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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 6: Inhaled Iodomethane: A Focused Research Program & Health-Based Risk Assessment
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Research Article

In vitro glutathione conjugation of methyl iodide in rat, rabbit, and human blood and tissues

Torka S. PoetBattelle, Pacific Northwest Division, Richland, Washington State, USACorrespondence[email protected]
,
Hong WuBattelle, Pacific Northwest Division, Richland, Washington State, USA
,
Richard A. CorleyBattelle, Pacific Northwest Division, Richland, Washington State, USA
&
Karla D. ThrallBattelle, Pacific Northwest Division, Richland, Washington State, USA
Pages 524-530 | Received 15 Oct 2008, Accepted 04 Nov 2008, Published online: 23 Mar 2009

References

  • Bogdanffy, M.S., Randall, H.W., and Morgan, K.T. 1987. Biochemical quantitation and histochemical localization of carboxylesterase in the nasal passages of the Fischer-344 rat and B6C3F1 mouse. Toxicol. Appl. Pharmacol. 88(2):183–194.
  • Chamberlain, M.P., Lock, E.A., and Reed, C.J. 1998. Investigations of the pathways of toxicity of methyl iodide in the rat nasal cavity. Toxicology 129(2–3):169–181.
  • Hallier, E., Deutschmann, S., Reichel, C., Bolt, H.M., and Peter, H. 1990. A comparative investigation of the metabolism of methyl bromide and methyl iodide in human erythrocytes. Int. Arch. Occup. Environ. Health 62(3):221–225.
  • Hallier, E., Schroder, K.R., Asmuth, K., Dommermuth, A., Aust, B., and Goergens, H.W. 1994. Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase theta (GST T1-1). Arch. Toxicol. 68(7):423–427.
  • Kedderis, G.L., Carfagna, M.A., Held, S.D., Batra, R., Murphy, J.E., and Gargas, M.L. 1993. Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicol. Appl. Pharmacol. 123(2):274–282.
  • Kim, C., Manning, R.O., Brown, R.P., and Brukner, J.V. 1996. Use of a vial equilibraton technique for determination of the metabolic rate constants for dichloromethane. Toxicol. Appl. Pharmacol. 139:243–251.
  • Nemec, M., Sloter, E., Stump, D., Holson, J., Kirkpatrick, D., Kinzell, J., and Kaufman, L. 2009. Prenatal developmental toxicity studies of inhaled methyl iodide vapor in rabbits reveal a susceptible window of exposure inducing late gestational fetotoxicity. Inhal. Toxicol.
  • Mileson, B., McDonald, T., Kirkpatrick, D., and Kinzell, J. 2009. Risk assessments for methyl iodide. Inhal. Toxicol.
  • Morgan, K.T. 1991. Approaches to the identification and recording of nasal lesions in toxicology studies. Toxicol. Pathol. 19(4 Pt 1):337–351.
  • Peter, H., Deutschmann, S., Reichel, C., and Hallier, E. 1989. Metabolism of methyl chloride by human erythrocytes. Arch. Toxicol. 63(5):351–355.
  • Poet, T.S., and Borghoff, S.J. 1997. In vitro uptake of methyl tert-butyl ether in male rat kidney: Use of a two-compartment model to describe protein interactions. Toxicol. Appl. Pharmacol. 145(2):340–348.
  • Reitz, R.H., Medrala, A.L., Park, C.N., Andersen, M.E., and Guengerich, F.P. 1988. Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: Implications for risk assessments. Toxicol. Lett. 43:97–116.
  • Sato, A., and Nakajima, T. 1979. A vial equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons. Toxicol. Appl. Pharmacol. 41:41–46.
  • Sloter, E., Nemec, M., Stump, D., Holson, J., Kirkpatrick, D., Gargas, M., and Kinzell, J. 2009. Methyl iodide-induced fetal hypothyroidism implicated in late-stage fetal death in rabbits. Inhal. Toxicol.
  • Sweeney, L., Kirman, C., Gannon, S., Thrall, K.D., Gargas, M.L., and Kinzell, J. 2009. Derivation of human toxicity reference values for methyl iodide using physiologically based pharmacokinetic (PBPK) modeling. Inhal. Toxicol.
  • Thrall, K.D., Woodstock, A., Soelberg, J., Gargas, M.L., Kinzell, J., and Corley, R. 2009. A real-time methodology to evaluate the nasal absorption of volatile compounds in anesthetized animals. Inhal. Toxicol.

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