Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens

References

• WHO. Lack of new antibiotics threatens global efforts to contain drug-resistant infections. 2020. [cited 2020 Dec 11]. Available from https://www.who.int/news/item/17-01-2020-lack-of-new antibiotics-threatens-global-efforts-to-contain-drug-resistant-infections.
   Google Scholar
• World Health Organization. Antimicrobial resistance. 2021. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.
   Google Scholar
• Tiwari P, Khare T, Shriram V, et al. Exploring synthetic biology strategies for producing potent antimicrobial phytochemicals. Biotechnol Adv. 2021;48:107729. doi: 10.1016/j.biotechadv.2021.107729.
   PubMed Web of Science ®Google Scholar
• Tiwari P, Srivastava Y, Bae H. Trends of pharmaceutical design of endophytes as anti-infective. Curr Top Med Chem. 2021;21:1572–1586. doi: 10.2174/1568026621666210524093234.
   PubMed Web of Science ®Google Scholar
• Tiwari P, Srivastava Y, Kumar V. Antimicrobial peptides as effective agents against drug-resistant pathogens. In: Kumar V, Shriram V, Paul A, Thakur M, editors. Antimicrobial resistance. Singapore: Springer; 2022. p. 289–322.
   Google Scholar
• World Health Organization. Antimicrobial Resistance: global Report on Surveillance 2014. Geneva: WHO; 2014.
   Google Scholar
• European Centre for Disease Prevention and Control. Surveillance of antimicrobial resistance in Europe 2018. Stockholm: ECDC; 2019.
   Google Scholar
• GBD. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2019;2022:s0140-6736(22)02185–02187. Antimicrobial Resistance Collaborators
   Google Scholar
• Hernando-Amado S, Coque TM, Baquero F, et al. Defining and combating antibiotic resistance from One Health and Global Health perspectives. Nat Microbiol. 2019;4:1432–1442. doi: 10.1038/s41564-019-0503-9.
   PubMed Web of Science ®Google Scholar
• Sharma A, Mistry V, Kumar V, et al. Production of effective phyto-antimicrobials via metabolic engineering strategies. Curr Top Med Chem. 2022;22:1068–1092. doi: 10.2174/1568026622666220310104645.
   PubMed Web of Science ®Google Scholar
• Wernli D, Jørgensen PS, Morel CM, et al. Mapping global policy discourse on antimicrobial resistance. BMJ Glob Health. 2017;2:e000378. doi: 10.1136/bmjgh-2017-000378.
   PubMed Web of Science ®Google Scholar
• Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med. 2004;10:S122–S129. doi: 10.1038/nm1145.
   PubMed Web of Science ®Google Scholar
• Yu Z, Tang J, Khare T, et al. The alarming antimicrobial resistance in ESKAPEE pathogens: can essential oils come to the rescue? Fitoterapia. 2020;140:104433. doi: 10.1016/j.fitote.2019.104433.
   PubMed Web of Science ®Google Scholar
• WHO. Critically important antimicrobials for human medicine. 2017. doi: 10.1017/CBO9781107415324.004.
   Google Scholar
• Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399:629–655. doi: 10.1016/S0140-6736(21)02724-0.
   PubMed Web of Science ®Google Scholar
• About Antimicrobial Resistance. 2018. www.cdc.gov.
   Google Scholar
• Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2019. US Department of Health and Human Services, Centres for Disease Control and Prevention. 2019. [accessed 2020 Nov 21]. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf.
   Google Scholar
• Dadgostar P. Antimicrobial resistance: implications and costs. Infect Drug Resist. 2019;12:3903–3910. doi: 10.2147/IDR.S234610.
   PubMed Web of Science ®Google Scholar
• Pulingam T, Parumasivam T, Mohd Gazzali A, et al. Antimicrobial resistance: prevalence, economic burden, mechanisms of resistance and strategies to overcome. Eur J Pharm Sci. 2022;170:106103. doi: 10.1016/j.ejps.2021.106103.
   PubMed Web of Science ®Google Scholar
• O’Neill J. Review on antimicrobial resistance. Antimicrobial Resistance: tackling a crisis for the health and wealth of nations. The review on antimicrobial resistance chaired by Jim O'Neill (2014). Available from: https://wellcomecollection.org/works/rdpck35v.
   Google Scholar
• World Health Organization. Global antimicrobial resistance and use surveillance system (GLASS) report: 2021. 2021.
   Google Scholar
• Diwan V, Tamhankar AJ, Khandal RK, et al. Antibiotics and antibiotic-resistant bacteria in waters associated with a hospital in Ujjain, India. BMC Public Health. 2010;10:414. doi: 10.1186/1471-2458-10-414.
   PubMed Web of Science ®Google Scholar
• Hartmann A, Golet EM, Gartiser S, et al. Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital wastewaters. Arch Environ Contam Toxicol. 1999;36:115–119. doi: 10.1007/s002449900449.
   PubMed Web of Science ®Google Scholar
• Hoffman SJ, Outterson K, Røttingen JA, et al. An international legal framework to address antimicrobial resistance. Bull World Health Organ. 2015;93:66–66. doi: 10.2471/BLT.15.152710.
   PubMed Web of Science ®Google Scholar
• COVID-19: U.S. impact on antimicrobial resistance, special report 2022. CDC; 2022. doi: 10.15620/cdc:117915.
   Google Scholar
• Ko KKK, Chng KR, Nagarajan N. Metagenomics-enabled microbial surveillance. Nat Microbiol. 2022;7:486–496. doi: 10.1038/s41564-022-01089-w.
   PubMed Web of Science ®Google Scholar
• WHO recommended surveillance standards. 2nd ed. Geneva: WHO; 1999.
   Google Scholar
• (HTM 04-01) safe water in healthcare premises. London: NHS England; 2017.
   Google Scholar
• Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pan drug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–281. doi: 10.1111/j.1469-0691.2011.03570.x.
   PubMed Web of Science ®Google Scholar
• The Pew Charitable Trusts. Tracking the global pipeline of antibiotics in development, April 2020. The Pew Charitable Trusts. 2020. https://www.pewtrusts.org/en/research-and-analysis/issue-briefs/2020/04/tracking the-global-pipeline-of-antibiotics-in-development.
   Google Scholar
• Beyer P, Paulin S. The antibacterial research and development pipeline need urgent solutions. ACS Infect Dis. 2020;6:1289–1291. doi: 10.1021/acsinfecdis.0c00044.
   Web of Science ®Google Scholar
• World Health Organization (WHO). Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline. 2019. https://apps.who.int/iris/bitstream/handle/10665/330420/9789240000193-eng.pdf.
   Google Scholar
• Stincon P, Brandelli A. Marine bacteria as a source of antimicrobial compounds. Crit Rev Biotechnol. 2020;40:306–319. doi: 10.1080/07388551.2019.1710457.
   PubMed Web of Science ®Google Scholar
• Crits-Christoph A, Diamond S, Butterfield CN, et al. Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis. Nature. 2018;558:440–444. doi: 10.1038/s41586-018-0207-y.
   PubMed Web of Science ®Google Scholar
• Liu G, Catacutan DB, Rathod K, et al. Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii. Nat Chem Biol. 2023;19:1342–1350. doi: 10.1038/s41589-023-01349-8.
   PubMed Web of Science ®Google Scholar
• Singh SB, Phillips JW, Wang J. Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing. Curr Opin Drug Discov Devel. 2007;10:160–166.
   PubMedGoogle Scholar
• La Fuente-Núñez C. d, Lu TK. CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects. Integr Biol (Camb). 2017;9:109–122. doi: 10.1039/c6ib00140h.
   PubMed Web of Science ®Google Scholar
• WHO global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. 2016. [cited 2021 May 1]. Available from https://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf?ua=1.
   Google Scholar
• Terreni M, Taccani M, Pregnolato M. New antibiotics for multidrug-resistant bacterial strains: latest research developments and future perspectives. Molecules. 2021;26:2671. doi: 10.3390/molecules26092671.
   PubMed Web of Science ®Google Scholar
• Strobel G. The emergence of endophytic microbes and their biological promise. JoF. 2018;4:57. doi: 10.3390/jof4020057.
   Google Scholar
• Tiwari P, Srivastava Y, Bajpai M, et al. Bioactive metabolites from natural sources: prospects and significance in drug discovery and research. Bioingene PSJ. 2021;1:1–14.
   Google Scholar
• Tiwari P, Bajpai M, Sharma A. Antimicrobials from medicinal plants: key examples, success stories and prospects in tackling antibiotic resistance. LDDD. 2023;20:420–438. doi: 10.2174/1570180819666220620102427.
   Google Scholar
• Tiwari P, Hanhong B. Endophytic Fungi: key Insights, emerging prospects, and challenges in natural product drug discovery. Microorganisms. 2022;10:360. doi: 10.3390/microorganisms10020360.
   PubMed Web of Science ®Google Scholar
• Tiwari P, Kang S, Bae H. Plant-endophyte associations: rich yet under-explored sources of novel bioactive molecules and applications. Microbiol Res. 2023;266:127241. doi: 10.1016/j.micres.2022.127241.
   PubMedGoogle Scholar
• Tiwari P, Chen J-T, Muhammed Adil, et al. Major bioactive metabolites and antimicrobial potential of Orchidaceae Fungal endophytes. In: Tiwari P, Chen J-T, editors. Advances in orchid biology, biotechnology, and omics. Vol. 1. Cham: Springer; 2023.
   Google Scholar
• Ngashangva N, Mukherjee P, Sharma KC, et al. Analysis of Antimicrobial peptide metabolome of bacterial endophyte isolated from traditionally used medicinal plant Millettia pachycarpa Benth. Front Microbiol. 2021;12:656896. doi: 10.3389/fmicb.2021.656896.
   PubMed Web of Science ®Google Scholar
• Maciá-Vicente JG, Shi YN, Cheikh-Ali Z, et al. Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery. Environ Microbiol. 2018;20:1253–1270. doi: 10.1111/1462-2920.14072.
   PubMed Web of Science ®Google Scholar
• Tiwari P. 2022c. Endophytes: types, Potential Uses, and Mechanisms of Action. Hauppauge (NY): Nova Publishers.
   Google Scholar
• Bose SK, Das J, Bajpai M, et al. Endophytic Actinomycetes: overview, distribution, and multi-faceted applications. In: Tiwari P, editor. Endophytes: types, potential uses, and mechanisms of action. Hauppauge (NY): Nova Publishers; 2022.
   Google Scholar
• Park SY, Yang D, Ha SH, et al. Metabolic engineering of microorganisms for the production of natural compounds. Adv Biosys. 2017;1700190:1–41.
   Google Scholar
• Souli M, Galani I, Giamarellou H. Emergence of extensively drug-resistant and pandrug-resistant Gram-negative Bacilli in Europe. Euro Surveill. 2008;13:19045.
   PubMedGoogle Scholar
• Arias CA, Murray BE. Antibiotic-resistant bugs in the 21st century-a clinical super-challenge. N Engl J Med. 2009;360:439–443. doi: 10.1056/NEJMp0804651.
   PubMed Web of Science ®Google Scholar
• Krause KM, Serio AW, Kane TR, et al. Aminoglycosides: an overview. Cold Spring Harb Perspect Med. 2016;6:a027029. doi: 10.1101/cshperspect.a027029.
   PubMed Web of Science ®Google Scholar
• Pryka RD, Rodvold KA, Rotschafer JC. Teicoplanin: an investigational glycopeptide antibiotic. Clin Pharm. 1988;7:647–658.
   PubMedGoogle Scholar
• Beauduy CE, Winsto LG. Beta-lactam and other cell wall- & membrane-active antibiotics. In: katzung, BG, editor. Basic & clinical pharmacology, 14th ed. San Francisco (CA): A Lange Medical Book; McGraw-Hill Education; 2018. p. 795–814.
   Google Scholar
• Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:1151–1161. doi: 10.1128/AAC.45.4.1151-1161.2001.
   PubMed Web of Science ®Google Scholar
• Scaglione F, Rossoni G. Comparative anti-inflammatory effects of roxithromycin, azithromycin, and clarithromycin. J Antimicrob Chemother. 1998;41(Suppl B):47–50. doi: 10.1093/jac/41.suppl_2.47.
   PubMedGoogle Scholar
• Eliopoulos GM, Huovinen P. Resistance to trimethoprim-sulfamethoxazole. Clin Infect Dis. 2001;32:1608–1614. doi: 10.1086/320532.
   PubMed Web of Science ®Google Scholar
• Fernandes P, Martens E. Antibiotics in late clinical development. Biochem Pharmacol. 2017;133:152–163. doi: 10.1016/j.bcp.2016.09.025.
   PubMed Web of Science ®Google Scholar
• Das S, Li J, Riccobene T, et al. Dose selection and validation for ceftazidime-avibactam in adults with complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial pneumonia. Antimicrob Agents Chemother. 2019;63:e02187–18. doi: 10.1128/AAC.02187-18.
   PubMed Web of Science ®Google Scholar
• Shields RK, Potoski BA, Haidar G, et al. Clinical outcomes, drug toxicity, and the emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections. Clin Infect Dis. 2016;63:1615–1618. doi: 10.1093/cid/ciw636.
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration. Drug Approval Package: ZEMDRI (plazomicin). South San Francisco (CA): Achaogen, Inc.; 2018. [cited 2020 Jun 8]. Available from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210303Orig1s000Approv.pdf.
   Google Scholar
• Eljaaly K, Alharbi A, Alshehri S, et al. Plazomicin: a novel aminoglycoside for the treatment of resistant Gram-negative bacterial infections. Drugs. 2019;79:243–269. doi: 10.1007/s40265-019-1054-3.
   PubMed Web of Science ®Google Scholar
• Bonomo RA. Cefiderocol: a novel siderophore cephalosporin defeating carbapenem-resistant pathogens. Clin Infect Dis. 2019;69:S519–S520. doi: 10.1093/cid/ciz823.
   PubMed Web of Science ®Google Scholar
• Donadio S, Maffioli S, Monciardini P, et al. Antibiotic discovery in the twenty-first century: current trends and future perspectives. J Antibiot. 2010;63:423–430. doi: 10.1038/ja.2010.62.
   PubMed Web of Science ®Google Scholar
• Karlowsky JA, Laing NM, Baudry T, et al. In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother. 2007;51:1580–1581. doi: 10.1128/AAC.01254-06.
   PubMed Web of Science ®Google Scholar
• Schneider T, Gries K, Josten M, et al. The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate. Antimicrob Agents Chemother. 2009;53:1610–1618. doi: 10.1128/AAC.01040-08.
   PubMed Web of Science ®Google Scholar
• Stachyra T, Levasseur P, Péchereau MC, et al. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. J Antimicrob Chemother. 2009;64:326–329. doi: 10.1093/jac/dkp197.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2016.[AQ]
   Google Scholar
• Gonçalves ASC, Leitão MM, Simões M, et al. The action of phytochemicals in biofilm control. Nat Prod Rep. 2023;40:595–627. doi: 10.1039/d2np00053a.
   PubMed Web of Science ®Google Scholar
• Prasch S, Bucar F. Plant derived inhibitors of bacterial efflux pumps: an update. Phytochem Rev. 2015;14:961–974. doi: 10.1007/s11101-015-9436-y.
   Web of Science ®Google Scholar
• Zhang QY, Yan ZB, Meng YM, et al. Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res. 2021;8:48. doi: 10.1186/s40779-021-00343-2.
   PubMed Web of Science ®Google Scholar
• Holaskova E, Galuszka P, Frebort I, et al. Antimicrobial peptide production and plant-based expression systems for medical and agricultural biotechnology. Biotechnol Adv. 2015;33:1005–1023. doi: 10.1016/j.biotechadv.2015.03.007.
   PubMed Web of Science ®Google Scholar
• Mahlapuu M, Björn C, Jonas Ekblom J. Antimicrobial peptides as therapeutic agents: opportunities and challenges. Crit Rev Biotechnol. 2020;40:978–992. doi: 10.1080/07388551.2020.1796576.
   PubMed Web of Science ®Google Scholar
• Pasupuleti M, Schmidtchen A, Malmsten M. Antimicrobial peptides: key components of the innate immune system. Crit Rev Biotechnol. 2012;32:143–171. doi: 10.3109/07388551.2011.594423.
   PubMed Web of Science ®Google Scholar
• Hardoim PR, Overbeek LS, Berg G, et al. The hidden world within plants: ecological and evolutionary considerations for defining functioning of microbial endophytes. Microbiol Mol Biol Rev. 2015;79:293–320. doi: 10.1128/MMBR.00050-14.
   PubMed Web of Science ®Google Scholar
• Tiwari P, Bae H. Trends in harnessing plant Endophytic microbiome for heavy metal mitigation in plants: a perspective. Plants. 2023c;12:1515. doi: 10.3390/plants12071515.
   Google Scholar
• Tiwari P, Bae H. Horizontal gene transfer and endophytes: an implication for the acquisition of novel traits. Plants. 2020;9:305. doi: 10.3390/plants9030305.
   Google Scholar
• Tiwari P, Mohd A, Bae H. Endophyte-mediated bioremediation- an efficient biological strategy in ecological subsistence and agriculture. In: Endophytic and arbuscular mycorrhizal fungi and their role in sustainable agriculture. Vol. 1. Hauppauge (NY): Nova Publishers USA; 2023. p. 200.
   Google Scholar
• Yu H, Zhang L, Li L, et al. Recent developments and future prospects of antimicrobial metabolites produced by endophytes. Microbiol Res. 2010;165:437–449. doi: 10.1016/j.micres.2009.11.009.
   PubMed Web of Science ®Google Scholar
• Caruso DJ, Palombo EA, Moulton SE, et al. Exploring the promise of Endophytic fungi: a review of novel antimicrobial compounds. Microorganisms. 2022;10:1990. doi: 10.3390/microorganisms10101990.
   PubMed Web of Science ®Google Scholar
• Digra S, Nonzom S. An insight into endophytic antimicrobial compounds: an updated analysis. Plant Biotechnol Rep. 2023;17:427–457. 2023 doi: 10.1007/s11816-023-00824-x.
   Web of Science ®Google Scholar
• Joo H-S, Deyrup ST, Shim SH. Endophyte-produced antimicrobials: a review of potential lead compounds with a focus on quorum-sensing disruptors. Phytochem Rev. 2020;20:543–568. doi: 10.1007/s11101-020-09711-7.
   Web of Science ®Google Scholar
• Zhao J, Zhou L, Wang J, et al. Endophytic fungi for producing bioactive compounds originally from their host plants. In: Current research, technology and education topics in applied microbiology and microbial biotechnology. Vol. 1, 1st ed. Badajoz (Spain): Formatex Research Center, 2010. p. 567–576.
   Google Scholar
• Zhao M, Yuan L-Y, Guo D-L, et al. Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica. Phytochemistry. 2018;148:97–103. 2018 doi: 10.1016/j.phytochem.2018.01.018.
   PubMed Web of Science ®Google Scholar
• Deshmukh SK, Gupta MK, Prakash V, et al. Endophytic fungi: a source of potential antifungal compounds. JoF. 2018;4:77. doi: 10.3390/jof4030077.
   Google Scholar
• He J, Li Z-H, Ai H-L, et al. Anti-bacterial chromones from cultures of the endophytic fungus Bipolaris eleusines. Nat Prod Res. 2019;33:3515–3520. doi: 10.1080/14786419.2018.1486313.
   PubMed Web of Science ®Google Scholar
• Rai N, Kumari Keshri P, Verma A, et al. Plant-associated fungal endophytes as a source of natural bioactive compounds. Mycology. 2021;12:139–159. doi: 10.1080/21501203.2020.1870579.
   PubMedGoogle Scholar
• Jin Z, Li D, Liu T, et al. Cultural endophytic fungi associated with Dendrobium officinale: identifcation, diversity estimation, and their antimicrobial potential. Curr Sci. 2017;112:1690–1697. doi: 10.18520/cs/v112/i08/1690-1697.
   Web of Science ®Google Scholar
• Strobel GA, Miller RV, Martinez-Miller C, et al. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology. 1999b;145(Pt 8):1919–1926. doi: 10.1099/13500872-145-8-1919.
   PubMed Web of Science ®Google Scholar
• Zou W, Meng J, Lu H, et al. Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. J Nat Prod. 2000;63:1529–1530. doi: 10.1021/np000204t.
   PubMed Web of Science ®Google Scholar
• Zhang G, Sun S, Zhu T, et al. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry. 2011;72:1436–1442. doi: 10.1016/j.phytochem.2011.04.014.
   PubMed Web of Science ®Google Scholar
• Castillo UF, Strobel GA, Ford EJ, et al. Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 3052, endophytic on Kennedia nigriscansa. Microbiology. 2002;148:2675–2685. doi: 10.1099/00221287-148-9-2675.
   PubMed Web of Science ®Google Scholar
• Xing YM, Chen J, Cui JL, et al. Antimicrobial activity and biodiversity of endophytic fungi in Dendrobium devonianum and Dendrobium thyrsiflorum from Vietnam. Curr Microbiol. 2010;62:1218–1224. doi: 10.1007/s00284-010-9848-2.
   PubMed Web of Science ®Google Scholar
• Zhang S-P, Huang R, Li F-F, et al. Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli. Fitoterapia. 2016;112:85–89. doi: 10.1016/j.fitote.2016.05.013.
   PubMed Web of Science ®Google Scholar
• Sunkar S, Nachiyar CV. Isolation and characterization of antimicrobial compounds produced by endophytic fungus Aspergillus sp. isolated from Writhtia tintorica. J Pharm Res. 2011;4:1136–1137.
   Google Scholar
• Sudharshana T, Venkatesh H, Nayana B, et al. Anti-microbial and anti-mycotoxigenic activities of endophytic Alternaria alternata isolated from Catharanthus roseus (L.) G. Don.: molecular characterization and bioactive compound isolation. Mycology 2019. 2019;10:40–48. doi: 10.1080/21501203.2018.1541933.
   Google Scholar
• Atri N, Rai N, Singh AK, et al. Screening for endophytic fungi with antibacterial efficiency from Moringa oleifera and Withania somnifera. JSR. 2020;64:127–133. doi: 10.37398/JSR.2020.640118.
   Google Scholar
• Liu F, Cai X-L, Yang H, et al. The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce. Planta Med. 2010;76:185–189. doi: 10.1055/s-0029-1186047.
   PubMed Web of Science ®Google Scholar
• Santos IP, Silva LCN, Silva MV, et al. Antibacterial activity of endophytic fungi from leaves of Indigofera suffruticosa Miller (Fabaceae). Front Microbiol. 2015;6:350. doi: 10.3389/fmicb.2015.00350.
   PubMed Web of Science ®Google Scholar
• Kumar S, Aharwal RP, Shukla H, et al. Endophytic fungi: as a source of antimicrobials bioactive compounds. World J Pharm Sci. 2014;3:1179–1197.
   Google Scholar
• Arivudainambi UE, Anand TD, Shanmugaiah V, et al. Novel bioactive metabolites producing endophytic fungus Colletotrichum gloeosporioides against multidrug-resistant Staphylococcus aureus. FEMS Immunol Med Microbiol. 2011;61:340–345. doi: 10.1111/j.1574-695X.2011.00780.x.
   PubMed Web of Science ®Google Scholar
• Ma YM, Liang XA, Zhang HC, et al. Cytotoxic and antibiotic cyclic pentapeptide from an endophytic Aspergillus tamarii of Ficus carica. J Agric Food Chem. 2016;64:3789–3793. 2016 doi: 10.1021/acs.jafc.6b01051.
   PubMed Web of Science ®Google Scholar
• Wu H, Yang H, You X, et al. Isolation and characterization of saponin-producing fungal endophytes from Aralia elata in Northeast China. Int J Mol Sci. 2012;13:16255–16266. doi: 10.3390/ijms131216255.
   PubMed Web of Science ®Google Scholar
• Saxena S, Meshram V, Kapoor N. Muscodor tigerii sp. nov.-volatile antibiotic producing endophytic fungus from the North-eastern Himalayas. Ann Microbiol. 2015;65:47–57. doi: 10.1007/s13213-014-0834-y.
   Web of Science ®Google Scholar
• Zaher AM, Makboul MA, Moharram AM, et al. A new Enniatin antibiotic from the endophyte Fusarium tricinctum Corda. J Antibiot. 2015;68:197–200. doi: 10.1038/ja.2014.129.
   PubMed Web of Science ®Google Scholar
• Ibrahim D, Lee CC, Yenn TW, et al. Effect of the extract of endophytic fungus, Nigrospora sphaerica CL-OP 30, against the growth of methicillin- resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia cells. Trop J Pharm Res. 2015;14:2091–2097. doi: 10.4314/tjpr.v14i11.20.
   Web of Science ®Google Scholar
• Bin G, Yanping C, Hong Z, et al. Isolation, characterization, and anti-multiple drug-resistant (MDR) bacterial activity of endophytic fungi isolated from the mangrove plant, Aegiceras corniculatum. Trop J Pharm Res. 2014;13:593–599. doi: 10.4314/tjpr.v13i4.16.
   Web of Science ®Google Scholar
• Ukwatta KM, Lawrence JL, Wijayarathna CD. The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica. Mycology. 2019;10:222–228. doi: 10.1080/21501203.2019.1620892.
   PubMedGoogle Scholar
• Jasim B, Sreelakshmi S, Mathew J, et al. Identification of endophytic Bacillus mojavensis with highly specialized broad-spectrum antibacterial activity. 3 Biotech. 2016;6:187. doi: 10.1007/s13205-016-0508-5.
   PubMedGoogle Scholar
• Tejesvi MV, Segura DR, Schnorr KM, et al. An antimicrobial peptide from endophytic Fusarium tricinctum of Rhododendron tomentosum Harmaja. Fungal Diversity. 2013;60:153–159. doi: 10.1007/s13225-013-0227-8.
   Web of Science ®Google Scholar
• Sharaf MH, Abdelaziz AM, Kalaba MH, et al. Antimicrobial, antioxidant, cytotoxic activities and phytochemical analysis of fungal endophytes isolated from Ocimum basilicum. Appl Biochem Biotechnol. 2022;194:1271–1289. doi: 10.1007/s12010-021-03702-w.
   PubMed Web of Science ®Google Scholar
• Nisa H, Kamili AN, Nawchoo IA, et al. Fungal endophytes as prolific source phytochemicals and other bioactive natural products: a review. Microb Pathog. 2015;82:50–59. doi: 10.1016/j.micpath.2015.04.001.
   PubMed Web of Science ®Google Scholar
• Bezerra JD, Nascimento CC, Barbosa RDN, et al. Endophytic fungi from medicinal plant Bauhinia forficata: diversity and biotechnological potential. Braz J Microbiol. 2015;46:49–57. 2015 doi: 10.1590/S1517-838246120130657.
   PubMed Web of Science ®Google Scholar
• El-Moslamy SH. Bioprocessing strategies for the cost-effective large-scale biogenic synthesis of nano-MgO from endophytic Streptomyces coelicolor strain E72 as an anti-multidrug-resistant pathogens agent. Sci Rep. 2018;8:3820. doi: 10.1038/s41598-018-22134-x.
   PubMed Web of Science ®Google Scholar
• Zin WWM, Buttachon S, Dethoup T, et al. Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006. Phytochemistry. 2017;141:86–97. doi: 10.1016/j.phytochem.2017.05.015.
   PubMed Web of Science ®Google Scholar
• Wang Q-X, Li S-F, Zhao F, et al. Chemical constituents from endophytic fungus Fusarium oxysporum. Fitoterapia. 2011;82:777–781. doi: 10.1016/j.fitote.2011.04.002.
   PubMed Web of Science ®Google Scholar
• Dissanayake RK, Ratnaweera PB, Williams DE, et al. Antimicrobial activities of endophytic fungi of the Sri Lankan aquatic plant Nymphaea nouchali and chaetoglobosin A and C, produced by the endophytic fungus Chaetomium globosum. Mycology. 2016a;7:1–8. doi: 10.1080/21501203.2015.1136708.
   PubMedGoogle Scholar
• Dissanayake RK, Ratnaweera PB, Williams DE, et al. Antimicrobial activities of mycoleptodiscin B isolated from endophytic fungus Mycoleptodiscus sp. of Calamus thwaitesii Becc. J Appl Pharm Sci. 2016b;6:1–6.
   Google Scholar
• Shi S, Li Y, Ming Y, et al. Biological activity and chemical composition of the endophytic fungus Fusarium sp. TP-G1 obtained from the root of Dendrobium officinale Kimura et Migo. RecNatProd. 2018;12:549–556. doi: 10.25135/rnp.62.17.12.201.
   Google Scholar
• Abdou R, Shaker K. Bioactive metabolites of the endophyte Khuskia oryzae isolated from the medicinal plant Bidens bipinnata. Asian J Pharm Life. 2013;3:137–145.
   PubMedGoogle Scholar
• Sun P, Huo J, Kurtán T, et al. Structural and stereochemical studies of hydroxyanthraquinone derivatives from the endophytic fungus Coniothyrium sp. Chirality. 2013;25:141–148. doi: 10.1002/chir.22128.
   PubMed Web of Science ®Google Scholar
• Zhang J, Liu D, Wang H, et al. Fusartricin, a sesquiterpenoid ether produced by an endophytic fungus Fusarium tricinctum Salicorn 19. Eur Food Res Technol. 2015;240:805–814. doi: 10.1007/s00217-014-2386-6.
   Web of Science ®Google Scholar
• Vaz ABM, Mota RC, Bomfim MRQ, et al. Antimicrobial activity of endophytic fungi associated with Orchidaceae in Brazil. Can J Microbiol. 2009;55:1381–1391. doi: 10.1139/W09-101.
   PubMed Web of Science ®Google Scholar
• Figueroa M, Jarmusch AK, Raja HA, et al. Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod. 2014;77:1351–1358. doi: 10.1021/np5000704.
   PubMed Web of Science ®Google Scholar
• Guo W, Zhang Z, Zhu T, et al. Penicyclones A–E, antibacterial polyketides from the deep-sea-derived fungus Penicillium sp. F23-2. J Nat Prod. 2015;78:2699–2703. doi: 10.1021/acs.jnatprod.5b00655.
   PubMed Web of Science ®Google Scholar
• Tedsree N, Likhitwitayawuid K, Sritularak B, et al. Antifungal activity of endophytic Streptomyces strains from Dendrobium orchids and the secondary metabolites of strain DR7-3 with its genome analysis. J Appl Pharm Sci. 2022;12:031–041.
   Google Scholar
• Castillo U, Harper JK, Strobel GA, et al. Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of Grevillea pteridifolia. FEMS Microbiol Lett. 2003;224:183–190. doi: 10.1016/S0378-1097(03)00426-9.
   PubMed Web of Science ®Google Scholar
• Hoffman AM, Mayer SG, Strobel GA, et al. Purification, identification, and activity of phomodione, a furandione from an endophytic Phoma species. Phytochemistry. 2008;69:1049–1056. doi: 10.1016/j.phytochem.2007.10.031.
   PubMed Web of Science ®Google Scholar
• Supong K, Thawai C, Choowong W, et al. Antimicrobial compounds from endophytic Streptomyces sp. BCC72023 isolated from rice (Oryza sativa L.). Res Microbiol. 2016;167:290–298. 2016 doi: 10.1016/j.resmic.2016.01.004.
   PubMed Web of Science ®Google Scholar
• Mangunwardoyo W, Suciatmih S, Gandjar I. Frequency of endophytic fungi isolated from Dendrobium crumenatum (Pigeon orchid) and antimicrobial activity. Biodiversitas. 2012;13:34–39.
   Google Scholar
• Ratnaweera PB, Williams DE, de Silva ED, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014;5:23–28. doi: 10.1080/21501203.2014.892905.
   PubMedGoogle Scholar
• Meng L-H, Li X-M, Liu Y, et al. Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach. RSC Adv. 2017;7:55026–55033. doi: 10.1039/C7RA12081H.
   Web of Science ®Google Scholar
• Rukachaisirikul V, Sommart U, Phongpaichit S, et al. Metabolites from the endophytic fungus Phomopsis sp. PSU-D15. Phytochemistry. 2008;69:783–787. doi: 10.1016/j.phytochem.2007.09.006.
   PubMed Web of Science ®Google Scholar
• Qi X, Li X, Zhao J, et al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019;72:237–240. doi: 10.1038/s41429-019-0144-5.
   PubMed Web of Science ®Google Scholar
• Subban K, Subramani R, Johnpaul M. A novel antibacterial and antifungal phenolic compound from the endophytic fungus Pestalotiopsis mangiferae. Nat Prod Res. 2013;27:1445–1449. doi: 10.1080/14786419.2012.722091.
   PubMed Web of Science ®Google Scholar
• Zhang W, Wei W, Shi J, et al. Natural phenolic metabolites from endophytic Aspergillus sp. IFB-YXS with antimicrobial activity. Bioorg Med Chem Lett. 2015;25:2698–2701. doi: 10.1016/j.bmcl.2015.04.044.
   PubMed Web of Science ®Google Scholar
• Kharwar RN, Verma VC, Kumar A, et al. Javanicin, an antibacterial Naphthaquinone from an Endophytic fungus of Neem, Chloridium sp. Curr Microbiol. 2009;58:233–238. doi: 10.1007/s00284-008-9313-7.
   PubMed Web of Science ®Google Scholar
• Khiralla A, Spina R, Varbanov M, et al. Evaluation of antiviral, antibacterial and antiproliferative activities of the endophytic fungus Curvularia papendorfii, and isolation of a new polyhydroxyacid. Microorganisms. 2020;8:1353. doi: 10.3390/microorganisms8091353.
   PubMed Web of Science ®Google Scholar
• Liu L, Liu S, Chen X, et al. Pestalofones A–E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorg Med Chem. 2009;17:606–613. doi: 10.1016/j.bmc.2008.11.066.
   PubMed Web of Science ®Google Scholar
• Oide S, Turgeon BG. Natural roles of nonribosomal peptide metabolites in fungi. Mycoscience. 2020;61:101–110. doi: 10.1016/j.myc.2020.03.001.
   Web of Science ®Google Scholar
• Xu W-F, Hou X-M, Yao F-H, et al. Xylapeptide A, an antibacteria cyclopentapeptide with an uncommon L-pipecolinic acid moiety from the associated fungus Xylaria sp. (GDG-102). Sci Rep. 2017;7:6937. doi: 10.1038/s41598-017-07331-4.
   PubMed Web of Science ®Google Scholar
• Guo J, Ran H, Zeng J, et al. Tafuketide, a phylogeny-guided discovery of a new polyketide from Talaromyces funiculosus Salicorn 58. Appl Microbiol Biotechnol. 2016;100:5323–5338. doi: 10.1007/s00253-016-7311-4.
   PubMed Web of Science ®Google Scholar
• Shi X-S, Wang D-J, Li X-M, et al. Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi. RSC Adv. 2017;7:51335–51342. doi: 10.1039/C7RA11122C.
   Web of Science ®Google Scholar
• Jouda J-B, Kusari S, Lamshöft M, et al. Penialidins A–C with strong antibacterial activities from Penicillium sp., an endophytic fungus harboring leaves of Garcinia nobilis. Fitoterapia. 2014;98:209–214. doi: 10.1016/j.fitote.2014.08.011.
   PubMed Web of Science ®Google Scholar
• Shi X-S, Meng L-H, Li X-M, et al. Antimicrobial Cadinane sesquiterpenes from Trichoderma virens QA-8, an endophytic fungus obtained from the medicinal plant Artemisia argyi. J Nat Prod. 2019;82:2470–2476. doi: 10.1021/acs.jnatprod.9b00139.
   PubMed Web of Science ®Google Scholar
• Ramos HP, Braun GH, Pupo MT, et al. Antimicrobial activity from endophytic fungi Arthrinium state of Apiospora montagnei Sacc. and Papulaspora immersa. Braz Arch Biol Technol. 2010;53:629–632. doi: 10.1590/S1516-89132010000300017.
   Web of Science ®Google Scholar
• Tonial F, Maia BH, Gomes-Figueiredo JA, et al. Influence of culturing conditions on bioprospecting and the antimicrobial potential of endophytic fungi from Schinus terebinthifolius. Curr Microbiol. 2016;72:173–183. doi: 10.1007/s00284-015-0929-0.
   PubMed Web of Science ®Google Scholar
• Guo B, Dai JR, Ng S, et al. Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species. J Nat Prod. 2000;63:602–604. doi: 10.1021/np990467r.
   PubMed Web of Science ®Google Scholar
• Strobel G, Ford E, Worapong J, et al. Ispoestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry. 2002;60:179–183. doi: 10.1016/s0031-9422(02)00062-6.
   PubMed Web of Science ®Google Scholar
• Zhang BG, Salituro D, Szalkowski Z, et al. Discovery of small molecule insulin mimetic with antidiabetic activity in mice. Science. 1999;284:974–977. doi: 10.1126/science.284.5416.974.
   PubMed Web of Science ®Google Scholar
• Borel JF, Kis ZL. The discovery and development of cyclosporine. Transplant Proc. 1991;23:1867–1874.
   PubMed Web of Science ®Google Scholar
• Wani MC, Taylor HL, Wall ME, et al. Plant antitumor agents VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93:2325–2327. doi: 10.1021/ja00738a045.
   PubMed Web of Science ®Google Scholar
• Toofanee SB, Dulymamode R. Fungal endophytes associated with Cordemoya integrifolia. Fungal Divers. 2002;11:169–175.
   Web of Science ®Google Scholar
• Christina A, Christapher V, Bhore SJ. Endophytic bacteria as a source of novel antibiotics: an overview. Pharmacogn Rev. 2013;7:11–16. doi: 10.4103/0973-7847.112833.
   PubMedGoogle Scholar
• Elfaky MA, Nasr H, Touiss I, et al. Streptomyces: a potential source of natural antimicrobial drug leads. In: Eco-friendly biobased products used in microbial diseases. 1st ed. Boca Raton (FL): CRC Press; 2022.
   Google Scholar
• Takahashi S, Takeuchi M, Arai M, et al. Studies on biosynthesis of pentalenolactone. V isolation of deoxypentalenylglucuron. J Antibiot. 1983;36:226–228. doi: 10.7164/antibiotics.36.226.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu W, Liang Z. Endophytic bacteria from Pinellia ternata, a new source of purine alkaloids and bacterial manure. Pharm Biol. 2015;53:1545–1548. doi: 10.3109/13880209.2015.1016580.
   PubMed Web of Science ®Google Scholar
• Singh M, Kumar A, Singh R, et al. Endophytic bacteria: a new source of bioactive compounds. 3 Biotech. 2017;7:315. doi: 10.1007/s13205-017-0942-z.
   PubMedGoogle Scholar
• Martinez-Klimova E, Rodríguez-Peña K, Sánchez S. Endophytes as sources of antibiotics. Biochem Pharmacol. 2017;134:1–17. doi: 10.1016/j.bcp.2016.10.010.
   PubMed Web of Science ®Google Scholar
• Chang S, Sievert DM, Hageman JC, et al. Vancomycin-resistant Staphylococcus aureus investigative team: infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene. N Engl J Med. 2003;348:1342–1347. 2003 doi: 10.1056/NEJMoa025025.
   PubMed Web of Science ®Google Scholar
• Sriravali K, Jindal AB, Singh BP, et al. Plant-associated endophytic fungi and its secondary metabolites against drug-resistant pathogenic microbes. In: Kumar V, Shriram V, Paul A, Thakur M, editors. Antimicrobial Resistance. Singapore: Springer; 2022.
   Google Scholar
• Yang H-Y, Duan Y-Q, Yang Y-K, et al. Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii. Phytochem Lett. 2017;22:266–269. doi: 10.1016/j.phytol.2017.10.021.
   Web of Science ®Google Scholar
• Nurunnabi TR, Nahar L, Al‐Majmaie S, et al. Anti‐MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp. growing on the Sundarbans mangrove plant Heritiera fomes. Phytother Res. 2018;32:348–354. doi: 10.1002/ptr.5983.
   PubMed Web of Science ®Google Scholar
• Xu J. Bioactive natural products derived from mangrove-associated microbes. RSC Adv. 2015;5:841–892. doi: 10.1039/C4RA11756E.
   Web of Science ®Google Scholar
• Ratnaweera PB, de Silva ED, Williams DE, et al. Antimicrobial activities of endophytic fungi obtained from the arid zone invasive plant Opuntia dillenii and the isolation of equisetin, from endophytic Fusarium sp. BMC Complement Altern Med. 2015;15:220. doi: 10.1186/s12906-015-0722-4.
   PubMed Web of Science ®Google Scholar
• Arora P, Wani ZA, Nalli Y, et al. Antimicrobial Potential of Thiodiketopiperazine derivatives produced by Phoma sp., an endophyte of Glycyrrhiza glabra Linn. Microb Ecol. 2016;72:802–812. doi: 10.1007/s00248-016-0805-x.
   PubMed Web of Science ®Google Scholar
• Macías-Rubalcava ML, Sánchez-Fernández RE. Secondary metabolites of endophytic Xylaria species with potential applications in medicine and agriculture. World J Microbiol Biotechnol. 2017;33:15. doi: 10.1007/s11274-016-2174-5.
   PubMed Web of Science ®Google Scholar
• Cadelis MM, Geese S, Uy BB, et al. Antimicrobial metabolites against methicillin-resistant Staphylococcus aureus from the endophytic fungus Neofusicoccum australe. Molecules. 2021;26:1094. doi: 10.3390/molecules26041094.
   PubMed Web of Science ®Google Scholar
• Silva N, Igrejas G, Rodrigues P, et al. Molecular characterization of vancomycin-resistant Enterococci and extended-spectrum β-lactamase-containing Escherichia coli isolates in wild birds from the Azores Archipelago. Avian Pathol. 2011;40:473–479. 2011 doi: 10.1080/03079457.2011.599061.
   PubMed Web of Science ®Google Scholar
• Ola ARB, Debbab A, Aly AH, et al. Absolute configuration and antibiotic activity of neosartorin from the endophytic fungus Aspergillus fumigatiaffinis. Tetrahedron Lett. 2014;55:1020–1023. 2014 doi: 10.1016/j.tetlet.2013.12.070.
   Web of Science ®Google Scholar
• Ola ARB, Thomy D, Lai D, et al. Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis. J Nat Prod. 2013;76:2094–2099. doi: 10.1021/np400589h.
   PubMed Web of Science ®Google Scholar
• Hemberger Y, Xu J, Wray V, et al. Pestalotiopens A and B: stereochemically challenging flexible sesquiterpene‐cyclopaldic acid hybrids from Pestalotiopsis sp. Chemistry. 2013;19:15556–15564. doi: 10.1002/chem.201302204.
   PubMed Web of Science ®Google Scholar
• Chen H-L, Zhao W-T, Liu Q-P, et al. Preisomide: a new alkaloid featuring a rare naturally occurring tetrahydro-2H-1, 2-oxazin skeleton from an endophytic fungus Preussia isomera by using OSMAC strategy. Fitoterapia. 2020;141:104475. (±) doi: 10.1016/j.fitote.2020.104475.
   PubMed Web of Science ®Google Scholar
• Yang S, Zhao W, Chen H, et al. Aureonitols A and B, two new C13‐polyketides from Chaetomium globosum, an endophytic fungus in Salvia miltiorrhiza. Chem Biodivers. 2019;16:e1900364. 2019 doi: 10.1002/cbdv.201900364.
   PubMed Web of Science ®Google Scholar
• Singh MP, Janso JE, Luckman SW, et al. Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. J Antibiot (Tokyo). 2000;53:256–261. doi: 10.7164/antibiotics.53.256.
   PubMed Web of Science ®Google Scholar
• Ariantari NP, Ancheeva E, Frank M, et al. Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B. 1, an endophyte of Terminalia catappa. RSC Adv. 20202020;10:7232–7240. doi: 10.1039/c9ra10685e.
   PubMed Web of Science ®Google Scholar
• Vivas R, Barbosa AAT, Dolabela SS, et al. Multidrug-resistant bacteria and alternative methods to control them: an overview. Microb Drug Resist. 2019;25:890–908. doi: 10.1089/mdr.2018.0319.
   PubMed Web of Science ®Google Scholar
• Kim S, Shin D-S, Lee T, et al. Periconicins, two new fusicoccane diterpenes produced by an endophytic fungus Periconia sp. with antibacterial activity. J Nat Prod. 2004;67:448–450. doi: 10.1021/np030384h.
   PubMed Web of Science ®Google Scholar
• Ymele-Leki P, Cao S, Sharp J, et al. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012;7:e31307. doi: 10.1371/journal.pone.0031307.
   PubMed Web of Science ®Google Scholar
• Yamazaki H, Wewengkang DS, Kanno S, et al. Papuamine and haliclonadiamine, obtained from an Indonesian sponge Haliclona sp., inhibited cell proliferation of human cancer cell lines. Nat Prod Res. 2013;27:1012–1015. doi: 10.1080/14786419.2012.688050.
   PubMed Web of Science ®Google Scholar
• Fadiji AE, Babalola OO. Elucidating mechanisms of endophytes used in plant protection and other bioactivities with multifunctional prospects. Front Bioeng Biotechnol. 2020;8:467. doi: 10.3389/fbioe.2020.00467.
   PubMed Web of Science ®Google Scholar
• Adeleke BS, Babalola OO. Pharmacological potential of fungal endophytes associated with medicinal plants: a review. JoF. 2021;7:147. doi: 10.3390/jof7020147.
   Google Scholar
• Davis RA, Carroll AR, Andrews KT, et al. Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp. Org Biomol Chem. 2010;8:1785–1790. doi: 10.1039/b924169h.
   PubMed Web of Science ®Google Scholar
• Kornsakulkarn J, Choowong W, Rachtawee P, et al. Bioactive hydroanthraquinones from endophytic fungus Nigrospora sp. BCC 47789. Phytochem Lett. 2018;24:46–50. doi: 10.1016/j.phytol.2018.01.015.
   Web of Science ®Google Scholar
• Ibrahim SRM, Asfour HZ. Bioactive gamma-butyrolactones from endophytic fungus Aspergillus versicolor. Int J Pharmacol. 2018;14:437–443. doi: 10.3923/ijp.2018.437.443.
   Google Scholar
• Aharwal RP, Kumar S, Sandhu SS. Endophytic mycoflora as a source of biotherapeutic compounds for disease treatment. J App Pharm Sci. 2016;6:242–254. doi: 10.7324/JAPS.2016.601034.
   Google Scholar
• Wang L-W, Wang J-L, Chen J, et al. A novel derivative of (-) mycousnine produced by the endophytic fungus Mycosphaerella nawae, exhibits high and selective immunosuppressive activity on T cells. Front Microbiol. 2017;8:1251. doi: 10.3389/fmicb.2017.01251.
   PubMed Web of Science ®Google Scholar
• Ferreira MC, Cantrell CL, Wedge DE, et al. Antimycobacterial and antimalarial activities of endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from Brazil. Mem Inst Oswaldo Cruz. 2017;112:692–697. doi: 10.1590/0074-02760170144.
   PubMed Web of Science ®Google Scholar
• Kumarihamy M, Ferreira D, Croom EM, Jr, et al. Antiplasmodial and cytotoxic cytochalasins from an endophytic fungus, Nemania sp. UM10M, isolated from a diseased Torreya taxifolia leaf. Molecules. 2019;24:777. doi: 10.3390/molecules24040777.
   PubMed Web of Science ®Google Scholar
• Ateba JET, Toghueo RMK, Awantu AF, et al. Antiplasmodial properties and cytotoxicity of endophytic fungi from Symphonia globulifera (Clusiaceae). JoF. 2018;4:70. doi: 10.3390/jof4020070.
   Google Scholar
• Toghueo RMK, Kemgne EAM, Eke P, et al. Antiplasmodial potential and GC-MS fingerprint of endophytic fungal extracts derived from Cameroonian Annona muricata. J Ethnopharmacol. 2019;235:111–121. doi: 10.1016/j.jep.2019.02.010.
   PubMed Web of Science ®Google Scholar
• Kaushik N, Murali T, Sahal D, et al. A search for antiplasmodial metabolites among fungal endophytes of terrestrial and marine plants of southern India. Acta Parasitol. 2014;59:745–757. doi: 10.2478/s11686-014-0307-2.
   PubMed Web of Science ®Google Scholar
• Pongcharoen W, Rukachaisirikul V, Phongpaichit S, et al. Metabolites from the endophytic fungus Xylaria sp. PSU-D14. Phytochemistry. 2008;69:1900–1902. doi: 10.1016/j.phytochem.2008.04.003.
   PubMed Web of Science ®Google Scholar
• Chen LZ, Chen JM, Zheng XS, et al. Identification and antifungal activity of the metabolite of endophytic fungi isolated from Llex cornuta. Chinese Journal of Pesticide Science. 2007;9:143–148.
   Google Scholar
• Dai J, Krohn K, Flörke U, et al. Metabolites from the endophytic fungus Nodulisporium sp. from Juniperus cedre. Eur J Org Chem. 2006;2006:3498–3506. doi: 10.1002/ejoc.200600261.
   Web of Science ®Google Scholar
• Macías-Rubalcava ML, Hernández-Bautista BE, Jiménez-Estrada M, et al. Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae. Phytochemistry. 2008;69:1185–1196. doi: 10.1016/j.phytochem.2007.12.006.
   PubMed Web of Science ®Google Scholar
• Cui HB, Mei WL, Miao CD, et al. Antibacterial constituents from the endophytic fungus Penicillium sp. 0935030 of mangrove plant Acrostichum aureurm. Chem J Chin Univ. 2008;33:407–410.
   Google Scholar
• Ruhe JJ, Monson T, Bradsher RW, et al. Use of long-acting tetracyclines for methicillin-resistant Staphylococcus aureus infections: case series and review of the literature. Clin Infect Dis. 2005;40:1429–1434. (pg. doi: 10.1086/429628.
   PubMed Web of Science ®Google Scholar
• Blanco AR, Nostro A, D'Angelo V, et al. Efficacy of a fixed combination of tetracycline, chloramphenicol, and colistimethate sodium for treatment of Candida albicans keratitis. Invest Ophthalmol Vis Sci. 2017;58:4292–4298. 2017 doi: 10.1167/iovs.17-22047.
   PubMed Web of Science ®Google Scholar
• Tan J, Jiang S, Tan L, et al. Antifungal activity of minocycline and azoles against fluconazole-resistant Candida species. Front Microbiol. 2021;12:649026. doi: 10.3389/fmicb.2021.649026.
   PubMed Web of Science ®Google Scholar
• Kumar G, Chandra P, Choudhary M. Endophytic fungi: a potential source of bioactive compounds. Chem Sci Rev Lett. 2017;6:2373–2381.
   Google Scholar
• Kamana S, Hemalatha K, Chandanavineela K, et al. Endophytic fungi: as the source of bioactive compound. World J Pharmacol Pharm Sci. 2016;5:1026–1040.
   Google Scholar
• Kouipou Toghueo RM, Boyom FF. Endophytic fungi from Terminalia species: a comprehensive review. JoF. 2019;5:43. doi: 10.3390/jof5020043.
   Google Scholar
• LaSarre B, Federle MJ. Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev. 2013;77:73–111. doi: 10.1128/MMBR.00046-12.
   PubMed Web of Science ®Google Scholar
• Mookherjee A, Singh S, Maiti MK. Quorum sensing inhibitors: can endophytes be prospective sources? Arch Microbiol. 2018;200:355–369. doi: 10.1007/s00203-017-1437-3.
   PubMed Web of Science ®Google Scholar
• Johann S, Rosa LH, Rosa CA, et al. Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis. Rev Iberoam Micol. 2012;29:205–209. doi: 10.1016/j.riam.2012.02.002.
   PubMed Web of Science ®Google Scholar
• Tanvir R, Sajid I, Hasnain S, et al. Rare actinomycetes Nocardia caishijiensis and Pseudonocardia carboxydivorans as endophytes, their bioactivity and metabolites evaluation. Microbiol Res. 2016;185:22–35. doi: 10.1016/j.micres.2016.01.003.
   PubMedGoogle Scholar
• Sun Z-L, Zhang M, Zhang J-F, et al. Antifungal and cytotoxic activities of the secondary metabolites from endophytic fungus Massrison sp. Phytomedicine. 2011;18:859–862. doi: 10.1016/j.phymed.2011.01.019.
   PubMed Web of Science ®Google Scholar
• Chomcheon P, Wiyakrutta S, Aree T, et al. Curvularides A–E: antifungal hybrid peptide–polyketides from the endophytic fungus Curvularia geniculata. Chemistry. 2010;16:11178–11185. doi: 10.1002/chem.201000652.
   PubMed Web of Science ®Google Scholar
• Barriuso J. Quorum sensing mechanisms in fungi. AIMS Microbiol. 2015;1:37–47. doi: 10.3934/microbiol.2015.1.37.
   Web of Science ®Google Scholar
• Albuquerque P, Casadevall A. Quorum sensing in fungi-a review. Med Mycol. 2012;50:337–345. doi: 10.3109/13693786.2011.652201.
   PubMed Web of Science ®Google Scholar
• Hall RA, Cottier F, Mühlschlegel FA. Molecular networks in the fungal pathogen Candida albicans. Adv Appl Microbiol. 2009;67:191–212. doi: 10.1016/S0065-2164(08)01006-X.
   PubMed Web of Science ®Google Scholar
• Pereira CS, Thompson JA, Xavier KB. AI-2-mediated signaling in bacteria. FEMS Microbiol Rev. 2013;37:156–181. doi: 10.1111/j.1574-6976.2012.00345.x.
   PubMed Web of Science ®Google Scholar
• Severin FF, Hyman AA. Pheromone induces programmed cell death in S. cerevisiae. Curr Biol. 2002;12:233–235.
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Mayville P, Muir TW, et al. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc Natl Acad Sci U S A. 2000;97:13330–13335. doi: 10.1073/pnas.97.24.13330.
   PubMed Web of Science ®Google Scholar
• Mishra, Sushma, Sharma, Shilpi, Priyanka, 2022. Metabolomic insights into Endophyte-derived bioactive compounds. Front Microbiol. 13, 835931 doi: 10.3389/fmicb.2022.835931.
   PubMed Web of Science ®Google Scholar
• Rajesh PS, Ravishankar Rai V. Hydrolytic enzymes and quorum sensing inhibitors from endophytic fungi of Ventilago madraspatana Gaertn. Biocatal Agric Biotechnol. 2013;2:120–124. doi: 10.1016/j.bcab.2013.01.002.
   Google Scholar
• Martín-Rodríguez AJ, Reyes F, Martín J, et al. Inhibition of bacterial quorum sensing by extracts from aquatic fungi: first report from marine endophytes. Mar Drugs. 2014;12:5503–5526. doi: 10.3390/md12115503.
   PubMed Web of Science ®Google Scholar
• Kusari S, Singh S, Jayabaskaran C. Biotechnological potential of plant-associated endophytic fungi: hope versus hype. Trends Biotechnol. 2014;32:297–303. doi: 10.1016/j.tibtech.2014.03.009.
   PubMed Web of Science ®Google Scholar
• Tourneroche A, Lami R, Hubas C, et al. Bacterial-fungal interactions in the kelp endomicrobiota drive autoinducer-2 quorum sensing. Front Microbiol. 2019;10:1693. doi: 10.3389/fmicb.2019.01693.
   PubMed Web of Science ®Google Scholar
• Eid SY, El-Readi MZ, Eldin EEMN, et al. Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukemia and colon cancer cells. Phytomedicine. 2013;21:47–61. doi: 10.1016/j.phymed.2013.07.019.
   PubMed Web of Science ®Google Scholar
• Lee S-Y, Rhee Y-H, Jeong S-J, et al. H. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011;26:424–431. doi: 10.1002/tox.20568.
   PubMed Web of Science ®Google Scholar
• Kennedy MJ, Armstrong DK, Huelskamp AM, et al. Phase I and pharmacologic study of the alkylating agent modulator novobiocin in combination with high-dose chemotherapy for the treatment of metastatic breast cancer. J Clin Oncol. 1995;13:1136–1143. doi: 10.1200/JCO.1995.13.5.1136.
   PubMed Web of Science ®Google Scholar
• Xu Y, Qiu L. Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when co-encapsulated with quinine in liposomes. Int J Nanomedicine. 2015;10:4225–4237. doi: 10.2147/IJN.S84555.
   PubMed Web of Science ®Google Scholar
• Paterson I, Anderson EA. The Renaissance of natural products as drug candidates. Science. 2005;310:451–453. doi: 10.1126/science.1116364.
   PubMed Web of Science ®Google Scholar
• Garyali S, Tandon P, Sudhakara Reddy M, et al. Exploitation of Fungal endophytes as bio-factories for production of functional metabolites through metabolic engineering; emphasizing on Taxol production. In: Saran S, Babu V, Chaubey A, editor. High value fermentation products: human health. New York: Wiley Publication; 2019. doi: 10.1002/9781119460053.
   Google Scholar
• Miller CM, Miller RV, Garton-Kenny D, et al. Ecomycins, unique antimycotics from Pseudomonas viridiflava. J Appl Microbiol. 1998;84:937–944. doi: 10.1046/j.1365-2672.1998.00415.x.
   PubMed Web of Science ®Google Scholar
• Harrison L, Teplow DB, Rinaldi M, et al. Pseudomycins, a family of novel peptides from Pseudomonas syringae possessing broad‑spectrum antifungal activity. J Gen Microbiol. 1991;137:2857–2865. doi: 10.1099/00221287-137-12-2857.
   PubMedGoogle Scholar
• Kusari S, Zühlke S, Kosuth J, et al. Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. J Nat Prod. 2009;72:1825–1835. doi: 10.1021/np9002977.
   PubMed Web of Science ®Google Scholar
• Tiwari P, Mohd A, Basavegowda N, et al. 2022d. Plant-associated endophytes: molecular mechanisms and significance in promoting sustainable agriculture. In: Tiwari P, editor., Endophytes: types, potential uses, and mechanisms of action. Hauppauge (NY): Nova Publishers.
   Google Scholar
• Bowater L. Antimicrobial stewardship: the role of scientists? J Antimicrob Chemother. 2015;70:1925–1927. doi: 10.1093/jac/dkv071.
   PubMed Web of Science ®Google Scholar
• Zhang R, Li C, Wang J, et al. Microbial production of small medicinal molecules and biologics: from nature to synthetic pathways. Biotechnol Adv. 2018;36:2219–2231. doi: 10.1016/j.biotechadv.2018.10.009.
   PubMed Web of Science ®Google Scholar
• Galanie S, Thodey K, Trenchard IJ, et al. Complete biosynthesis of opioids in yeast. Science. 2015;349:1095–1100. doi: 10.1126/science.aac9373.
   PubMed Web of Science ®Google Scholar
• Kotopka BJ, Li Y, Smolke CD. Synthetic biology strategies toward heterologous phytochemical production. Nat Prod Rep. 2018;35:902–920. doi: 10.1039/c8np00028j.
   PubMed Web of Science ®Google Scholar
• Li R, Li R, Li X, et al. Multiplexed CRISPR/Cas9-mediated metabolic engineering of γ-aminobutyric acid levels in Solanum lycopersicum. Plant Biotechnol J. 2018;16:415–427. doi: 10.1111/pbi.12781.
   PubMed Web of Science ®Google Scholar
• Li S, Li Y, Smolke CD. Strategies for microbial synthesis of high-value phytochemicals. Nature Chem. 2018;10:395–404. 2018 Aprdoi: 10.1038/s41557-018-0013-z.
   PubMed Web of Science ®Google Scholar
• Becker J, Wittmann C. Systems metabolic engineering of Escherichia coli for the heterologous production of high-value molecules- a veteran at new shores. Curr Opin Biotechnol. 2016;42:178–188. doi: 10.1016/j.copbio.2016.05.004.
   PubMed Web of Science ®Google Scholar
• Joung JK, Sander JD. TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol. 2013;14:49–55. doi: 10.1038/nrm3486.
   PubMed Web of Science ®Google Scholar
• Ledford H. CRISPR: gene editing is just the beginning. Nature. 2016;531:156–159. doi: 10.1038/531156a.
   PubMed Web of Science ®Google Scholar
• Gomaa A, Klumpe H, Luo M, et al. Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems. Am. Soc. Microbiol. 2013;5:e00928–e01013.
   Google Scholar
• Bikard D, Euler CW, Jiang W, et al. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol. 2014;32:1146–1150. doi: 10.1038/nbt.3043.
   PubMed Web of Science ®Google Scholar
• Citorik RJ, Mimee M, Lu TK. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol. 2014;32:1141–1145. doi: 10.1038/nbt.3011.
   PubMed Web of Science ®Google Scholar
• Kim J, Cho D, Park M, et al. CRISPR/Cas9-mediated re-sensitization of antibiotic-resistant Escherichia coli harboring extended-spectrum β-lactamases. J Microbiol Biotechnol. 2016;26:394–401. doi: 10.4014/jmb.1508.08080.
   PubMed Web of Science ®Google Scholar
• Müller V, Rajer F, Frykholm K, et al. Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping. Sci Rep. 2016;6:37938. doi: 10.1038/srep37938.
   PubMed Web of Science ®Google Scholar
• Li L, He Z, Wei X, et al. Challenges in CRISPR/Cas9 delivery: potential roles of nonviral vectors. Hum Gene Ther. 2015;26:452–462. doi: 10.1089/hum.2015.069.
   PubMed Web of Science ®Google Scholar
• Ali J, Rafiq QA, Ratcliffe E. Antimicrobial resistance mechanisms and potential synthetic treatments. Future Sci OA. 2018;4: FSO290. (2018) doi: 10.4155/fsoa-2017-0109.
   PubMed Web of Science ®Google Scholar
• Goh S, Loeffler A, Lloyd DH, et al. Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro. BMC Microbiol. 2015;15:262. doi: 10.1186/s12866-015-0599-x.
   PubMed Web of Science ®Google Scholar
• Bhargava P, Collins JJ. Boosting bacterial metabolism to combat antibiotic resistance. Cell Metab. 2015;21:154–155. doi: 10.1016/j.cmet.2015.01.012.
   PubMed Web of Science ®Google Scholar
• Zurawski D, Reinhart A, Alamneh Y, et al. SPR741, an antibiotic adjuvant, potentiates the in vitro and in vivo activity of rifampin against clinically relevant XDR-Acinetobacter baumannii. Antimicr. Agents Chemother. 2017;61:e01239-17. pii:
   PubMed Web of Science ®Google Scholar
• Draughn GL, Allen CL, Routh P, et al. Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Des Devel Ther. 2017;11:153–162. doi: 10.2147/DDDT.S111865.
   PubMed Web of Science ®Google Scholar