Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 6
Submit an article Journal homepage
287
Views
85
CrossRef citations to date
0
Altmetric
Research Article

Impact of Inhalation Exposure Modality and Particle Size on the Respiratory Deposition of Ricin in BALB/c Mice

Chad J. Roy Division of Toxinology and Aerobiology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
,
Martha Hale Division of Toxinology and Aerobiology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
,
Justin M. Hartings Division of Toxinology and Aerobiology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
,
Louise Pitt Division of Toxinology and Aerobiology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
&
Steven Duniho Division of Pathology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
Pages 619-638 | Published online: 01 Oct 2008

  • Anderson, G. W., Leary, S. C., Williamson, E. D., Titball, R. W., Welkos, S. L., Worsham, P. L., Friedlander, A. M. 1996. Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1 -capsule-positive and -negative strains of Yersinia pestis. Infect. Immun. 64(11):4580-4585.
  • Bensch, K. G., Dominguez, E., and Leibow, A. A. 1967. Absorption of intact protein molecules across the pulmonary air-tissue barrier. Science 157:1204-1206.
  • Brown, R. F. R., and White, D. E. 1997. Ultrastructure of rat lung following inhalation of ricin aerosol. Intl. J. Exp. Pathol. 78:267-276.
  • Cannon, W. C., Blanton, E. F., and McDonald, K. E. 1983. The flow-past chamber: an improved noseonly exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44:923-928.
  • Davies, C. N., and Cheah, P. K. P. 1984. Spinning generators of homogenous aerosols. J. Aerosol Sci. 15(6):719-739.
  • Doebler, J. A., Wiltshire, N. D., Mayer, T. W., Estep, J. E., Moeller, R. B., Traub, R. K., Broomfield, C. A., Calamaio, C. A., Thompson, W. L, and Pitt, M. L. 1995. The distribution of (125l)ricin following aerosol inhalation exposure. Toxicology 98:137-149.
  • Druett, H. A., Henderson, D. W., and Peacock, S. 1953. The influence of particle size on respiratory infection with anthrax spores. J. Hyg. (Cambridge) 51:359-371.
  • Druett, H. A., Robinson, J. M., Henderson, D. W., Packman, L., and Peacock, S. 1956a. Studies on repiratory infection: II. The influence of aerosol particle size on infection of the guinea pigs with Pasteurella pestis.J. Hyg. (Cambridge) 53:37-48.
  • Druett, H. A., Henderson, D. W., and Peacock, S. 1956b. Studies on repiratory infection: III. experiments with Brucella suis. J. Hyg. (Cambridge) 54(1):49-57.
  • Fok, T. F., AI-Essa, M., Kirpalani, H., Monkman, S., Bowen, B., Coates, G., and Dolovich, M. 1999. Estimation of pulmonary deposition of aerosol using gamma scintigraphy. J. Aerosol Med. 12(1): 9-15.
  • Franz, D. 1997. Defense against toxin weapons. In Textbook of military medicine: Part I, Medical aspects of chemical and biological warfare, chap. 30. Washington, DC: Office of the Surgeon General of the Army, TMM Publications.
  • Gerrard, C. S., Gerrity, T. R., and Yeates, D. B. 1986. The relationships of aerosol deposition, lung size, and the rate of mucociliary clearance. Arch. Environ. Health 41 (1) :11-15.
  • Gordon, T., and Amdur, M. 1991. Reponses of the respiratory system to toxic agents. In Toxicology, 4th ed., chap. 12. New York: Pergamon Press.
  • Guyton, A. 1947. Measurement of the repiratory volumes of laboratory animals. Am. J. Physiol. 150: 70-77.
  • Hewetson, J., Rivera, V., Lemley, P., Pitt, L., and Creasia, D. 1996. A formalized toxoid for protection of mice from inhaled ricin. Vaccine Res. 4:179-187.
  • Hyde, D. M., Magliago, D. J., and Plopper, C. G. 1991. Morphometric assessment of pulmonary toxicity in the rodent lung. Toxicol. Pathol. 19(4):428-446.
  • Jakab, G. J., and Hemenway, D. R. 1989. Restraint of animals required for nose-only inhalation toxicologie studies supresses pulomnary antibacterial defenses, lnhal. Toxicol. 1:289-300.
  • Jemski, J. V., and Phillips, G. B. 1965. Aerosol challenge of animals. In Methods of animal experimentation, vol. 1, ed. W. Gay, pp. 274-341. New York: Academic Press.
  • Kreyling, W. G., Blanchard, J. D., Godleski, J. J., Haeussermann, S., Heyder, J., Hutzler, P., Schultz, H., Sweeney, T. D., Takenaka, S., and Ziesenis, A. 1999. Anatomic localization of 24- and 96-hour particle retention in canine airways. J. Appl. Physiol. 87(1):269-284.
  • Leong, K. J., Coombs, J. K., Sabaitis, D. A., Rop, D. A., and Aaron, C. S. 1998. Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats. J. Appl. Toxicol. 18:149-160.
  • Ménache, M. G., Miller, F. J., and Raabe, O. G. 1995. Particle inhalability curves for humans and small laboratory animals. Ann. Occup. Hyg. 39(3):317-328.
  • Mercer, R., and Crapo, J. D. 1991. Architecture of the acinus. In Treatise on pulmonary toxicology: Comparative biology of the normal lung. ed. R. A. Parent, pp. 109-119. Boca Raton, FL: CRC Press.
  • Mitchell, J. P. 1984. The production of aerosols from aqueous solutions using the spinning top generator. J. Aerosol Sci. 15(1):35-45.
  • Moores, S. R., Black, A., Lambert, B. E., Lindop, P. J., Morgan, A., Pritchard, J., and Walsh, M. 1980. Deposition of thorium and plutonium oxides in the respiratory tract of the mouse. In Proceedings of the Nineteenth Annual Hanford Life Sciences Symposium, eds. C. L. Sanders, F. T. Cross, G. E. Dagle, and J. A. Mahaffey, pp. 103-118. Washington, DC: Technical Information Center, Department of Energy.
  • Olsnes, S., and Kozlov, J. 2001. Ricin. Toxicon 39:1723-1728.
  • Poli, M. A., Rivera, V. R., Pitt, M. L., and Vogel, P. 1996. Aerosolized specific antibody protects mice from lung injury associated with aerosolized ricin exposure. Toxicon 34(9):1037-1044.
  • Raabe, O. G., AI-Bayati, M. A., Teague, S. V., and Rasolt, A. 1988. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann. Occup. Hyg. 32(1):53-63.
  • Ramsden, C., Drayson, M., and Bell, E. 1989. The toxicity, distribution, and excretion of ricin holotoxin in rats. Toxicology 55:161-171.
  • Schlesinger, R. B. 1985. Comparative deposition of inhaled aerosols in experimental animals and humans: A review. J. Toxicol. Environ. Health 15:197-214.
  • Schwebach, J. R., Chen, B., Glatman-Freedman, A., Casadevall, A., McKinney, J. D., Harb, J. L., McGuire, P. J., Barkley, W. E., Bloom, B. R., and Jacobs, W. R. 2002. Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of innocula and design of an ultrasafe facility. Appl. Environ. Microbiol. 68(9):4646-4649.
  • Snipes, M. B., Olson, T. R., and Yeh, H. C. 1987. Deposition and retention patterns for 3-, 9-, and 15µm latex microspheres inhaled by rats and guinea pigs. Exp. Lung Res. 14:37-50.
  • Snipes, M. B. 1989. Long-term retention and clearance of particles inhaled by mammalian species. CRC Crit Rev. Toxicol. 20:175-211.
  • Stephenson, E. H., Moeller, R. B., York, C. G., and Young, H. W. 1988. Nose-only versus whole-body aerosol exposure for induction of upper respiratory infections of laboratory mice. Am. Ind. Hyg. Assoc.J. 49(3):128-135.
  • Svartengren, M., Skogward, P., Nerbrink, O., and Dalback, M. 1998. Regional deposition of inhaled Evan's blue dye in mechanically ventilated rabbits with air or helium oxygen mixture, Exp. Lung Res. 24:159-172.
  • Sweeney, T. D., and Brain, J. D. 1991. Pulmonary deposition: determinants and measurement techniques. Toxicol. Pathol. 19(4):384-397.
  • Wilhelmsen C. 2000. Inhaled ricin dose ranging and pathology in inbred strains of mice. Defense Tech. Rep. Accession Number ADB254692, unclassified (Department of Defense distribution only).
  • Wilhelmsen, C., and Pitt, L. 1993. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet. Pathol. 154:227-234.
  • Yan, C., Rill, W. L., MaIIi, R., Hewetson, J., Naseem, H., Tammariello, R., and Kende, M. 1996. Intranasal stimulation of long-lasting immunity against aerosol challenge with ricin toxoid vaccine encapsulated in polymeric microspheres. Vaccine 14(11):1031-1038.
  • Yeh, H. C., Snipes, M. B., Eidson, A. F., Hobbs, C. H., and Henry, M. C. 1990. Comparative evaluation of nose-only versus whole-body inhalation exposures for rats-Aerosol characteristics and lung deposition, lnhal. Toxicol. 2:205-221.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.