Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 24, 2007 - Issue 2
231
Views
41
CrossRef citations to date
0
Altmetric
Original

Daily Variations of Homocysteine Concentration May Influence Methylation of DNA in Normal Healthy Individuals

, , , , , , , & show all
Pages 315-326 | Received 16 Oct 2006, Accepted 22 Dec 2006, Published online: 07 Jul 2009

References

  • Akhtar R A, Reddy A B, Maywood E S, Clayton J D, King V M, Smith A G, Gant T W, Hastings M H, Kyriacou C P. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol. 2002; 12: 540–550
  • Bates D. Fitting linear mixed models in R. R News 2005; 5: 27–30
  • Bestor T H. The DNA methyltransferases of mammals. Hum. Mol. Genet. 2000; 9: 2395–2402
  • Bleich S, Degner D, Wiltfang J, Maler J M, Niedmann P, Cohrs S, Mangholz A, Porzig J, Sprung R, Rüther E, Kornhuber J. Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 2000; 35: 351–354
  • Bleich S, Carl M, Bayerlein K, Reulbach U, Biermann T, Hillemacher T, Bönsch D, Kornhuber J. Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Alcohol Clin. Exp. Res. 2005; 29: 334–336
  • Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S. Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J. Neural. Transm. 2004; 111: 1611–1616
  • Bönsch D, Lenz B, Kornhuber J, Bleich S. DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. NeuroReport 2005; 16: 167–170
  • Buysse D J, Monk T H, Berman S R, Kupfer D J. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989; 28: 193–213, Reynolds CF 3rd
  • Castro R, Rivera I, Struys E A, Jansen E E, Ravasco P, Camilo M E, Blom H J, Jakobs C, Tavares de Almeida I. Increased homocysteine and S‐adenosythomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. Chem. 2003; 49: 1292–1296
  • Cravo M L, Gloria L M, Selhub J, Nadeau M R, Camilo M E, Resende M P, Cardoso J N, Leitao C N, Mira F C. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B‐12, and vitamin B‐6 status. Am. J. Clin. Nutr. 1996; 63: 220–224
  • de Bree A, Verschuren W M, Blom H J, Kromhout D. Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am. J. Epidemiol. 2001; 154: 150–154
  • Detich N, Hamm S, Just G, Knox J D, Szyf M. The methyl donor S‐adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S‐adenosylmethionine. J. Biol. Chem. 2003; 278: 20812–20820
  • Doerfler W. DNA methylation and gene activity. Annu. Rev. Biochem. 1983; 52: 93–124
  • Duffield G E. DNA microarray analyses of circadian timing: the genomic basis of biological time. J. Neuroendocrinol. 2003; 15: 991–1002
  • Duffield G E, Best J D, Meurers B H, Bittner A, Loros J J, Dunlap J C. Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr. Biol. 2002; 12: 551–557
  • Gekakis N, Staknis D, Nguyen H B, Davis F C, Wilsbacher L D, King D P, Takahashi J S, Weitz C J. Role of the CLOCK protein in the mammalian circadian mechanism. Science 1998; 280: 1564–1569
  • Guttormsen A B, Solheim E, Refsum H. Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24‐h observation period. Am. J. Clin. Nutr. 2004; 79: 76–79
  • Horne J A, Östberg O. A self‐assessment questionnaire to determine morningness‐eveningness in human circadian rhythms. Int. J. Chronobiol. 1976; 4: 97–110
  • Ingrosso D, Cimmino A, Perna A F, Masella L, De Santo N G, De Bonis M L, Vacca M, D'Esposito M, D'Urso M, Galletti P, Zappia V. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet 2003; 361: 1693–1699
  • Jordan W, Berger C, Cohrs S, Rodenbeck A, Mayer G, Niedmann P D, von Ahsen N, Rüther E, Kornhuber J, Bleich S. CPAP‐therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome. J. Neural. Transm. 2004; 111: 683–689
  • Lavie L, Lavie P. Daily rhythms in plasma levels of homocysteine. J. Circadian Rhythms. 2004; 2: 5
  • Lavie L, Lavie P. Elevated plasma homocysteine in older shift‐workers: a potential risk factor for cardiovascular morbidity. Chronobiol Int. 2007; 24: 115–128
  • Lowrey P L, Takahashi J S. Mammalian circadian biology: elucidating genome‐wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 2004; 5: 407–441
  • Martino T, Arab S, Straume M, Belsham D D, Tata N, Cai F, Liu P, Trivieri M, Ralph M, Sole M J. Day/night rhythms in gene expression of the normal murine heart. J. Mol. Med. 2004; 82: 256–264
  • Martins P J, D'Almeida V, Vergani N, Perez A B, Tufik S. Increased plasma homocysteine levels in shift working bus drivers. Occup. Environ. Med. 2003; 60: 662–666
  • Martins P J, Galdieri L C, Souza F G, Andersen M L, Benedito‐Silva A A, Tufik S, D'Almeida V. Physiological variation in plasma total homocysteine concentrations in rats. Life Sci. 2005; 76: 2621–2629
  • Nygard O, Refsum H, Ueland P M, Vollset S E. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr. 1998; 67: 263–270
  • Panda S, Antoch M P, Miller B H, Su A I, Schook A B, Straume M, Schultz P G, Kay S A, Takahashi J S, Hogenesch J B. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002; 109: 307–320
  • Pinheiro C, Bates D M. Mixed‐effects models in “S” and “S‐PLUS,”. Springer Verlag, New York 2000
  • Pogribny I, Yi P, James S J. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem. Biophys. Res. Commun. 1999; 262: 624–628
  • R Development Core Team. R: A language and environment for statistical computing. 2006, R Foundation for Statistical Computing Available at: http://www.R‐project.org Accessed June 16 June
  • Reppert S M, Weaver D R. Coordination of circadian timing in mammals. Nature 2002; 418: 935–941
  • Shih M C, Yeh K T, Tang K P, Chen J C, Chang J G. Promoter methylation in circadian genes of endometrial cancers detected by methylation‐specific PCR. Mol. Carcinog. 2006; 45: 732–740
  • Smith S S, Crocitto L. DNA methylation in eukaryotic chromosome stability revisited: DNA methyltransferase in the management of DNA conformation space. Mol. Carcinog. 1999; 26: 1–9
  • Staels B. When the clock stops ticking, metabolic syndrome explodes. Nat. Med. 2006; 12: 54–55
  • Stunkard A J, Messick S. The three‐factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J. Psychosom. Res. 1985; 29: 71–83
  • Touitou Y, Smolensky M H, Portaluppi F. Ethics, standards, and procedures for animal and human chronobiology research. Chronobiol. Int. 2006; 23: 1083–1096
  • Ueda H R, Chen W, Adachi A, Wakamatsu H, Hayashi S, Takasugi T, Nagano M, Nakahama K, Suzuki Y, Sugano S, Iino M, Shigeyoshi Y, Hashimoto S. A transcription factor response element for gene expression during circadian night. Nature 2002; 418: 534–539
  • Ueland P M, Nygård O, Vollset S E, Refsum H. The hordaland homocysteine studies. Lipids 1987; 36: 33–39
  • Yeh K T, Yang M Y, Liu T C, Chen J C, Chan W L, Lin S F, Chang J G. Abnormal expression of period 1 (PER1) in endometrial carcinoma. J. Pathol. 2005; 206: 111–120
  • Yi P, Melnyk S, Pogribna M, Pogribny I P, Hine R J, James S J. Increase in plasma homocysteine is associated with parallel increases in plasma S‐adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 2000; 275: 29318–29323

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.