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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 2
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Research Article

Design and Testing of Electrostatic Aerosol In Vitro Exposure System (EAVES): An Alternative Exposure System for Particles

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Pages 91-101 | Received 13 Feb 2008, Accepted 27 Apr 2008, Published online: 01 Feb 2009

References

  • S. Abe, H. Takizawa, I. Sugawara, and S. Kudoh. 2000. Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: A study with a new cell exposure system to freshly generated DE in vitro. Am. J. Respir. Cell Mol. Biol. 22 (3):296–303.
  • R. Atkinson. 2000. Atmospheric chemistry of VOCs and NOx. Atmos. Environ. 34:2063–2101.
  • M. Aufderheide, and U. Mohr. 2000. CULTEX—An alternative technique for cultivation and exposure of cells of the respiratory tract to airborne pollutants at the air/liquid interface. Exp. Toxicol. Pathol. 52 (3):265–270.
  • H. Bayram, J. L. Devalia, R. J. Sapsford, T. Ohtoshi, Y. Miyabara, M. Sagai, and R. J. Davies. 1998. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell. Mol. Biol. 18 (3):441–448.
  • K. J. Boelter, and J. H. Davidson. 1997. Ozone generation by indoor, electrostatic air cleaners. Aerosol Sci. Technol. 27 (6):689.
  • S. Boland, A. Baeza-Squiban, T. Fournier, O. Houcine, M. C. Gendron, M. Chévrier, G. Jouvenot, A. Coste, M. Aubier, and F. Marano. 1999. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production. Am. J. Physiol. Lung Cell Mol. Physiol 276:L604–L613.
  • K. de Bruijne. 2007. Electrostatic aerosol in vitro exposure system (EAVES) as an alternative exposure system for mixtures of gases and particles. Master's technical report, prepared for Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill.
  • R. Devlin, M. L. Frampton, and A. J. Ghio. 2005. In vitro studies: What is their role in toxicology?. Exp. Toxicol. Pathol. 57:183–188.
  • M. Doyle, K. G. Sexton, H. E. Jeffries, K. Bridge, and I. Jaspers. 2004. Effects of 1-3-butadiene, isoprene, and their photochemical degradation products on human lung cells. Environ. Health Perspect. 112:1488–1495.
  • M. Doyle, K. G. Sexton, H. E. Jeffries, and I. I. Jaspers. 2006. Atmospheric photochemical transformations enhance 1,3-butadiene-induced inflammatory responses in human epithelial cells: The role of ozone and other photochemical degradation products. Chem. Biol. Interact 166 (1–3):163–169.
  • Z. Fan, R. M. Kamens, J. Hu, J. Zhang, and S. R. McDow. 1996. Photostability of nitro-polycyclic aromatic hydrocarbons on combustion soot particles in sunlight. Environ. Sci. Technol. 30:1358–1364.
  • R. Griffin, D. Cocker, J. Seinfeld, and D. Dabdub. 1999. Estimate of global atmospheric organic aerosol from oxidation of biogenic hydrocarbons. Geophys. Res. Lett. 26 (17):2721–2724.
  • W. C. Hinds. 1999. Aerosol technology: Properties, behavior, and measurement of airborne particlesm 2nd ed. New York: John Wiley & Sons.
  • I. Jaspers, W. Zhang, A. Fraser, J. M. Samet, and W. Reed. 2001. Hydrogen peroxide has opposing effects on IKK activity and IKappaBalpha breakdown in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 24 (6):769–777.
  • I. Jaspers, J. Ciencewicki, W. Zhang, L. Brighton, J. Carson, M. Beck, and M. Madden. 2005. Diesel exhaust enhances influenza virus infections in respiratory epithelial cells. Toxicol. Sci. 85:990–1002.
  • I. Jaspers, E. Flescher, and L. C. Chen. 1997. Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol 272:L504–511. (3 Pt 1)
  • H. E. Jeffries, D. L. Fox, and R. M. Kamens. 1976. Outdoor smog chamber studies: Light effects relative to indoor chambers. Environ. Sci. Technol. 10:1006–1011.
  • H. E. Jeffries, K. G. Sexton, R. M. Kamens, and M. S. Holleman. 1985. Outdoor smog chamber experiments: Reactivity of methanol exhaust, ed. C. A. Harvey. Ann Arbor, MI: Environmental Protection Agency, Office of Mobile Sources.
  • Y.-M. Kim, W. Reed, A. G. Lenz, I. Jaspers, R. Silbajoris, H. S. Nick, and J. M. Samet. 2005. Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells. Am. J. Respir. Cell Mol Biol 288:L432–L441.
  • J. W. Knebel, D. Ritter, and M. Aufderheide. 2002. Exposure of human lung cells to native diesel motor exhaust—Development of an optimized in vitro test strategy. Toxicol. In Vitro 16:185–192.
  • E. O. Knutson, and K. T. Whitby. 1975. Aerosol classification by electric mobility: apparatus, theory, and applications. J. Aerosol Sci. 6:443–451.
  • S. W. Lake. 2005. Electrostatic precipitation as an alternative method for in vitro human lung cell aerosol exposures. Master's thesis, prepared for Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
  • S. Lee, M. Jang, and R. M. Kamens. 2004. SOA formation from the photooxidation of a-pinene in the presence of freshly emitted diesel soot exhaust. Atmos. Environ. 38:2597–2605.
  • N. Li, S. Kim, M. Wang, J. Froines, C. Sioutas, and A. Nel. 2002. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal. Toxicol. 14:459–486.
  • M. Lieber, B. Smith, A. Szakal, W. Nelson-Rees, and G. Todaro. 1976. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 17:62–70.
  • M. Lippmann. 1977 Regional deposition of particles in the human respiratory tract. In Handbook of physiology: Section IV, Environmental physiology, 2nd ed., ed. M. S. Lee, DHK, pp. 213–232. Philadelphia: Williams & Wilkins.
  • M. C. Madden, L. A. Dailey, J. G. Stonehuerner, and B. D. Harris. 2003. Responses of cultured human airway epithelial cells treated with diesel exhaust extracts will vary with the engine load. J. Toxicol. Environ. Health A 66:2281–2297.
  • G. Mainelis, S. A. Grinshpun, K. Willeke, T. Reponen, V. Ulevicius, and P. J. Hintz. 1999. Collection of airborne microorganisms by electrostatic precipitation. Aerosol Sci. Technol. 30 (2):127–144.
  • G. Mainelis, and K. Willeke. 2002. Design and collection efficiency of a new electrostic precipitator for bioaerosol collection. Aerosol Sci. Technol. 36:1073–1085.
  • T. F. Mar, K. Ito, J. Q. Koenig, T. V. Larson, D. J. Eatough, R. C. Henry, E. Kim, F. Laden, R. Lall, L. Neas, M. Stolzel, P. Paatero, P. K. Hopke, and G. D. Thurston. 2005. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM(2.5) and daily mortality in Phoenix, AZ. J. Expos. Anal. Environ. Epidemiol. 16:311–320.
  • G. Mazzarella, F. Ferraraccio, M. V. Prati, S. Annunziata, A. Bianco, A. Mezzogiorno, G. Liguori, I. F. Angelillo, and M. Cazzola. 2007. Effects of diesel exhaust particles on human lung epithelial cells: An in vitro study. Respir. Med. 101:1155–1162.
  • J. McDonald, E. Barr, R. White, J. Chow, J. Schauer, B. Zielinska, and E. Grosjean. 2004. Generation and characterization of four dilutions of diesel engine exhaust for a subchronic inhalation study. Environ. Sci. Technol. 38 (9):2513–2522.
  • R. McDonald, and P. Biswas. 2004. A methodology to establish the morphology of ambient aerosols. Air Waste Manage. Assoc. 54:1069–1078.
  • J. Myoseon, and C. Gang. 2006. Deposition of magnetic nanoparticles suspended in the gas phase on a specific target area. Environ. Sci. Technol. 40 (21):6730–6737.
  • C. A. PopeIII, and D. W. Dockery. 2006. Health effects of fine particulate air pollution: lines that connect. J. Air Waste Manage. Assoc. 56 (6):709.
  • S. Salvi, A. Blomberg, B. Rudell, F. Kelly, T. Sandström, S. T. Holgate, and A. Frew. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159 (3):702–709.
  • S. Salvi, C. Nordenhall, A. Blomberg, B. Rudell, J. Pourazar, F. J. Kelly, S. Wilson, T. Sandström, S. T. Holgate, and A. J. Frew. 2000. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am. J. Respir. Crit. Care Med. 161 (2):550–557.
  • J. Seagrave, S. Dunaway, J. D. McDonald, J. L. Mauderly, P. Hayden, and C. Stidley. 2007. Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air–liquid interface. Exp. Lung Res. 33 (1):27–51.
  • J. Seagrave, J. D. McDonald, and J. L. Mauderly. 2005. In vitro versus in vivo exposure to combustion emissions. Exp. Toxicol. Pathol 57 (Suppl. 1):233–238.
  • K. G. Sexton, H. E. Jeffries, M. Jang, R. M. Kamens, M. Doyle, I. Voicu, and I. Jaspers. 2004. Photochemical products in urban mixtures enhance inflammatory responses in lung cells. Inhal. Toxicol 16 (Suppl. 1):107–114.
  • P. Singh, D. M. DeMarini, C. A. J. Dick, D. G. Tabor, J. V. Ryan, W. P. Linak, T. Kobayashi, and M. I. Gilmour. 2004. Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice. Environ. Health. Perspect. 112 (8):820–825.
  • C. Sioutas, P. Koutrakis, and B. A. Olson. 1994. Development and evaluation of a low cutpoint virtual impactor. Aerosol Sci. Technol. 21 (3):223–235.
  • C. Sioutas, E. Abt, J. M. Wolfson, and P. Koutrakis. 1999. Evaluation of the measurement performance of the scanning mobility particle sizer and aerodynamic particle sizer. Aerosol Sci. Technol. 30:84–92.
  • P. A. Steerenberg, J. A. Zonnenberg, J. A. Dormans, P. N. Joon, I. M. Wouters, L. van Bree, P. T. Scheepers, and H. Van Loveren. 1998. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp. Lung Res. 24 (1):85–100.
  • TSI Inc. 2008. TSI particle instruments 2007. Accessed February 11, 2008, http://www.tsi.com/pages/particle/history.aspx#1960.
  • A. Tsien, D. Diaz-Sanchez, J. Ma, and A. Saxton. 1997. the organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol. Appl. Pharmacol. 142:256–263.
  • U.S. Environmental Protection Agency. 1999. The benefits and costs of the Clean Air Act 1990 to 2010. EPA Report to Congress, ed. Office of Air and Radiation Office of Policy. Washington, DC: U.S. EPA.
  • K. T. Whitby, R. E. Charlson, W. E. Wilson, and R. K. Stevens. 1974. The size of suspended particle matter in air. Science 183:1098–1099.
  • J. Yu, H. E. Jeffries, and R. Le Lacheur. 1995. Identifying airborne carbonyl compounds in isoprene atmospheric photo oxidation products by their PFBHA oximes using gas chromatography/ion trap mass spectrometry. Environ. Sci. Technol. 29:1923–1932.
  • J. Yu, H. Jeffries, and K. G. Sexton. 1997. Atmospheric photo oxidation of alkylbenzenes—I. Carbonyl product analyses. Atmos. Environ 31 (15):2261–2280.

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