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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 37, 2008 - Issue 5-6
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Original

Pattern Recognition at the Maternal-Fetal Interface

Pages 427-447 | Published online: 07 Jul 2009

REFERENCES

  • Abrahams V. M., Bole-Aldo P., Kim Y. M., Straszewski-Chavez S. L., Chaiworapongsa T., Romero R., Mor G. Divergent trophoblast responses to bacterial products mediated by TLRs. J. Immunol. 2004; 173: 4286–4296
  • Abrahams V. M., Visintin I., Aldo P. B., Guller S., Romero R., Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J. Immunol. 2005; 175: 8096–8104
  • Abrahams V. M., Schaefer T. M., Fahey J. V., Visintin I., Wright J. A., Aldo P. B., Romero R., Wira C. R., Mor G. Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Hum. Reprod. 2006; 21: 2432–2439
  • Abrahams V. M., Aldo P. B., Murphy S. P., Visintin I., Koga K., Wilson G., Roberto R., Sharma S., Mor G. TLR6 modulates first trimester trophoblast responses to peptidoglycan. J. Immunol. 2008; 180: 6035–6043
  • Adams K. M., Lucas J., Kapur R. P., Stevens A. M. LPS induces translocation of TLR4 in amniotic epithelium. Placenta 2007; 28: 477–481
  • Akira S. Toll-like receptor signaling. J. Biol. Chem. 2003; 278: 38105–38108
  • Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004; 4: 499–511
  • Aliprantis A. O., Yang R. B., Mark M. R., Suggett S., Devaux B., Radolf J. D., Klimpel G. R., Godowski P., Zychlinsky A. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999; 285: 736–739
  • Amer A., Franchi L., Kanneganti T. D., Body-Malapel M., Ozoren N., Brady G., Meshinchi S., Jagirdar R., Gewirtz A., Akira S., Nunez G. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J. Biol. Chem. 2006; 281: 35217–35223
  • Anderson K. V., Bokla L., Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 1985; 42: 791–798
  • Arechavaleta-Velasco F., Koi H., Strauss J. F., 3rd, Parry S. Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation?. J. Reprod. Immunol. 2002; 55: 113–121
  • Baboonian C., Smith D. A., Shapland D., Arno G., Zal B., Akiyu J., Kaski J. C. Placental infection with Chlamydia pneumoniae and intrauterine growth restriction. Cardiovasc. Res. 2003; 60: 165–169
  • Baud D., Regan L., Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr. Opin. Infect. Dis. 2008; 21: 70–76
  • Beagley K. W., Timms P. Chlamydia trachomatis infection: incidence, health costs and prospects for vaccine development. J. Reprod. Immunol. 2000; 48: 47–68
  • Bertin J., Nir W. J., Fischer C. M., Tayber O. V., Errada P. R., Grant J. R., Keilty J. J., Gosselin M. L., Robison K. E., Wong G. H., Glucksmann M. A., DiStefano P. S. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. J. Biol. Chem. 1999; 274: 12955–12958
  • Bochud P. Y., Bochud M., Telenti A., Calandra T. Innate immunogenetics: a tool for exploring new frontiers of host defence. Lancet Infect. Dis. 2007; 7: 531–542
  • Buendia A. J., Sanchez J., Martinez M. C., Camara P., Navarro J. A., Rodolakis A., Salinas J. Kinetics of infection and effects on placental cell populations in a murine model of Chlamydia psittaci-induced abortion. Infect Immun 1998; 66: 2128–2134
  • Buhimschi I. A., Jabr M., Buhimschi C. S., Petkova A. P., Weiner C. P., Saed G. M. The novel antimicrobial peptide beta3-defensin is produced by the amnion: a possible role of the fetal membranes in innate immunity of the amniotic cavity. Am. J. Obstet. Gynecol. 2004; 191: 1678–1687
  • Canavan T. P., Simhan H. N. Innate immune function of the human decidual cell at the maternal-fetal interface. J. Reprod. Immunol. 2007; 74: 46–52
  • Chamaillard M., Hashimoto M., Horie Y., Masumoto J., Qiu S., Saab L., Ogura Y., Kawasaki A., Fukase K., Kusumoto S., Valvano M. A., Foster S. J., Mak T. W., Nunez G., Inohara N. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 2003; 4: 702–707
  • Chan G., Guilbert L. J. Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll-like receptor-2 and tumour necrosis factor-alpha dependent manner. J. Pathol. 2006; 210: 111–120
  • Chin A. I., Dempsey P. W., Bruhn K., Miller J. F., Xu Y., Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 2002; 416: 190–194
  • Chuang T. H., Ulevitch R. J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 2000; 11: 372–378
  • Costello M. J., Joyce S. K., Abrahams V. M. NOD protein expression and function in first trimester trophoblast cells. Am. J. Reprod. Immunol. 2007; 57: 67–80
  • Crider K. S., Whitehead N., Buus R. M. Genetic variation associated with preterm birth: a HuGE review. Genet. Med. 2005; 7: 593–604
  • Dong F., Pirbhai M., Xiao Y., Zhong Y., Wu Y., Zhong G. Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells. Infect. Immun. 2005; 73: 1861–1864
  • Dong Z. W., Li Y., Zhang L. Y., Liu R. M. Detection of Chlamydia trachomatis intrauterine infection using polymerase chain reaction on chorionic villi. Int. J. Gynaecol. Obstet. 1998; 61: 29–32
  • Elovitz M. A., Wang Z., Chien E. K., Rychlik D. F., Phillippe M. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am. J. Pathol. 2003; 163: 2103–2111
  • Elovitz M. A., Mrinalini C. Animal models of preterm birth. Trends Endocrinol. Metab. 2004; 15: 479–487
  • Equils O., Lu D., Gatter M., Witkin S. S., Bertolotto C., Arditi M., McGregor J. A., Simmons C. F., Hobel C. J. Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4. J. Immunol. 2006; 177: 1257–1263
  • Espinoza J., Erez O., Romero R. Preconceptional antibiotic treatment to prevent preterm birth in women with a previous preterm delivery. Am. J. Obstet. Gynecol. 2006; 194: 630–637
  • Ferrero-Miliani L., Nielsen O. H., Andersen P. S., Girardin S. E. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin. Exp. Immunol. 2007; 147: 227–235
  • Franchi L., Amer A., Body-Malapel M., Kanneganti T. D., Ozoren N., Jagirdar R., Inohara N., Vandenabeele P., Bertin J., Coyle A., Grant E. P., Nunez G. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 2006; 7: 576–582
  • Fritz J. H., Ferrero R. L., Philpott D. J., Girardin S. E. Nod-like proteins in immunity, inflammation and disease. Nat. Immunol. 2006; 7: 1250–1257
  • Gewirtz A. T., Navas T. A., Lyons S., Godowski P. J., Madara J. L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 2001; 167: 1882–1885
  • Girardin S. E., Tournebize R., Mavris M., Page A. L., Li X., Stark G. R., Bertin J., DiStefano P. S., Yaniv M., Sansonetti P. J., Philpott D. J. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep. 2001; 2: 736–742
  • Girardin S. E., Boneca I. G., Carneiro L. A., Antignac A., Jehanno M., Viala J., Tedin K., Taha M. K., Labigne A., Zahringer U., Coyle A. J., DiStefano P. S., Bertin J., Sansonetti P. J., Philpott D. J. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003a; 300: 1584–1587
  • Girardin S. E., Boneca I. G., Viala J., Chamaillard M., Labigne A., Thomas G., Philpott D. J., Sansonetti P. J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 2003b; 278: 8869–8872
  • Goldenberg R. L., Hauth J. C., Andrews W. W. Intrauterine infection and preterm delivery. N. Engl. J. Med. 2000; 342: 1500–1507
  • Goncalves L. F., Chaiworapongsa T., Romero R. Intrauterine infection and prematurity. Ment. Retard. Dev. Disabil. Res. Rev. 2002; 8: 3–13
  • Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004; 303: 1526–1529
  • Hirschfeld A. F., Jiang R., Robinson W. P., McFadden D. E., Turvey S. E. Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage. Hum. Reprod. 2007; 22: 440–443
  • Hogan R. J., Mathews S. A., Mukhopadhyay S., Summersgill J. T., Timms P. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 2004; 72: 1843–1855
  • Holmlund U., Cebers G., Dahlfors A. R., Sandstedt B., Bremme K., Ekstrom E. S., Scheynius A. Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology 2002; 107: 145–151
  • Honig A., Rieger L., Kapp M., Sutterlin M., Dietl J., Kammerer U. Indoleamine 2,3-dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance. J. Reprod. Immunol. 2004; 61: 79–86
  • Hsu C. D., Witter F. R. Urogenital infection in pre-eclampsia. Int. J. Gynaecol. Obstet. 1995; 49: 271–275
  • Ilievski V., Lu S. J., Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod. Sci. 2007; 14: 315–320
  • Inohara N., Koseki T., del Peso L., Hu Y., Yee C., Chen S., Carrio R., Merino J., Liu D., Ni J., Nunez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 1999; 274: 14560–14567
  • Inohara N., Koseki T., Lin J., del Peso L., Lucas P. C., Chen F. F., Ogura Y., Nunez G. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 2000; 275: 27823–27831
  • Inohara N., Ogura Y., Fontalba A., Gutierrez O., Pons F., Crespo J., Fukase K., Inamura S., Kusumoto S., Hashimoto M., Foster S. J., Moran A. P., Fernandez-Luna J. L., Nunez G. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 2003; 278: 5509–5512
  • Iwaki D., Mitsuzawa H., Murakami S., Sano H., Konishi M., Akino T., Kuroki Y. The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 2002; 277: 24315–24320
  • Jacobsson B., Holst R. M., Wennerholm U. B., Andersson B., Lilja H., Hagberg H. Monocyte chemotactic protein-1 in cervical and amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation, and preterm delivery. Am. J. Obstet. Gynecol. 2003; 189: 1161–1167
  • Janeway C. A., Jr., Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20: 197–216
  • Kanneganti T. D., Ozoren N., Body-Malapel M., Amer A., Park J. H., Franchi L., Whitfield J., Barchet W., Colonna M., Vandenabeele P., Bertin J., Coyle A., Grant E. P., Akira S., Nunez G. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006; 440: 233–236
  • Kawai T., Akira S. Antiviral signaling through pattern recognition receptors. J. Biochem. 2007; 141: 137–145
  • Keelan J. A., Yang J., Romero R. J., Chaiworapongsa T., Marvin K. W., Sato T. A., Mitchell M. D. Epithelial cell-derived neutrophil-activating peptide-78 is present in fetal membranes and amniotic fluid at increased concentrations with intra-amniotic infection and preterm delivery. Biol. Reprod. 2004; 70: 253–259
  • Kim Y. M., Romero R., Chaiworapongsa T., Kim G. J., Kim M. R., Kuivaniemi H., Tromp G., Espinoza J., Bujold E., Abrahams V. M., Mor G. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am. J. Obstet. Gynecol. 2004; 191: 1346–1355
  • King A. E., Paltoo A., Kelly R. W., Sallenave J. M., Bocking A. D., Challis J. R. Expression of natural antimicrobials by human placenta and fetal membranes. Placenta. 2009; 28: 161–169
  • Kobayashi K., Inohara N., Hernandez L. D., Galan J. E., Nunez G., Janeway C. A., Medzhitov R., Flavell R. A. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002; 416: 194–199
  • Krediet T. G., Wiertsema S. P., Vossers M. J., Hoeks S. B., Fleer A., Ruven H. J., Rijkers G. T. Toll-like receptor 2 polymorphism is associated with preterm birth. Pediatr. Res. 2007; 62: 474–476
  • Krikun G., Lockwood C. J., Abrahams V. M., Mor G., Paidas M., Guller S. Expression of Toll-like receptors in the human decidua. Histol. Histopathol. 2007; 22: 847–854
  • Krutzik S. R., Ochoa M. T., Sieling P. A., Uematsu S., Ng Y. W., Legaspi A., Liu P. T., Cole S. T., Godowski P. J., Maeda Y., Sarno E. N., Norgard M. V., Brennan P. J., Akira S., Rea T. H., Modlin R. L. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat. Med. 2003; 9: 525–532
  • Kumazaki K., Nakayama M., Yanagihara I., Suehara N., Wada Y. Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Hum. Pathol. 2004; 35: 47–54
  • Lamkanfi M., Amer A., Kanneganti T. D., Munoz-Planillo R., Chen G., Vandenabeele P., Fortier A., Gros P., Nunez G. The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J. Immunol. 2007; 178: 8022–8027
  • Lamont R. F. The role of infection in preterm labour and birth. Hosp. Med. 2003; 64: 644–647
  • Lappas M., Permezel M., Georgiou H. M., Rice G. E. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol. Reprod. 2002; 67: 668–673
  • LeBouder E., Rey-Nores J. E., Rushmere N. K., Grigorov M., Lawn S. D., Affolter M., Griffin G. E., Ferrara P., Schiffrin E. J., Morgan B. P., Labeta M. O. Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J. Immunol. 2003; 171: 6680–6689
  • Lemaitre B., Nicolas E., Michaut L., Reichhart J. M., Hoffmann J. A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973–983
  • Lien E., Sellati T. J., Yoshimura A., Flo T. H., Rawadi G., Finberg R. W., Carroll J. D., Espevik T., Ingalls R. R., Radolf J. D., Golenbock D. T. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 1999; 274: 33419–33425
  • Liu H., Redline R. W., Han Y. W. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J. Immunol. 2007; 179: 2501–2508
  • Ma Y., Krikun G., Abrahams V. M., Mor G., Guller S. Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection. Placenta 2007; 28: 1024–1031
  • Martinon F., Agostini L., Meylan E., Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 2004; 14: 1929–1934
  • McDonagh S., Maidji E., Ma W., Chang H. T., Fisher S., Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J. Infect. Dis. 2004; 190: 826–834
  • Medzhitov R., Preston-Hurlburt P., Janeway C. A., Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394–397
  • Medzhitov R., Janeway C. A., Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296: 298–300
  • Meylan E., Tschopp J., Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006; 442: 39–44
  • Mitsunari M., Yoshida S., Shoji T., Tsukihara S., Iwabe T., Harada T., Terakawa N. Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells. J. Reprod. Immunol. 2006; 72: 46–59
  • Miwa N., Hayakawa S., Miyazaki S., Myojo S., Sasaki Y., Sakai M., Takikawa O., Saito S. IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion. Mol. Hum. Reprod. 2005; 11: 865–870
  • Munn D. H., Zhou M., Attwood J. T., Bondarev I., Conway S. J., Marshall B., Brown C., Mellor A. L. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281: 1191–1193
  • Murray P. J. NOD proteins: an intracellular pathogen-recognition system or signal transduction modifiers?. Curr. Opin. Immunol. 2005; 17: 352–358
  • Netea M. G., Azam T., Ferwerda G., Girardin S. E., Walsh M., Park J. S., Abraham E., Kim J. M., Yoon D. Y., Dinarello C. A., Kim S. H. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl. Acad. Sci. USA 2005; 102: 16309–16314
  • Ogura Y., Inohara N., Benito A., Chen F. F., Yamaoka S., Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J. Biol. Chem. 2001; 276: 4812–4818
  • Opitz B., Schroder N. W., Spreitzer I., Michelsen K. S., Kirschning C. J., Hallatschek W., Zahringer U., Hartung T., Gobel U. B., Schumann R. R. Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation. J. Biol. Chem. 2001; 276: 22041–22047
  • Opitz B., Forster S., Hocke A. C., Maass M., Schmeck B., Hippenstiel S., Suttorp N., Krull M. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 2005; 96: 319–326
  • Opitz B., Puschel A., Beermann W., Hocke A. C., Forster S., Schmeck B., van Laak V., Chakraborty T., Suttorp N., Hippenstiel S. Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J. Immunol. 2006; 176: 484–490
  • Paguirigan A. M., Byrne G. I., Becht S., Carlin J. M. Cytokine-mediated indoleamine 2,3-dioxygenase induction in response to Chlamydia infection in human macrophage cultures. Infect. Immun. 1994; 62: 1131–1136
  • Pal S., Peterson E. M., De La Maza L. M. A murine model for the study of Chlamydia trachomatis genital infections during pregnancy. Infect. Immun. 1999; 67: 2607–2610
  • Pantoja L. G., Miller R. D., Ramirez J. A., Molestina R. E., Summersgill J. T. Inhibition of Chlamydia pneumoniae replication in human aortic smooth muscle cells by gamma interferon-induced indoleamine 2, 3-dioxygenase activity. Infect. Immun. 2000; 68: 6478–6481
  • Poltorak A., He X., Smirnova I., Liu M. Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085–2088
  • Prince L. S., Okoh V. O., Moninger T. O., Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am. J. Physiol. Lung Cell Mol. Physiol. 2004; 287: L999–1006
  • Rindsjo E., Holmlund U., Sverremark-Ekstrom E., Papadogiannakis N., Scheynius A. Toll-like receptor-2 expression in normal and pathologic human placenta. Hum. Pathol. 2007; 38: 468–473
  • Rock F. L., Hardiman G., Timans J. C., Kastelein R. A., Bazan J. F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA 1998; 95: 588–593
  • Romero R., Espinoza J., Chaiworapongsa T., Kalache K. Infection and prematurity and the role of preventive strategies. Semin. Neonatol. 2002; 7: 259–274
  • Romero R., Chaiworapongsa T., Espinoza J. Micronutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndrome. J. Nutr. 2003; 133: 1668S–1673S
  • Romero R., Gotsch F., Pineles B., Kusanovic J. P. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007; 65: S194–202
  • Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C. J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 1999; 274: 17406–17409
  • Seth R. B., Sun L., Chen Z. J. Antiviral innate immunity pathways. Cell Res. 2006; 16: 141–147
  • Shimoya K., Moriyama A., Matsuzaki N., Ogata I., Koyama M., Azuma C., Saji F., Murata Y. Human placental cells show enhanced production of interleukin (IL)-8 in response to lipopolysaccharide (LPS), IL-1 and tumour necrosis factor (TNF)-alpha, but not to IL-6. Mol. Hum. Reprod. 1999; 5: 885
  • Simhan H. N., Chiao J. P., Mattison D. R., Caritis S. N. Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Am. J. Obstet. Gynecol. 2008; 198(119)e111–114
  • Srinivasan M., Kodumudi K. N., Zunt S. L. Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clin. Immunol. 2008; 126: 31–37
  • Straszewski-Chavez S. L., Abrahams V. M., Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr. Rev. 2005; 26: 877–897
  • Strober W., Murray P. J., Kitani A., Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 2006; 6: 9–20
  • Svinarich D. M., Gomez R., Romero R. Detection of human defensins in the placenta. Am. J. Reprod. Immunol. 1997; 38: 252–255
  • Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21: 335–376
  • Takeuchi O., Hoshino K., Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 2000; 165: 5392–5396
  • Takeuchi O., Kawai T., Muhlradt P. F., Morr M., Radolf J. D., Zychlinsky A., Takeda K., Akira S. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 2001; 13: 933–940
  • Tuffrey M., Falder P., Gale J., Taylor-Robinson D. Failure of Chlamydia trachomatis to pass transplacentally to fetuses of TO mice infected during pregnancy. J. Med. Microbiol. 1988; 25: 1–5
  • Uehara A., Yang S., Fujimoto Y., Fukase K., Kusumoto S., Shibata K., Sugawara S., Takada H. Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol. 2005; 7: 53–61
  • Varner M. W., Esplin M. S. Current understanding of genetic factors in preterm birth. British Journal of Obstetrics Gynecology 2005; 112(Suppl 1)28–31
  • von Dadelszen P., Magee L. A. Could an infectious trigger explain the differential maternal response to the shared placental pathology of pre-eclampsia and normotensive intrauterine growth restriction?. Acta Obstet. Gynecol. Scand. 2002; 81: 642–648
  • von Dadelszen P., Magee L. A., Krajden M., Alasaly K., Popovska V., Devarakonda R. M., Money D. M., Patrick D. M., Brunham R. C. Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia. Bjog 2003; 110: 725–730
  • Waldorf K. M., Persing D., Novy M. J., Sadowsky D. W., Gravett M. G. Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys. Reprod. Sci. 2008; 15: 121–127
  • Wang H., Hirsch E. Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biol. Reprod. 2003; 69: 1957–1963
  • Welter-Stahl L., Ojcius D. M., Viala J., Girardin S., Liu W., Delarbre C., Philpott D., Kelly K. A., Darville T. Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell. Microbiol. 2006; 8: 1047–1057
  • Wiesenfeld H. C., Hillier S. L., Krohn M. A., Amortegui A. J., Heine R. P., Landers D. V., Sweet R. L. Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet. Gynecol. 2002; 100: 456–463
  • Williams M. J., Rodriguez A., Kimbrell D. A., Eldon E. D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. Embo J. 1997; 16: 6120–6130
  • Xiao Y., Zhong Y., Greene W., Dong F., Zhong G. Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine. Infect. Immun. 2004; 72: 5470–5474
  • Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., Akira S. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J. Immunol. 2002; 169: 6668–6672
  • Ying S., Seiffert B. M., Hacker G., Fischer S. F. Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis. Infect. Immun. 2005; 73: 1399–1403
  • Yoo N. J., Park W. S., Kim S. Y., Reed J. C., Son S. G., Lee J. Y., Lee S. H. Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. Biochem. Biophys. Res. Commun. 2002; 299: 652–658
  • Yoshimura A., Lien E., Ingalls R. R., Tuomanen E., Dziarski R., Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 1999; 163: 1–5
  • Zaga V., Estrada-Gutierrez G., Beltran-Montoya J., Maida-Claros R., Lopez-Vancell R., Vadillo-Ortega F. Secretions of interleukin-1beta and tumor necrosis factor alpha by whole fetal membranes depend on initial interactions of amnion or choriodecidua with lipopolysaccharides or group B streptococci. Biol. Reprod. 2004; 71: 1296–1302
  • Zarember K. A., Godowski P. J. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 2002; 168: 554–561
  • Zhang D., Zhang G., Hayden M. S., Greenblatt M. B., Bussey C., Flavell R. A., Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303: 1522–1526
  • Zhang J., Wei H., Wu D., Tian Z. Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBA x DBA/2 mice. J. Reprod. Immunol. 2007; 74: 61–67

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