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Inhalation Toxicology
International Forum for Respiratory Research
Volume 33, 2021 - Issue 2
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Research Articles

Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats

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Pages 66-80 | Received 30 Nov 2020, Accepted 27 Jan 2021, Published online: 18 Feb 2021

References

  • Alfadda AA, Fatma S, Chishti MA, Al-Naami MY, Elawad R, Mendoza CD, Jo H, Lee YS. 2012. Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans. Mol Cells. 33(1):35–41.
  • Ameen M, Musthapa M, Ahmad I, Ansari F, Baig M, Rahman Q. 2003. Alteration in cellular and biochemical markers of pulmonary toxicity in rat lung exposed to carpet dusts. Inhal Toxicol. 15(11):1119–1131.
  • Andrews S. 2010. FastQC: a quality control tool for high throughput sequence data. http://www.bioinformatics.babraham.ac.uk/projects/fastqc.
  • Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Toxicol Sci. 28(1):41–50.
  • Bakand S, Hayes A, Dechsakulthorn F. 2012. Nanoparticles: a review of particle toxicology following inhalation exposure. Inhal Toxicol. 24(2):125–135.
  • Beck S, Bouchard J, Berry R. 2012. Dispersibility in water of dried nanocrystalline cellulose. Biomacromolecules. 13(5):1486–1494.
  • Bertaggia E, Scabia G, Dalise S, Lo Verso F, Santini F, Vitti P, Chisari C, Sandri M, Maffei M. 2014. Haptoglobin is required to prevent oxidative stress and muscle atrophy. PLoS One. 9(6):e100745.
  • Bolger AM, Lohse M, Usadel B. 2014. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 30(15):2114–2120.
  • Butler C. 1976. Lung surface area in various morphological forms of human emphysema. American Rev Resp Diseases. 114:347–352.
  • Charreau H, Foresti ML, Vazquez A. 2013. Nanocellulose patents trends: a comprehensive review on patents on cellulose nanocrystals, microfibrillated and bacterial cellulose. Recent Pat Nanotechnol. 7(1):56–80.
  • Clift MJ, Foster EJ, Vanhecke D, Studer D, Wick P, Gehr P, Rothen-Rutishauser B, Weder C. 2011. Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture. Biomacromolecules. 12(10):3666–3673.
  • Cullen RT, Searl A, Miller BG, Davis JM, Jones AD. 2000. Pulmonary and intraperitoneal inflammation induced by cellulose fibres. J Appl Toxicol. 20(1):49–60.
  • Ede JD, Ong KJ, Goergen M, Rudie A, Pomeroy-Carter CA, Shatkin JA. 2019. Risk analysis of cellulose nanomaterials by inhalation: current state of science. Nanomaterials (Basel). 9(3):337.
  • Endes C, Schmid O, Kinnear C, Mueller S, Camarero-Espinosa S, Vanhecke D, Foster EJ, Petri-Fink A, Rothen-Rutishauser B, Weder C, et al. 2014. An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles. Part Fibre Toxicol. 11(1):40.
  • Farcas MT, Kisin ER, Menas AL, Gutkin DW, Star A, Reiner RS, Yanamala N, Savolainen K, Shvedova AA. 2016. Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice. J Toxicol Environ Health A. 79(21):984–997.
  • Fulkerson PC, Zimmermann N, Hassman LM, Finkelman FD, Rothenberg ME. 2004. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. J Immunol. 173(12):7565–7574.
  • Gerard C, Rollins BJ. 2001. Chemokines and disease. Nat Immunol. 2(2):108–115.
  • Gordon S. 2003. Alternative activation of macrophages. Nat Rev Immunol. 3(1):23–35.
  • Greenberg MI, Waksman J, Curtis J. 2007. Silicosis: a review. Dis Mon. 53(8):394–416.
  • Habibi Y, Lucia LA, Rojas OJ. 2010. Cellulose nanocrystals: chemistry, self-assembly, and applications. Chem Rev. 110(6):3479–3500.
  • Hubbe MA, Orlando JR, Lucian DL, Mohini S. 2008. Cellulose nanocomposites: a review. Bioresources. 3:929–980.
  • Huber-Lang M, Younkin EM, Sarma JV, Riedemann N, McGuire SR, Lu KT, Kunkel R, Younger JG, Zetoune FS, Ward PA. 2002. Generation of C5a by phagocytic cells. Am J Pathol. 161(5):1849–1859.
  • Husain M, Wu D, Saber AT, Decan N, Jacobsen NR, Williams A, Yauk CL, Wallin H, Vogel U, Halappanavar S. 2015. Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice. Nanotoxicology. 9(8):1013–1022.
  • Katsuyama M, Matsuno K, Yabe-Nishimura C. 2012. Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr. 50(1):9–22.
  • Kim D, Langmead B, Salzberg SL. 2015. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 12(4):357–360.
  • Kisin ER, Yanamala N, Rodin D, Menas A, Farcas M, Russo M, Guppi S, Khaliullin TO, Iavicoli I, Harper M, et al. 2020. Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals. Chemosphere. 250:126170.
  • Kurfurstova D, Bartkova J, Vrtel R, Mickova A, Burdova A, Majera D, Mistrik M, Kral M, Santer FR, Bouchal J, et al. 2016. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. Mol Oncol. 10(6):879–894.
  • Law CW, Alhamdoosh M, Su S, Dong X, Tian L, Smyth GK, Ritchie ME. 2016. RNA-seq analysis is easy as 1-2-3 with limma. F1000Res. 5:1408.
  • Lee KY, Tammelin T, Schulfter K, Kiiskinen H, Samela J, Bismarck A. 2012. High performance cellulose nanocomposites: comparing the reinforcing ability of bacterial cellulose and nanofibrillated cellulose. ACS Appl Mater Interfaces. 4(8):4078–4086.
  • Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R. 2009. The sequence alignment/map format and SAMtools. Bioinformatics. 25(16):2078–2079.
  • Ligresti G, Aplin AC, Dunn BE, Morishita A, Nicosia RF. 2012. The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties. PLoS One. 7(8):e41387.
  • Loke P, Nair MG, Parkinson J, Guiliano D, Blaxter M, Allen JE. 2002. IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunol. 3:7.
  • Lowe GD. 2001. The relationship between infection, inflammation, and cardiovascular disease: an overview. Ann Periodontol. 6(1):1–8.
  • Lukacs NW, Hogaboam C, Campbell E, Kunkel SL. 1999. Chemokines: function, regulation and alteration of inflammatory responses. Chem Immunol. 72:102–120.
  • Luster AD. 1998. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med. 338(7):436–445.
  • Manke A, Wang L, Rojanasakul Y. 2013. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013:942916.
  • Mann PC, Vahle J, Keenan CM, Baker JF, Bradley AE, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, et al. 2012. International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol. 40(4 Suppl):7S–13S.
  • Mathew AP, Oksman K, Pierron D, Harmand MF. 2013. Biocompatible fibrous networks of cellulose nanofibres and collagen crosslinked using genipin: potential as artificial ligament/tendons. Macromol Biosci. 13(3):289–298.
  • McKinney W, Chen B, Schwegler-Berry D, Frazer DG. 2013. Computer-automated silica aerosol generator and animal inhalation exposure system. Inhal Toxicol. 25(7):363–372.
  • Menas AL, Yanamala N, Farcas MT, Russo M, Friend S, Fournier PM, Star A, Iavicoli I, Shurin GV, Vogel UB, et al. 2017. Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: cytotoxicity or inflammation? Chemosphere. 171:671–680.
  • Moon RJ, Martini A, Nairn J, Simonsen J, Youngblood J. 2011. Cellulose nanomaterials review: structure, properties and nanocomposites. Chem Soc Rev. 40(7):3941–3994.
  • Morgan DL. 2006. NTP Toxicity Study Report on the atmospheric characterization, particle size, chemical composition, and workplace exposure assessment of cellulose insulation (CELLULOSEINS). Toxic Rep Ser. 74:1–62, A1–C2.
  • Mroz RM, Schins RP, Li H, Jimenez LA, Drost EM, Holownia A, MacNee W, Donaldson K. 2008. Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J. 31(2):241–251.
  • Nair MG, Guild KJ, Artis D. 2006. Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol. 177(3):1393–1399.
  • Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, et al. 2008. Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol. 180(9):6262–6269.
  • NIOSH. 2019. The National Institute for Occupational Safety and Health (NIOSH) pocket guide to chemical hazards – cellulose. The Centers for Disease Control and Prevention; [Accessed 2020 Nov 2]. https://www.cdc.gov/niosh/npg/npgd0110.html.
  • Ohashi T, Pinkerton K, Ikegami M, Jobe AH. 1994. Changes in alveolar surface area, surfactant protein A, and saturated phosphatidylcholine with postnatal rat lung growth. Pediatr Res. 35(6):685–689.
  • Ono SJ, Nakamura T, Miyazaki D, Ohbayashi M, Dawson M, Toda M. 2003. Chemokines: roles in leukocyte development, trafficking, and effector function. J Allergy Clin Immunol. 111(6):1185–1199.
  • Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, et al. 2004. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med. 351(25):2599–2610.
  • Pandya PH, Wilkes DS. 2014. Complement system in lung disease. Am J Respir Cell Mol Biol. 51(4):467–473.
  • Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E, Case CP. 2007. The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials. 28(19):2946–2958.
  • Park EJ, Khaliullin TO, Shurin MR, Kisin ER, Yanamala N, Fadeel B, Chang J, Shvedova AA. 2018. Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice. J Immunotoxicol. 15(1):12–23.
  • R Core Team. 2018. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. http://www.R-project.org/.
  • Raes G, De Baetselier P, Noel W, Beschin A, Brombacher F, Hassanzadeh Gh G, 2002. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol. 71(4):597–602.
  • Roberts JR, Anderson SE, Kan H, Krajnak K, Thompson JA, Kenyon A, Goldsmith WT, McKinney W, Frazer DG, Jackson M, et al. 2014. Evaluation of pulmonary and systemic toxicity of oil dispersant (COREXIT EC9500A(®) following acute repeated inhalation exposure. Environ Health Insights. 8(Suppl 1):63–74.
  • Rol F, Sillard C, Bardet M, Yarava JR, Emsley L, Gablin C, Leonard D, Belgacem N, Bras J. 2020. Cellulose phosphorylation comparison and analysis of phosphorate position on cellulose fibers. Carbohydr Polym. 229:115294.
  • Saber AT, Jacobsen NR, Jackson P, Poulsen SS, Kyjovska ZO, Halappanavar S, Yauk CL, Wallin H, Vogel U. 2014. Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 6(6):517–531.
  • Sack GH. Jr., 2018. Serum amyloid A – a review. Mol Med. 24(1):46.
  • Sager T. 2019. Functional significance of the SLC26A4 gene in silica-induced pulmonary toxicity. Toxicol Suppl Toxicol Sci. 168, Abstract No. 2017.
  • Sager T, Umbright C, Mustafa M, Yanamala N, Leonard H, McKinney W, Kashon M, Joseph P. 2020. Tobacco smoke exposure exacerbated crystalline silica-induced lung toxicity in rats. Toxicol Sci. 178(2):375–390.
  • Sai T, Fujita K. 2020. A review of pulmonary toxicity studies of nanocellulose. Inhal Toxicol. 32(6):231–239.
  • Sarma VJ, Huber-Lang M, Ward PA. 2006. Complement in lung disease. Autoimmunity. 39(5):387–394.
  • Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR, Wepf RA, Vallelian F, Schaer DJ. 2013. Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death Differ. 20(11):1569–1579.
  • Seabra AB, Bernardes JS, Favaro WJ, Paula AJ, Duran N. 2018. Cellulose nanocrystals as carriers in medicine and their toxicities: a review. Carbohydr Polym. 181:514–527.
  • Sellamuthu R, Umbright C, Roberts JR, Chapman R, Young SH, Richardson D, Leonard H, McKinney W, Chen B, Frazer D, et al. 2011. Blood gene expression profiling detects silica exposure and toxicity. Toxicol Sci. 122(2):253–264.,
  • Shackelford C, Long G, Wolf J, Okerberg C, Herbert R. 2002. Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies. Toxicol Pathol. 30(1):93–96.
  • Shatkin JA, Oberdorster G. 2016. Comment on Shvedova et al. (2016), "gender differences in murine pulmonary responses elicited by cellulose nanocrystals". Part Fibre Toxicol. 13(1):59.
  • Shvedova AA, Kisin ER, Yanamala N, Farcas MT, Menas AL, Williams A, Fournier PM, Reynolds JS, Gutkin DW, Star A, et al. 2016. Gender differences in murine pulmonary responses elicited by cellulose nanocrystals. Part Fibre Toxicol. 13(1):28.
  • Siro L, Plackett M. 2010. Microfibrillated cellulose and new nanocomposite materials: a review. Cellulose. 17(3):459–494.
  • Sollie S, Michaud DS, Sarker D, Karagiannis SN, Josephs DH, Hammar N, Santaolalla A, Walldius G, Garmo H, Holmberg L, et al. 2019. Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study. BMC Cancer. 19(1):858.
  • Stefaniak AB, Seehra MS, Fix NR, Leonard SS. 2014. Lung biodurability and free radical production of cellulose nanomaterials. Inhal Toxicol. 26(12):733–749.
  • Strunk RC, Eidlen DM, Mason RJ. 1988. Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J Clin Invest. 81(5):1419–1426.
  • Varsano S, Kaminsky M, Kaiser M, Rashkovsky L. 2000. Generation of complement C3 and expression of cell membrane complement inhibitory proteins by human bronchial epithelium cell line. Thorax. 55(5):364–369.
  • Volanakis JE. 1995. Transcriptional regulation of complement genes. Annu Rev Immunol. 13:277–305.
  • Yanamala N, Farcas MT, Hatfield MK, Kisin ER, Kagan VE, Geraci CL, Shvedova AA. 2014. In vivo evaluation of the pulmonary toxicity of cellulose nanocrystals: a renewable and sustainable nanomaterial of the future. ACS Sustain Chem Eng. 2(7):1691–1698.

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