Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 28, 2016 - Issue 11
138
Views
4
CrossRef citations to date
0
Altmetric
Review Article

Evaluation of neural reflex activation as a mode of action for the acute respiratory effects of ozone

&
Pages 484-499 | Received 17 Feb 2016, Accepted 11 Jul 2016, Published online: 28 Aug 2016

References

  • Adriaensen D, Timmermans JP. (2011). Breath-taking complexity of vagal C-fibre nociceptors: implications for inflammatory pulmonary disease, dyspnoea and cough. J Physiol 589:3–4. doi: 10.1113/jphysiol.2010.201434
  • Alexis N, Urch B, Tarlo S, et al. (2000). Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals. Inhal Toxicol 12:1205–24
  • Alfaro MF, Putney L, Tarkington BK, et al. (2004). Effect of rapid shallow breathing on the distribution of 18O-labeled ozone reaction product in the respiratory tract of the rat. Inhal Toxicol 16:77–85. doi: 10.1080/08958370490264852
  • Aris RM, Christian D, Hearne PQ, et al. (1993). Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 148:1363–72
  • Balmes JR, Chen LL, Scannell C, et al. (1996). Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 153:905–9
  • Barnes PJ. (1996). Neuroeffector mechanisms: the interface between inflammation and neuronal responses. J Allergy Clin Immunol 98:S73–83. doi: 10.1016/S0091-6749(96)70020-9
  • Beckett WS, McDonnell WF, Horstman DH, House DE. (1985). Role of the parasympathetic nervous system in acute lung response to ozone. J Appl Physiol 59:1879–85
  • Blomberg A, Mudway IS, Nordenhall C, et al. (1999). Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 13:1418–28
  • Boobis AR, Doe JE, Heinrich-Hirsch B, et al. (2008). IPCS framework for analyzing the relevance of a noncancer mode of action for humans. Crit Rev Toxicol 38:87–96
  • Coffey MJ, Wheeler CS, Gross KB, et al. (1996). Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology 114:187–97. doi: 10.1016/S0300-483X(96)03487-7
  • Coleridge HM, Coleridge JC, Ginzel KH, et al. (1976). Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandins. Nature 264:451–3
  • Coleridge JC, Coleridge HM, Schelegle ES, Green JF. (1993). Acute inhalation of ozone stimulates bronchial C-fibers and rapidly adapting receptors in dogs. J Appl Physiol 74:2345–52
  • Devlin RB, McDonnell WF, Becker S, et al. (1996). Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure. Toxicol Appl Pharmacol 138:176–85. doi: 10.1006/taap.1996.0111
  • Devlin RB, McDonnell WF, Mann R, et al. (1991). Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 4:72–81
  • Franco-Penteado CF, De Souza IA, Camargo EA, et al. (2005). Mechanisms involved in the enhancement of allergic airways neutrophil influx by permanent C-fiber degeneration in rats. J Pharmacol Exp Ther 313:440–8. doi: 10.1124/
  • Fu L, Kaneko T, Ikeda H, et al. (2002). Tachykinins via tachykinin NK(2) receptor activation mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. Br J Pharmacol 135:1331–5. doi: 10.1038/sj.bjp.0704572
  • Goodman JE, Prueitt RL, Chandalia J, Sax SN. (2014). Evaluation of adverse human lung function effects in controlled ozone exposure studies. J Appl Toxicol 34:516–24. doi: 10.1002/jat.2905
  • Goodman JE, Seeley M, Mattuck R, Thakali S. (2015). Do group responses mask the effects of air pollutants on potentially sensitive individuals in controlled human exposure studies? Regul Toxicol Pharmacol 71:552–64. doi: 10.1016/j.yrtph.2015.02.002
  • Harkema JR, Carey SA, Wagner JG. (2006). The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium. Toxicol Pathol 34:252–69
  • Hatch GE, McKee J, Brown J, et al. (2013). Biomarkers of dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats. Biomark Insights 8:53–67
  • Hatch GE, Slade R, Harris LP, et al. (1994). Ozone dose and effect in humans and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med 150:676–83
  • Hazbun ME, Hamilton R, Holian A, Eschenbacher WL. (1993). Ozone-induced increases in substance P and 8-epi-prostaglandin F2 alpha in the airways of human subjects. Am J Respir Cell Mol Biol 9:568–72
  • Hazucha MJ, Bates DV, Bromberg PA. (1989). Mechanism of action of ozone on the human lung. J Appl Physiol 67:1535–41
  • Hazucha MJ, Madden M, Pape G, et al. (1996). Effects of cyclo-oxygenase inhibition on ozone-induced respiratory inflammation and lung function changes. Eur J Appl Physiol Occup Physiol 73:17–27. doi: 10.1007/BF00262805
  • Hill AB. (1965). The environment and disease: association or causation? Proc R Soc Med 58:295–300
  • Ho CY, Gu Q, Hong JL, Lee LY. (2000). Prostaglandin E(2) enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat. Am J Respir Crit Care Med 162:528–33. doi: 10.1164/ajrccm.162.2.9910059
  • Ho CY, Lee LY. (1998). Ozone enhances excitabilities of pulmonary C fibers to chemical and mechanical stimuli in anesthetized rats. J Appl Physiol 85:1509–15
  • Hoffmeyer F, Sucker K, Monse C, et al. (2013). Relationship of pulmonary function response to ozone exposure and capsaicin cough sensitivity. Inhal Toxicol 25:569–76. doi: 10.3109/08958378.2013.812699
  • Jancso G, Kiraly E, Jancso-Gabor A. (1977). Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741–3. doi: 10.1038/270741a0
  • Jimba M, Skornik WA, Killingsworth CR, et al. (1995). Role of C fibers in physiological responses to ozone in rats. J Appl Physiol 78:1757–63
  • Krishna MT, Chauhan AJ, Frew AJ, Holgate ST. (1998). Toxicological mechanisms underlying oxidant pollutant-induced airway injury. Rev Environ Health 13:59–71
  • Krishna MT, Springall D, Meng QH, et al. (1997). Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans. Am J Respir Crit Care Med 156:943–50. doi: 10.1164/ajrccm.156.3.9612088
  • Lee LY, Dumont C, Djokic TD, et al. (1979). Mechanism of rapid, shallow breathing after ozone exposure in conscious dogs. J Appl Physiol Respir Environ Exerc Physiol 46:1108–14
  • Lee LY, Widdicombe JG. (2001). Modulation of airway sensitivity to inhaled irritants: role of inflammatory mediators. Environ Health Perspect 109:585–9
  • McDonnell WF, III, Horstman DH, Abdul-Salaam S, House DE. (1985). Reproducibility of individual responses to ozone exposure. Am Rev Respir Dis 131:36–40
  • Meek ME, Boobis A, Cote I, et al. (2014a). New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis. J Appl Toxicol 34:1–18. doi: 10.1002/jat.2949
  • Meek ME, Palermo CM, Bachman AN, et al. (2014b). Mode of action human relevance (species concordance) framework: evolution of the Bradford Hill considerations and comparative analysis of weight of evidence. J Appl Toxicol 34:595–606. doi: 10.1002/jat.2984
  • Meirer K, Steinhilber D, Proschak E. (2014). Inhibitors of the arachidonic acid cascade: interfering with multiple pathways. Basic Clin Pharmacol Toxicol 114:83–91. doi: 10.1111/bcpt.12134
  • Midgren B, Hansson L, Karlsson JA, et al. (1992). Capsaicin-induced cough in humans. Am Rev Respir Dis 146:347–51
  • Miller FJ. (1995). Uptake and fate of ozone in the respiratory tract. Toxicol Lett 82–83:277–85
  • Mudway IS, Housley D, Eccles R, et al. (1996). Differential depletion of human respiratory tract antioxidants in response to ozone challenge. Free Radic Res 25:499–513. doi: 10.3109/10715769609149072
  • Mudway IS, Kelly FJ. (2000). Ozone and the lung: a sensitive issue. Mol Aspects Med 21:1–48
  • Mudway IS, Kelly FJ. (2004). An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults. Am J Respir Crit Care Med 169:1089–95
  • O'Byrne PM, Walters EH, Aizawa H, et al. (1984). Indomethacin inhibits the airway hyperresponsiveness but not the neutrophil influx induced by ozone in dogs. Am Rev Respir Dis 130:220–4. doi: 10.1164/arrd.1984.130.2.220
  • Oslund KL, Hyde DM, Putney LF, et al. (2008). Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. Am J Respir Cell Mol Biol 39:279–88. doi: 10.1165/rcmb.2008-0009OC
  • Passannante AN, Hazucha MJ, Bromberg PA, et al. (1998). Nociceptive mechanisms modulate ozone-induced human lung function decrements. J Appl Physiol 85:1863–70
  • Perepu RS, Garcia C, Dostal D, Sethi R. (2010). Enhanced death signaling in ozone-exposed ischemic-reperfused hearts. Mol Cell Biochem 336:55–64
  • Rogerio AP, Andrade EL, Calixto JB. (2011). C-fibers, but not the transient potential receptor vanilloid 1 (TRPV1), play a role in experimental allergic airway inflammation. Eur J Pharmacol 662:55–62. doi: 10.1016/j.ejphar.2011.04.027
  • Samet JM, Hatch GE, Hortsman D, et al. (2001). Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am J Respir Crit Care Med 164:819–25
  • Schelegle ES, Adams WC, Siefkin AD. (1987). Indomethacin pretreatment reduces ozone-induced pulmonary function decrements in human subjects. Am Rev Respir Dis 136:1350–4. doi: 10.1164/ajrccm/136.6.1350
  • Schelegle ES, Alfaro MF, Putney L, et al. (2001b). Effect of C-fiber-mediated, ozone-induced rapid shallow breathing on airway epithelial injury in rats. J Appl Physiol 91:1611–8
  • Schelegle ES, Carl ML, Coleridge HM, et al. (1993). Contribution of vagal afferents to respiratory reflexes evoked by acute inhalation of ozone in dogs. J Appl Physiol 74:2338–44
  • Schelegle ES, Eldridge MW, Cross CE, et al. (2001a). Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects. Am J Respir Crit Care Med 163:1121–7
  • Schelegle ES, Siefkin AD, McDonald RJ. (1991). Time course of ozone-induced neutrophilia in normal humans. Am Rev Respir Dis 143:1353–8
  • Schelegle ES, Walby WF, Adams WC. (2007). Time course of ozone-induced changes in breathing pattern in healthy exercising humans. J Appl Physiol 102:688–97
  • Seltzer J, Bigby BG, Stulbarg M, et al. (1986). O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 60:1321–6
  • Shimasaki H, Takatori T, Anderson WR, et al. (1976). Alteration of lung lipids in ozone exposed rats. Biochem Biophys Res Commun 68:1256–62
  • Sterner-Kock A, Vesely KR, Stovall MY, et al. (1996). Neonatal capsaicin treatment increases the severity of ozone-induced lung injury. Am J Respir Crit Care Med 153:436–43. doi: 10.1164/ajrccm.153.1.8542155
  • Takebayashi T, Abraham J, Murthy GG, et al. (1998). Role of tachykinins in airway responses to ozone in rats. J Appl Physiol 85:442–50
  • United States Environmental Protection Agency (US EPA). (2008). Integrated science assessment for sulfur oxides – health criteria. Office of Research and Development, EPA/600/R-08/047F, September
  • United States Environmental Protection Agency (US EPA). (2013). Integrated science assessment for ozone and related photochemical oxidants (final). National Center for Environmental Assessment (NCEA), EPA/600/R–10/076F, 1,251 p., February
  • United States Environmental Protection Agency (US EPA). (2015a). Integrated science assessment for oxides of nitrogen – health criteria (Second External Review Draft). National Center for Environmental Assessment (NCEA), EPA/600/R-14/006, 1,135 p., January
  • United States Environmental Protection Agency (US EPA). (2015b). National ambient air quality standards for ozone (final rule). Fed Reg 80(206):65292-65468. 40 CFR Parts 50, 51, 52, 53 and 58, October 26
  • United States Environmental Protection Agency (US EPA). (2015c). Integrated science assessment for sulfur oxides – health criteria (external review draft). National Center for Environmental Assessment (NCEA), EPA/600/R-15/066, 694 p., November
  • Vesely KR, Hyde DM, Stovall MY, et al. (1999). Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. J Appl Physiol 86:951–62
  • Wu H, Guan C, Qin X, et al. (2007). Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation. Pulm Pharmacol Ther 20:513–24. doi: 10.1016/j.pupt.2006.04.002
  • Ying RL, Gross KB, Terzo TS, Eschenbacher WL. (1990). Indomethacin does not inhibit the ozone-induced increase in bronchial responsiveness in human subjects. Am Rev Respir Dis 142:817–21. doi: 10.1164/ajrccm/142.4.817

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.