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Research Article

Immunosuppressive Drug Use in Pregnancy

Michelle Petri Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 7500, Baltimore, MD 21205, USA
Pages 51-56 | Published online: 07 Jul 2009

  • Petri, M, Howard, D. and Repke, J. (1991) "Frequency of lupusflare in pregnancy: the Hopkins Lupus Pregnancy Centerexperience", Arthritis Rheum. 34, 1538-1545.
  • Ruiz-Irastorza, G., Lima, E, Alves, I., Khamashta, M.A., Simpson,I., Hughes, G.R. and Buchanan, N.M. (1996) "Increased rate oflupus flare during pregnancy and the puerperium: a prospectivestudy of 78 pregnancies", Br. J. Rheumatol. 35(2), 133-138.
  • Laskin, C.A., Bombardier, C., Hannah, M.E., Mandel, F.P.,Ritchie, J.W.K., Farewell, V, Farine, D., Spitzer, K., Fielding, L.,Soloninka, C.A. and Yeung, M. (1997) "Prednisone and aspirin inwomen with autoantibodies and unexplained recurrent fetal loss",N. Engl. J. Med. 337, 148-153.
  • Rider, L.G., Buyon, J.P., Rutledge, I. and Sherry, D. (1993)'Treatment of neonatal lupus: case report and review of theliterature", J. Rheumatol. 20, 1208-1211.
  • Carreira, P.E., Gutierrez-Larraya, F. and Gomez-Reino, J.J. (1993)"Successful intrauterine therapy with dexamethasone for fetalmyocarditis and heart block in a woman with systemic lupuserythematosus", J. Rheumatol. 20, 1204-1207.
  • Petri, M. (1994) "Systemic lupus erythematosus and pregnancy",Rheum. Dis. Clin. N. Am. 20, 87-118.
  • Cowchock, F.S., Reece, E.A., Balaban, D., Branch, D.W. andPlouffe, L. (1992) "Repeated fetal losses associated withantiphospholipid antibodies: a collaborative randomized trialcomparing prednisone with low-dose heparin treatment", Am.J. Obstet. Gynecol. 166, 1318-1323.
  • Silver, R.K., MacGregor, S.N., Sholl, J.S., Hobart, J.M., Neerhof,M.G. and Ragin, A. (1993) "Comparative trial of prednisone plusaspirin versus aspirin alone in the treatment of anticardiolipinantibody-positive obstetric patients", Am. J. Obstet. Gynecol.169(6), 1411-1417.
  • Stanford, AT. and Murphy, B.P. (1977) "In vitro metabolism ofprednisone, dexamethasone, and cortisol by the human placenta",Am. J. Obstet. Gynecol. 127, 264-267.
  • Anderson, G.G., Rotchell, Y. and Kaiser, D.G. (1981) "Placenta!transfer of methylprednisolone following maternal intravenousadministration", Am. J. Obstet. Gynecol. 140, 699-701.
  • Lockshin, M.D. and Sammaritano, L.R. (1998) "Corticosteroidsduring pregnancy", Scand. J. Rheumatol. Suppl. 107, 136-138.
  • Rayburn, W.F. (1992) "Glucocorticoid therapy for rheumaticdiseases: maternal, fetal, and breast-feeding considerations", Am.J. Reprod. Immunol. 28(3-4), 138-140.
  • Bongiovanni, A.M. and McPadden, A.I. (1960) "Steroids duringpregnancy and possible fetal consequences", Fertil. Steril. 11,181-186.
  • Cote, C.J., Meuwissen, I. and Picketing, R. (1974) "Effects on theneonate of prednisone and azathioprine administered to the motherduring pregnancy", J. Pediatr. 85, 324-328.
  • Cederqvist, L., Merkatz, I. and Litwin, S. (1977) "Fetalimmunoglobulin synthesis following maternal immunosuppres-sion", Am. J. Obstet. Gynecol. 129, 687-690.
  • Kraus, A.M. (1975) "Congenital cataract and maternal steroidinjection", J. Pediatr. Ophthalmol. 12, 107-108.
  • Reinisch, J.M., Simon, N.G., Karow, W.G. and Gandelman, R.(1978) "Prenatal exposure to prednisone in humans and animalsretards intrauterine growth", Science 202, 436-438.
  • Scott, J. (1977) "Fetal growth retardation associated with maternaladministration of immunosuppressive drugs", Am. J. Obstet.Gynecol. 128, 668-676.
  • Out, H.J., Bruinse, H.W., Christiaens, G.C., van Vliet, M., deGroot, P.G., Nieuwenhuis, H.K., et al. (1992) "A prospective,controlled multicenter study on the obstetric risks of pregnantwomen with antiphospholipid antibodies", Am. J. Obstet. Gynecol.167(1), 26-32.
  • Mintz, G., Niz, J., Gutierrez, C., Garcia-Alonso, A. and Karchmer,S. (1986) "Prospective study of pregnancy in systemic lupuserythematosus: results of a multidisciplinary approach",J. Rheumatol. 13, 732-739.
  • Logaridis, T.E., Doran, T.A., Scott, J.G. and Gare, D.G. andComtesse, C. (1983) "The effect of maternal steroid administration on fetal platelet count in immunologie thrombocytopenicpurpura", Am. J. Obstet. Gynecol. 145, 147-151.
  • Sermant, H., Charpin, J., Tessier, G., et ai (1968) "Corticotherapieet grossesse", Bull. Fed. Soc. Gynecol. Obstet. Franc. 20,159-161.
  • Heinonen, O.P., Slone, D. and Shapiro, S. (1977) Birth Defectsand Drugs in Pregnancy (Publishing Science Group, Littleton,MA).
  • Houser, M.T., Fish, A.J., Tagatz, G.E., Williams, P.P. and Michael,A.F. (1980) "Pregnancy and systemic lupus erythematosus", Am.J. Obstet. Gynecol. 138, 409-413.
  • Zulman, J.I., Talal, N., Huffman, G.S. and Epstein, W.V. (1980)"Problems associated with the management of pregnancies inpatients with systemic lupus erythematosus", J. Rheumatol. 7,37-49.
  • Varner, M.W., Meehan, R.T., Syrop, C.H., Strottmann, M.P. andGoblerud, C.P. (1983) "Pregnancy in patients with systemic lupuserythematosus", Am. J. Obstet. Gynecol. 145, 1025-1040.
  • Lubbe, W.F., Butler, W.S., Palmer, S.J. and Liggins, G.C. (1983)"Fetal survival after prednisone suppression of maternal lupusanticoagulant", Lancet 1, 1361-1363.
  • Lockshin, M.D., Reinitz, E., Druzin, M.L., Murrman, M. andEstes, D. (1984) "Lupus pregnancy I. Case-control prospectivestudy demonstrating absence of lupus exacerbation during or afterpregnancy", Am. J. Med 77, 893-898.
  • Committee on Drugs, American Academy of Pediatrics (1989)"The transfer of drugs and other chemicals into human breastmilk", Pediatrics 84, 924-936.
  • Ost, L., Wettrell, G., Bjorkhem, I. and Rane, A. (1985)"Prednisolone excretion in human milk", J. Pediatr. 106,1008-1011.
  • Fox, R.I. (1993) "Mechanism of action of hydroxychloroquine asan antirheumatic drug", Semin. Arthritis Rheum. 23(Suppl. 1),82-91.
  • Wolfe, M. and Cordero, J. (1985) "Safety of chloroquine inchemosuppression of malaria during pregnancy", Br. Med. J. 290,1446-1447.
  • (1983) "Malaria in pregnancy", Lancet 2(JuIy, 8341), 84-85.
  • McCarty, G.A., personal communication.
  • Tsakonas, E., Joseph, L., Esdaile, J.M., Choquette, D., Senecal,J.L., Cividino, A., Danoff, D., Osterland, C.K., Yeadon, C. andSmith, C.D. (1998) "A long-term study of hydroxychloroquinewithdrawal on exacerbations in systemic lupus erythematosus. TheCanadian Hydroxychloroquine Study Group", Lupus 7, 80-85.
  • Borden, M.B. and Parke, A.L. (2001) "Antimalarial drugs insystemic lupus erythematosus: use in pregnancy", Drug Saf.24(14), 1055-1063.
  • McChesney, E.W. (1983) "Animal toxicity and pharmacokineticsof hydroxychloroquine sulfate", Am. J. Med. 75(1A), 11-18.
  • Ullberg, S., Lindquist, N. and Sjostrand, S. (1970) "Accumulationof chorioretinotoxic drugs in the foetal eye", Nature 227,1257-1258.
  • Fail, P.A., Martin, P. and Sokal, D. (2000) "Comparative effects ofquinacrine and erythromycin in adult female rats: a nonsurgicalsterilization study", Fertil. Steril. 73, 387-394.
  • Hart, C. and Naunton, R. (1964) "The ototoxicity of chloroquinephosphate", Arch. Otolaryngol. Head Neck Surg. 80, 407-412.
  • Panfique, L. and Magnard, P. (1969) "Retinal degeneration in 2children following preventive antimalarial treatment of motherduring pregnancy", BuIl. Soc. Ophthamol. Fr. 69, 466-467.
  • Levy, M., Buskila, D., Gladman, D.D., Urowitz, M.B. and Koren,G. (1991) "Pregnancy outcome following first trimester exposureto chloroquine", Am. J. Perinatal 8, 174-178.
  • Buchanan, N.M.M., Toubi, E., Khamashta, M.A., Lima, F.,Kerslake, S. and Hughes, G.R.V. (1996) "Hydroxychloroquine andlupus pregnancy: review of a series of 36 cases", Ann. Rheum. Dis.55, 486-488.
  • Parke, A. and West, B. (1996) "Hydroxychloroquine in pregnantpatients with systemic lupus erythematosus", J. Rheumatol. 23,1715-1718.
  • Levy, R.A., Vilela, V.S., Cataldo, M.J., Ramos, R.C., Duarte, J.L.,Tura, B.R., Albuquerque, E.M. and Jesus, N.R. (2001) "Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind andplacebo-controlled study", Lupus 10, 401-404.
  • Briggs, G.G., Freeman, R.K., Yaffe, S.J., eds, (1990) Drugs inPregnancy and Lactation, 3rd ed. (Williams and Wilkins,Baltimore).
  • Penn, I., Makowski, E. and Harris, P. (1980) "Parenthoodfollowing renal transplantation", Kidney Int. 18, 221-233.
  • Pirson, Y., Van Lierde, M., Ghysen, J., Squifflet, I.P., Alexandre,G.PJ. and van Ypersele de Strihou, C. (1985) "Retardation of fetalgrowth in patients receiving immunosuppressive therapy [letter]",N. Engl J. Med. 313, 328.
  • Report from the Registration Committee of the European Dialysisand Transplant Association (1980) "Successful pregnancies inwomen treated by dialysis and kidney transplantation", Br.J. Obstet. Gynaecol. 87, 839-845.
  • Davison, J.M. and Lindheimer, M.D. (1982) "Pregnancy in renaltransplant recipients", J. Reprod. Med. 27, 613-621.
  • Marushak, A., Weber, T., Bock, I., Birkeland, S.A., Hansen, H.E.,Klebe, I., Kristoffersen, K., Rasmussen, K. and Olgaard, K. (1986)"Pregnancy following kidney transplantation", Acta Obstet.Gynecol. Scand. 65, 557-559.
  • Rudolph, J., Schweizer, R. and Bartus, S. (1979) "Pregnancy inrenal transplant patients", Transplantation 27, 36-39.
  • Hadi, H.A., Stafford, C.R., Williamson, J.R., Fade), H.E. andDevoe, L.D. (1986) "Pregnancy outcome in renal transplantrecipients", South Med, J. 79, 959-964.
  • Registration Committee of the European Dialysis and TransplantAssociation(1980) "Successful pregnancies in women treated bydialysis and kidney transplantation", Br. J. Obstet. Gynaecol. 87,839-845.
  • Meehan, R.T. and Dorsey, J.K. (1987) "Pregnancy among patientswith systemic lupus erythematosus receiving immunosuppressivetherapy", J. Rheumatol 14, 252-258.
  • Ramsey-Goldman, R., Mientus, I.M., Kutzer, J.E., Mulvihill, J.I.and Medsger, Jr., TA. (1993) "Pregnancy outcome in women withsystemic lupus erythematosus treated with immunosuppressivedrugs", J. Rheumatol 20, 1152-1157.
  • Martinez-Rueda, O., Arce-Salinas, A., Kraus, A., et al. (1993)"Factors associated with fetal wastage in 73 pregnanciesof women with severe lupus [abstract]", Arthritis Rheum.36(Suppl.), S74.
  • Leb, D., Weisskopf, B. and Kanovitz, B. (1971) "Chromosomeaberrations in the child of a kidney transplant recipient", Arch.Intern. Med. 128, 441-444.
  • Davison, I.M., Dellagrammatikas, H. and Parkin, J.M. (1985)"Maternal azathioprine therapy and depressed haemopoiesis in thebabies of renal allograft patients", Br. J. Obstet. Gynaecol. 92,233-239.
  • Lower, G.D., Stevens, L.E., Najarian, I.S. and Reemtsma, K.(1971) "Problems from immunosuppressives during pregnancy",Am. J. Obstet. Gynecol. 111, 1120-1121.
  • Price, H.V, Salaman, J.R., Laurence, K.M. and Langmaid, H.(1976) "Immunosuppressive drugs and the fetus", Transplantation21, 294-298.
  • DeWitte, D.B., Buick, M.K., Cyran, S.E. and Maisels, M.J. (1984)"Neonatal pancytopenia and severe combined immunodeficiencyassociated with antenatal administration of azathioprine andprednisone", J. Pediatr. 105, 625-628.
  • Roubenoff, R., Hoyt, M., Petri, M., Hochberg, M. and Hellmann,D. (1988) "Effects of antiinflammatory and immunosuppresivedrugs on pregnancy and fertility", Semin. Arthritis Rheum. 18,88-110.
  • Coulam, C.B., Moyer, T.P., Jiang, N.S. and Zincke, H. (1982)"Breast-feeding after renal transplantation", Transplant. Proc. 14,605-609.
  • Chan, T.M., Li, F.K., Tang, C.S., Wong, R.W., Fang, G.X., Ji, Y.L.,Lau, C.S., Wong, A.K., Tong, M.K., Chan, K.W. and Lai, K.N.(2000) "Efficacy of mycophenolate mofetil in patientswith diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group", N. Engl. J. Med.343(16), 1156-1162.
  • Ines, L.S. and Petri, M. (2001) "Mycophenolate Mofetil: anemerging therapeutic option for systemic lupus erythematosus",Acta Reumatologica Portuguesa 26, 153-162.
  • Hussein, M.M., Mooij, J.M.V. and Roujouleh, H. (1993)"Cyclosporine in the treatment of lupus nephritis includingtwo patients treated during pregnancy", Clin. Nephrol. 40,160-163.
  • Favre, H., et al. (1989) "Cyclosporin in the treatment of lupusnephritis", Am. J. Nephrol. 9(Suppl. 1), 57-60.
  • Feutren, G., Querin, S., Tran, F., et al. (1986) "The effects of cyclosporine in patients with systemic lupus erythematosus", Transplant. Proc. 18, 634-644.
  • Winter, H., Mackenzie, W.E. and Newton, J.R. (1990) "Successful pregnancy following liver transplantation in a patient taking cyclosporine A", J. Obstet. Gynaecol. 10, 396-397.
  • Flechner, S.M., Katz, A.R., Rogers, A.J., Van Buren, C. and Kahan, B.D. (1985) "The presence of cyclosporine in body tissues and fluids during pregnancy", Am. J. Kidney Dis. 5, 60-63.
  • Klintmalm, G., Althoff, P., Appleby, G. and Segerbrandt, E. (1984) "Renal function in a newborn baby delivered of a renal transplant patients taking cyclosporine", Transplantation 38, 98-99.
  • Grischke, E., Kaufmann, M., Dreikorn, K., Linderkamp, O. and Kubli, F. (1986) "Erfolgreiche Schwangerschaft bei nierentransplantation und cyclosporin A", Geburtsh u. Gmuenheilk 46, 176-179.
  • Endler, M., Derfler, K., Schaller, A. and Nowotny, C. (1987) "Schwangerschaft und geburt nach nierentransplantation unter cyclosporin A", Geburtsh u. Grauenheilk 47, 660-663.
  • Bourget, R, Fernandez, H. and Delouis, C. (1991) "Accumulation of cyclosporine in the conceptus during the first trimester of pregnancy after liver transplantation", Transplantation 51, 1306-1307.
  • Cockburn, I., Krupp, R and Monka, C. (1989) "Present experience of Sandimmune in pregnancy", Transplant. Proc. 21, 3730-3732.
  • Hou, S. (1989) "Pregnancy in organ transplant recipients", Med. Clin. N. Am. 73, 667-683.
  • Hangen, G., Fauchald, P., Sodal, G., Halvorsen, S., Oldereid, N. and Moe, N. (1991) "Pregnancy outcome in renal allograft recipients: influence of cyclosporin A", Ear. J. Obstet. Gynecol. Reprod. Biol. 39, 25-29.
  • Arellano, F., Monka, C. and Krupp, P. (1991) "Tratamiento con ciclosporina A en Ia gestante [letter]", Med. Clin. (Bare.) 96, 194.
  • Pickrell, M.D. and Sawers, R. (1988) "Pregnancy after renal transplantation: severe intrauterine growth retardation during treatment with cyclosporine A [letter]", Br. Med. J. 296, 825.
  • Muirhead, N., Sabharwal, A.R., Rieder, M.J., Lazarovits, A.L and Hollomby, D.I. (1992) "The outcome of pregnancy following renal transplantation--the experience of a single center", Transplantation 54, 429-432.
  • Ostensen, M. (1992) 'Treatment with immunosuppressive and disease modifying drugs during pregnancy and lactation", Am. J. Reprod. Immunol. 28(3-4), 148-152.
  • Imbasciati, E. and Ponticelli, C. (1991) "Pregnancy and renal disease: predictors for fetal and maternal outcome", Am. J. Nephrol. 11, 353-362.
  • Pujals, J.M., Figueras, G. and Puig, J.M. (1989) 'Osseous malformation in baby born to woman on cyclosporin [letter]", Lancet 1, 667.
  • Takahashi, N., Nishida, H. and Hoshi, J. (1994) "Severe B-cell depletion in newboms from renal transplant mothers taking immunosuppressive agents", Transplantation 57, 1617-1621.
  • Rose, M.L., Dominguez, M., Leaver, N., Lachno, R. and Yacoub, M.H. (1989) "Analysis of T-cell subpopulations and cyclosporine levels in the blood of two neonates born to immunosuppressed heart-lung transplant recipients", Transplantation 48, 223-226.
  • American Academy of Pediatrics Committee on Drugs (1989) 'Transfer of drugs and other chemicals into human milk", Pediatrics 84, 924-936.
  • Boumpas, D.T., Austin, III, H.A., Vaughan, E.M., Yarboro, C.H., Klippel, J.H. and Balow, I.E. (1993) "Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy", Ann. Intern. Med. 119, 366-369.
  • Radis, C.D., Kahl, L.E., Baker, G.L., Wasko, M.C., Cash, J.M., Gallatin, A., Stolzer, B.L., Agarwal, A.K., Medsger, T.A., Jr. and Kwoh, C.K. (1995) "Effects of cyclophosphoamide on the development of malignancy and on the long-term survival of patients with rheumatoid arthritis: a 20-year followup study", Arthritis Rheum. 38, 1120-1127.
  • D'Incalci, M., Sessa, C., Columbo, N., de PaIo, G., Semprini, A.E. and Pardi, G. (1982) "Transplacental passage of cyclophosphamide", Cancer Treat. Rep. 66, 1681-1682.
  • Greenberg, L.H. and Tanaka, K.R. (1964) "Congenital anomalies probably induced by cyclophosphamide", JAMA 188, 423-426.
  • Kirshon, B., Wasserstrum, N., Willis, R., Herman, G.E. and McCabe, E.R.B. (1988) "Teratogenic effects of Ist-trimester cyclophosphamide therapy", Obstet. Gynecol. 72, 462-464.
  • Murray, C.L., Reichert, J.A., Anderson, J. and Twiggs, L.B. (1984) "Multimodal cancer therapy for breast cancer in the first trimester of pregnancy", JAMA 252, 2607-2608.
  • Mutchinick, O., Aizpuru, E. and Grether, P. (1992) "The human teratogenic effect of cyclophosphamide", Aust. Teratog. Abs. 45, 329.
  • Toledo, T.M., Harper, R.C. and Moser, R.H. (1971) "Fetal effects during cyclophosphamide and irradiation therapy", Ann. Intern. Med. 74, 87-91.
  • Zemlickis, D., Lishner, M., Erlich, R. and Koren, G. (1993) "Teratogenicity and carcinogenicity in a twin exposed in utero to cyclophosphamide", Teratog. Carcinog. Mittagen. 13, 139-143.
  • Enns, G.M., Roeder, E., Chan, R.T., Ali-Khan Cans, Z., Cox, VA. and Golabi, M. (1999) "Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?", Am. J. Med. Genet. 86(3), 237-241.
  • Durodola, J.I. (1979) "Administration of cyclophosphamide during late pregnancy and early lactation: a case report", J. Noll Med. Assoc. 71, 165-166.
  • Haerr, R.W. and Pratt, A.T. (1985) "Multiagent chemotherapy forsarcoma diagnosed during pregnancy", Cancer 56, 1028-1033.
  • Nicholson, H.O. (1968) "Cytotoxic drugs in pregnancy: review ofreported cases", J. Obstet. Cynaecol. 75, 307-312.
  • Pizzuto, J., Aviles, A., Noriega, L., Niz, J., Morales, M. and Romero, F. (1980) 'Treatment of acute leukemia during pregnancy: presentation of nine cases", Cancer Treat. Rep. 64, 679-683.
  • Sanders, I.E., Hawley, J., Levy, W, Gooley, T., Buckner, C.D., Deeg, H.J., Doney, K., Storb, R., Sullivan, K., Witherspoon, R. and Appelbaum, F.R. (1996) "Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or totalbody irradiation and bone marrow transplantation", Blood 87, 3045-3052.
  • Sweet, D.L. and Kinzie, J. (1976) "Consequences of radiotherapy and antineoplastic therapy for the fetus", J. Reprod. Med. 17, 241-246.
  • Wiemik, RH. and Duncan, I.H. (1971) "Cyclophosphamide in human milk", Lancet 1, 912.

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