Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress

References

• Kuroki L, Guntupalli SR. Treatment of epithelial ovarian cancer. BMJ. 2020;371:1. doi:10.1136/bmj.m3773
   Google Scholar
• Xu J, Fang Y, Chen K, et al. Single-Cell RNA sequencing reveals the tissue architecture in human high-Grade serous ovarian cancer. Clin Cancer Res. 2022;28(16):3590–10. doi:10.1158/1078-0432.CCR-22-0296
   PubMed Web of Science ®Google Scholar
• Millstein J, Budden T, Goode EL, et al. Prognostic gene expression signature for high-grade serous ovarian cancer. Ann Oncol. 2020;31(9):1240–1250. doi:10.1016/j.annonc.2020.05.019
   PubMed Web of Science ®Google Scholar
• Chen X, Lan H, He D, et al. Multi-omics profiling identifies risk hypoxia-related signatures for ovarian cancer prognosis. Front Immunol. 2021;12:645839. doi:10.3389/fimmu.2021.645839
   PubMed Web of Science ®Google Scholar
• Pereira M, Matuszewska K, Jamieson C, et al. Characterizing endocrine status, tumor hypoxia and immunogenicity for therapy success in epithelial ovarian cancer. Front Endocrinol. 2021;12:772349. doi:10.3389/fendo.2021.772349
   PubMed Web of Science ®Google Scholar
• Poltavets V, Kochetkova M, Pitson SM, et al. The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity. Front Oncol. 2018;8:431. doi:10.3389/fonc.2018.00431
   PubMed Web of Science ®Google Scholar
• Maia J, Caja S, Strano MM, et al. Exosome-based cell-cell communication in the tumor microenvironment. Front Cell Dev Biol. 2018;6:18. doi:10.3389/fcell.2018.00018
   PubMed Web of Science ®Google Scholar
• Feng W, Dean DC, Hornicek FJ, et al. Exosomes promote pre-metastatic niche formation in ovarian cancer. Mol Cancer. 2019;18(1):124. doi:10.1186/s12943-019-1049-4
   PubMed Web of Science ®Google Scholar
• He L, Zhu W, Chen Q, et al. Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis. Theranostics. 2019;9(26):8206–8220. doi:10.7150/thno.37455
   PubMed Web of Science ®Google Scholar
• Neviani P, Wise PM, Murtadha M, et al. Natural Killer-Derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms. Cancer Res. 2019;79(6):1151–1164. doi:10.1158/0008-5472.CAN-18-0779
   PubMed Web of Science ®Google Scholar
• Wang L, Yang G, Zhao D, et al. CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. Mol Cancer. 2019;18(1):86. doi:10.1186/s12943-019-0997-z
   PubMedGoogle Scholar
• Au YC, Co NN, Tsuruga T, et al. Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1. Nat Commun. 2016;7:11150.
   PubMed Web of Science ®Google Scholar
• Kanlikilicer P, Bayraktar R, Denizli M, et al. Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer. Ebiomedicine. 2018;38:100–112. doi:10.1016/j.ebiom.2018.11.004
   PubMed Web of Science ®Google Scholar
• Nowak M, Klink M. The role of tumor-associated macrophages in the progression and chemoresistance of ovarian cancer. Cells. 2020;9(5):1299. doi:10.3390/cells9051299
   PubMed Web of Science ®Google Scholar
• Yoshida K, Yokoi A, Kato T, et al. The clinical impact of intra- and extracellular miRNAs in ovarian cancer. Cancer Sci. 2020;111(10):3435–3444. doi:10.1111/cas.14599
   PubMed Web of Science ®Google Scholar
• Pan C, Stevic I, Muller V, et al. Exosomal microRNAs as tumor markers in epithelial ovarian cancer. Mol Oncol. 2018;12(11):1935–1948. doi:10.1002/1878-0261.12371
   PubMed Web of Science ®Google Scholar
• Sun P, Zhang D, Huang H, et al. MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B. Biol Chem. 2019;400(2):237–246. doi:10.1515/hsz-2018-0265
   PubMed Web of Science ®Google Scholar
• Zhong R, Li S, Fang K, et al. microRNA-1225 inhibit apoptosis of pancreatic cancer cells via targeting JAK1. Cell Cycle. 2019;18(9):990–1000. doi:10.1080/15384101.2019.1608127
   PubMed Web of Science ®Google Scholar
• Tokuhisa M, Ichikawa Y, Kosaka N, et al. Exosomal miRNAs from peritoneum lavage fluid as potential prognostic biomarkers of peritoneal metastasis in gastric cancer. PLOS One. 2015;10(7):e130472.
   PubMed Web of Science ®Google Scholar
• Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–455. doi:10.1038/nature12034
   PubMed Web of Science ®Google Scholar
• Yang F, Ning Z, Ma L, et al. Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts. Mol Cancer. 2017;16(1):148–110. doi:10.1186/s12943-017-0718-4
   PubMed Web of Science ®Google Scholar
• Mori MA, Ludwig RG, Garcia-Martin R, et al. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–673. doi:10.1016/j.cmet.2019.07.011
   PubMed Web of Science ®Google Scholar
• Song M, Yeku OO, Rafiq S, et al. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. 2020;11(1):6298. doi:10.1038/s41467-020-20140-0
   PubMed Web of Science ®Google Scholar
• Chen X, Ying X, Wang X, et al. Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization. Oncol Rep. 2017;38(1):522–528. doi:10.3892/or.2017.5697
   PubMed Web of Science ®Google Scholar
• Genin M, Clement F, Fattaccioli A, et al. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer. 2015;15(1):577. doi:10.1186/s12885-015-1546-9
   PubMedGoogle Scholar
• Klemm P, Behnke M, Solomun JI, et al. Self-assembled PEGylated amphiphilic polypeptides for gene transfection. J Mater Chem B. 2021;9(39):8224–8236. doi:10.1039/D1TB01495A
   PubMed Web of Science ®Google Scholar
• Rupaimoole R, Wu SY, Pradeep S, et al. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun. 2014;5(1):5202. doi:10.1038/ncomms6202
   PubMedGoogle Scholar
• El-Andaloussi S, Lee Y, Lakhal-Littleton S, et al. Exosome-mediated delivery of siRNA in vitro and in vivo. Nat Protoc. 2012;7(12):2112–2126. doi:10.1038/nprot.2012.131
   PubMed Web of Science ®Google Scholar
• Rehman FU, Liu Y, Yang Q, et al. Heme oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy. J Control Release. 2022;345:696–708. doi:10.1016/j.jconrel.2022.03.036
   PubMed Web of Science ®Google Scholar
• Helwa I, Cai J, Drewry MD, et al. A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLOS One. 2017;12(1):e170628.
   PubMed Web of Science ®Google Scholar
• El-Arabey AA, Alkhalil SS, Al-Shouli ST, et al. Revisiting macrophages in ovarian cancer microenvironment: development, function and interaction. Med Oncol. 2023;40(5):142. doi:10.1007/s12032-023-01987-x
   PubMed Web of Science ®Google Scholar
• Han Q, Zhao H, Jiang Y, et al. HCC-derived exosomes: critical player and target for cancer immune escape. Cells. 2019;8(6):558. doi:10.3390/cells8060558
   PubMed Web of Science ®Google Scholar
• El-Arabey AA, Abdalla M. GATA3 as a regulator for naughty cancer-associated fibroblasts in the microenvironment of high-grade serous ovarian cancer. Hum Cell. 2021;34(6):1934–1936. doi:10.1007/s13577-021-00598-w
   PubMed Web of Science ®Google Scholar
• El-Arabey AA, Denizli M, Kanlikilicer P, et al. GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2020;68:109539. doi:10.1016/j.cellsig.2020.109539
   PubMed Web of Science ®Google Scholar
• El-Arabey AA, Abdalla M, Abd-Allah AR. GATA3 and stemness of high-grade serous ovarian carcinoma: novel hope for the deadliest type of ovarian cancer. Hum Cell. 2020;33(3):904–906. doi:10.1007/s13577-020-00368-0
   PubMed Web of Science ®Google Scholar
• Zhao S, Mi Y, Guan B, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. J Hematol Oncol. 2020;13(1):156. doi:10.1186/s13045-020-00991-2
   PubMed Web of Science ®Google Scholar
• Song J, Yang P, Li X, et al. Esophageal cancer-derived extracellular vesicle miR-21-5p contributes to EMT of ESCC cells by disorganizing macrophage polarization. Cancers. 2021;13(16):4122. doi:10.3390/cancers13164122
   PubMed Web of Science ®Google Scholar
• Ospelt C, Gay S. TLRs and chronic inflammation. Int J Biochem Cell Biol. 2010;42(4):495–505. doi:10.1016/j.biocel.2009.10.010
   PubMed Web of Science ®Google Scholar
• Girkin J, Loo SL, Esneau C, et al. TLR2-mediated innate immune priming boosts lung anti-viral immunity. Eur Respir J. 2021;58(1):2001584. doi:10.1183/13993003.01584-2020
   PubMed Web of Science ®Google Scholar
• McCoy MG, Nascimento DW, Veleeparambil M, et al. Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis. Sci Signal. 2021;14(666):eabc5371. doi:10.1126/scisignal.abc5371
   PubMed Web of Science ®Google Scholar
• Lin H, Yan J, Wang Z, et al. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in toll-like receptor 2-deficient mice. Hepatology. 2013;57(1):171–182. doi:10.1002/hep.25991
   PubMed Web of Science ®Google Scholar
• Shi W, Su L, Li Q, et al. Suppression of toll-like receptor 2 expression inhibits the bioactivity of human hepatocellular carcinoma. Tumour Biol. 2014;35(10):9627–9637. doi:10.1007/s13277-014-2268-3
   PubMed Web of Science ®Google Scholar
• Lowe EL, Crother TR, Rabizadeh S, et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLOS One. 2010;5(9):e13027. doi:10.1371/journal.pone.0013027
   PubMed Web of Science ®Google Scholar
• Scheeren FA, Kuo AH, van Weele LJ, et al. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol. 2014;16(12):1238–1248. doi:10.1038/ncb3058
   PubMed Web of Science ®Google Scholar
• Feng Y, Ren J, Gui Y, et al. Wnt/β-catenin-promoted macrophage alternative activation contributes to kidney fibrosis. J Am Soc Nephrol. 2018;29(1):182–193. doi:10.1681/ASN.2017040391
   PubMed Web of Science ®Google Scholar
• Arend RC, Londoño-Joshi AI, Straughn JM, et al. The wnt/β-catenin pathway in ovarian cancer: a review. Gynecol Oncol. 2013;131(3):772–779. doi:10.1016/j.ygyno.2013.09.034
   PubMed Web of Science ®Google Scholar
• Zhao SJ, Kong FQ, Jie J, et al. Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3beta/beta-catenin pathway. Theranostics. 2020;10(1):17–35. doi:10.7150/thno.36930
   PubMed Web of Science ®Google Scholar
• Chen W, Liu Y, Chen J, et al. The notch-signaling pathway regulates macrophage polarization in liver diseases. Int Immunopharmacol. 2021;99:107938. doi:10.1016/j.intimp.2021.107938
   PubMed Web of Science ®Google Scholar
• Liu C, Hu F, Jiao G, et al. Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFkappaB P65 signaling pathway after spinal cord injury. J Nanobiotechnology. 2022;20(1):65. doi:10.1186/s12951-022-01273-4
   PubMed Web of Science ®Google Scholar
• Yin Z, Ma T, Lin Y, et al. IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. J Cell Biochem. 2018;119(11):9419–9432. doi:10.1002/jcb.27259
   PubMed Web of Science ®Google Scholar