Orally administered collagen peptide protects against UVB-induced skin aging through the absorption of dipeptide forms, Gly-Pro and Pro-Hyp

References

• Imokawa G. Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase. Arch Dermatol Res. 2008 Apr;300(Suppl 1):S7–20. PubMed PMID: 17968573.
   PubMedGoogle Scholar
• Boelsma E, Hendriks HF, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. Am J Clin Nutr. 2001 May;73(5):853–864. PubMed PMID: 11333837.
   PubMed Web of Science ®Google Scholar
• Brennan M, Bhatti H, Nerusu KC, et al. Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin. Photochem Photobiol. 2003 Jul;78(1):43–48. PubMed PMID: 12929747.
   PubMed Web of Science ®Google Scholar
• Rosch R, Klinge U, Si Z, et al. A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? BMC Med Genet. 2002;3:2. PubMed PMID: 11872152; PubMed Central PMCID: PMCPMC65699
   PubMedGoogle Scholar
• Welgus HG, Jeffrey JJ, Eisen AZ. The collagen substrate specificity of human skin fibroblast collagenase. J Biol Chem. 1981 Sep 25;256(18):9511–9515. PubMed PMID: 6270089.
   PubMed Web of Science ®Google Scholar
• Vaalamo M, Mattila L, Johansson N, et al. Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. J Invest Dermatol. 1997 Jul;109(1):96–101. PubMed PMID: 9204962.
   PubMed Web of Science ®Google Scholar
• Matsuda N, Koyama Y, Hosaka Y, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006 Jun;52(3):211–215. PubMed PMID: 16967766.
   PubMed Web of Science ®Google Scholar
• Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999 May;25(2):379–395. PubMed PMID: 10356424.
   PubMed Web of Science ®Google Scholar
• Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016 Sep;96(12):4077–4081. PubMed PMID: 26840887.
   PubMed Web of Science ®Google Scholar
• Iba Y, Yokoi K, Eitoku I, et al. Oral administration of collagen hydrolysates improves glucose tolerance in normal mice through GLP-1-dependent and GLP-1-independent mechanisms. J Med Food. 2016 Sep;19(9):836–843. PubMed PMID: 27540823.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhao M, Wang J, et al. Oral administration of skin gelatin isolated from Chum salmon (Oncorhynchus keta) enhances wound healing in diabetic rats. Mar Drugs. 2011;9(5):696–711. PubMed PMID: 21673883; PubMed Central PMCID: PMCPMC3111176.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wang J, Ding Y, et al. Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats. J Sci Food Agric. 2011 Sep;91(12):2173–2179. PubMed PMID: 21560132.
   PubMed Web of Science ®Google Scholar
• Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485–1496. PubMed PMID: 18416885.
   PubMed Web of Science ®Google Scholar
• Gelse K, Poschl E, Aigner T. Collagens–structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531–1546. PubMed PMID: 14623400.
   PubMed Web of Science ®Google Scholar
• Djagny VB, Wang Z, Xu S. Gelatin: a valuable protein for food and pharmaceutical industries: review. Crit Rev Food Sci Nutr. 2001 Sep;41(6):481–492. PubMed PMID: 11592686.
   PubMed Web of Science ®Google Scholar
• Shrikant Sharma RS, Rana S. Bioactive peptides: a review. Int J Bioautomation. 2011 june 02;14(4):223–250.
   Google Scholar
• Ramshaw JA, Shah NK, Brodsky B. Gly-X-Y tripeptide frequencies in collagen: a context for host-guest triple-helical peptides. PubMed PMID: 9724608 J Struct Biol. 1998;1221–2:86–91.
   PubMed Web of Science ®Google Scholar
• Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci U S A. 1978 Feb;75(2):871–875. PubMed PMID: 204938; PubMed Central PMCID: PMCPMC411359.
   PubMed Web of Science ®Google Scholar
• Knight CG, Morton LF, Onley DJ, et al. Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen. Cardiovasc Res. 1999 Feb;41(2):450–457. PubMed PMID: 10341844.
   PubMed Web of Science ®Google Scholar
• Wisniewski K, Artemowicz B, Lutostanska A, et al. Central activity of peptide Gly-Pro-Hyp–the main component of collagen degradation products mixture. Acta Neurobiol Exp (Wars). 1994;54(1):33–38. PubMed PMID: 8023712.
   PubMed Web of Science ®Google Scholar
• Ohara H, Ichikawa S, Matsumoto H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. 2010 Apr;37(4):330–338. PubMed PMID: 20507402.
   PubMed Web of Science ®Google Scholar
• Nakatani S, Mano H, Sampei C, et al. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthritis Cartilage. 2009 Dec;17(12):1620–1627. PubMed PMID: 19615963.
   PubMed Web of Science ®Google Scholar
• Iwai K, Hasegawa T, Taguchi Y, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005 Aug 10;53(16):6531–6536. PubMed PMID: 16076145.
   PubMed Web of Science ®Google Scholar
• Ichikawa S, Morifuji M, Ohara H, et al. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Int J Food Sci Nutr. 2010 Feb;61(1):52–60. PubMed PMID: 19961355.
   PubMed Web of Science ®Google Scholar
• Shigemura Y, Akaba S, Kawashima E, et al. Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate. Food Chem. 2011 Dec 1;129(3):1019–1024. PubMed PMID: 25212331.
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Deguchi K, Onuma M, et al. Absorption and urinary excretion of peptides after collagen tripeptide ingestion in humans. Biol Pharm Bull. 2016;39(3):428–434. PubMed PMID: 26934933.
   PubMed Web of Science ®Google Scholar
• Backwell FR, Wilson D, Schweizer A. Evidence for a glycyl-proline transport system in ovine enterocyte brush-border membrane vesicles. Biochem Biophys Res Commun. 1995 Oct 13;215(2):561–565. PubMed PMID: 7487992.
   PubMed Web of Science ®Google Scholar
• Ganapathy V, Mendicino JF, Leibach FH. Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit. J Biol Chem. 1981 Jan 10;256(1):118–124. PubMed PMID: 7451429.
   PubMed Web of Science ®Google Scholar
• Ichimura T, Yamanaka A, Otsuka T, et al. Antihypertensive effect of enzymatic hydrolysate of collagen and Gly-Pro in spontaneously hypertensive rats. Biosci Biotechnol Biochem. 2009 Oct;73(10):2317–2319. PubMed PMID: 19809172.
   PubMed Web of Science ®Google Scholar
• Asselin J, Knight CG, Farndale RW, et al. Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI. Biochem J. 1999 Apr 15;339(Pt 2):413–418. PubMed PMID: 10191274; PubMed Central PMCID: PMCPMC1220172.
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Hayasaka F, Deguchi K, et al. Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats. Biosci Biotechnol Biochem. 2015;79(12):2026–2033. PubMed PMID: 26155906.
   PubMed Web of Science ®Google Scholar
• Sontakke SB, Jung JH, Piao Z, et al. Orally available collagen tripeptide: enzymatic stability, intestinal permeability, and absorption of Gly-Pro-Hyp and Pro-Hyp. J Agric Food Chem. 2016 Sep 28;64(38):7127–7133. PubMed PMID: 27573716.
   PubMed Web of Science ®Google Scholar
• Chen T, Hou H, Fan Y, et al. Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway. J Photochem Photobiol B. 2016 Dec;165:34–41. PubMed PMID: 27768951.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):930–932. PubMed PMID: 19352014.
   PubMed Web of Science ®Google Scholar
• Quan T, Qin Z, Xia W, et al. Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc. 2009 Aug;14(1):20–24. PubMed PMID: 19675548; PubMed Central PMCID: PMCPMC2909639.
   PubMedGoogle Scholar
• Shigemura Y, Iwai K, Morimatsu F, et al. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009 Jan 28;57(2):444–449. PubMed PMID: 19128041.
   PubMed Web of Science ®Google Scholar
• Ganapathy V, Leibach FH. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J Biol Chem. 1983 Dec 10;258(23):14189–14192. PubMed PMID: 6643475.
   PubMed Web of Science ®Google Scholar
• Lee KO, Kim SN, Kim YC. Anti-wrinkle effects of water extracts of teas in hairless mouse. Toxicol Res. 2014 Dec;30(4):283–289. . PubMed PMID: 25584148; PubMed Central PMCID: PMCPMC4289929.
   PubMedGoogle Scholar
• Sparr E, Millecamps D, Isoir M, et al. Controlling the hydration of the skin though the application of occluding barrier creams. J R Soc Interface. 2013 Mar 6;10(80):20120788. PubMed PMID: 23269846; PubMed Central PMCID: PMCPMC3565729.
   PubMed Web of Science ®Google Scholar
• Pyun HB, Kim M, Park J, et al. Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Prev Nutr Food Sci. 2012 Dec;17(4):245–253. PubMed PMID: 24471092; PubMed Central PMCID: PMCPMC3866733.
   PubMedGoogle Scholar
• Choi SY, Ko EJ, Lee YH, et al. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014 Jun;16(3):132–137. PubMed PMID: 24131075.
   PubMed Web of Science ®Google Scholar