RAT LUNG TUMORS INDUCED BY EXPOSURE TO SELECTED POORLY SOLUBLE NONFIBROUS PARTICLES

REFERENCES

• Boorman, G., and Eustis, S. L. 1990. Lung. In Pathology of the Fischer rat: Reference and atlas, eds. G. A. Boorman, S. L. Eustis, B. R. Elwell, C. A. Montgomery, and W. F. MacKenzie, pp. 339–367. San Diego, CA: Academic Press.
   Google Scholar
• Boorman, G. A., Brockmann, M., Carlton, W. W., Davis, J. M. G., Dungworth, D. L., Hahn, F. F., Mohr, U., Reichhelm, H.-B. R., Turusov, V. S., and Wagner, B. M. 1996. Classification of cystic keratinizingsquamous lesions of the rat lung: Report of a workshop. Toxicol. Pathol. 24(5):564–572.
   Google Scholar
• Brightwell, J., Fouillet, X., Cassano-Zoppi, A.-L., Bernstein, D., Crawley, F., Douchosal, F., Gatz, R., Perczel, S., and Pfeifer, H. 1989. Tumors of the respiratory tract in rats and hamsters following chronic inhalation of engine exhaust emissions.]. Appl. Toxicol. 9: 23–31.
   Google Scholar
• Carlton, W. W. 1994. Proliferative keratin cyst, a lesion in the lungs of rats following chronic expo-sure to para-aramid fibrils. Fundam. AppL Toxicol. 23:304–307.
   PubMedGoogle Scholar
• Dagle, G. E., Wehner, A. P., Clarke, M. L., and Buschbom, R. L. 1986. Chronic inhalation exposure of rats to quartz. In Silica, silicosis and cancer, eds. D. F. Goldsmith, D. M. Winn, and C. M. Shy, pp. 255–266. New York: Praeger.
   Google Scholar
• Drozdowicz, B. Z., and Kelly, C. M. 1989. Genetic and Animal Toxicity Testing of Solvent Refined Coal-I (SRC-I) Products, Intermediates, and Waste Materials, Final Report: DOE-OR-21446-T1, Appendix C, Lifetime Inhalation Carcinogenicity Studies of First-Stage Solid Produce (SRC Solids). Allentown, PA: Air Products and Chemicals, Inc.
   Google Scholar
• Finch, G. L., Hoover, M. D., Hahn, F. F., Nikula, K. J., Belinsky, S. A., Haley, P. J., and Griffith, W. C. 1996. Animal models of beryllium-induced lung disease. Environ. Health Perspect. 104(5):1-7. Glaser, U., Hochrainer, D., Otto, F. J., and Oldiges, H. 1990. Carcinogenicity and toxicity of four cadmium compounds inhaled by rats. ToxicoL Environ. Chem. 27:153–162.
   Google Scholar
• Groth, D. H., Stettler, L. E., Burg, J. R., Busey, W. M., Grang, G. C., and Wong, L. 1986. Carcino-genic effects of antimony trioxide and antimony ore concentrate in rats. J. ToxicoL Environ. Health 18:607–626.
   PubMed Web of Science ®Google Scholar
• Hahn, F. F., and Boorman, G. A. 1997. Neoplasia and preneoplasia of the lung. In Pathology of neo-plasia and preneoplasia in rodents, vol. 2, EULEP Color Atlas, eds. P. Bannasch and W. Gossner, pp. 20–42. Stuttgart, Germany: Schattauer.
   Google Scholar
• Heinrich, U., Peters, L., Funcke, W., Potts, F., Mohr, U., and Stöber, W. 1982. Investigations of toxic and carcinogenic effects of diesel exhaust in long-term inhalation exposure of rodents. In Toxico-logical effects of emissions from diesel engines, ed. J. Lewtas, pp. 225–242. Amsterdam: Elsevier.
   Google Scholar
• Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., Fuhst, R., Mohr, U., Pott, F., and Stöber, W. 1986. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine em issions. J. AppL ToxicoL 6(6):383–395.
   PubMed Web of Science ®Google Scholar
• Heinrich, U., Peters, L., Creutzenberg, 0., Dasenbrock, C., and Hoymann, H.-G. 1994. Inhalation exposure of rats to tar/pitch condensation aerosol or carbon black alone or in combination with irritant gases. In Toxic and carcinogenic effects of solid particles in the respiratory tract, eds. U. Mohr, D. L. Dungworth, J. L. Mauderly, and G. Oberdörster, pp. 433–442. Washington, DC: ILSI Press.
   Google Scholar
• Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, 0., Bellmann, B., Koch, W., and Levsen, K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. InhaL ToxicoL 7:533–556.
   Web of Science ®Google Scholar
• Heuper, W. C. 1958. Experimental studies in metal cancerigenesis. IX. Pulmonary lesions in guinea pigs and rats exposed to prolonged inhalation of powdered metallic nickel. AMA Arch. PathoL 65:600–607.
   Google Scholar
• Holland, L. M., Wilson, J. S., Tillery, M. I., and Smith, D. M. 1986. Lung cancer in rats exposed to fibrogenic dusts. In Silica, silicosis, and cancer, eds. D. F. Goldsmith, D. M. Winn, and C. M. Shy, pp. 267–270. New York: Praeger.
   Google Scholar
• International Agency for Research on Cancer. 1984. Polynuclear aromatic compounds, industrial ex-posures in aluminum production, coal gasification, coke production, and iron and steel found-ing. ARC Monogr. Eval. Carcinogen. Risks Hum. 34(3).
   Google Scholar
• International Agency for Research on Cancer. 1987a. Overall evaluations of carcinogenicity: An updating of IARC monographs. ARC Monogr. Eval. Carcinogen. Risks Hum. 1-42\(suppl. 7). International Agency for Research on Cancer. 1987b. Silica and some silicates. ARC Monogr. Eval. Carcinogen. Risks Hum. 42.
   Google Scholar
• International Agency for Research on Cancer. 1989a. Diesel and gasoline engine exhausts and some nitroarenes. ARC Monogr. Eval. Carcinogen. Risks Chem. Hum. 46.
   Google Scholar
• International Agency for Research on Cancer. 1989b. Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. ARC Monogr. Eval. Carcinogen. Risks Hum. 47.
   Google Scholar
• International Agency for Research on Cancer. 1990. Chromium, nickel, and welding. ARC Monogr. Eval. Carcinogen. Risks Hum. 49.
   Google Scholar
• International Agency for Research on Cancer. 1993. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. ARC Monogr. Eval. Carcinogen. Risks Hum. 58.
   Google Scholar
• International Agency for Research on Cancer. 1996. Printing processes and printing inks, carbon black and some nitro compounds. ARC Monogr. Eval. Carcinogen. Risks Hum. 65.
   Google Scholar
• Ishinishi, N., Kuwabara, N., Nagase, S., Suzuki, T., Shoji, I., and Kohno, T. 1986. Long-term inhala-tion studies of exhaust from heavy and light duty diesel engines on F344 rats. In Carcinogenic and mutagenic effects of diesel engine exhaust, eds. N. Ishinishi, A. Koizumi, R. 0. McClellan, and W. Stöber, pp. 329–348. New York: Elsevier.
   Google Scholar
• Iwai, K., Udagawa, T., Yamagishi, M., and Yamada, H. 1986. Long-term inhalation studies of diesel exhaust on F344 SPF rats: Incidence of lung cancer and lymphoma. In Carcinogenic and mutagenic effects of diesel engine exhaust, eds. N. Ishinishi, A. Koizumi, R. 0. McClellan, and W. Stöber, pp. 349–360. New York: Elsevier.
   Google Scholar
• Kanematsu, N., Hara, M., and Kada, T. 1980. REC assay and mutagenicity studies on metal com-pounds. Mutat. Res. 77:109–116.
   PubMed Web of Science ®Google Scholar
• Kaplan, H. L., Springer, K. J., and MacKenzie, W. F. 1983. Studies of Potential Health Effects of Long-Term Exposure to Diesel Exhaust Emissions. Final Report No. 01-0750-103 (SWRI) and No. 1239 (SFRE). San Antonio, TX: Southwest Research Institute.
   Google Scholar
• Kittel, B., Ernst, H., Dungworth, D. L., Rittinghausen, S., Nolte, T., Kamino, K., Stuart, B., Lake, S. G., Cardera, A., Morawietz, G., and Mohr, U. 1993. Morphological comparison between benign keratinizing cystic squamous cell tumors of the lung and squamous cystic lesions of the skin in rats. Exp. Toxicol. Pathol. 45:357–367.
   Google Scholar
• Klonne, D. R., Burns, J. M., Haider, C. A., Holdsworth, C. E., and Ulrich, C. E. 1987. Two-year inhalation toxicity study of petroleum coke in rats and monkeys. Am.]. Ind. Med. 11:375–389.
   PubMed Web of Science ®Google Scholar
• Lee, K. P., Trochimowicz, H. J., and Reinhard, C. F. 1985. Pulmonary response of rats exposed to titanium dioxide (Ti02) by inhalation for 2 years. Toxicol. Appl. PharmacoL 79:179–192.
   PubMed Web of Science ®Google Scholar
• Lee, K. P., Kelly, D. P., Schneider, P. W., and Trochimowicz, H. J. 1986. Inhalation toxicity study on rats exposed to titanium tetrachloride atmospheric hydrolysis products for 2 years. Toxicol. AppL PharmacoL 83:30–45.
   PubMed Web of Science ®Google Scholar
• Lee, K. P., Ulrich, C. E., Geil, R. G., and Trochimowicz, H. J. 1988. Effects of inhaled chromium dioxide dust on rats exposed for two years. Fundam. Appl. Toxicol. 10:125–145.
   PubMedGoogle Scholar
• Lewis, T. R., Green, F. H. Y., Moorman, W. J., Burg, J. R., and Lynch, D. W. 1989. A chronic inhala-tion toxicity study of diesel engine emissions and coal dust, alone and combined.]. Am. Coll. Toxicol. 8:345–375.
   Google Scholar
• MacFarland, H. N., Coate, W. B., Disbennett, D. B., and Ackerman, L. J. 1982. Long-term inhalation studies with raw and processed shale dusts. Ann. Occup. Hyg. 26:213–226.
   PubMedGoogle Scholar
• Martin, J. C., Daniel, H., and LeBouffant, L. 1977. Short- and long-term experimental study of the toxicity of coal-mine dust and of some of its constituents. In Inhaled particles IV, ed. W. H. Walton, pp. 361-370. Oxford: Pergamon Press.
   Google Scholar
• Mauderly, J. L. 1996. Lung overload: The dilemma and opportunities for resolution. Inhal. Toxicol. 8(suppl.):1–28.
   Google Scholar
• Mauderly, J. L. 1997. Relevance of particle-induced rat lung tumors for assessing lung carcinogenic hazard and human lung cancer risk. Environ. Health Perspect.105\(suppl. 5):1337–1346.
   Google Scholar
• Mauderly, J. L, Jones, R. K., Griffith, W. C., Henderson, R. F., and McClellan, R. 0. 1987. Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. AppL Toxicol. 9:208–221.
   PubMedGoogle Scholar
• Mauderly, J. L., Cheng, Y. S., and Snipes, M. B. 1990. Particle overload in toxicological studies: Friend or foe?]. Aerosol Med. 3(1):S169–5187.
   Google Scholar
• Mauderly, J. L., Snipes, M. B., Barr, E. B., Belinsky, S. A., Bond, J. A., Brooks, A. L., Chang, L.-Y., Cheng, Y. S., Gillett, N. A., Griffith, W. C., Henderson, R. F., Mitchell, C. E., Nikula, K. J., and Thomassen, D. G. 1994. Pulmonary Toxicity of Inhaled Diesel Exhaust and Carbon Black in Chronically Exposed Rats, Part I, Neoplastic and Nonneoplastic Lung Lesions. Cambridge, MA: Research Report Number 68. Health Effects Institute.
   Google Scholar
• Mauderly, J. L., Banas, D. A., Griffith, W. C., Hahn, F. F., Henderson, R. F., and McClellan, R. 0. 1996. Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats. Fundam. AppL Toxicol. 30:233–242.
   PubMedGoogle Scholar
• Mohr, U., Rittinghausen, S., Takenaka, S., Ernst, H., Dungworth, D. L., and Pylev, L. N. 1990. Tumours of the lower respiratory tract and pleura in the rat. In Pathology of tumours in laboratory animals. Vol. 1-Tumours of the rat, 2nd ed., eds. V. Turusov and U. Mohr, pp. 275–289. Lyon: IARC.
   Google Scholar
• Muhle, H., Bel[mann, B., Creutzenberg, 0., Dasenbrock, C., Ernst H., Kilpper L., MacKenzie, J. C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. 1991. Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17: 280–299.
   Google Scholar
• National Toxicology Program. 1993. Toxicology and Carcinogenesis Studies of Talc (CAS No. 14807-96-6) (Non-Asbestiform) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report 421. Research Triangle Park, NC: NTP.
   Google Scholar
• National Toxicology Program. 1994a. Toxicology and Carcinogenesis Studies of Nickel Oxide (CAS No. 1313-99-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report 451. Research Triangle Park, NC: NTP.
   Google Scholar
• National Toxicology Program. 1994b. Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report 453. Research Triangle Park, NC: NTP.
   Google Scholar
• Nauss, K. M., and the Diesel Working Group. 1995. Critical issues in assessing the carcinogenicity of diesel exhaust: A synthesis of current knowledge. In Diesel exhaust: A critical analysis of emis-sions, exposure, and health effects, pp. 11–61. Cambridge, MA: Health Effects Institute.
   Google Scholar
• Nikula, K. J., Snipes, M. B., Barr, E. B., Griffith, W. C., Henderson, R. F., and Mauderly, J. L. 1995. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. Appl. Toxicol. 25:80–94.
   PubMedGoogle Scholar
• Nikula, K. J., Avila, K. J., Griffith, W. C., and Mauderly, J. L. 1997. Lung tissue responses and sites of particle retention differ between rats and cynomolgus monkeys exposed chronically to diesel exhaust and coal dust. Fundam. Appl. Toxicol. 37:37–53.
   PubMedGoogle Scholar
• Pepelko, W. E. 1984. Experimental respiratory carcinogenesis in small laboratory animals. Environ. Res. 33:144–188.
   PubMed Web of Science ®Google Scholar
• Pepelko, W. E., and Peirano, W. B. 1983. Health effects of exposure to diesel engine emissions: A summary of animal studies conducted by the U.S. Environmental Protection Agency's Health Effects Research Laboratories at Cincinnati, OH.]. Am. Coll. Toxicol. 2(4):253–306.
   Web of Science ®Google Scholar
• Saffioti, U., Williams, A. 0., Lambert, N. D., Kaighn, M. E., Mao, Y., and Shi, X. 1995. Carcinogenesis by crystalline silica: Animal, cellular, and molecular studies. In Silica and silica-induced lung diseases, eds. V. Castranova, V. Vallyathan, and W. E. Wallace, pp. 345–381. Boca Raton, FL: CRC Press.
   Google Scholar
• Schepers, G. W. H. 1961. Neoplasia experimentally induced by beryllium compounds. Prog. Exp. Tumor Res. 2:203–244.
   PubMedGoogle Scholar
• Schepers, G. W. H. 1971. Lung tumors of primates and rodents. Ind. Med. 40(11):23–31.
   Google Scholar
• Shirnamé-Moré, L. 1995. Genotoxicity of diesel emissions. Part I: Mutagenicity and other genetic effects. In Diesel exhaust: A critical analysis of emissions, exposure, and health effects, pp. 185–220. Cambridge, MA: Health Effects Institute.
   Google Scholar
• Sunderman, F. W. 1966. Metastasizing pulmonary tumors in rats induced by the inhalation of nickel carbonyl. Int. Conf. Lung Tumors in Animals-Proc. 3rd Quad. Conf, ed. L. Seven, pp. 551–564. Perugia, Italy: Perugia Division of Cancer Research.
   Google Scholar
• Takaki, Y., Kitamura, S., Kuwabara, N., and Fukuda, Y. 1989. Long-term inhalation studies of exhaust from the diesel engine in F-344 rats: The quantitative relationship between pulmonary hyper-plasia and anthracosis. Exp. PathoL 37:56–61.
   PubMedGoogle Scholar
• Takemoto, K., Yoshimura, H., and Katayama, H. 1986. Effects of chronic inhalation exposure to diesel exhaust on development of lung tumors in di-isopropanol-nitrosamine-treated F344 rats and newborn C57BL and ICR mice. In Carcinogenic and mutagenic effects of diesel engine exhaust, eds. N. Ishinishi, A. Koizumi, R. 0. McClellan, and W. Stöber, pp. 311–327. New York: Elsevier.
   Google Scholar
• Trochimowicz, H. J., Lee, K. P., and Reinhardt, C. F. 1988. Chronic inhalation exposure of rats to titanium dioxide dust.]. Appl. Toxicol. 8:383–385.
   PubMedGoogle Scholar
• Wagner, W. D., Groth, D. H., Holtz, J. L., Madden, G. E., and Stokinger, H. E. 1969. Comparative chronic inhalation toxicity of beryllium ores, bertrandite and beryl, with production of pul-monary tumors by beryl. Toxicol. Appl. Pharmacol. 15:10–29.
   PubMed Web of Science ®Google Scholar
• Wehner, A. P., Dagle, G. E., Clark, M. L., and Buschbom, R. L. 1986. Lung changes in rats following inhalation exposure to volcanic ash for 2 years. Environ. Res. 40:499–517.
   PubMed Web of Science ®Google Scholar