Lupeol, a Dietary Triterpene, Inhibited Growth, and Induced Apoptosis Through Down-Regulation of DR3 in SMMC7721 Cells

REFERENCES

• Parkin D. M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74–108
   PubMed Web of Science ®Google Scholar
• Kojiro M. Histopathology of liver cancers. Best Pract Res Clin Gastroenterol 2005; 19: 39–62
   PubMed Web of Science ®Google Scholar
• Lee S. M., Li M. L., Tse Y. C., et al. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci 2002; 71: 2267–2277
   PubMed Web of Science ®Google Scholar
• Zhang Y. H., Peng H. Y., Xia G. H., et al. Anticancer effect of two diterpenoid compounds isolated from Annona glabra Linn. Acta Pharmacol Sin 2004; 25: 937–942
   PubMed Web of Science ®Google Scholar
• Jung E. M., Lim J. H., Lee T. J., et al. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005; 26: 1905–1913
   PubMed Web of Science ®Google Scholar
• Yeh C. T., Yen G. C. Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. J Agric Food Chem 2005; 53: 1740–1749
   PubMed Web of Science ®Google Scholar
• Song G., Luo Q., Qin J., et al. Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids Surf B Biointerfaces 2006; 48: 1–5
   PubMed Web of Science ®Google Scholar
• Selvendiran K., Koga H., Ueno T., et al. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: An implication for the antitumor potential of flavonoids. Cancer Res 2006; 66: 4826–4834
   PubMed Web of Science ®Google Scholar
• Saleem M., Alam A., Arifin S., et al. Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin. Pharmacol Res 2001; 43: 127–134
   PubMed Web of Science ®Google Scholar
• Beveridge T. H., Li T. S., Drover J. C. Phytosterol content in American ginseng seed oil. J Agric Food Chem 2002; 50: 744–750
   PubMed Web of Science ®Google Scholar
• Kakuda R., Iijima T., Yaoita Y., et al. Triterpenoids from Gentiana scabra. Phytochemistry 2002; 59: 791–794
   Google Scholar
• Aratanechemuge Y., Hibasami H., Sanpin K., et al. Induction of apoptosis by lupeol isolated from mokumen (Gossampinus malabarica L. Merr) in human promyelotic leukemia HL-60 cells. Oncol Rep 2004; 11: 289–292
   PubMed Web of Science ®Google Scholar
• Hata K., Hori K., Takahashi S. Role of p38 MAPK in lupeol-induced B16 2F2 mouse melanoma cell differentiation. J Biochem (Tokyo) 2003; 134: 441–445
   PubMed Web of Science ®Google Scholar
• Hata K., Hori K., Ogasawara H., et al. Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene. Toxicol Lett 2003; 143: 1–7
   PubMed Web of Science ®Google Scholar
• Saleem M., Afaq F., Adhami V. M., et al. Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 2004; 23: 5203–5214
   PubMed Web of Science ®Google Scholar
• Saleem M., Kweon M. H., Yun J. M., et al. A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model. Cancer Res 2005; 65: 11203–11213
   PubMed Web of Science ®Google Scholar
• Saleem M., Kaur S., Kweon M. H., et al. Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. Carcinogenesis 2005; 26: 1956–1964
   PubMed Web of Science ®Google Scholar
• Gout S., Morin C., Houle F., et al. Death receptor-3, a new E-Selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation. Cancer Res 2006; 66: 9117–9124
   PubMed Web of Science ®Google Scholar
• Rokhlin O. W., Glover R. A., Cohen M. B. Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7. Cancer Res 1998; 58: 5870–5875
   PubMed Web of Science ®Google Scholar
• Jiang S., Song M. J., Shin E. C., et al. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology 1999; 29: 101–110
   PubMed Web of Science ®Google Scholar
• Sarka F. H., Li Y. Cell signaling pathways altered by natural chemopreventive agents. Mutat Res 2004; 555: 53–64
   PubMed Web of Science ®Google Scholar
• Kinghorn A. D., Su B. N., Jang D. S., et al. Natural inhibitors of carcinogenesis. Planta Med 2004; 70: 691–705
   PubMed Web of Science ®Google Scholar
• Hsu S. H., Tsai T. R., Lin C. N., et al. Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR I which may lead to cell apoptosis. Biochem Biophys Res Commun 1996; 229: 1–5
   PubMed Web of Science ®Google Scholar
• Kuo K. W., Hsu S. H., Li Y. P., et al. Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochem Pharmacol 2000; 60: 1865–1873
   PubMed Web of Science ®Google Scholar
• Lyu S. Y., Choi S. H., Park W. B. Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch Pharm Res 2002; 25: 93–101
   PubMed Web of Science ®Google Scholar
• Marsters S. A., Sheridan J. P., Pitti R. M., et al. Identification of a ligand for the death-domain-containing receptor Apo3. Curr Biol 1998; 8: 525–528
   PubMed Web of Science ®Google Scholar
• Chinnaiyan A. M., O'Rourke K., Yu G. L., et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274: 990–992
   PubMed Web of Science ®Google Scholar
• Higaki K., Yano H., Kojiro M. Fas antigen expression and its relationship with apoptosis in human hepatocellular carcinoma and noncancerous tissues. Am J Pathol 1996; 149: 429–437
   PubMed Web of Science ®Google Scholar
• Beg A. A., Sha W. C., Bronson R. T., et al. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995; 376: 167–170
   PubMed Web of Science ®Google Scholar
• Barkett M., Gilmore T. D. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 1999; 18: 6910–6924
   PubMed Web of Science ®Google Scholar
• Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221–227
   PubMed Web of Science ®Google Scholar
• Bamias G., Mishina M., Nyce M., et al. Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc Natl Acad Sci USA 2006; 103: 8441–8446
   PubMed Web of Science ®Google Scholar
• Young H. A., Tovey M. G. TL1A: A mediator of gut inflammation. Proc Natl Acad Sci U SA 2006; 103: 8303–8304
   PubMed Web of Science ®Google Scholar