Comparative pulmonary toxicities of lunar dusts and terrestrial dusts (TiO₂ & SiO₂) in rats and an assessment of the impact of particle-generated oxidants on the dusts’ toxicities

References

• Alien C, Morris RV., Jager KM, Golden, DC, Lindstrom DJ, Lindstrom MM, and Lockwood JP. 1998. JSC Mars-1: A Martian soil simulant. Space 98 Proceedings of the Conference of American Society of Civil Engineers; 26–30 April, Albuquerque, NM. Reston, VA: ASCE. p. 469–475.
   Google Scholar
• Bermudez E, Mangum JB, Asgharian B, Wong BA, Reverdy EE, Janszen DB, Hext PM, Warheit DB, Everitt JI. 2002. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol Sci. 70(1):86–97.
   PubMed Web of Science ®Google Scholar
• Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI. 2004. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci. 77(2):347–357.
   PubMed Web of Science ®Google Scholar
• Bilder RB. 2009. A legal regime for the mining of helium-3 on the moon: U.S. policy options. Fordham. Int. Law J. 33:243–298.
   Google Scholar
• Carter JM, Driscoll KE. 2001. The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison. J Environ Pathol Toxicol Oncol. 20(Suppl 1):12–43.
   Google Scholar
• Caston R, Luc K, Hendrix D, Hurowitz JA, Demple B. 2018. Assessing toxicity and nuclear and mitochondrial DNA damage caused by exposure of mammalian cells to lunar regolith simulants. Geohealth. 2 (4):139–148.
   PubMed Web of Science ®Google Scholar
• Cederbaum AI. 2017. Cytochrome P450 and oxidative stress in the liver. in: liver pathophysiology therapies and antioxidants chapter 31, Ed.: P Muriel. New York, NY: Elsevier Inc. https://www.sciencedirect.com/science/article/pii/B978012804274800031X
   Google Scholar
• Cooper BL, McKay DS, Taylor LA, Kawamoto H, Riofrio LM, Gonzalez CP. 2010. Extracting respirable particles from lunar regolith for toxicology studies. In Proceedings of the 12th International Conference on Engineering, Science, Construction, and Operations in Challenging Environments. 12:66–73.
   Google Scholar
• Driscoll KE, Deyo LC, Carter JM, Howard BW, Hassenbein DG, Bertram TA. 1997. Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis. 18(2):423–430.
   PubMed Web of Science ®Google Scholar
• Donaldson K, Beswick PH, Gilmour PS. 1996. Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? Toxicol Lett. 88(1-3):293–298.
   PubMed Web of Science ®Google Scholar
• ESA 2015. International symposium on moon 2020–2030, a new era of coordinated human and robotic exploration. European Space Research and Technology Centre of the European Space Agency (ESA/ESTEC) in the Netherlands. December 15–16. http://spaceflight.esa.int/humanrobotics/.
   Google Scholar
• ESA 2017. Lunar 3D printing. [Accessed June 2017]. http://m.esa.int/Highlights/Lunar_3D_printing
   Google Scholar
• Fubini B. 1998. Surface chemistry and quartz hazard. Ann Occup Hyg. 42(8):521–530.
   PubMed Web of Science ®Google Scholar
• Groth DH, Stettler LE, Platek SF, Lal JB, Burg JR. 1986. Lung tumors in rats treated with quartz by intratracheal instillation. In: Goldsmith DF, Winn DM, Shy CM, eds. Silica, silicosis, and cancer: Controversy in occupational medicine. New York, NY: Praeger Publishers, p. 243–253. Cancer Research Monographs, Vol. 2.
   Google Scholar
• Gustafson R. 2004. JSC‐1A lunar regolith simulant availability and characterization. https://www.nasa.gov/sites/default/files/atoms/files/03_jsc-1a_lunar_regsimulant_update_bgustafson.pdf
   Google Scholar
• Harrington AD, Schmidt MP, Szema AM, Galdanes K, Tsirka SE, Gordon T, Schoonen MAA. 2017. The role of Iraqi dust in inducing lung injury in United States soldiers-An interdisciplinary study: Iraqi Dust and U. Geohealth. 1(5):237–246.
   PubMed Web of Science ®Google Scholar
• Harrington AD, McCubbin FM, Kaur J, Smirnov A, Galdanes K, Schoonen MA, Chen LC, Tsirka SE, Gordon T. 2017. Acute meteorite dust exposure and pulmonary inflammation – implications for human space exploration. Lunar and Planetary Science XLVIII 2017. 2922. https://www.hou.usra.edu/meetings/lpsc2017/pdf/2922.pdf.
   Google Scholar
• Horwell CJ, Fenoglio I, Ragnarsdottir KV, Sparks RSJ, Fubini B. 2003. Surface reactivity of volcanic ash from the eruption of Soufrière Hills volcano, Montserrat, West Indies with implications for health hazards. Environ Res. 93(2):202–215.
   PubMed Web of Science ®Google Scholar
• IARC 1997. Silica, some silicates, coal dust and para-aramid fibrils. IARC monographs on the evaluation of carcinogenic risks to humans, No. 68. International Agency for Research on Cancer; 1997. https://www.ncbi.nlm.nih.gov/books/NBK410038.
   Google Scholar
• James JT, Lam C-W, Santana PA, Scully RR. 2013. Estimate of safe human exposure levels for lunar dust based on comparative benchmark dose modeling. Inhal Toxicol. 25(5):243–256.
   PubMed Web of Science ®Google Scholar
• James JT, Lam C-w, Scully RR, Meyers VE, McCoy JT. 2014. Lunar dust toxicity: final report (NASA On-line Report). https://humanresearchroadmap.nasa.gov/gaps/closureDocumentation/Lunar%20Dust%20Toxicity%20FINAL%20REPORT.pdf?rnd=0.157545329144944.
   Google Scholar
• Jones A. 2021. China displays crewed moon landing mission elements. SpaceNews. https://spacenews.com/china-displays-crewed-moon-landing-mission-elements
   Google Scholar
• Knaapen AM1, Borm PJ, Albrecht C, Schins RP. 2004. Inhaled particles and lung cancer. Part A: mechanisms. Int J Cancer. 109(6):799–809.
   PubMed Web of Science ®Google Scholar
• Lam C-w, Driscoll KE, McClellan R, James JT, Zhang Y, Scully RR, Ryder V, Hunter R, McCluskey R, Zeidler-Erdely PC, Castranova V. (In preparation). Comparative Toxicities of Lunar Dusts and Terrestrial Dusts (Quartz & TiO2) and a Proposed Mechanism for the Particle-Induced Lung Diseases.
   Google Scholar
• Lam C-w, Scully RR, Zhang Y, Renne RA, Hunter RL, McCluskey RA, Chen BT, Castranova V, Driscoll KE, Gardner DE, et al. 2013. Toxicity of lunar dust assessed in inhalation-exposed rats. Inhal Toxicol. 25(12):661–678.
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, McCluskey R, Cowper S, Balis J, Muro-Cacho C. 2002. Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation. Inhal Toxicol. 14(9):901–916.
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, Latch JN, Hamilton RF, Jr, Holian A. 2002. Pulmonary toxicity of simulated lunar and Martian dusts in mice: II. Biomarkers of acute responses after intratracheal instillation. Inhal Toxicol. 14(9):917–928.
   PubMed Web of Science ®Google Scholar
• Latch JN, Hamilton RF, Jr, Holian A, James JT, Lam CW. 2008. Toxicity of lunar and martian dust simulants to alveolar macrophages isolated from human volunteers. Inhal Toxicol. 20(2):157–165.
   PubMed Web of Science ®Google Scholar
• Liu J, Pang Z, Wang G, Guan X, Fang K, et al. 2017. Advanced role of neutrophils in common respiratory diseases. J Immunol Res:Article ID. 6710278:1–21.
   Google Scholar
• Lodovici M, Bigagli E. 2011. Oxidative Stress and Air Pollution Exposure. J. Toxicol. Article ID. 2011:1–9.
   Google Scholar
• McKay DS, Carter JL, Boles WW, Allen CC, Alton JH. 1994. JSC-1: a new lunar soil simulant. In: Engineering, construction and operations in space IV, Proceedings of Space ’94, sponsored by the Aerospace Division/ASCE, held February 26 – March 3, Albuquerque, NM.
   Google Scholar
• McKay DS, Cooper BL, Taylor LA, James JT, Thomas-Keprta K, Pieters CM, Wentworth SJ, Wallace WT, Lee TS. 2015. Physicochemical properties of respirable-size lunar dust. Acta Astronaut (UK). 107:163–176.
   Web of Science ®Google Scholar
• Morrow PE, Haseman JK, Hobbs CH, Driscoll KE, Vu V, Oberdörster G. 1996. The maximum tolerated dose for inhalation bioassays: toxicity vs overload. Fundam Appl Toxicol. 29(2):155–167.
   PubMedGoogle Scholar
• Mossman BT, Borm PJ, Castranova V, Costa DL, Donaldson K, Kleeberger SR. 2007. Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases. Part Fibre Toxicol. 4:4–14.
   PubMedGoogle Scholar
• Nakamura T, Noguchi T, Tanaka M, Zolensky ME, Kimura M, Tsuchiyama A, Nakato A, Ogami T, Ishida H, Uesugi M, et al. 2011. Itokawa dust particles: a direct link between S-type asteroids and ordinary chondrites. Science. 333 (6046):1113–1116.
   PubMed Web of Science ®Google Scholar
• Nakamura E, Makishima A, Moriguti T, Kobayashi K, Tanaka R, Kunihiro T, Tsujimori T, Sakaguchi C, Kitagawa H, Ota T, et al. 2012. Space environment of an asteroid preserved on micrograins returned by the Hayabusa spacecraft. Proc Natl Acad Sci USA. 109(11):E624–E629.
   PubMed Web of Science ®Google Scholar
• NASA 2004, President Bush Delivers Remarks On U.S. Space Policy https://www.nasa.gov/pdf/54868main_bush_trans.pdf.
   Google Scholar
• NASA 2018. Building a lunar base with 3D printing. http://sservi.nasa.gov/articles/building-a-lunar-base-with-3d-printing/. (Accessed July 2018).
   Google Scholar
• Pauluhn J, Wieman M. 2011. Siderite (FeCO3) and magnetite (Fe3O4) overload-dependent pulmonary toxicity is determined by the poorly soluble particle not the iron content. Inhal Toxicol. 23(13):763–783.
   PubMed Web of Science ®Google Scholar
• Roberts JR, Mercer RR, Chapman RS, Cohen GM, Bangsaruntip S, Schwegler-Berry D, et al. 2012. Pulmonary toxicity, distribution, and clearance of intratracheally instilled silicon nanowires in rats. J Nanomaterials 2012:398302.
   PubMed Web of Science ®Google Scholar
• Robinson JP. 1998. Oxygen and nitrogen reactive metabolites and phagocytic cells. In: Robinson JP, Babcock GF, editor(s). Phagocyte function: a guide for research and clinical evaluation. New York (NY): Wiley-Liss. p. 217–252.
   Google Scholar
• Rydell-Törmänen K, Uller L, Erjefält JS. 2006. Direct evidence of secondary necrosis of neutrophils during intense lung inflammation. Eur Respir J. 28(2):268–274.
   PubMed Web of Science ®Google Scholar
• Saran M, Summer KH. 1999. Assaying for hydroxyl radicals: Hydroxylated terephthalate is a superior fluorescence marker than hydroxylated benzoate. Free Radic Res. 31(5):429–436.
   PubMed Web of Science ®Google Scholar
• Schmitt HH. 2005. Return to the moon: exploration, enterprise, and energy in the human settlement of space. New York: Springer.
   Google Scholar
• Scully RR, Lam CW, James JT. 2013. Estimating safe human exposure levels for lunar dust using benchmark dose modeling of data from inhalation studies in rats. Inhal Toxicol. 25(14):785–793.
   PubMed Web of Science ®Google Scholar
• Shen H, Anastasio C. 2012. A comparison of hydroxyl radical and hydrogen peroxide generation in ambient particle extracts and laboratory metal solutions. Atmos Environ. 46:665–668.
   Web of Science ®Google Scholar
• Silva MT, do Vale A, dos Santos NM. 2008. Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications. Apoptosis. 13(4):463–482.
   PubMed Web of Science ®Google Scholar
• Space News 2018. Urban planning for the Moon Village by Jeff Foust. Alexandria, Virginia: Space News. https://spacenews.com/urban-planning-for-the-moon-village/
   Google Scholar
• Space 2020. Trump signs executive order to support moon mining, tap asteroid resources by M. Wall. Space.com April 06, 2020. https://www.space.com/trump-moon-mining-space-resources-executive-order.html
   Google Scholar
• Specktor B. 2018. Moon dust is super toxic to human cells. Live science. https://www.livescience.com/62590-moon-dust-bad-lungs-brain.html.
   Google Scholar
• Taylor LA, Yang L. 2010. Important considerations for lunar soil simulants. Earth and Space 2010: engineering, science, construction, and operations in challenging environments.
   Google Scholar
• Turci F, Corazzari I, Alberto G, Martra G, Fubini B. 2015. Free-radical chemistry as a means to evaluate lunar dust health hazard in view of future missions to the moon. Astrobiology. 15(5):371–380.
   PubMed Web of Science ®Google Scholar
• Vallyathan V. 1994. Generation of oxygen radicals by minerals and its correlation to cytotoxicity. Environ. Health Perspect. 102(10):111–115.
   PubMedGoogle Scholar
• Vallyathan V, Castranova V, Pack D, Leonard S, Shumaker J, Hubbs AF, Shoemaker DA, Ramsey DM, Pretty JR, McLaurin JL, et al. 1995. Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals. Am J Respir Crit Care Med. 152(3):1003–1009.
   PubMed Web of Science ®Google Scholar
• Vallyathan V, Shi XL, Dalal NS, Irr W, Castranova V. 1988. Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury. Am Rev Respir Dis. 138(5):1213–1219.
   PubMedGoogle Scholar
• Vandette K. 2018. Moon dust is extremely toxic and poses health hazards for astronauts. https://www.earth.com/news/moon-dust-toxic-health/
   Google Scholar
• Wallace WT, Taylor LA, Liu Y, Cooper BL, McKAY DS, Chen B, Jeevarajan AS. 2009. Lunar dust and lunar simulant activation and monitoring. Meteorit & Planet Sci. 44(7):961–970.
   Web of Science ®Google Scholar
• Zhang DD, Hartsky MA, Warheit DB. 2002. Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp Lung Res. 28(8):641–670.
   PubMed Web of Science ®Google Scholar