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Inhalation Toxicology
International Forum for Respiratory Research
Volume 28, 2016 - Issue 14
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Research Article

Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions

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Pages 658-669 | Received 05 May 2016, Accepted 05 Oct 2016, Published online: 10 Nov 2016

References

  • Allen JG, Flanigan SS, Leblanc M, et al. (2016). Flavoring chemicals in E-cigarettes: diacetyl, 2,3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored E-cigarettes. Env Heal Perspect 124:733–9
  • American Society of Heating, Refrigerating and Air-Conditioning Engineers. (2003). ANSI/ASHRAE Standard 62-2001. Ventilation for Acceptable Indoor Air Quality
  • Behar RZ, Davis B, Wang Y, et al. (2014). Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol Vitr 28:198–208
  • Berg CJ, Haardoerfer R, Escoffery C, et al. (2015). Cigarette users' interest in using or switching to electronic nicotine delivery systems for smokeless tobacco for harm reduction, cessation, or novelty: a cross-sectional survey of US adults. Nicotine Tob Res 17:245–55
  • Brobell D, Tröller S, Dziurowitz N, et al. (2013). A thermal precipitator for the deposition of airborne nanoparticles onto living cells - rationale and development. J Aerosol Sci 63:75–86
  • Cameron JM, Howell DN, White JR, et al. (2014). Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions. Tob Control 23:77–8
  • Cervellati F, Muresan XM, Sticozzi C, et al. (2014). Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol Vitr 28:999–1005
  • Chang C, Demokritou P, Shafer M, Christiani D. (2013). Physicochemical and toxicological characteristics of welding fume derived particles generated from real time welding processes. Environ Sci Process Impacts 15:214–24
  • Cheah NP, Chong NWL, Tan J, et al. (2014). Electronic nicotine delivery systems: regulatory and safety challenges: Singapore perspective. Tob Control 23:119–25
  • Cohen J, Deloid G, Pyrgiotakis G, Demokritou P. (2013). Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry. Nanotoxicology 7:417–31
  • Cohen JM, DeLoid M, Demokritou P. (2015). A critical review of in vitro dosimetry for engineered nanomaterials. Nanomedicine 10:3015–32
  • Cohen JM, Teeguarden JG, Demokritou P. (2014). An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol 11:20
  • Coleman BN, Johnson SE, Tessman GK, et al. (2016). "It’s not smoke. It's not tar. It's not 4000 chemicals. Case closed": exploring attitudes, beliefs, and perceived social norms of e-cigarette use among adult users. Drug Alcohol Depend 159:80–5
  • Dawkins L, Turner J, Roberts A, Soar K. (2013). ‘Vaping' profiles and preferences: an online survey of electronic cigarette users. Addiction 108:1115–25
  • DeLoid G, Cohen JM, Darrah T, et al. (2014). Estimating the effective density of engineered nanomaterials for in vitro dosimetry. Nat Commun 5:3514
  • DeLoid GM, Cohen JM, Pyrgiotakis G, et al. (2015). Advanced computational modeling for in vitro nanomaterial dosimetry. Part Fibre Toxicol 12:32
  • Demokritou P, Gupta T, Koutrakis P. (2002). A high volume apparatus for the condensational growth of ultrafine particles for inhalation toxicological studies. Aerosol Sci Technol 36:1061–72
  • Demokritou P, Lee SJ, Ferguson ST, Koutrakis P. (2004). A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. J Aerosol Sci 35:281–99
  • Dockrell M, Morrison R, Bauld L, McNeill A. (2013). E-cigarettes: prevalence and attitudes in Great Britain. Nicotine Tob Res 15:1737–44
  • Etter JF, Zäther E, Svensson S. (2013). Analysis of refill liquids for electronic cigarettes. Addiction 108:1671–9
  • Evans P. (2015). E-Cigarette Makers Face Rise of Fakes. E-cigarette global sales hit $7 billion at the end of 2014. The Wall Street Journal. Feb. 20 2015
  • Farsalinos KE, Romagna G, Tsiapras D, et al. (2013). Evaluation of electronic cigarette use (Vaping) topography and estimation of liquid consumption: implications for research protocol standards definition and for public health authorities' regulation. Int J Environ Res Public Health 10:2500–14
  • Farsalinos K, Romagna G, Tsiapras D, et al. (2014). Characteristics, perceived side effects and benefits of electronic cigarette use: a worldwide survey of more than 19,000 consumers. Int J Environ Res Public Health 11:4356–73
  • Feng Y, Kleinstreuer C, Rostami A. (2015). Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit. J Aerosol Sci 80:58–74
  • Fuoco F, Buonanno G, Stabile L, Vigo P. (2014). Influential parameters on particle concentration and size distribution in the mainstream of e-cigarettes. Environ Pollut 184:523–9
  • Ganong WF. (2010). Review of medical physiology. 23rd ed. New York: The McGraw- Hill Companies, Inc
  • Geiss O, Bianchi I, Barahona F, Barrero-Moreno J. (2014). Characterisation of mainstream and passive vapours emitted by selected electronic cigarettes. Int J Hyg Environ Health 218:169–80
  • Giovenco DP, Lewis MJ, Delnevo CD. (2014). Factors associated with e-cigarette use: a national population survey of current and former smokers. Am J Prev Med 47:476–80
  • Goniewicz ML, Knysak J, Gawron M, et al. (2014). Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 23:133–9
  • Goniewicz ML, Kuma T, Gawron M, et al. (2012). Nicotine levels in electronic cigarettes. Nicotine Tob Res 15:158–66
  • Gowadia N, Oldham MJ, Dunn-Rankin D. (2009). Particle size distribution of nicotine in mainstream smoke from 2R4F, Marlboro Medium, and Quest1 cigarettes under different puffing regimens. Inhal Toxicol 21:435–46
  • Gupta T, Demokritou P, Koutrakis P. (2004a). Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhal Toxicol 16:851–62
  • Gupta T, Demokritou P, Koutrakis P. (2004b). Effects of physicochemical properties of ultrafine particles on the performance of an ultrafine particle concentrator. Aerosol Sci Technol 38:37–45
  • Hecht SS, Carmella SG, Kotandeniya D, et al. (2015). Evaluation of toxicant and carcinogen metabolites in the urine of E-cigarette users versus cigarette smokers. Nicotine Tob Res. 6:704–9
  • Herrington JS, Myers C. (2015). Electronic cigarette solutions and resultant aerosol profiles. J Chromatogr A 1418:192–9
  • Hinds W. (1999). Aerosol technology – properties, behavior, and measurement of airborne particles. 2nd ed. New York: John Wiley
  • Ingebrethsen BJ, Cole SK, Alderman SL. (2012). Electronic cigarette aerosol particle size distribution measurements. Inhal Toxicol 24:976–84
  • Invernizzi G, Ruprecht A, De Marco C, et al. (2007). Residual tobacco smoke: measurement of its washout time in the lung and of its contribution to environmental tobacco smoke. Tob Control 16:29–33
  • ISO. (2012). ISO 3308: routine analytical cigarette-smoking machine – definitions and standard conditions. Geneva, Switzerland: International Organization for Standardization (ISO)
  • Jensen P, Luo W, Pankow J, et al. (2015). Hidden formaldehyde in e-cigarette aerosols. N Engl J Med 372:389–92
  • Kanji GK. (2006). 100 Statistical tests. 3rd ed. London: Sage Publications
  • Kim AE, Arnold KY, Makarenko O. (2014). E-cigarette advertising expenditures in the U.S., 2011-2012. Am J Prev Med 46:409–12
  • Kim K-H, Kabir E, Kabir S. (2015). A review on the human health impact of airborne particulate matter. Environ Int 74:136–43
  • King B, Patel R, Nguyen K, Dube SR. (2015). Trends in awareness and use of electronic cigarettes among US adults, 2010–2013. Nicotine Tob Res 17:219–27
  • Kosmider L, Sobczak A, Fik M, et al. (2014). Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Tob Res 16:1319–26
  • Laugesen M. (2008). Safety report on the Ruyan® e-cigarette cartridge and inhaled aerosol. Christchurch, New Zealand: Health New Zealand Ltd. p 1–23
  • Laugesen M, Thornley S, Mcrobbie H, Bullen C. (2008). How safe is an E-cigarette? The results of an independent chemical and microbiological analysis. SRNT Conference Portland Oregon. March 2008, poster. p 1–14
  • Lauterstein DE, Tijerina PB, Corbett K, et al. (2016). Frontal cortex transcriptome analysis of mice exposed to electronic cigarettes during early life stages. Int J Environ Res Public Health 13:1–14
  • Lee YH, Gawron M, Goniewicz ML. (2015). Changes in puffing behavior among smokers who switched from tobacco to electronic cigarettes. Addict Behav 48:1–4
  • Lerner C, Sundar I, Watson R, et al. (2015). Environmental health hazards of e-cigarettes and their components: oxidants and copper in e-cigarette aerosols chad. Env Pollut 198:100–7
  • Lerner CA, Sundar IK, Yao H, et al. (2015). Vapors produced by electronic cigarettes and E-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10:1–26
  • Lim HB, Kim SH. (2014). Inhalation of e-cigarette cartridge solution aggravates allergen-induced airway inflammation and hyper-responsiveness in mice. Toxicol Res 30:13–18
  • Londahl J, Pagels J, Swietlicki E, et al. (2006). A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans. J Aerosol Sci 37:1152–63
  • Lu X, Miousse IR, Pirela SV, et al. (2016). In vivo epigenetic effects induced by engineered nanomaterials: a case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology 10:629–39
  • Marco E, Grimalt JO. (2015). A rapid method for the chromatographic analysis of volatile organic compounds in exhaled breath of tobacco cigarette and electronic cigarette smokers. J Chromatogr A 1410:51–9
  • Marini S, Buonanno G, Stabile L, Ficco G. (2014). Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide. Toxicol Appl Pharmacol 278:9–15
  • McAuley TR, Hopke PK, Zhao J, Babaian S. (2012). Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol 24:850–7
  • Pal AK, Bello D, Cohen J, Demokritou P. (2015). Implications of in-vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials. Nanotoxicology 9:871–85
  • Pal AK, Watson CY, Pirela SV, et al. (2015). Linking exposures of particles released from nano-enabled products to toxicology: an integrated methodology for particle sampling, extraction, dispersion, and dosing. Toxicol Sci 146:321–33
  • Pellegrino RM, Tinghino B, Mangiaracina G, et al. (2012). Electronic cigarettes: an evaluation of exposure to chemicals and fine particulate matter (PM). Ann Ig 24:279–88
  • Pirela S, Molina R, Watson C, et al. (2013). Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model. Inhal Toxicol 25:498–508
  • Pirela SV, Lu X, Miousse I, et al. (2016). Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: a case study of toxicological implications from nanomaterials released during consumer use. NanoImpact 1:1–8
  • Pirela SV, Pyrgiotakis G, Bello D, et al. (2014). Development and characterization of an exposure platform suitable for physico-chemical, morphological and toxicological characterization of printer-emitted particles (PEPs). Inhal Toxicol 26:400–8
  • Pisinger C, Døssing M. (2014). A systematic review of health effects of electronic cigarettes. Prev Med (Baltim) 69:248–60
  • Repace J. (2005). Controlling tobacco smoke pollution. ASHRAE IAQ Applications. Vol, 6, No. 3, Summer 2005
  • Robinson RJ, Oldham MJ, Clinkenbeard RE, Rai P. (2006). Experimental and numerical smoke carcinogen deposition in a multi-generation human replica tracheobronchial model. Ann Biomed Eng 34:373–83
  • Rowell TR, Tarran R. (2015). Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol 309:L1398–409
  • Rubenstein DA, Hom S, Ghebrehiwet B, Yin W. (2015). Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses. Mol Immunol 67:652–60
  • Salturk Z, Çakir Ç, Sünnetçi G, et al. (2015). Effects of electronic nicotine delivery system on larynx: experimental study. J Voice 29:560–3
  • Schober W, Szendrei K, Matzen W, et al. (2014). Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J Hyg Environ Health 217:628–37
  • Schripp T, Markewitz D, Uhde E, Salthammer T. (2013). Does e-cigarette consumption cause passive vaping? Indoor Air 23:25–31
  • Sisler JD, Pirela SV, Friend S, et al. (2015). Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model. Nanotoxicology 9:769–79
  • Strak M, Janssen NAH, Godri KJ, et al. (2012). Respiratory health effects of airborne particulate matter: The role of particle size, composition, and oxidative potential-the RAPTES project. Environ Health Perspect 120:1183–9
  • Tayyarah R, Long GA. (2014). Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air. Regul Toxicol Pharmacol 70:704–10
  • Trehy ML, Ye W, Hadwiger ME, et al. (2011). Analysis of electronic cigarette cartridges, refill solutions, and smoke for nicotine and nicotine related impurities. J Liq Chromatogr Relat Technol 34:1442–58
  • Wang M, SaiYin H, LokTung L, Lam T. (2015). Addictive behaviors electronic cigarette use and its association with smoking in Hong Kong Chinese adolescents. Addict Behav 50:124–7
  • Watson C, Ge J, Cohen J, et al. (2014). High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using cometchip technology. ACS Nano 8:2118–33
  • Westenberger BJ. (2009). Evaluation of e-cigarettes. Washington, DC: U.S. Food and Drug Administration
  • White J, Li J, Newcombe R, Walton D. (2015). Tripling use of electronic cigarettes among New Zealand adolescents between 2012 and 2014. J Adolesc Health 56:522–8
  • Williams M, Villarreal A, Bozhilov K, et al. (2013). Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One 8:e57987
  • World Health Organization. (2014). Electronic nicotine delivery systems. Conference of the Parties to the WHO Framework Convention on Tobacco Control, Sixth session Moscow, Russian Federation
  • Yingst JM, Veldheer S, Hrabovsky S, et al. (2015). Factors associated with electronic cigarette users' device preferences and transition from first generation to advanced generation devices. Nicotine Tob Res 17:1242–6
  • Zhang Y, Sumner W, Chen D-R. (2013). In vitro particle size distributions in electronic and conventional cigarette aerosols suggest comparable deposition patterns. Nicotine Tob Res 15:501–8
  • Zhu S-H, Sun JY, Bonnevie E, et al. (2014). Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob Control 23:iii3–9

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