Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways

References

• Neurath MF. Cytokines in inflammatory bowel disease [Research Support, Non-U S Gov’t Review]. Nat Rev Immunol. 2014 May;14(5):329–342.
   PubMed Web of Science ®Google Scholar
• Bernstein CN, Fried M, Krabshuis JH, et al. World gastroenterology organization practice guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 2010 Jan;16(1):112–124.
   PubMed Web of Science ®Google Scholar
• Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2018 Dec 23;390(10114):2769–2778.
   PubMed Web of Science ®Google Scholar
• Guan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res. 2019;2019:7247238.
   PubMed Web of Science ®Google Scholar
• Lee SH, Kwon JE, Cho M-L. Immunological pathogenesis of inflammatory bowel disease. Intest Res. 2018 Jan;16(1):26–42.
   PubMed Web of Science ®Google Scholar
• Rosillo MA, Sanchez-Hidalgo M, Cardeno A, et al. Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats Research Support, Non-U S Gov’t. Pharmacol Res. 2012 Sep;663:235–242.
   PubMed Web of Science ®Google Scholar
• Shishodia S, Aggarwal BB. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression. Oncogene. 2006 Mar 9;25(10):1463–1473.
   PubMed Web of Science ®Google Scholar
• Billiet T, Rutgeerts P, Ferrante M, et al. Targeting TNF-α for the treatment of inflammatory bowel disease Review. Expert Opin Biol Ther. 2014 Jan;141:75–101.
   PubMed Web of Science ®Google Scholar
• Fukuda T, Majumder K, Zhang H, et al. Adenine inhibits TNF-α signaling in intestinal epithelial cells and reduces mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model. J Agric Food Chem. 2016 Jun 1;64(21):4227–4234.
   PubMed Web of Science ®Google Scholar
• Almeer RS, Mahmoud SM, Amin HK, et al. Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. Food Chem Toxicol. 2018 May;115:49–62.
   PubMed Web of Science ®Google Scholar
• Lee HS, Park S-K, Park DI. Novel treatments for inflammatory bowel disease. Korean J Intern Med. 2018 Jan;33(1):20–27.
   PubMed Web of Science ®Google Scholar
• Kandhare A, Phadke U, Mane A, et al. Add-on therapy of herbal formulation rich in standardized fenugreek seed extract in type 2 diabetes mellitus patients with insulin therapy: an efficacy and safety study Basic Research. Asian Pac J Trop Biomed. 2018 September 1;8(9):446.
   Web of Science ®Google Scholar
• Kandhare AD, Rais N, Moulick ND, et al. Efficacy and safety of herbal formulation rich in standardized fenugreek seed extract as add-on supplementation in patients with type 2 diabetes mellitus on sulfonylurea therapy: A 12-week, randomized, double-blind, placebo-controlled, multi-center study. Pharmacogn Mag. 2018;14(57):393–402.
   Web of Science ®Google Scholar
• Zhou Z, Kandhare AD, Kandhare AA, et al. Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-β1/Smad3/AMPK and IκBα/NF-κB pathways. Excli J. 2019;18:723–745.
   PubMed Web of Science ®Google Scholar
• Bodhankar S, Zhang L, Wu T, et al. Elucidation of the molecular mechanism of tempol in pentylenetetrazol-induced epilepsy in mice: role of gamma-aminobutyric acid, tumor necrosis factor-alpha, interleukin-1β and c-Fos Original Article. Pharmacogn Mag. 2018 December 1;14(59):520.
   Web of Science ®Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. Patentability of animal models: india and the globe. Int J Pharm Biol Arc. 2011;2(4):1024–1032.
   Google Scholar
• Luo X, Yu Z, Deng C, et al. Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice. Sci Rep. 2017 Nov 27;7(1):16374.
   PubMedGoogle Scholar
• Suzuki R, Katakura K, Fujiwara T, et al. Imiquimod-induced CCR9 ameliorates murine TNBS colitis. Fukushima J Med Sci. 2016 Dec 16;62(2):90–100.
   PubMedGoogle Scholar
• Kandhare AD, Thakurdesai PA, Wangikar P, et al. A systematic literature review of fenugreek seed toxicity by using ToxRTool: evidence from preclinical and clinical studies. Heliyon. 2019 Apr;5(4):e01536.
   PubMed Web of Science ®Google Scholar
• Patil SP, Niphadkar PV, Bapat MM. Allergy to Fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol. 1997;78(3):297–300.
   PubMed Web of Science ®Google Scholar
• Vasil’eva IS, Vaniushkin SA, Zinov’eva SV, et al. Photosynthetic pigments of tomato under conditions of biotic stress and effects of furostanol glycosides. Prikl Biokhim Mikrobiol. 2003 Nov-Dec;39(6):689–696.
   PubMedGoogle Scholar
• Dubinskaia VA, Strelkova LB, Vasil’eva IS, et al. Anabolic properties of furostanol glycosides from Dioscorea deltoidea wall. Biull Eksp Biol Med. 1998 Aug;126(8):178–181.
   PubMedGoogle Scholar
• Park S-W, Lee C-H, Shin D-H, et al. Effect of SA1, a herbal formulation, on sexual behavior and penile erection. Biol Pharm Bull. 2006 Jul;29(7):1383–1386.
   PubMed Web of Science ®Google Scholar
• Raju J, Patlolla JM, Swamy MV, et al. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1392–1398.
   PubMed Web of Science ®Google Scholar
• Li F, Fernandez PP, Rajendran P, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197–207.
   PubMed Web of Science ®Google Scholar
• Huang C-H, Ku C-Y, Jan T-R. Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy. Planta Med. 2009 Oct;75(12):1300–1305.
   PubMed Web of Science ®Google Scholar
• Zhu S, Tang S, Su F. Dioscin inhibits ischemic strokeinduced inflammation through inhibition of the TLR4/MyD88/NFkappaB signaling pathway in a rat model. Mol Med Rep. 2018 Jan;17(1):660–666.
   PubMed Web of Science ®Google Scholar
• Li X, Yang X, Cai Y, et al. Proanthocyanidins from grape seeds modulate the NF-κB signal transduction pathways in rats with TNBS-induced ulcerative colitis Research Support, Non-U.S. Gov’t. Molecules. 2011 Aug 8;16(8):6721–6731.
   PubMed Web of Science ®Google Scholar
• Kandhare AD, Ghosh P, Ghule AE, et al. Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: role of phyllanthin and hypophyllanthin. Apollo Medicine. 2013;10(1):87–97.
   Google Scholar
• Kumar VS, Rajmane AR, Adil M, et al. Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 2014;28(2):132–145.
   PubMedGoogle Scholar
• Kandhare AD, Bodhankar SL, Mohan V, et al. Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem Biol Interact. 2015;237:151–165.
   PubMed Web of Science ®Google Scholar
• Yang M, Lin H-B, Gong S, et al. Effect of astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis Research Support, Non-U S Gov’t . Cytokine. 2014 Dec;70(2):81–86.
   PubMed Web of Science ®Google Scholar
• Antoniou E, Margonis GA, Angelou A, et al. The TNBS-induced colitis animal model: an overview. Ann Med Surg (Lond). 2016 Nov;11:9–15.
   PubMed Web of Science ®Google Scholar
• Visnagri A, Kandhare AD, Kumar VS, et al. Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol. 2012;2(4):157–172.
   Google Scholar
• Yin H, Bodhankar S, Zhang G, et al. Ameliorative effect of morin, a plant flavonoid against Freund’s complete adjuvant-induced polyarthritis in rats Original Article. Pharmacogn Mag. 2019 January 1;15(60):43.
   Web of Science ®Google Scholar
• Raygude KS, Kandhare AD, Ghosh P, et al. Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology. 2012 Dec;20(6):331–341.
   PubMedGoogle Scholar
• Kandhare AD, Ghosh P, Ghule AE, et al. Elucidation of molecular mechanism involved in neuroprotective effect of coenzyme Q10 in alcohol-induced neuropathic pain. Fundam Clin Pharmacol. 2013 Dec;27(6):603–622.
   PubMed Web of Science ®Google Scholar
• Kruidenier L, Kuiper I, Van Duijn W, et al. Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease Research Support, Non-U.S. Gov’t . J Pathol. 2003 Sep;2011:17–27.
   PubMed Web of Science ®Google Scholar
• Kruidenier L, Verspaget HW. Oxidative stress as a pathogenic factor in inflammatory bowel disease - radicals or ridiculous? Review. Aliment Pharmacol Ther. 2002;16(12):1997–2015.
   PubMed Web of Science ®Google Scholar
• Wang H-W, Liu H-J, Cao H, et al. Diosgenin protects rats from myocardial inflammatory injury induced by ischemia-reperfusion. Med Sci Monit. 2018 Jan 12;24:246–253.
   PubMed Web of Science ®Google Scholar
• Adil M, Kandhare AD, Dalvi G, et al. Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 2016 Jul;38(6):996–1006.
   PubMed Web of Science ®Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed. 2012 May;2(5):337–344.
   PubMedGoogle Scholar
• Ketkar S, Rathore A, Kandhare A, et al. Alleviating exercise-induced muscular stress using neat and processed bee pollen: oxidative markers, mitochondrial enzymes, and myostatin expression in rats. Integr Med Res. 2015 Sep;4(3):147–160.
   PubMed Web of Science ®Google Scholar
• Visnagri A, Kandhare AD, Chakravarty S, et al. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol. 2014 Jul;52(7):814–828.
   PubMed Web of Science ®Google Scholar
• Patil MVK, Bhise S, Kandhare A. Pharmacological evaluation of ameliorative effect of aqueous extract of Cucumis sativus L. fruit formulation on wound healing in Wistar rats. Chronicles of Young Scientists. 2011;2(4):207–213.
   Google Scholar
• Patil MVK, Kandhare AD, Bhise SD. Anti-inflammatory effect of Daucus carota root on experimental colitis in rats. Int J Pharm Pharm Sci. 2012;4(1):337–343.
   Google Scholar
• Adil M, Kandhare AD, Ghosh P, et al. Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1. Ren Fail. 2016 Jul;38(6):1007–1020.
   PubMed Web of Science ®Google Scholar
• Ghule AE, Kandhare AD, Jadhav SS, et al. Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis. Int Immunopharmacol. 2015 Sep;28(1):751–763.
   PubMed Web of Science ®Google Scholar
• Goswami S, Kandhare A, Zanwar AA, et al. Oral L-glutamine administration attenuated cutaneous wound healing in Wistar rats. Int Wound J. 2016 Feb;13(1):116–124.
   PubMed Web of Science ®Google Scholar
• Honmore V, Kandhare A, Zanwar AA, et al. Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers. Pharm Biol. 2015 Apr;53(4):571–581.
   PubMed Web of Science ®Google Scholar
• Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer Research Support, N I H, Extramural Research Support, Non-U S Gov’t. Cancer Cell. 2009 Feb 3;15(2):103–113.
   PubMed Web of Science ®Google Scholar
• Umehara Y, Kudo M, Nakaoka R, et al. Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. Hepatogastroenterology. 2006 Nov-Dec;53(72):879–882.
   PubMedGoogle Scholar
• Amasheh M, Grotjohann I, Amasheh S, et al. Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines Research Support, Non-U S Gov’t. Scand J Gastroenterol. 2009;44(10):1226–1235.
   PubMed Web of Science ®Google Scholar
• Han YM, Koh J, Kim JW, et al. NF-kappa B activation correlates with disease phenotype in Crohn’s disease. PLoS One. 2017;12(7):e0182071.
   PubMed Web of Science ®Google Scholar
• Liu T, Zhang L, Joo D, et al. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2(1):17023.
   PubMed Web of Science ®Google Scholar
• Ghasemzadeh MR, Amin B, Mehri S, et al. Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats. J Ethnopharmacol. 2016 Dec 24;194:117–130.
   PubMed Web of Science ®Google Scholar
• Visnagri A, Kandhare AD, Bodhankar SL. Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. Ren Fail. 2015 Apr;37(3):482–493.
   PubMed Web of Science ®Google Scholar
• Adil M, Kandhare AD, Visnagri A, et al. Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α. Ren Fail. 2015;37(8):1396–1407.
   PubMed Web of Science ®Google Scholar
• Cui J, Wang G, Kandhare AD, et al. Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: possible role of PPAR-γ, Bax/Bcl-2, and caspase-3. Food Chem Toxicol. 2018 Nov;121:95–108.
   PubMed Web of Science ®Google Scholar
• Guo G, Shi F, Zhu J, et al. Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IκB-α/NF-κB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice. Hum Exp Toxicol. 2020 Apr;39(4):477–491.
   PubMed Web of Science ®Google Scholar
• Fabian A, Rutka M, Ferenci T, et al. The use of complementary and alternative medicine is less frequent in patients with inflammatory bowel disease than in patients with other chronic gastrointestinal disorders. Gastroenterol Res Pract. 2018;2018:9137805.
   PubMed Web of Science ®Google Scholar
• Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci. 2018 April 1;17(2):97–106.
   Google Scholar
• Dong M, Meng Z, Kuerban K, et al. Diosgenin promotes antitumor immunity and PD-1 antibody efficacy against melanoma by regulating intestinal microbiota. Cell Death Dis. 2018 Oct 10;9(10):1039.
   PubMedGoogle Scholar
• Lepage C, Léger D, Bertrand J, et al. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett. 2011;301(2):193–202.
   PubMed Web of Science ®Google Scholar
• Malisetty VS, Patlolla JM, Raju J, et al. Chemoprevention of colon cancer by diosgenin, a steroidal saponin constituent of fenugreek. Cancer Res. 2005;65(9 Sup):580–581.
   Google Scholar