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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 11-12
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Research Articles

Pulmonary and systemic toxicity in rats following inhalation exposure of 3-D printer emissions from acrylonitrile butadiene styrene (ABS) filament

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Pages 403-418 | Received 10 Jun 2020, Accepted 01 Oct 2020, Published online: 20 Oct 2020

References

  • Ahn SH, Lee J, Park SA, Kim WD. 2016. Three-dimensional bio-printing equipment technologies for tissue engineering and regenerative medicine. Tissue Eng Regen Med. 13:663–676.
  • Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol. 28:41–50.
  • Arango Duque G, Descoteaux A. 2014. Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol. 5:491–491.
  • Azimi P, Zhao D, Pouzet C, Crain NE, Stephens B. 2016. Emissions of ultrafine particles and volatile organic compounds from commercially available desktop three-dimensional printers with multiple filaments. Environ Sci Technol. 50:1260–1268.
  • Betsuyaku T, Kuroki Y, Nagai K, Nasuhara Y, Nishimura M. 2004. Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid. Eur Respir J. 24:964–970.
  • Castranova V, Robinson VA, Tucker JH, Schwegler D, Rose DA, DeLong DS, Frazer DG. 1987. Time course of pulmonary response to inhalation of cotton dust in guinea pigs and rats. Cotton dust: proceedings of Eleventh Cotton Dust Research Conference, Beltwide Cotton Research Conferences; Dallas, Texas.
  • Chan FL, House R, Kudla I, Lipszyc JC, Rajaram N, Tarlo SM. 2018. Health survey of employees regularly using 3D printers. Occup Med (Lond). 68:211–214.
  • Davis AY, Zhang Q, Wong JPS, Weber RJ, Black MS. 2019. Characterization of volatile organic compound emissions from consumer level material extrusion 3D printers. Build Environ. 160:106209.
  • Deng Y, Cao SJ, Chen A, Guo Y. 2016. The impact of manufacturing parameters on submicron particle emissions from a desktop 3D printer in the perspective of emission reduction. Build Environ. 104:311–319.
  • Ding S, Ng BF, Shang X, Liu H, Lu X, Wan MP. 2019. The characteristics and formation mechanisms of emissions from thermal decomposition of 3D printer polymer filaments. Sci Total Environ. 692:984–994.
  • Farcas MT, Stefaniak AB, Knepp AK, Bowers L, Mandler WK, Kashon M, Jackson SR, Stueckle TA, Sisler JD, Friend SA, et al. 2019. Acrylonitrile butadiene styrene (ABS) and polycarbonate (PC) filaments three-dimensional (3-D) printer emissions-induced cell toxicity. Toxicol Lett. 317:1–12.
  • Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. 2013. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 9:786–794.
  • Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ. 2012. Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes. Inhal Toxicol. 24:831–838.
  • Fujii T, Hayashi S, Hogg JC, Mukae H, Suwa T, Goto Y, Vincent R, van Eeden SF. 2002. Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. Am J Respir Cell Mol Biol. 27:34–41.
  • Goto Y, Ishii H, Hogg JC, Shih CH, Yatera K, Vincent R, van Eeden SF. 2004. Particulate matter air pollution stimulates monocyte release from the bone marrow. Am J Respir Crit Care Med. 170:891–897.
  • Gu J, Wensing M, Uhde E, Salthammer T. 2019. Characterization of particulate and gaseous pollutants emitted during operation of a desktop 3D printer. Environ Int. 123:476–485.
  • Gumperlein I, Fischer E, Dietrich-Gumperlein G, Karrasch S, Nowak D, Jorres RA, Schierl R. 2018. Acute health effects of desktop 3D printing (fused deposition modeling) using acrylonitrile butadiene styrene and polylactic acid materials: an experimental exposure study in human volunteers. Indoor Air. 28:611–623.
  • Haczku A. 2008. Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation. J Allergy Clin Immunol. 122:861–879.
  • Hermans C, Dong P, Robin M, Jadoul M, Bernard A, Bersten AD, Doyle IR. 2003. Determinants of serum levels of surfactant proteins A and B and Clara cell protein CC16. Biomarkers. 8:461–471.
  • Honda Y, Takahashi H, Kuroki Y, Akino T, Abe S. 1996. Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers. Chest. 109:1006–1009.
  • House R, Rajaram N, Tarlo SM. 2017. Case report of asthma associated with 3D printing. Occup Med (Lond). 67:652–654.
  • Kim Y, Yoon C, Ham S, Park J, Kim S, Kwon O, Tsai PJ. 2015. Emissions of nanoparticles and gaseous material from 3D printer operation. Environ Sci Technol. 49:12044–12053.
  • Kingma PS, Whitsett JA. 2006. In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol. 6:277–283.
  • Koh TJ, DiPietro LA. 2011. Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med. 13:e23.
  • Ley B, Brown KK, Collard HR. 2014. Molecular biomarkers in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 307:L681–L691.
  • Lorenz HP, Longaker MT. 2008. Chapter 191–208, Wounds: biology, pathology, and management. In: NJAe, editor. Surgery. New York (NY): Springer.
  • Mandler WK, Qi C, Orandle MS, Sarkisian K, Mercer RR, Stefaniak AB, Knepp AK, Bowers LN, Battelli LA, Shaffer J, et al. 2019. Mouse pulmonary response to dust from sawing Corian®, a solid-surface composite material. J Toxicol Environ Health Part A. 82:645–663.
  • McDonnell B, Guzman XJ, Dolack M, Simpson TW, Cimbala JM. 3D Printing in the Wild: A Preliminary Investigation of Air Quality in College Maker Spaces. Solid Freeform Fabrication Symposium Proceedings. 2016.
  • Mosser DM. 2003. The many faces of macrophage activation. J Leukoc Biol. 73:209–212.
  • Nielsen GD, Alarie Y. 1982. Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: Prediction of safe industrial exposure levels and correlation with their thermodynamic properties. Toxicol Appl Pharmacol. 65:459–477.
  • Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA. 2004. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect. 112:1299–1306.
  • Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V. 2008. Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Part Fibre Toxicol. 5:1.
  • Oberdorster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 113:823–839.
  • Pastva AM, Wright JR, Williams KL. 2007. Immunomodulatory roles of surfactant proteins A and D: implications in lung disease. Proc Am Thorac Soc. 4:252–257.
  • Potter PM, Al-Abed SR, Lay D, Lomnicki SM. 2019. VOC emissions and formation mechanisms from carbon nanotube composites during 3D printing. Environ Sci Technol. 53:4364–4370.
  • Poursafa P, Kelishadi R. 2010. Air pollution, platelet activation and atherosclerosis. Inflamm Allergy Drug Targets. 9:387–392.
  • Rundell KW, Hoffman JR, Caviston R, Bulbulian R, Hollenbach AM. 2007. Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function. Inhal Toxicol. 19:133–140.
  • Silveyra P, Floros J. 2012. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci (Landmark Ed). 17:407–429.
  • Simon TR, Lee WJ, Spurgeon BE, Boor BE, Zhao F. 2018. An experimental study on the energy consumption and emission profile of fused deposition modeling process. Procedia Manuf. 26:920–928.
  • Sittig M. 1985. Handbook of toxic and hazardous chemicals and carcinogens. 2nd ed. Park Ridge (NJ): Noyes Publications.
  • Sorensen GL, Hjelmborg J, Kyvik KO, Fenger M, Hoj A, Bendixen C, Sorensen TI, Holmskov U. 2006. Genetic and environmental influences of surfactant protein D serum levels. Am J Physiol Lung Cell Mol Physiol. 290:L1010–L1017.
  • Stefaniak A, Johnson A, Du Preez S, Hammond D, Wells J, Ham J, LeBouf R, Martin S, Duling M, Bowers L, et al. 2019. Insights into emissions and exposures from use of industrial-scale additive manufacturing machines. Saf Health Work. 10:229–236.
  • Stefaniak A, LeBouf R, Duling M, Yi J, Abukabda A, McBride C, Nurkiewicz T. 2017a. Inhalation exposure to three-dimensional printer emissions stimulates acute hypertension and microvascular dysfunction. Toxicol Appl Pharmacol. 335:1–5.
  • Stefaniak A, LeBouf R, Yi J, Ham J, Nurkewicz T, Schwegler-Berry D, Chen B, Wells J, Duling M, Lawrence R, et al. 2017b. Characterization of chemical contaminants generated by a desktop fused deposition modeling 3-dimensional Printer. J Occup Environ Hyg. 14:540–550.
  • Stephens B, Azimi P, El Orch Z, Ramos T. 2013. Ultrafine particle emissions from desktop 3D printers. Atmos Environ. 79:334–339.
  • Trenfield SJ, Awad A, Madla CM, Hatton GB, Firth J, Goyanes A, Gaisford S, Basit AW. 2019. Shaping the future: recent advances of 3D printing in drug delivery and healthcare. Expert Opin Drug Deliv. 16:1081–1094.
  • U.S. Environmental Protection Agency. 1987. Health assessment document for acetaldehyde. Research Triangle Park (NC): Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development. EPA/600/8-86-015A.
  • Vaisanen AJK, Hyttinen M, Ylonen S, Alonen L. 2019. Occupational exposure to gaseous and particulate contaminants originating from additive manufacturing of liquid, powdered, and filament plastic materials and related post-processes. J Occup Environ Hyg. 16:258–271.
  • Van Winkle LS, Bein K, Anderson D, Pinkerton KE, Tablin F, Wilson D, Wexler AS. 2015. Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses. Toxicol Sci. 143:349–359.
  • Wang J, Yu Y, Guo J, Lu W, Wei Q, Zhao Y. 2020. The construction and application of three-dimensional biomaterials. Adv Biosyst. 4:e1900238.
  • Wiegant FA, Prins HA, Van Wijk R. 2011. Postconditioning hormesis put in perspective: an overview of experimental and clinical studies. Dose Response. 9:209–224.
  • Wojtyła S, Klama P, Baran T. 2017. Is 3D printing safe? Analysis of the thermal treatment of thermoplastics: ABS, PLA, PET, and nylon. J Occup Environ Hyg. 14:D80–D85.
  • Wojtyła S, Śpiewak K, Baran T. 2020. Synthesis, characterization and activity of doped graphitic carbon nitride materials towards photocatalytic oxidation of volatile organic pollutants emitted from 3D printer. J Photochem Photobiol A. 391:112355.
  • Yi J, Duling MG, Bowers LN, Knepp AK, LeBouf RF, Nurkiewicz TR, Ranpara A, Luxton T, Martin SB, Burns DA, et al. 2019. Particle and organic vapor emissions from children’s 3-D pen and 3-D printer toys. Inhalation Toxicol. 31:432–445.
  • Young JT. 1981. Histopathologic examination of the rat nasal cavity. Fundam Appl Toxicol. 1:309–312.
  • Zhang Q, Pardo M, Rudich Y, Kaplan-Ashiri I, Wong JP, Davis A, Black M, Weber R. 2019. Chemical composition and toxicity of particles emitted from a consumer-level 3D printer using various materials. Environ Sci Technol. 53:12054–12061.
  • Zhang Q, Wong J, Davis A, Black M, Weber R. 2017. Characterization of particle emissions from consumer fused deposition modeling 3D printers. Aerosol Sci Technol. 51:1275–1286.
  • Zitting A, Savolainen H. 1980. Effects of single and repeated exposures to thermo-oxidative degradation products of poly(acrylonitrile-butadiene-styrene) (ABS) on rat lung, liver, kidney, and brain. Arch Toxicol. 46:295–304.

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