Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 6: Inhaled Iodomethane: A Focused Research Program & Health-Based Risk Assessment
Submit an article Journal homepage
72
Views
7
CrossRef citations to date
0
Altmetric
Research Article

A real-time methodology to evaluate the nasal absorption of volatile compounds in anesthetized animals

Karla D. ThrallBiological Monitoring & Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington, USACorrespondence[email protected]
,
Angela D. WoodstockBiological Monitoring & Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington, USA
,
Jolen J. SoelbergBiological Monitoring & Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington, USA
,
Michael L. GargasThe Sapphire Group, Inc., Dayton, Ohio, USA
,
John H. KinzellArysta Life Science Corporation, Cary, North Carolina, USA
&
Richard A. CorleyBiological Monitoring & Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington, USA
Pages 531-536 | Received 15 Oct 2008, Accepted 04 Nov 2008, Published online: 23 Mar 2009

References

  • Aharonson, E.S., Menkes, H., Gurtner, G., Swift, D.L., and Proctor, D.F. 1974. Effect of respiratory flow rate on removal of soluble vapors by the nose. J. Appl. Physiol. 37:654–657.
  • Arms, A.D., and Travis, C.C. 1988. Reference physiological parameters in pharmacokinetic modeling, US EPA/600/6-88/004, US Department of Commerce, Springfield, VA.
  • Cameron, G.R., Gaddum, J.H., and Short, R.H.D. 1946. The absorption of war gases by the nose. J. Pathol. 58:449–455.
  • Frederick, C.B., Gentry, P.R., Bush, M.L., Lomax, L.G., Black, K.A., Finch, L., Kimbell, J.S., Morgan, K.T., Subramaniam, R.P., Morris, J.B., and Ultman, J.S. 2001. A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure. Inhal. Toxicol. 13:359–376.
  • Harkness, J.E., and Wagner, J.E. 1989. The biology and medicine of rabbits and rodents, 3rd ed. Philadelphia: Lea & Febiger.
  • Johanson, G. 1991. Modelling of respiratory exchange of polar solvent. Ann. Occup. Hyg. 35:323–339.
  • Miller, F.J., McNeal, C.A., Kirtz, J.M., Gardner, D.E., Coffin, D.L., and Menzel, D.B. 1979. Nasopharyngeal removal of ozone in rabbits and guinea pigs. Toxicologist 14:273–281.
  • Morris, J.B. 1997. Uptake of acetaldehyde vapor and aldehydes dehydrogenase levels in the upper respiratory tracts of the mouse, rat, hamster, and guinea pig. Fundam. Appl. Toxicol. 35:91–100.
  • Morris, J.B. 1999. A method for measuring upper respiratory tract vapor uptake and its applicability to quantitative inhalation risk assessment. Inhal. Toxicol. 11:101–123.
  • Morris, J.B. 2001. Overview of upper respiratory tract vapor uptake studies. Inhal. Toxicol. 13:335–345.
  • Reed, C.J., Gaskell, B.A., Banger, K.K., and Lock, E.A. 1995. Olfactory toxicity of methyl iodide in the rat. Arch. Toxicol. 70:51–56.
  • Thrall, K.D., Schwartz, R.E., Weitz, K.K., Soelberg, J.J., Foureman, G.L., Prah, J.D., and Timchalk, C. 2003. A real-time method to evaluate the nasal deposition and clearance of acetone in the human volunteer. Inhal. Toxicol. 15:523–538.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.