi:https://doi.org/10.31989/ffhd.v9i9.621.
- Yin P, Wang Y, Yang L, Sui J, Liu Y. Hypoglycemic effects in alloxan-induced diabetic rats of the phenolic extract from Mongolian oak cups enriched in ellagic acid, kaempferol and their derivatives. Molecules (Basel, Switzerland). 2018;23(5):1046. doi:https://doi.org/10.3390/molecules23051046.
- Agomuo EN, Amadi PU, Adumekwe C. Gestational geophagia affects nephrocardiac integrity, ATP-driven proton pumps, the renin–angiotensin–aldosterone system, and F2-isoprostane status. Med Sci. 2019;7(2):13. doi:https://doi.org/10.3390/medsci7020013.
- Biicher T, Hohorst HJ. Methods of enzymatic analysis. Bergmeyer, HU, editor. New York: Academic Press; 1963. p. 246–52.
- Kinney LaPier TL, Rodnick KJ. Effects of aerobic exercise on energy metabolism in the hypertensive rat heart. Phys Ther. 2001;81(4):1006–17. doi:https://doi.org/10.1093/ptj/81.4.1006.
- Baginsky ES, Foa PP, Zak B. Glucose-6-phosphatase. In: Bergymeyer HU, editor. Methods of enzymatic analysis. Vol 2, 2nd ed. New York: Academic Press; 1974. p. 788–92.
- Castaño JG, Nieto A, Felı´U JE. Inactivation of phosphofructokinase by glucagon in rat hepatocytes. J Biol Chem. 1979;254(13):5576–9.
- Gancedo JM, Gancedo C. Fructose-1,6-diphosphatase, phospho-fructokinase and glucose-6-phosphate dehydrogenase from fermenting and non-fermenting yeasts. Archiv Mikrobiol. 1971;76(2):132–38. doi:https://doi.org/10.1007/BF00411787.
- Mommsen TP, Walsh PJ, Moon TW. Gluconeogenesis in hepatocytes and kidney of Atlantic salmon. Mol Physiol. 1985;8:89–100.
- Pogson CI, Denton RM. Effect of alloxan diabetes, starvation and refeeding on glycolytic kinase activities in rat epididymal adipose tissue. Nature. 1967;216(5111):156–57. doi:https://doi.org/10.1038/216156a0.
- Duncan MJ, Fraenkel DG. Alpha-ketoglutarate dehydrogenase mutant of rhizobium meliloti. J Bacteriol. 1979;137(1):415–9. doi:https://doi.org/10.1128/JB.137.1.415-419.1979.
- Veeger C, DerVartanian DV, Zeylemaker WP. Succinate dehydrogenase. Methods Enzymol. 1969;13:81–90.
- Shonk CE, Boxer GE. Enzyme patterns in human tissues–l. Methods for the determination of glycolytic enzymes. Cancer Res. 1964;24:709 721.
- Ong KC, Khoo HE. Effects of myricetin on glycemia and glycogen metabolism in diabetic rats. Life Sci. 2000;67(14):1695–705. doi:https://doi.org/10.1016/S0024-3205(00)00758-X.
- Tian ZH, Miao FT, Zhang X, Wang QH, Lei N, Guo LC. Therapeutic effect of okra extract on gestational diabetes mellitus rats induced by streptozotocin. Asia Pac J Tropic Med. 2015;8(12):1038–42. doi:https://doi.org/10.1016/j.apjtm.2015.11.002.
- Fan S, Zhang Y, Sun Q, Yu L, Li M, Zheng B, Wu X, Yang B, Li Y, Huang C. Extract of okra lowers blood glucose and serum lipids in high-fat dietinduced obese C57BL/6 mice. The J Nutrit Biochem. 2014;25(7):702–9. doi:https://doi.org/10.1016/j.jnutbio.2014.02.010.
- Fauza A, Al-Baarri AN, Djamiatun K. Potency of okra flour (Abelmoschus esculentus) in improving adiponectin level and total antioxidant capacity of high fat diet streptozotocin rat model. Potr S J F Sci. 2019;13(1):644–50. doi:https://doi.org/10.5219/1136.
- Li Y, Li JY, Gao MT, Zeng LL, Xu L, Meng LQ, Zheng YN. Hypoglycemic effect of okra extract on type 2 diabetic mice and correlation with TNF-α and IDE. Chin Trad Herb Drugs. 2017;48(15):3131–7.
- Haedersdal S, Lund A, Knop FK, Vilsbøll T. The role of glucagon in the pathophysiology and treatment of type 2 diabetes. Mayo Clin Proc. 2018;93(2):217–39. doi:https://doi.org/10.1016/j.mayocp.2017.12.003.
- Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes. 2011;60(1):288–97. doi:https://doi.org/10.2337/db10-0818.
- Gothandam K, Ganesan VS, Ayyasamy T, Ramalingam S. Protective effect of theaflavin on glycoprotein components and TCA cycle enzymes in high-fat diet and streptozotocin-induced diabetic rats. J Basic Appl Zool. 2019;80(1):43. doi:https://doi.org/10.1186/s41936-019-0115-1.
- Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol. 2000;73(3):461–70. doi:https://doi.org/10.1016/S0378-8741(00)00319-6.
- Ugochukwu N, Babady N. Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats. Life Sci. 2003;73(15):1925–38. doi:https://doi.org/10.1016/S0024-3205(03)00543-5.