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Inhalation Toxicology
International Forum for Respiratory Research
Volume 20, 2008 - Issue 3
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Research Article

Health Effects of Organic Aerosols

&
Pages 257-288 | Received 22 May 2007, Accepted 10 Nov 2007, Published online: 06 Oct 2008

REFERENCES

  • Albert R. E., Lewtas J., Nesnow S., Thorslund T. W., Anderson E. Comparative potency method for cancer risk assessment: Application to diesel particulate emissions. Risk Anal. 1983; 3: 101–117
  • Altshuller A. P. The production of carbon monoxide by the homogeneous NOx-induced photooxidation of volatile organic compounds in the troposphere. J. Atmos. Chem. 1991; 13: 155–182
  • Alves C., Oliveira T., Pio C., Silvestre A. J. D., Fialho P., Barata F., Legrand M. Characterisation of carbonaceous aerosols from the Azorean Island of Terceira. Atmos. Environ. 2007; 41(7)1359–1373
  • Anderson H. R., Bremner S. A., Atkinson R. W., Harrison R. M., Walters S. Particulate matter and daily mortality and hospital admissions in the west midlands conurbation of the United Kingdom: Associations with fine and coarse particles, black smoke and sulphate. Occup. Environ. Med. 2001; 58(8)504–510
  • Arey J. B., Harger W. P., Atkinson R., Winer A. M. The contribution of nitrofluoranthenes and nitropyrenes to the mutagenic activity of ambient particulate organic matter collected in southern California. Mutat. Res. 1988; 207: 45–51
  • Arey J. A tale of two diesels. Environ. Health Perspect. 2004; 112: 812–813
  • Atkinson R. W., Bremner S. A., Anderson H. R., Strachan D. P., Bland J. M., de Leon A. P. Short-term associations between emergency hospital admissions for respiratory and cardiovascular disease and outdoor air pollution in London. Arch. Environ. Health 1999; 54(6)398–411
  • Bechtold W. E., Dutcher J. S., Mokler B. V., Lopez J. A., Wolf I., Li A. P., Henderson T. R., McClellan R. O. Chemical and biological properties of diesel exhaust particles collected during selected segments of a simulated driving cycle. Fundam. Appl. Toxicol. 1984; 4: 370–377
  • Birch M. E., Cary R. A. Elemental carbon-based method for occupational monitoring of particulate diesel exhaust: Methodology and exposure issues. Analyst 1996; 121: 1183–1190
  • Bond T. C., Streets D. G., Yarber K. F., Nelson S. M., Woo J. H., Klimont Z. A technology-based global inventory of black and organic carbon emissions from combustion. J. Geophys. Res. 2004; 109(D14), D14203
  • Brunekreef B, Janssen N AH, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology 1997; 8(3)298–303
  • CARB. CCAQS data management—Policies and procedures. Prepared by California Air Resources Board, Sacramento, CA 2007, http://www.arb.ca.gov/airways/CRPAQS/lookups.htm
  • California Environmental Protection Agency. Proposed identification of diesel exhaust as a toxic air contaminant: Health risk assessment for diesel exhaust—Appendix III, Part B. California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, Sacramento 1998
  • Campen M. L., Babu N. S., Helms G. A., Pett S., Wernly J., Hehran R., McDonald J. D. Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE–/– mice. Toxicol. Sci. 2005; 88: 95–102
  • Cao G. L., Zhang X. Y., Zheng F. C. Inventory of black carbon and organic carbon emissions from China. Atmos. Environ. 2006; 40(34)6516–6527
  • Capen C. C. Toxic responses of the endocrine system. Casarett and Doull's toxicology: The basis science of poisons, C. D. Klaassen. McGraw-Hill, New York 2001; 711–759
  • Chen L.-W. A., Chow J. C., Watson J. G., Moosmüller H., Arnott W. P. Modeling reflectance and transmittance of quartz-fiber filter samples containing elemental carbon particles: Implications for thermal/optical analysis. J. Aerosol Sci. 2004; 35(6)765–780
  • Chen L.-W. A., Watson J. G., Chow J. C., Magliano K. L. Quantifying PM2.5 source contributions for the San Joaquin Valley with multivariate receptor models. Environ. Sci. Technol. 2007; 41(8)2818–2826
  • Chow J. C., Watson J. G., Pritchett L. C., Pierson W. R., Frazier C. A., Purcell R. G. The DRI Thermal/Optical Reflectance carbon analysis system: Description, evaluation and applications in U.S. air quality studies. Atmos. Environ. 1993; 27A(8)1185–1201
  • Chow J. C. 2001 Critical review discussion—Diesel engines: Environmental impact and control. J. Air Waste Manage. Assoc. 2001; 51(9)1258–1270
  • Chow J. C., Watson J. G., Crow D., Lowenthal D. H., Merrifield T. M. Comparison of IMPROVE and NIOSH carbon measurements. Aerosol Sci. Technol. 2001; 34(1)23–34
  • Chow J. C., Engelbrecht J. P., Watson J. G., Wilson W. E., Frank N. H., Zhu T. Designing monitoring networks to represent outdoor human exposure. Chemosphere 2002; 49(9)961–978
  • Chow J. C., Watson J. G., Chen L.-W. A., Arnott W. P., Moosmüller H., Fung K. K. Equivalence of elemental carbon by Thermal/Optical Reflectance and Transmittance with different temperature protocols. Environ. Sci. Technol. 2004a; 38(16)4414–4422
  • Chow J. C., Watson J. G., Kuhns H. D., Etyemezian V., Lowenthal D. H., Crow D. J., Kohl S. D., Engelbrecht J. P., Green M. C. Source profiles for industrial, mobile, and area sources in the Big Bend Regional Aerosol Visibility and Observational (BRAVO) Study. Chemosphere 2004b; 54(2)185–208
  • Chow J. C., Watson J. G., Chen L. W. A., Paredes-Miranda G., Chang M.-C. O., Trimble D., Fung K. K., Zhang H., Yu J. Z. Refining temperature measures in thermal/optical carbon analysis. Atmos. Chem. Phys. 2005; 5(4)2961–2972
  • Chow J. C., Watson J. G. Overview of ultrafine particles and human health. WIT Trans. Ecol. Environ. 2006; 99: 619–632, http://library.witpress.com/pages/PaperInfo.asp?PaperID=17217
  • Chow J. C., Watson J. G., Mauderly J. L., Costa D. L., Wyzga R. E., Vedal S., Hidy G. M., Altshuler S. L., Marrack D., Heuss J. M., Wolff G. T., Pope C. A., III, Dockery D. W. 2006 critical review discussion—Health effects of fine particulate air pollution: Lines that connect. J. Air Waste Manage. Assoc. 2006; 56(10)1368–1380
  • Chow J. C., Watson J. G. Survey of measurement and composition of ultrafine particles. Aerosol Air Qual. Res. 2007; 7(2)121–173
  • Chow J. C., Watson J. G., Chen L.-W. A., Chang M. C. O., Robinson N. F., Trimble D. L., Kohl S. D. The IMPROVE_A temperature protocol for thermal/optical carbon analysis: Maintaining consistency with a long-term data base. J. Air Waste Manage. Assoc. 2007a; 57: 1014–1023
  • Chow J. C., Yu J. Z., Watson J. G., Ho S. S. H., Bohannan T. L., Hays M. D., Fung K. K. The application of thermal methods for determining chemical composition of carbonaceous aerosols: A Review. J. Environ. Sci. Health A 2007b; 42(11)1521–1541
  • Chow J. C., Watson J. G., Lowenthal D. H., Chen L. W. A., Zielinska B., Mazzoleni L. R., Magliano K. L. Evaluation of organic markers for chemical mass balance source apportionment at the Fresno supersite. Atmos. Chem. Phys. 2007c; 71: 741–754
  • Chow J. C., Watson J. G., Chen L.-W. A., Ho S. S. H., Sodeman D. A., Doraiswamy P. Advances in integrated and continuous measurements for particle mass and chemical composition. J. Air Waste Manage. Assoc. 2008; 58: 141–163
  • Chung M. Y., Lazaro R. A., Lim D., Jackson J., Lyon J., Rendulic D., Hasson A. S. Aerosol-borne quinones and reactive oxygen species generation by particulate matter extracts. Environ. Sci. Technol. 2006; 40(16)4880–4886
  • Clark C. R., Dutcher J. S., Henderson T. R., McClellan R. O., Marshall W. E., Naman T. M., Seizinger D. E. Mutagenicity of automotive particulate exhaust: Influence of fuel extenders, additives and aromatic content. Adv. Mod. Environ. Toxicol. 1984; 6: 109–122
  • Clausen P. A., Wilkins C. K., Wolkof P., Nielsen G. D. Chemical and biological evaluation of a reaction mixture of R-(+)-limonene/ozone: Formation of strong airway irritants. Environ. Int. 2001; 26: 511–522
  • Crimmins B. S., Baker J. E. Improved GC/MS methods for measuring hourly PAH and nitro-PAH concentrations in urban particulate matter. Atmos. Environ. 2006; 40(35)6764–6779
  • Delfino R. J., Sioutas C., Malik S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ. Health Perspect. 2005; 113(8)934–946
  • DeMarini D. M., Brooks L. R., Warren S. H., Kobayashi T., Gilmour M. I., Singh P. Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles. Environ. Health Perspect. 2004; 112: 814–819
  • Dentener F. J., Crutzen P. J. Reaction of N2O5 on tropospheric aerosols: Impact on the global distributions of NOx,O3 and OH. J. Geophys. Res. 1993; 98: 7149–7163
  • Diaz-Sanchez D., Tsien A., Fleming J., Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J. Immunol. 1997; 158(5)2406–2413
  • Donaldson K., Stone V., Seaton A., MacNee W. Ambient particle inhalation and the cardiovascular system: Potential mechanisms. Environ. Health Perspect. 2001; 109(Suppl. 4)523–527
  • Dung C. H., Wu S. C., Yen G. C. Genotoxicity and oxidative stress of the mutagenic compounds formed in fumes of heated soybean oil, sunflower oil, and lard. Toxicol. In Vitro 2006; 20(4)439–447
  • Eatough D. J., Sedar B., Lewis L., Hansen L. D., Lewis E. A., Farber R. J. Determination of semivolatile organic compounds in particles in the Grand Canyon area. Aerosol Sci. Technol. 1989; 10: 438–449
  • Eatough D. J., Aghdaie N., Cottam M., Gammon T., Hansen L. D., Lewis E. A., Farber R. J. Loss of semi-volatile organic compounds from particles during sampling on filters. Transactions, visibility and fine particles, C. V. Mathai. Air & Waste Management Association, Pittsburgh, PA 1990; 146–156
  • Eiguren-Fernandez A., Miguel A. H., Froines J. R., Thurairatnam S., Avol E. L. Seasonal and spatial variation of polycyclic aromatic hydrocarbons in vapor-phase and PM2.5 in Southern California urban and rural communities. Aerosol Sci. Technol. 2004; 38(5)447–455
  • Elder A., Gelein R., Finkelstein J., Phipps R., Frampton M., Utell M., Kittelson D. B., Watts W. F., Hopke P. K., Jeong C. H., Kim E., Liu W., Zhao W. X., Zhuo L. M., Vincent R., Kumarathasan P., Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal. Toxicol. 2004a; 16(Suppl. 1)41–53
  • Elder A. C. P., Gelein R., Azadniv M., Frampton M., Finkelstein J., Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal. Toxicol. 2004b; 16(6–7)461–471
  • Elder A., Couderc J. P., Gelein R., Eberly S. I., Cox C., Xia X., Zareba W., Hopke P. K., Watts W., Kettelson D. B., Frampton M., Utell M., Oberdorster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal. Toxicol. 2007; 19: 1–12
  • Engling G., Carrico C. M., Kreidenweis S. M., Collett J. L., Jr., Day D. E., Malm W. C., Lincoln E., Hao W. M., Iinuma Y., Herrmann H. Determination of levoglucosan in biomass combustion aerosol by high performance anion exchange chromatography with pulsed amperometric detection. Atmos. Environ. 2006a; 40: S299–S311, (Suppl.2)
  • Engling G., Herckes P., Kreidenweis S. M., Malm W. C., Collett J. L. Composition of the fine organic aerosol in Yosemite National Park during the 2002 Yosemite Aerosol Characterization Study. Atmos. Environ. 2006b; 40(16)2959–2972
  • Ewing P., Blomgren B., Ryrfeldt A., Gerde P. Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated, ventilated, and perfused lung of the rat. Toxicol Sci. 2006; 91(2)332–340
  • Fine P. M., Cass G. R., Simoneit B. R. T. Chemical characterization of fine particle emissions from the fireplace combustion of wood types grown in the Midwestern and Western United States. Environ. Eng. Sci. 2004; 21(3)387–409
  • Fine P. M., Chakrabarti B., Krudysz M., Schauer J. J., Sioutas C. Diurnal variations of individual organic compound constituents of ultrafine and accumulation mode particulate matter in the Los Angeles basin. Environ. Sci. Technol. 2004; 38(5)1296–1304
  • Fraser M. P., Yue Z. W., Tropp R. J., Kohl S. D., Chow J. C. Molecular composition of organic fine particulate matter in Houston, TX. Atmos. Environ. 2002; 36(38)5751–5758
  • Fraser M. P., Cass G. R., Simoneit B. R. T. Air quality model evaluation data for organics 6. C3–C24 organic acids. Environ. Sci. Technol. 2003; 37(3)446–453
  • Fraser M. P., Buzcu B., Yue Z. W., McGaughey G. R., Desai N. R., Allen D. T., Seila R. L., Lonneman W. A., Harley R. A. Separation of fine particulate matter emitted from gasoline and diesel vehicles using chemical mass balancing techniques. Environ. Sci. Technol. 2003; 37(17)3904–3909
  • Gao S., Hegg D. A., Hobbs P. V., Kirchstetter T. W., Magi B. I., Sadilek M. Water-soluble organic components in aerosols associated with savanna fires in southern Africa: Identification, evolution and distribution. J. Geophys. Res. 2003; 108(D13)SAF27-1–SAF27-16
  • Ghio A. J., Quigley D. R. Complexation of iron by humic-like substances in lung tissue: Role in coal workers' pneumoconiosis. Am. J. Physiol. 1994; 267: L173–L179
  • Ghio A. J., Stonehuerner J., Quigley D. R. Humic-like substances in cigarette smoke condensate and lung tissue of smokers. Am. J. Physiol 1994; 266: L382–L388
  • Ghio A. J. Biological effects of Utah Valley ambient air particles in humans: A review. J. Aerosol Me. Deposition Clearance Effects Lung 2004; 17(2)157–164
  • Gillies J. A., Gertler A. W., Sagebiel J. C., Dippel W. A. On-road PM2.5 and PM10 emissions in the Sepulveda Tunnel, Los Angeles, California. Proceedings, PM2.5: A fine particle standard, J. C. Chow, P. Koutrakis. Air & Waste Management Association, Pittsburgh, PA 1998; 677–698
  • Gora R., Hutta M. Reversed-phase liquid chromatographic characterization and analysis of air particulates humic-like substances in presence of pollen. J. Chromatogr. A 2005; 1084: 39–45
  • Graber E. R., Rudich Y. Atmospheric HULIS: How humic-like are they? A comprehensive and critical review. Atmos. Chem. Phys. 2006; 6: 729–753
  • Green L. C., Armstrong S. R. Particulate matter in ambient air and mortality: toxicologic perspectives. Regul. Toxicol. Pharmacol. 2003; 38(3)326–335
  • Gregus Z., Klaassen C. D. Mechanisms of toxicity. Casarett and Doull's toxicology: The basic science of poisons, C. D. Klaassen. McGraw-Hill, New York 2001; 35–81
  • Hansen D. A., Edgerton E., Hartsell B., Jansen J., Burge H., Koutrakis P., Rogers C., Suh H., Chow J. C., Zielinska B., McMurry P., Mulholland J., Russell A., Rasmussen R. Air quality measurements for the aerosol research and inhalation epidemiology study. J. Air Waste Manage. Assoc. 2006; 56(10)1445–1458
  • Hays M. D., Lavrich R. J. Developments in direct thermal extraction—GC/MS of fine aerosols. Trends Anal. Chem. 2007; 26(2)88–102
  • Heintzenberg J. Fine particles in the global troposphere. Tellus Ser. B Chem. Phys. Meteorol. 1989; 41B: 149–160
  • Highwood E. J., Kinnersley R. P. When smoke gets in our eyes: The multiple impacts of atmospheric black carbon on climate, air quality and health. Environ. Int. 2006; 32(4)560–566
  • Hinds W. C. Aerosol technology: Properties, behavior, and measurement of airborne particles, 2nd ed. John Wiley and Sons, New York 1999
  • Ho S. S. H., Yu J. Feasibility of collection and analysis of airborne carbonyls by on-sorbent derivatization and thermal desorption. Anal. Chem. 2002; 74(6)1232–1240
  • Ho S. S. H., Yu J. Z. Determination of airborne carbonyls: Comparison of a thermal desorption/GC method with the standard DNPH/HPLC method. Environ. Sci. Technol. 2004a; 38(3)862–870
  • Ho S. S. H., Yu J. Z. In-injection port thermal desorption and subsequent gas chromatography-mass spectrometric analysis of polycyclic aromatic hydrocarbons and n-alkanes in atmospheric aerosol samples. J. Chromatogr. A 2004b; 1059(1–2)121–129
  • Ho S. S. H., Yu J. Z., Chu K. W., Yeung L. L. Carbonyl emissions from commercial cooking sources in Hong Kong. J. Air Waste Manage. Assoc. 2006; 56(8)1091–1098
  • Hoek G., Brunekreef B., Goldbohm S., Fischer P., van den Brandt P. A. Association between mortality and indicators of traffic-related air pollution in the Netherlands: A cohort study. Lancet 2002; 360(9341)1203–1209
  • Hopke P. K., Ito K., Mar T., Christensen W. F., Eatough D. J., Henry R. C., Kim E., Laden F., Lall R., Larson T. V., Liu H., Neas L., Pinto J., Stolzel M., Suh H., Paatero P., Thurston G. D. PM source apportionment and health effects: 1. Intercomparison of source apportionment results. J. Expos. Anal. Environ. Epidemiol. 2005; 16: 275–286
  • Horvath H. Discussion: Black smoke as a surrogate for PM10 in health studies. Atmos. Environ. 1996; 30(14)2649–2650
  • Huebert B. J., Charlson R. J. Uncertainties in data on organic aerosols. Tellus 2000; 52B(5)1249–1255
  • IPCC. Climate change 2007: The physical science basis. Summary for policymakers. 2007, http://www.ipcc.ch/SPM2feb07.pdf Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. Prepared by Intergovernmental Panel on Climate Change (IPCC), Geneva, Switzerland.
  • Jacobs J., Kreutzer R., Smith D. Burning and asthma hospitalizations, Butte County, California. Environ. Health Perspect. 1997; 105: 980–985
  • Kafoury R. M., Kelley J. Ozone enhances diesel exhaust particles (DEP)-induced interleukin-8 (IL-8) gene expression in human airway epithelial cells through activation of nuclear factors-kappaB (NF-kappaB) and IL-6 (NF-IL6). Int. J. Environ. Res. Public Health 2005; 2(3–4)403–410
  • Kawamura K., Yasui O. Diurnal changes in the distribution of dicarboxylic acids, ketocarboxylic acids and dicarbonyls in the urban Tokyo atmosphere. Atmos. Environ. 2005; 39(10)1945–1960
  • Khalek I. A. Nitro-PAH artifact investigation, final report. Southwest Research Institute, San Antonio, TX 2004
  • Kim E., Hopke P. K. Source apportionment of fine particles at Washington, DC, utilizing temperature-resolved carbon fractions. J. Air Waste Manage. Assoc. 2004; 54(7)773–785
  • Kirchstetter T. W., Corrigan C. E., Novakov T. Laboratory and field investigation of the adsorption of gaseous organic compounds onto quartz filters. Atmos. Environ. 2001; 35(9)1663–1671
  • Kittelson D. B., Watts W. F., Johnson J. P., Remerowki M. L., Ische E. E., Oberdörster G., Gelein R. A., Elder A., Hopke P. K., Kim E., Zhao W., Zhou L., Jeong C. H. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhal. Toxicol. 2004; 16(Suppl. 1)31–39
  • Klassen C. D. Cassarett and Doull's toxicology: The basic science of poisons. McGraw-Hill, New York 2001
  • Klemm R. J., Lipfert F. W., Wyzga R. E., Gust C. Daily mortality and air pollution in Atlanta: Two years of data from ARIES. Inhal. Toxicol. 2004; 16(Suppl. 1)131–141
  • Klena J., Wolkoff P. Changes in eye blink frequency as a measure of trigeminal stimulation by exposure to limonene oxidation products, isoprene oxidation products, and nitrate radicals. Int. Arch. Occup. Environ. Health 2004; 77: 235–243
  • Knaapen A. M., Borm P. J. A., Albrecht C., Schins R. P. F. Inhaled particles and lung cancer. Part A: Mechanisms. Int. J. Cancer 2004; 109(6)799–809
  • Kumagai Y., Koide S., Taguchi K., Endo A., Nakai Y., Yoshikawa T., Shimojo N. Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles. Chem. Res. Toxicol. 2002; 15(4)483–489
  • Kunzli N., Avol E., Wu J., Gauderman W. J., Rappaport E., Millstein J., Bennion J., McConnell R., Gilliland F. D., Berhane K., Lurmann F., Winer A., Peters J. M. Health effects of the 2003 Southern California wildfires on children. Am. J. Respir. Crit. Care Med. 2006; 174(11)1221–1228
  • Laeher L. P., Brauer M., Lipsett M., Zelikoff J. T., Simpson C. D., Koenig J. Q., Smith K. R. Woodsmoke health effects: A review. Inhal. Toxicol. 2007; 19: 67–106
  • Lai H. K., Bayer-Oglesby L., Colvile R., Gotschi T., Jantunen M. J., Kunzli N., Kulinskaya E., Schweizer C., Nieuwenhuijsen M. J. Determinants of indoor air concentrations of PM2.5, black smoke and NO2 in six European cities (EXPOLIS study). Atmos. Environ. 2006; 40(7)1299–1313
  • Lewtas J. Genotoxicity of complex mixtures: Strategies for the identification and comparative assessment of airborne mutagens and carcinogens from combustion sources. Fundam. Appl. Toxicol. 1988; 10: 571–589
  • Lewtas J. Combustion emissions: Contribution to air pollution, human exposure, and risk for cancer and related effects. Air pollutants and the respiratory tract, 2nd ed., Volume 204, W. M. Foster, D. L. Costa. Taylor & Francis, Boca Raton, FL 2005; 357–403
  • Li N., Sioutas C., Cho A., Schmitz D., Misra C., Sempf J., Wang M. Y., Oberley T., Froines J., Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect. 2003; 111(4)455–460
  • Limbeck A., Handler M., Neuberger B., Klatzer B., Puxbaum H. Carbon specific analysis of humic like substances in atmospheric aerosol and precipitation samples. Anal. Chem. 2005; 77: 7288–7293
  • Lin C. Y., Boland B. C., Lee Y. J., Salemi M. R., Morin D., Miller L. A., Plopper C. G., Buckpitt A. R. Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. Proteomics 2006; 6: 972–982
  • Lipfert F. W., Baty J. D., Miller J. P., Wyzga R. E. PM2.5 constituents and related air quality variables as predictors of survival in a cohort of U. S. military veterans. Inhal. Toxicol. 2006; 18(9)645–657
  • Lippmann M., Gordon T., Chen L. C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: I. Introduction, objectives, and experimental plan. Inhal. Toxicol. 2005; 17(4–5)177–187
  • Lloyd A. C., Cackette T. A. Critical review—Diesel engines: Environmental impact and control. J. Air Waste Manage. Assoc. 2001; 51(6)809–847
  • Lund A. K., Knuckles T. L., Akata C. O., Shohet R., McDonald J. D., Gigliotti A., Seagrave J. C., Campen M. J. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol. Sci. 2007; 95: 485–494
  • Maciejczyk P., Chen L. C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhal. Toxicol. 2005; 17(4–5)243–253
  • Madden M. C., Richards J. H., Dailey L. A., Hatch G. E., Ghio A. J. Effect of ozone on diesel exhaust particle toxicity in rat lung. Toxicol. Appl. Pharmacol. 2000; 168(2)140–148
  • Maejima K., Tamura K., Nakajima T., Taniguchi Y., Saito S., Takenaka H. Effects of the inhalation of diesel exhaust, kanto loam dust, or diesel exhaust without particles on immune responses in mice exposed to Japanese cedar (Cryptomeria japonica) pollen. Inhal. Toxicol. 2001; 13: 1047–1063
  • Mar T. F., Norris G. A., Koenig J. Q., Larson T. V. Associations between air pollution and mortality in Phoenix, 1995–1997. Environ. Health Perspect. 2000; 108(4)347–353
  • Martin O. V., Lester J. N., Voulvoulis N., Boobis A. R. Human health and endocrine disruption: A simple multi-criteria framework for the quantitative assessment of endpoint_Specific risks in a context of scientific uncertainty. Toxicol. Sci. 2007; 98(2)332–347
  • Matsumoto K., Uematsu M. Free amino acids in marine aerosols over the western North Pacific Ocean. Atmos. Environ. 2005; 39(11)2163–2170
  • Mauderly J. L., McCunney R. J. Particle overload in the rat lung and lung cancer: Implications for human risk assessment. Taylor & Francis, Washington, DC 1996
  • Mauderly J. L. Health effects of complex mixtures: Where are we and where do we need to be?. Effects of air contaminants on the respiratory tract—Interpretations from molecules to meta analysis. IRB Verlag, Fraunhofer 2004; 43–52
  • Mauderly J. L. Health hazards of complex environmental exposures: A difficult challenge to inhalation toxicology. Inhal. Toxicol. 2006; 18(2)137–141
  • Mauderly J. L., Garshick E. Diesel exhaust. Environmental toxicants: Human exposures and their health effects, 3rd ed., M. Lippmann. Wiley, New York 2007, chap. 17
  • Mazurek M. A., Hildemann L. M., Cass G. R., Simoneit B. R. T., Rogge W. F. Methods of analysis for complex organic aerosol mixtures from urban emission sources of particulate carbon. Sampling and analysis of airborne pollutants, E. D. Winegar, L. H. Keith. Lewis, Boca Raton, FL: 1993; 177–190
  • McDonald J. D., Barr E. B., White R. K., Chow J. C., Schauer J. J., Zielinska B., Grosjean E. Generation and characterization of four dilutions of diesel engine exhaust for a subchronic inhalation study. Environ. Sci. Technol. 2004a; 38(9)2513–2522
  • McDonald J. D., Eide I., Seagrave J., Zielinska B., Whitney K., Lawson D. R., Mauderly J. L. Relationship between composition and toxicity of motor vehicle emission samples. Environ. Health Perspect. 2004b; 112(15)1527–1538
  • McDonald J. D., White R. K., Barr E. B., Zielinska B., Chow J. C., Grosjean E. Generation and characterization of hardwood smoke inhalation exposure atmospheres. Aerosol Sci. Technol. 2006; 40(8)573–584
  • McDonald J. D., Reed M. D., Barrett E. G., Campen M. J., Seagrave J. C., Mauderly J. L. Health effects of inhaled gasoline engine emissions. Inhal. Toxicol. 2007; 19(Suppl.1)107–116
  • McDow S. R., Huntzicker J. J. Vapor adsorption artifact in the sampling of organic aerosol: Face velocity effects. Atmos. Environ. 1990; 24A(10)2563–2571
  • Meems N., Steinberg C. E. W., Wiegand C. Direct and interacting toxicological effects on the waterflea (Daphnia magna) by natural organic matter, synthetic humic substances and cypermethrin. Sci. Total Environ. 2004; 319(1–3)123–136
  • Miguel A. H., Eiguren-Fernandez A., Jaques P. A., Froines J. R., Grant B. L., Mayo P. R., Sioutas C. Seasonal variation of the particle size distribution of polycyclic aromatic hydrocarbons and of major aerosol species in Claremont, California. Atmos. Environ. 2004; 38(20)3241–3251
  • Mills N. L., Tornqvist H., Robinson S. D., Gonzalez M., Darnley K., MacNee W., Boon N. A., Donaldson K., Blomberg A., Sandstrom T., Newby D. E. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005; 112(25)3930–3936
  • Molinelli A. R., Santacana G. E., Madden M. C., Jimenez B. D. Toxicity and metal content of organic solvent extracts from airborne particulate matter in Puerto Rico. Environ. Res. 2006; 102: 314–325
  • Morawska L., Thomas S., Gilbert D., Greenaway C., Rijnders E. A study of the horizontal and vertical profile of submicrometer particles in relation to a busy road. Atmos. Environ. 1999; 33(8)1261–1274
  • Muir D., Laxen D. P. H. Black smoke as a surrogate for PM10 in health studies?. Atmos. Environ. 1995; 29(8)959–962
  • Muir D., Laxen D. P. H. Authors' reply. Atmos. Environ. 1996; 30(14)2648
  • Muranaka M., Suzuki S., Koizumi K., Takafuji S., Miyamoto T., Ikemori R., Tokiwa H. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J. Allergy Clin. Immunol. 1986; 77(4)616–623
  • Naeher L. P., Brauer M., Lipsett M., Zelikoff J. T., Simpson C. D., Koenig J. Q., Smith K. R. Woodsmoke health effects: A review. Inhal. Toxicol. 2007; 19(1)67–106
  • National Research Council. Research priorities for airborne particulate matter IV. Continuing research progress. National Academies Press, Washington, DC 2004
  • NIOSH. Method 5040 Issue 3 (Interim): Elemental carbon (diesel exhaust). NIOSH manual of analytical methods. National Institute of Occupational Safety and Health, Cincinnati, OH 1999; 1–9
  • Ostro B., Broadwin R., Green S., Feng W.-Y., Lipsett M. Fine particulate air pollution and mortality in nine California counties: Results from CALFINE. Environ. Health Perspect. 2006; 114: 29–33
  • Pankow J. F. A simple box model for the annual cycle of partitioning of semi-volatile organic compounds between the atmosphere and the Earth's surface. Atmos. Environ. 1993; 27A(7)1139–1152
  • Park S K, O'Neill M S, Wright R O, Hu H, Vokonas P S, Sparrow D, Suh H, Schwartz J. HFE genotype, particulate air pollution, and heart rate variability: A gene–environment interaction. Circulation 2006; 114: 2798–2805
  • Paulson S. E., Seinfeld J. H. Development and evaluation of a photooxidation mechanism for isoprene. J. Geophys. Res. 1992; 97(D18)20703–20715
  • Penttinen P., Alm S., Ruuskanen J., Pekkanen J. Measuring reflectance of TSP-filters for retrospective health studies. Atmos. Environ. 2000; 34(16)2581–2586
  • Peterson M. R., Richards M. H. Thermal-optical-transmittance analysis for organic, elemental, carbonate, total carbon, and OCX2 in PM2.5 by the EPA/NIOSH method. Proceedings, Symposium on Air Quality Measurement Methods and Technology—2002, E. D. Winegar, R. J. Tropp. Air & Waste Management Association, Pittsburgh, PA 2002; 83-1–83-19
  • Poore M. W. Levoglucosan in PM2.5 at the Fresno supersite. J. Air Waste Manage. Assoc. 2002; 52(1)3–4
  • Pope C. A., III, Dockery D. W. Health effects of fine particulate air pollution: Lines that connect. J. Air Waste Manage. Assoc. 2006; 56(6)709–742
  • Prince M. M., Ruder A. M., Hein M. J., Waters M. A., Whelan E. A., Nilsen N., Ward E. M., Schnorr T. M., Laber P. A., Davis-King K. E. Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Environ. Health Perspect. 2006; 114(10)1508–1514
  • Rinehart L. R., Fujita E. M., Chow J. C., Magliano K. L., Zielinska B. Spatial distribution of PM2.5 associated organic compounds in central California. Atmos. Environ. 2006; 40(2)290–303
  • Rogge W. F., Hildemann L. M., Mazurek M. A., Cass G. R., Simoneit B. R. T. Sources of fine organic aerosol—1. Charbroilers and meat cooking operations. Enivron. Sci. Technol. 1991; 25(6)1112–1125
  • Rogge W. F., Hildemann L. M., Mazurek M. A., Cass G. R., Simoneit B. R. T. Sources of fine organic aerosol—9. Pine, oak, and synthetic log combustion in residential fireplaces. Enivron. Sci. Technol. 1998; 32(1)13–22
  • Rohr A. C., Wilkins C. K., Clausen P. A., Hammer M., Nielsen G. D., Spengler J. D., Wolkoff P. Upper airway and pulmonary effects of oxidation products of (+)-alpha-pinene, d-limonene, and isoprene in BALB/c mice. Inhal. Toxicol. 2002; 14(7)663–684
  • Rohr A. C., Shore S. A., Spengler J. D. Repeated exposure to isoprene oxidation products causes enhanced respiratory tract effects in multiple murine strains. Inhal. Toxicol. 2003; 15(12)1191–1207
  • Rudell B., Blomberg A., Helleday R., Ledin M. C., Lundback B., Stjernberg N., Horstedt P., Sandstrom T. Bronchoalveolar inflammation after exposure to diesel exhaust: Comparison between unfiltered and particle trap filtered exhaust. Occup. Environ. Med. 1999; 56(8)527–534
  • Saldiva P. H. N., Clarke R. W., Coull B. A., Stearns R. C., Lawrence J., Krishna Murthy G. G., Diaz E., Koutrakis P., Suh H., Tsuda A., Godleski J. J. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am. J. Respir. Crit. Care Med. 2002; 165(12)1610–1617
  • Samet J. M. What properties of particulate matter are responsible for health effects?. Inhal. Toxicol. 2000; 12: 19–21, (Suppl 1)
  • Saxena P., Hildemann L. M. Water-soluble organics in atmospheric particles: A critical review of the literature and application of thermodynamics to identify candidate compounds. Atmos. Chem. 1996; 24(1)57–109
  • Schauer J. J., Kleeman M. J., Cass G. R., Simoneit B. R. T. Measurement of emissions from air pollution sources—5. C1–C32 organic compounds from gasoline-powered motor vehicles. Environ. Sci. Technol. 2002; 36(6)1169–1180
  • Schlesinger R. B., Kunzli N., Hidy G. M., Gotschi T., Jerrett M. The health relevance of ambient particulate matter characteristics: Coherence of toxicological and epidemiological inferences. Inhal. Toxicol. 2006; 18(2)95–125
  • Schuetzle D., Lewtas J. Bioassay-directed chemical analysis in environmental research. Anal. Chem. 1986; 58: 1060A–1075A
  • Schwartz J., Park S. K., O'Neill M. S., Vokonas P. S., Sparrow D., Weiss S., Kelsey K. Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: Gene-by-drug-by-environment interaction. Am. J. Respir. Crit Care Med. 2005; 172: 1529–1533
  • Seagrave J. C., Berger J., Zielinska B., Sagebiel J., Rogers C. F., McDonald J. D., Mauderly J. L. Comparative acute toxicities of particulate matter (PM) and semi-volatile organic compound (SVOC) fractions of traffic tunnel air. Toxicologist 2001; 60(1)192
  • Seagrave J. C., McDonald J. D., Gigliotti A. P., Nikula K. J., Seilkop S. K., Gurevich M., Mauderly J. L. Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions. Toxicol. Sci. 2002; 70(2)212–226
  • Seagrave J. C., Mauderly J. L., Seilkop S. K. In vitro relative toxicity screening of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions. J. Toxicol. Environ. Health A 2003; 66(12)1113–1132
  • Seagrave J. C., Gigliotti A., McDonald J. D., Seilkop S. K., Whitney K. A., Zielinska B., Mauderly J. L. Composition, toxicity, and mutagenicity of particulate and semivolatile emissions from heavy-duty compressed natural gas-powered vehicles. Toxicol. Sci. 2005; 87(1)232–241
  • Seagrave J., McDonald J. D., Bedrick E., Edgerton E. S., Gigliotti A. P., Jansen J. J., Ke L., Naeher L. P., Seilkop S. K., Zheng M., Mauderly J. L. Lung toxicity of ambient particulate matter from southeastern US sites with different contributing sources: Relationships between composition and effects. Environ. Health Perspect. 2006; 114(9)1387–1393
  • Seinfeld J. H., Pankow J. F. Organic atmospheric particulate material. Annu. Rev. Phys Chem. 2003; 54: 121–140
  • Simoneit B. R. T., Mazurek M. A. Organic matter of the troposphere II—Natural background of biogenic lipid matter in aerosols over the rural western United States. Atmos. Environ. 1982; 16(9)2139–2159
  • Simoneit B. R. T. A review of biomarker compounds as source indicators and tracers for air pollution. Environ. Sci. Pollut. Res. 1999; 6(3)159–169
  • Simoneit B. R. T., Schauer J. J., Nolte C. G., Oros D. R., Elias V. O., Fraser M. P., Rogge W. F., Cass G. R. Levoglucosan, a tracer for cellulose in biomass burning and atmospheric particles. Atmos. Environ. 1999; 33(2)173–182
  • Simoneit B. R. T., Rushdi A. I., Bin Abas M. R., Didyk B. M. Alkyl amides and nitriles as novel tracers for biomass burning. Environ. Sci. Technol. 2003; 37(1)16–21
  • Singh P., DeMarini D. M., Dick C. A. J., Tabor D. G., Ryan J. V., Linak W. P., Kobayashi T., Gilmour M. I. Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice. Environ. Health Perspect. 2004; 112(8)820–825
  • Solomons T. W. G. Organic chemistry, 6th ed. John Wiley & Sons, New York 1996
  • South Coast Air Quality Management District. Multiple air toxics exposure study in the South Coast Air Basin MATES-II—Final report. South Coast Air Quality Management District, Diamond Bar, CA 2000
  • Steerenberg P. A., van Amelsvoort L., Lovik M., Hetland R. B., Alberg T., Halatek T., Bloemen H. J. T., Rydzynski K., Swaen G., Schwarze P., Dybing E., Cassee F. R. Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: An exploratory study. Inhal. Toxicol. 2006; 18(5)333–346
  • Stenfors N., Nordenhall C., Salvi S. S., Mudway I., Soderberg M., Blomberg A., Helleday R., Levin J. O., Holgate S. T., Kelly F. J., Frew A. J., Sandstrom T. Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. Eur.Respir J. 2004; 23(1)82–86
  • Surratt J. D., Kroll J. H., Kleinsienst T. E., Edney E. O., Claeys M., Sorooshian A., Ng N. L., Offenberg J. H., Lewandowski M., Jaoui M., Jaouri R., Flagan R. C., Seinfield J. H. Evidence for organosulfates in secondary organic aerosol. Environ. Sci. Technol. 2007; 41(2)517–527
  • Tai M.-H., Upham B. L., Olson L. K., Tsa M.-S., Reed D. N., Jr., Trosk J. E. Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells. Int. J. Cancer 2007; 120(9)1855–1862
  • Takanaka H., Zhang K., Diaz-Sanchez D., Tsien A., Saxon A. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: Direct effects on B-cell IgE production. J. Allergy Clin. Immunol. 1995; 95(1)103–115
  • Thompson A. M., Stewart R. W. Effect of chemical kinetics uncertainties on calculated constituents in a tropospheric photochemical model. J. Geophys. Res. 1991; 96: 13089–13108
  • Timofeyev M. A., Shatilina Z. M., Bedulina D. S., Menzel R., Steinberg C. E. Natural organic matter (NOM) has the potential to modify the multixenobiotic resistance (MXR) activity in freshwater amphibipods Eulimnogammarus cyaneus E. verrucosus. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2007; 146(4)496–503
  • Tolbert P., Klein M., Metzger K., Peel J., Flanders W. D., Todd K., Mulholland J., Ryan P. B., Frumkin H. Particulate pollution and cardiorespiratory emergency department visits in Atlanta, August 1998–August 2000 (ARIES/SOPHIA studies). Epidemiology 2001; 12(4)S54
  • Tonne C. S. M., Mittleman M., Coull B., Goldberg R., Schwartz J. A case-control analysis of exposure to traffic and acute myocardial infarction. Environ. Health Perspect. 2007; 115: 53–57
  • Topping D., Coe H., McFiggans G., Burgess R., Allan J., Alfarra M. R., Bower K., Choularton T. W., Decesari S., Facchini M. C. Aerosol chemical characteristics from sampling conducted on the Island of Jeju, Korea during ACE Asia. Atmos. Environ. 2004; 38(14)2111–2123
  • Tsien A., Diaz-Sanchez D., Ma J., Saxon A. The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol. Appl. Pharmacol. 1997; 142(2)256–263
  • Tsigaridis K., Kanakidou M. Global modelling of secondary organic aerosol in the troposphere: A sensitivity analysis. Atmos. Chem. Phys. 2003; 3: 1849–1869
  • Turpin B. J., Huntzicker J. J., Hering S. V. Investigation of organic aerosol sampling artifacts in the Los Angeles Basin. Atmos. Environ. 1994; 28(19)3061–3071
  • Turpin B. J., Saxena P., Andrews E. Measuring and simulating particulate organics in the atmosphere: Problems and prospects. Atmos. Environ. 2000; 34(18)2983–3013
  • U.S. Environmental Protection Agency. Guidance for network design and optimum site exposure for PM2.5 and PM10. Prepared by U.S. Environmental Protection Agency, Research Triangle Park, NC 1997, http://www.epa.gov/ttn/amtic/pmstg.html Report No. EPA-454/R-99-022
  • U.S. Environmental Protection Agency. Compendium of Methods for the determination of toxic organic compounds in ambient air, Method TO-11A: Determination of formaldehyde in ambient air using adsorbent cartridge followed by high performance liquid chromatography (HPLC). Center for Environmental Research Information, Office of Research and Development, U.S. EPA, Cincinnati, OH 1999a, http://www.epa.gov/ttn/amtic/files/ambient/airtox/to-11ar.pdf
  • U.S. Environmental Protection Agency. National air toxics program: The integrated urban strategy. Fed. Reg. 1999b; 64(137)38706
  • U.S. Environmental Protection Agency. Toxic organic compounds in Ambient Air Compendium Method TO-15: Determination of volatile organic compounds (VOCs) in air collected in specially-prepared canisters and analyzed by gas chromatography/mass spectrometry (GC/MS). 1999c, http://www.epa.gov/ttn/amtic/files/ambient/airtox/to-15r.pdf
  • U.S. Environmental Protection Agency. Supplementary guidance for conducting health risk assessment of chemical mixtures. 2000, http://www.epa.gov/NCEA/raf/pdfs/chem_mix/chem_mix_08_2001.pdf
  • U.S. Environmental Protection Agency. Health assessment document for diesel engine exhaust. National Center for Environmental Assessment, Office of Research and Development, Washington, DC 2002
  • U.S. Environmental Protection Agency. Air quality criteria for particulate matter, Vol. 1 and 2. US EPA, National Center for Environmental Assessment, Office of Research and Development, Research Triangle Park, NC 2004a
  • U.S. Environmental Protection Agency. Six principal air pollutants. Air trends. U.S. EPA, Office of Air and Radiation. 2004b, http://www.epa.gov/airtrends/2007/report/sixprincipalpollutants.pdf
  • U.S. Environmental Protection Agency. 1999 National scale air toxics assessment. 2006, http://www.epa_gov/ttn/atw/nata/ Technology Transfer Network, Office of Air and Radiation (online)
  • van Vaeck L., van Cauwenberghe K., Janssens J. The gas-particle distribution of organic aerosol constituents: measurements of the volatilisation artifact in Hi-Vol cascade impactor sampling. Atmos. Environ. 1984; 18: 417–430
  • Venkatachari P., Hopke P. K., Brune W. H., Ren X. R., Lesher R., Mao J. Q., Mitchel M. Characterization of wintertime reactive oxygen species concentrations in Flushing, New York. Aerosol Sci. Technol. 2007; 41(2)97–111
  • Wang G. H., Kawamura K., Lee S., Ho K. F., Cao J. J. Molecular, seasonal, and spatial distributions of organic aerosols from fourteen Chinese cities. Environ. Sci. Technol. 2006a; 40(15)4619–4625
  • Wang S. L., Chang Y. C., Chao H. R., Li C. M., Li L. A., Lin L. Y., Papke O. Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women. Environ. Health Perspect. 2006b; 114(5)740–745
  • Watanabe N., Kurita M. The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust. Environ. Health Perspect. 2001; 109: 111–119
  • Watanabe N., Ohsawa M. Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods. BMC Pregnancy Childbirth 2002; 22: 11
  • Watanabe N. Decreased number of sperms and sertoli cells in mature rats exposed to diesel exhaust as fetuses. Toxicol.Lett. 2005; 155: 51–58
  • Watson J. G. Visibility: Science and regulation. J. Air Waste Manage. Assoc. 2002; 52(6)628–713
  • Watson J. G., Chen L.-W. A., Chow J. C., Lowenthal D. H., Doraiswamy P. Source apportionment: Findings from the U.S. Supersite Program. J. Air Waste Manage. Assoc. 2008; 58(2)265–288
  • Watson J. G., Chow J. C. A wintertime PM2.5 episode at the Fresno, CA, supersite. Atmos. Environ. 2002a; 36(3)465–475
  • Watson J. G., Chow J. C. Comparison and evaluation of in-situ and filter carbon measurements at the Fresno Supersite. J. Geophys. Res. 2002b; 107(D21)ICC 3-1–ICC 3-15
  • Watson J. G., Chow J. C., Chen L.-W. A. Summary of organic and elemental carbon/black carbon analysis methods and intercomparisons. Aerosol Air Qual. Res. 2005; 5(1)65–102
  • Watson J. G., Chow J. C., Lowenthal D. H., Pritchett L. C., Frazier C. A., Neuroth G. R., Robbins R. Differences in the carbon composition of source profiles for diesel-and gasoline-powered vehicles. Atmos. Environ. 1994; 28(15)2493–2505
  • Wellenius G. A., Coull B. A., Godleski J. J., Koutrakis P., Okabe K., Savage S. T., Lawrence J. E., Murthy G. G. K., Verrier R. L. Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs. Environ. Health Perspect. 2003; 111(4)402–408
  • Welthagen W., Schnelle-Kreis J., Zimmermann R. Search criteria and rules for comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry analysis of airborne particulate matter. J. Chromatogr. A 2003; 1019(1–2)233–249
  • Wigle D. T., Arbuckle T. E., Walker M., Wade M. G., Liu S. L., Krewski D. Environmental hazards: Evidence for effects on child health. J. Toxicol. Environ. Health B 2007; 10(1–2)3–39
  • Wilkins C. K., Wolkoff P., Clausen P. A., Hammer M., Nielsen G. D. Upper airway irritation of terpene/ozone oxidation products (TOPS). Dependence on reaction time, relative humidity and initial ozone concentration. Toxicol. Lett. 2003; 143(2)109–114
  • Williams B. J., Goldstein A. H., Kreisberg N. M., Hering S. V. An in-situ instrument for speciated organic composition of atmospheric aerosols: Thermal Desorption Aerosol GC/MS-FID (TAG). Aerosol Sci. Technol. 2006; 40(8)627–638
  • Xiao J. Z., Kondo S., Yanagisawa N., Miyaji K., Enomoto K., Sakoda T., Iwatsuki K., Enomoto T. Clinical efficacy of probiotic bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol.Int. 2007; 56: 67–75
  • Yang H., Li Q. F., Yu J. Z. Comparison of two methods for the determination of water-soluble organic carbon in atmospheric particles. Atmos. Environ. 2003; 37(6)865–870
  • Yang H., Xu J., Wu W. S., Wan C. H., Yu J. Z. Chemical characterization of water-soluble organic aerosols at Jeju Island collected during ACE-Asia. Environ. Chem. 2004; 1: 13–17
  • Yang M. H., Park M. S., Lee H. S. Endocrine disrupting chemicals: Human exposure and health risks. J. Environ. Sci. Health C Environ. Carcinogen. Ecotoxicol. Rev. 2006; 24(2)183–224
  • Yue Z. W., Fraser M. P. Characterization of nonpolar organic fine particulate matter in Houston, Texas. Aerosol Sci. Technol. 2004; 38(Suppl. 1)60–67
  • Zhang Q., Anastasio C. Free and combined amino compounds in atmospheric fine particles (PM2.5) and fog waters from Northern California. Atmos. Environ. 2003; 37(16)2247–2258
  • Zheng M., Cass G. R., Schauer J. J., Edgerton E. S. Source apportionment of PM2.5 in the southeastern United States using solvent-extractable organic compounds as tracers. Environ. Sci. Technol. 2002; 36(11)2361–2371
  • Zheng M., Ke L., Edgerton E. S., Schauer J. J., Dong M. Y., Russell A. G. Spatial distribution of carbonaceous aerosol in the southeastern United States using molecular markers and carbon isotope data. J. Geophys. Res. 2006; 111(D10), D10S06
  • Zhu Y. F., Hinds W. C., Kim S., Shen S., Sioutas C. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos. Environ. 2002a; 36(27)4323–4335
  • Zhu Y. F., Hinds W. C., Kim S., Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. J. Air Waste Manage. Assoc. 2002b; 52(9)1032–1042
  • Zhu Y. F., Hinds W. C., Shen S., Sioutas C. Seasonal trends of concentration and size distribution of ultrafine particles near major highways in Los Angeles. Aerosol Sci. Technol. 2004; 38(Suppl. 1)5–13
  • Zielinska B., Sagebiel J., Arnott W. P., Rogers C. F., Kelly K. E., Wagner D. A., Lighty J. S., Sarofim A. F., Palmer G. Phase and size distribution of polycyclic aromatic hydrocarbons in diesel and gasoline vehicle emissions. Environ. Sci. Technol. 2004; 38(9)2557–2567

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