187
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Protective effect of naringin ameliorates TNBS‐induced colitis in rats via improving antioxidant status and pro-inflammatory cytokines

&
Pages 373-386 | Received 14 Nov 2021, Accepted 25 Feb 2022, Published online: 10 Mar 2022

References

  • Szandruk M, Merwid-Ląd A, Szeląg A. The impact of mangiferin from Belamcanda chinensis on experimental colitis in rats. Inflammopharmacology. 2018;26(2):571–581.
  • Da-Silva N, Arasaradnam R, Getliffe K, et al. Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease. Dig Liver Dis. 2010;42(8):544–548.
  • DeRoche TC, Xiao SY, Liu X. Histological evaluation in ulcerative colitis. Gastroenterol Rep. 2014;2(3):178–192.
  • Sonnenberg E, Siegmund B. Ulcerative colitis. Digestion. 2016;94(4):181–185.
  • Park SC, Jeen YT. Current and emerging biologics for ulcerative colitis. Gut Liver. 2015;9(1):18–27.
  • Yao J, Wang JY, Liu L, et al. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res. 2010;41(4):288–294.
  • Burisch J, Pedersen N, Čuković-Čavka S, et al. East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut. 2014;63(4):588–597.
  • Dyson JK, Rutter MD. Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk? World J Gastroenterol. 2012;18(29):3839–3848.
  • Molodecky NA, Soon INGS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases. Gastroenterol. 2012;142(1):46–54.
  • Actis GC, Pellicano R, Rosina F. Inflammatory bowel diseases: current problems and future tasks. World J Gastrointest Pharmacol Ther. 2014;5(3):169–174.
  • Shaker ME, Ashamallah SA, Houssen ME. Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis. Chem Biol Interact. 2014;210(1):26–33.
  • Malik T, Mannon P. Inflammatory bowel diseases: emerging therapies and promising molecular targets. Front Biosci. 2012;4(3):1172–1189.
  • Khanna PV, Shih DQ, Haritunians T, et al. Use of animal models in elucidating disease pathogenesis in IBD. Semin Immunopathol. 2014;36(5):541–551.
  • de Almeida ABA, Sánchez-Hidalgo M, Martín AR, et al. Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. J Ethnopharmacol. 2013;146(1):300–310.
  • Isik F, Tunali Akbay T, Yarat A, et al. Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci. 2011;56(3):721–730.
  • Kiesler P, Fuss IJ, Strober W. Experimental models of inflammatory bowel diseases. Cell Mol Gastroenterol Hepatol. 2015;1(2):154–170.
  • Bryant RV, Brain O, Travis SPL. Conventional drug therapy for inflammatory bowel disease. Scand J Gastroenterol. 2015;50(1):90–112.
  • Rosenberg LN, Peppercorn MA. Efficacy and safety of drugs for ulcerative colitis. Expert Opin Drug Saf. 2010;9(4):573–592.
  • Glässer G, Graefe EU, Struck F, et al. Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites. Phytomedicine. 2002;9(1):33–40.
  • Maksimovíc Z, Maleňcíc D, Kovǎcevíc N. Polyphenol contents and antioxidant activity of maydis stigma extracts. Bioresour Technol. 2005;96(8):873–877.
  • Jagetia GC, Reddy TK. The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. Mutat Res Genet Toxicol Environ Mutagen. 2002;519(1–2):37–48.
  • Jang MH, Piao XL, Kim JM, et al. Inhibition of cholinesterase and amyloid-beta aggregation by resveratrol oligomers from Vitis amurensis. Phytother Res. 2008;22(4):544–549.
  • Cells NS, Kim H, Song JY, et al. Naringin protects against rotenone-induced apoptosis in human. J Physiol Pharmacol. 2009;13(4):281–285.
  • Jagetia GC, Reddy TK. Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. Life Sci. 2005;77(7):780–794.
  • Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. Toxicology. 2006;228(2–3):259–268.
  • Gopinath K, Prakash D, Sudhandiran G. Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. Neurochem Int. 2011;59(7):1066–1073.
  • Ahmad SF, Zoheir KMA, Abdel-Hamied HE, et al. Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. Cell Immunol. 2014;287(2):112–120.
  • Organisation for Economic Co-operation and Development. Guidance document on acute oral toxicity testing series on testing and assessment no. 24. Paris: OECD Environment, health and safety publications; 2001 [cited 2008 May 12]. Available from: www.oecd.org/ehs
  • Morampudi V, Bhinder G, Wu X, et al. DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat. J Vis Exp. 2014;(84):1–8.
  • Hsieh H, Morin J, Filliettaz C, et al. Fecal lipocalin-2 as a sensitive and noninvasive biomarker in the TNBS Crohn's inflammatory bowel disease model. Toxicol Pathol. 2016;44(8):1084–1094.
  • Xu B, Li YL, Xu M, et al. Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function. Acta Pharmacol Sin. 2017;38(5):688–698.
  • Kumar VS, Rajmane AR, Adil M, et al. Naringin ameliorates acetic acid-induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 2014;28(2):132–145.
  • Martín AR, Villegas I, La Casa C, et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol. 2004;67(7):1399–1410.
  • Bobin-Dubigeon C, Collin X, Grimaud N, et al. Effects of tumor necrosis factor-α synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis. Eur J Pharmacol. 2001;431(1):103–110.
  • Pohlmann A, Tilling LC, Robinson A, et al. Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI. Inflamm Bowel Dis. 2009;15(4):534–545.
  • Misra HP, Fridovich I. The generation of superoxide radical during the autoxidation of ferredoxins. J Biol Chem. 1971;246(22):6886–6890.
  • Slater TF, Sawyer BC. The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used. Biochem J. 1971;123(5):805–814.
  • Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. BBA Gen Subj. 1979;582(1):67–78.
  • Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952;195(1):133–140.
  • Barone FC, Hillegass LM, Tzimas MN, et al. Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke. Mol Chem Neuropathol. 1995;24(1):13–30.
  • Park JH, Peyrin-Biroulet L, Eisenhut M, et al. IBD immunopathogenesis: a comprehensive review of inflammatory molecules. Autoimmun Rev. 2017;16(4):416–426.
  • Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14(5):329–342.
  • Lee EJ, Kim DI, Kim WJ, et al. Naringin inhibits matrix metalloproteinase-9 expression and AKT phosphorylation in tumor necrosis factor-alpha-induced vascular smooth muscle cells. Mol Nutr Food Res. 2009;53(12):1582–1591.
  • Luo X, Yu Z, Deng C, et al. Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling Cascade and NLRP3 inflammasome activation in mice. Sci Rep. 2017;7(1):1–14.
  • Suzuki R, Katakura K, Fujiwara T, et al. Imiquimod-induced CCR9 ameliorates murine TNBS Colitis. Fukushima J Med Sci. 2016;62(2):90–100.
  • Liu Y, Wang X, Hu CAA. Therapeutic potential of amino acids in inflammatory bowel disease. Nutr. 2017;9(9):1–18.
  • Kandhare AD, Raygude KS, Ghosh P, et al. Effect of hydroalcoholic extract of Hibiscus rosa-sinensis linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed. 2012;2(5):337–344.
  • De Faria FM, Luiz-Ferreira A, Socca EAR, et al. Effects of rhizophora mangle on experimental colitis induced by TNBS in rats. Evidence Based Complement Altern Med. 2012;2012:1–11.
  • Randhawa PK, Singh K, Singh N, et al. A review on chemical-induced inflammatory bowel disease models in rodents. Korean J Physiol Pharmacol. 2014;18(4):279–288.
  • Cai H, Xu Y, Xie L, et al. Investigation on the spectrum-effect correlation between constituents absorbed into blood and bioactivities of Baizhu Shaoyao San before and after processing on ulcerative colitis rats by UHPLC/Q-TOF-MS/MS coupled with gray correlation analysis. Molecules. 2019;24(5):1–26.
  • Gassull MA. Nutrition and inflammatory bowel disease: its relation to pathophysiology, outcome and therapy. Dig Dis. 2003;21(3):220–227.
  • Goh J, O'Morain CA. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther. 2003;17(3):307–320.
  • Jagtap AG, Niphadkar PV, Phadke AS. Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice. Indian J Exp Biol. 2011;49(5):343–351.
  • Alabi Q, Akomolafe R, Olukiran O, et al. Assessment of haematological and biochemical effects of kolaviron in male Wistar rats. BJPR. 2017;16(3):1–14.
  • Liu X, Wang J. Anti-inflammatory effects of iridoid glycosides fraction of folium syringae leaves on TNBS-induced colitis in rats. J Ethnopharmacol. 2011;133(2):780–787.
  • Barollo M, D'Inca R, Scarpa M, et al. Effects of iron manipulation on trace elements level in a model of colitis in rats. World J Gastroenterol. 2005;11(28):4396–4399.
  • Alzoghaibi MA. Concepts of oxidative stress and antioxidant defense in Crohn's disease. World J Gastroenterol. 2013;19(39):6540–6547.
  • Kandhare AD, Bodhankar SL, Mohan V, et al. Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem Biol Interact. 2015;237:151–165.
  • Witaicenis A, Seito LN, Da Silveira Chagas A, et al. Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives. Phytomedicine. 2014;21(3):240–246.
  • Honmore V, Kandhare A, Zanwar AA, et al. Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers . Pharm Biol. 2015;53(4):571–581.
  • Oz HS, Chen T, de Villiers WJS. Green tea polyphenols and sulfasalazine have parallel anti-inflammatory properties in colitis models. Front Immunol. 2013;4:1–11.
  • Yamada T, Grisham MB. Role of neutrophil-derived oxidants in the pathogenesis of intestinal inflammation. Klin Wochenschr. 1991;69(21–23):988–994.
  • Schreiber S, Hämling J, Zehnter E, et al. Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate. Gut. 1997;40(6):761–766.
  • Nishitani Y, Zhang L, Yoshida M, et al. Intestinal anti-Inflammatory activity of lentinan: Influence on IL-8 and TNFR1 expression in intestinal epithelial cells. PLOS One. 2013;8(4):e62441.
  • Wei Shen SKD. Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease. Physiol Behav. 2011;176(10):139–148.
  • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1756–1767.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.