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ORIGINAL ARTICLESCellular and Molecular Biology

Statin-Induced Inhibition of MCF-7 Breast Cancer Cell Proliferation is Related to Cell Cycle Arrest and Apoptotic and Necrotic Cell Death Mediated by an Enhanced Oxidative Stress

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Pages 698-707 | Published online: 11 Jun 2009

REFERENCES

  • Jakobisiak M., Golab J. Potential antitumor effects of statins. Int J Oncol 2003; 23: 1055–1069
  • Ongini E., Impagnatiello F., Bonazzi A., Guzzetta M., Govoni M., Monopoli A., Del Soldato P., Ignarro L. J. Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proc Natl Acad Sci USA 2004; 101: 8497–8502
  • Farmer J. A. Pleiotropic effects of statins. Curr Atherosclero Rep 2000; 2: 208–217
  • Gotto A. M., Jr., Farmer J. A. Pleiotropic effects of statins: do they matter?. Curr Opin Lipidol 2001; 12: 391–394
  • LaRosa J. C. Pleiotropic effects of statins and their clinical significance. Am J Cardiol 2001; 88: 291–293
  • Schwartz G. G., Olsson A. G., Ezekowitz M. D., Ganz P., Oliver M. F., Waters D., Zeiher A., Chaitman B. R., Leslie S., Stern T. Myocardial ischemia reduction with aggressive cholesterol lowering (MIRACL) study investigators. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. J Am Med Assoc 2001; 285: 711–718
  • Mach F. Toward a role for statins in immunomodulation. Mol Interv 2002; 2: 478–480
  • Mulhaupt F., Matter C. M., Kwak B. R., Pelli G., Veillard N. R., Burger F., Graber P., Lüscher T. F., Mach F. Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. Cardiovasc Res 2003; 59: 755–766
  • Bellosta S., Ferri N., Bernini F., Paoletti R., Corsini A. Non-lipid-related effects of statins. Ann Med 2000; 32: 164–176
  • Hess D. C., Fagan S. C. Pharmacology and clinical experience with simvastatin. Expert Opin Pharmacother 2001; 2: 153–163
  • Graaf M. R., Richel D. J., van Noorden C. J., Guchelaar H. J. Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat Rev 2004; 30: 609–641
  • Muck A. O., Seeger H., Wallwiener D. Inhibitory effect of statins on the proliferation of human breast cancer cells. Int J Clin Pharmacol Ther 2004; 42: 695–700
  • Dimitroulakos J., Ye L. Y., Benzaquen M., Moore M. J., Kamel-Reid S., Freedman M. H., Yeger H., Penn L. Z. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. Clin Cancer Res 2001; 7: 158–167
  • Horiguchi A., Sumitomo M., Asakuma J., Asano T., Asano T., Hayakawa M. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis. Clin Cancer Res 2004; 10: 8648–8655
  • Keyomarsi K., Sandoval L., Band V., Pardee A. B. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 1991; 51: 3602–3609
  • Mueck A. O., Seeger H., Wallwiener D. Effect of statins combined with estradiol on the proliferation of human receptor-positive and receptor-negative breast cancer cells. Menopause 2003; 10: 332–336
  • Seeger H., Wallwiener D., Mueck A. O. Statins can inhibit proliferation of human breast cancer cells in vitro. Exp Clin Endocrinol Diabetes 2003; 111: 47–48
  • Gronich N., Drucker L., Shapiro H., Radnay J., Yarkosi S., Lishner M. Symvastatin induces death of multiple myeloma cell lines. J Invest Med 2004; 52: 335–344
  • Janosi J., Sebestyen A., Bocsi J., Barna G., Nagy K., Vályi-Nagy I., Kopper L. Mevastatin-induced apoptosis and growth suppression in U266 myeloma cells. Anticancer Res 2004; 24: 1817–1822
  • Liu Z. L., Luo J. M., Dong Z. R., Wang F. X., Zhang X. J., Yang J. C., Du X. Y., Yao L. In vitro effects of mevastatin on the proliferation and apoptosis in human multiple myeloma cell line U266. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004; 12: 340–345
  • Shibata M. A., Ito Y., Morimoto J., Otsuki Y. Lovastatin inhibits tumor growth and lung metastatsis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism. Carcinogene 2004; 25: 1887–1898
  • Czarna M., Jarmuszkiewicz W. Role of mitochondria in reactive oxygen species generation and removal; relevance to signaling and programmed cell death. Postepy Biochem 2006; 52: 145–156
  • Santillo M., Mondola P., Gioielli A., Serù R., Iossa S., Annella T., Vitale M., Bifulco M. Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells. Biochem Biophys Res Commun 1996; 229: 739–745
  • Castelazo G., Molotla D., Basavilvazo M. A., Angeles L., Zarate A., Hernandez M. Survival of breast cancer patients treated with inhibitors of the aromatase vs tamoxifen. Ginecol Obstet Mex 2004; 72: 493–499
  • Valladares A., Salamanca F., Madrigal-Bujaidar E., Arenas D. Identification of chromosomal changes with comparative genomic hybridization in sporadic breast cancer in Mexican women. Cancer Genet Cytogenet 2004; 152: 163–166
  • Denoyelle C., Vasse M., Korner M., Mishal Z., Ganné F., Vannier J. P., Soria J., Soria C. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic propeties of highly invasive breast cancer cell lines: an in vitro study. Carcinogene 2001; 22: 1139–1148
  • Kueng W., Silber E., Eppenberg V. Quantification of cells cultured on 96-well plates. Analytical Biochem 1989; 186: 16–19
  • Zapata E., Ventura J. L., De la Cruz K., Rodriguez E., Damián P., Massó F., Montaño L. F., López-Marure R. Dehydroepiandrosterone inhibits the proliferation of HUVEC by enhancing the expression of p53 and p21, restricting the phosphorylation of RB, and is androgen- and estrogen-receptor independent. FEBS J 2005; 272: 1343–1353
  • Zhang Y. H., Peng H. Y., Xia G. H., Wang M. Y., Han Y. Anticancer effect of two diterpenoid compounds isolated from Annona glabra Linn. Acta Pharmacol Sin 2004; 25: 937–942
  • Rothe G., Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J Leukoc Biol 1990; 47: 440–448
  • Haugland R. P. Handbook of fluorescent probes and research chemicals. Molecular Probes Inc., Eugene, OR 1996
  • Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med 2004; 8: 455–464
  • Duncan R. E., Lau D., El-Sohemy A., Archer M. C. Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem Pharmacol 2004; 68: 1739–1747
  • Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam. Clin Pharmacol 2005; 19: 117–125
  • Lennernas H., Fager G. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clin Pharmacokinet 1997; 32: 403–425
  • Lopez E., Sepulveda A. C., Rivera H., Cerecedo F., Valdez M., Villasis M. A. Security and maximal tolerated doses of fluvastatin in pediatric cancer patients. Arch Med Res 1999; 30: 128–131
  • Serajuddin A. T., Ranadive S. A., Mahoney E. M. Relative lipophilicities, solubilities, and structure-pharmacological considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin. J Pharm Sci 1991; 80: 830–834
  • Hamelin B. A., Turgeon J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci 1998; 19: 26–37
  • Li L., Zou L. Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem 2005; 94: 298–306
  • Addeo R., Altucci L., Battista T., Bonapace I. M., Cancemi M., Cicatiello L., Germano D., Pacilio C., Salzano S., Bresciani F., Weisz A. Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest HMG-CoA reductase inhibitors. Biochem Biophys Res Commun 1996; 220: 864–870
  • Sutter A. P., Maaser K., Hopfner M., Huether A., Schuppan D., Scherubl H. Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor. J Hepatol 2005; 43: 808–816
  • Holstein S. A., Hohl R. J. Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther 2001; 1: 141–149
  • Kozar K., Kaminski R., Legat M., Kopec M., Nowis D., Skierski J. S., Koronkiewicz M., Jakóbisiak M., Golab J. Cerivastatin demonstrated enhanced antitumor activity against human breast cancer cell lines when used in combination with doxorubicin or cisplatin. Int J Oncol 2004; 24: 1149–1157
  • Chapman-Shimshoni D., Yuklea M., Radnay J., Shapiro H., Lishner M. Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9. Exp Hematol 2003; 31: 779–783
  • Stoll L. L., McCormick M. L., Denning G. M., Weintraub N. L. Antioxidant effects of statins. Timely Top Med Cardiovasc Dis 2005; 9: E1
  • Hu T. P., Xu F. P., Li Y. J., Luo J. D. Simvastatin inhibits leptin-induced hypertrophy in cultured neonatal rat cardiomyocytes. Acta Pharmacol Sin 2006; 27: 419–422
  • Arai M., Imai H., Koumura T., Yoshida M., Emoto K., Umeda M., Chiba N., Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem 1999; 274: 4924–4933
  • Wei N., Mi M. T., Zhou Y. Influences of lovastatin on membrane ion flow and intracellular signaling in breast cancer cells. Cell Mol Biol Lett 2007; 12: 1–15
  • Xu R., Chen J., Cong X., Hu S., Chen X. Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2. J Cell Biochem 2007; 103: 256–269
  • Kaufmann P., Török M., Zahno A., Waldhauser K. M., Brecht K., Krähenbühl S. Toxicity of statins on rat skeletal muscle mitochondria. Cell Mol Life Sci 2006; 63: 2415–2425
  • Kim Y. C., Song S. B., Lee M. H., Kang K. I., Lee H., Paik S. G., Kim K. E., Kim Y. S. Simvastatin induces caspase-independent apoptosis in LPS-activated RAW264.7 macrophage cells. Biochem Biophys Res Commun 2006; 339: 1007–1014
  • Koyuturk M., Ersoz M., Altiok N. Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen independent pathway requiring signalling through JNK. Cancer Lett 2007; 250: 220–228
  • Cafforio P., Dammacco F., Gernone A., Silvestris F. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 2005; 26: 883–891
  • Zalatnai A. Review: potential role of cell cycle synchronizing agents in combination treatment modalities of malignant tumors. In Vivo 2005; 19: 85–91
  • Kotamraju S., Williams C. L., Kalyanaraman B. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer Res 2007; 67: 7386–7394

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