pH-Responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties

References

• Schoener , CA , Hutson , HN , Fletcher , GK and Peppas , NA . 2011 . Amphiphilic interpenetrating networks for the delivery of hydrophobic, low molecular weight therapeutic agents . Industrial & Engineering Chemistry Research , 50 : 12556
   PubMed Web of Science ®Google Scholar
• Schoener , CA , Hutson , HN and Peppas , NA . 2012 . pH-Responsive hydrogels with dispersed hydrophobic nanoparticles for the delivery of hydrophobic therapeutic agents . Polymer International , 61 : 874
   PubMed Web of Science ®Google Scholar
• Fisher , OZ , Kim , T , Dietz , SR and Peppas , NA . 2009 . Enhanced core hydrophobicity, functionalization and cell uptake of polybasic nanomatrices . Pharmaceutical Research , 26 : 51
   PubMed Web of Science ®Google Scholar
• Owens , DE III , Jian , Y , Fang , JE , Slaughter , BV , Chen , YH and Peppas , NA . 2007 . Thermally-responsive swelling properties of polyacrylamide/poly(acrylic acid) interpenetrating polymer network nanoparticles . Macromolecules , 40 : 7306
   Web of Science ®Google Scholar
• Sato , K , Yoshida , K , Takahashi , S and Anzai , J . 2011 . pH- and sugar-senstive layer-by-layer films and microcapsules for drug delivery . Advanced Drug Delivery Reviews , 63 : 809
   PubMed Web of Science ®Google Scholar
• Huh , KM , Kang , HC , Lee , YJ and Bae , YH . 2012 . pH-Sensitive polymers for drug delivery . Macromolecular Research , 20 : 224
   Web of Science ®Google Scholar
• Tang , Y , Heaysman , CL , Willis , S and Lewis , AL . 2011 . Physical hydrogels with self-assembled nanostructures as drug delivery systems . Expert Opinion on Drug Delivery , 8 : 1141
   PubMed Web of Science ®Google Scholar
• Liu , G , Franssen , E , Fitch , MI and Warner , E . 1997 . Patient preferences for oral versus intravenous palliative chemotherapy . Journal of Clinical Oncology , 15 : 110
   PubMed Web of Science ®Google Scholar
• Irshad , S and Maisey , N . 2010 . Considerations when choosing oral chemotherapy: identifying and responding to patient need . European Journal of Cancer Care , 19 : 5
   PubMed Web of Science ®Google Scholar
• DeMario , MD and Ratain , MJ . 1998 . Oral chemotherapy: rationale and future directions . Journal of Clinical Oncology , 16 : 2557
   PubMed Web of Science ®Google Scholar
• Peppas , NA , Wood , KM and Blanchette , JO . 2004 . Hydrogels for oral delivery of therapeutic proteins . Expert Opinion on Biological Therapy , 4 : 881
   PubMed Web of Science ®Google Scholar
• Peppas , NA , Bures , P , Leobandung , W and Ichikawa , H . 2000 . Hydrogels in pharmaceutical formulations . European Journal of Pharmaceutics and Biopharmaceutics , 50 : 27
   PubMed Web of Science ®Google Scholar
• Peppas , NA , Hilt , JZ , Khademhosseini , A and Langer , R . 2006 . Hydrogels in biology and medicine: from molecular principles to bionanotechnology . Advanced Materials , 18 : 1345
   Web of Science ®Google Scholar
• Zhang , J and Peppas , NA . 2001 . Molecular interactions in poly(methacrylic acid)/poly(N-isopropyl acrylamide) interpenetrating polymer networks . Journal of Applied Polymer Science , 82 : 1077
   Web of Science ®Google Scholar
• Leobandung , W , Ichikawa , H , Fukumori , Y and Peppas , NA . 2002 . Preparation of stable insulin-loaded nanospheres of poly(ethylene glycol) macromers and n-isopropyl acrylamide . Journal of Controlled Release , 80 : 357
   PubMed Web of Science ®Google Scholar
• Bell , CL and Peppas , NA . 1996 . Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol) . Biomaterials , 17 : 1203
   PubMed Web of Science ®Google Scholar
• Mundargi , RC , Patil , SA , Kulkarni , PV , Mallikarjuna , NN and Aminabhavi , TM . 2008 . Sequential interpenetrating polymer network hydrogel microspheres of poly(methacrylic acid) and poly(vinyl alcohol) for oral controlled drug delivery to intestine . Journal of Microencapsulation , 25 : 228
   PubMed Web of Science ®Google Scholar
• Peppas , NA and Klier , J . 1991 . Controlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels . Journal of Controlled Release , 16 : 203
   Web of Science ®Google Scholar
• Park , SE , Nho , YC , Lim , YM and Kim , HI . 2003 . Preparation of pH-sensitive poly(vinyl-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogels by gamma ray irradiation and their insulin release behavior . Journal of Applied Polymer Science , 91 : 636
   Web of Science ®Google Scholar
• Peppas , N.A. 2009 . “ Poly(2-hydroxy ethyl methacrylate) ” . In Polymer data handbook , 2nd ed. , Edited by: Mark , J.E. New York : Oxford University Press .
   Google Scholar
• Papa , V , Pezzino , V , Costantino , A , Belfiore , A , Giuffrida , D Frittitta , L . 1990 . Elevated insulin receptor content in human breast cancer . Journal of Clinical Investigation , 86 : 1503
   PubMed Web of Science ®Google Scholar
• Frasca , F , Pandini , G , Scalia , P , Sciacca , L , Mineo , R Costantino , A . 1999 . Insulin receptor Isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells . Molecular and Cellular Biology , 19 : 3278
   PubMed Web of Science ®Google Scholar
• Chiu , HC , Hsiue , GH , Lee , YP and Huang , LW . 1999 . Synthesis and characterization of pH-sensitive dextran hydrogels as potential colon-specific drug delivery system . Journal of Biomaterials Science, Polymer Edition , 10 : 591
   PubMed Web of Science ®Google Scholar
• Evans , DF , Pye , G , Bramley , R , Clark , AG , Dyson , TJ and Hardcastle , JD . 1988 . Measurement of gastrointestinal pH profiles in normal ambulant human subjects . Gut , 29 : 1035
   PubMed Web of Science ®Google Scholar
• Chourasia , MK and Jain , SK . 2004 . Polysaccharides for colon targeted drug delivery . Drug Delivery , 11 : 129
   PubMed Web of Science ®Google Scholar
• Tsukita , S and Furuse , M . 1999 . Occludin and claudins in tight junctions: leading or supporting players? . Trends in Cell Biology , 9 : 268
   PubMed Web of Science ®Google Scholar
• Fasano , A and Nataro , JP . 2004 . Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins . Advanced Drug Delivery Reviews , 56 : 795
   PubMed Web of Science ®Google Scholar
• Foss , AC and Peppas , NA . 2004 . Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with caco-2 cultures . European Journal of Pharmaceutics and Biopharmaceutics , 57 : 447
   PubMed Web of Science ®Google Scholar
• Ichikawa , H and Peppas , NA . 2003 . Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers . Journal of Biomedical Materials Research. Part A , 67A : 609
   Web of Science ®Google Scholar
• Blanchette , J , Kavimandan , N and Peppas , NA . 2004 . Biomedicine & Pharmacotherapy , 58 : 142
   PubMed Web of Science ®Google Scholar
• Bast , RC , Kufe , DW , Pollock , RE , Weichselbaum , RR , Holland , JF and Frei , E . 2000 . Cancer medicine e.5 , Hamilton : BC Decker .
   Google Scholar
• Delie , F and Rubas , W . 1997 . A human colon cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model . Critical Reviews in Therapeutic Drug Carrier Systems , 14 : 221
   PubMed Web of Science ®Google Scholar
• Behrens , I and Kissel , T . 2003 . Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers . European Journal of Pharmaceutical Science , 19 : 433
   PubMed Web of Science ®Google Scholar
• Hilgendorf , C , Spahn-Langguth , H , Regårdh , CG , Lipka , E , Amidon , GL and Langguth , P . 2000 . Caco-2 versus caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport . Journal of Pharmaceutical Sciences , 89 : 63
   PubMed Web of Science ®Google Scholar
• Schoener CA, Hutson HN, Peppas NA. pH-Responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics. Journal of Biomedical Materials Research Part A. 2012.
   Google Scholar
• Schoener CA, Carillo-Conde B, Peppas NA. An inulin and doxorubicin conjugate for improving cancer therapy. Journal of Drug Delivery Science and Technology. 2012.
   Google Scholar
• Torres-Lugo , M , García , M , Record , R and Peppas , NA . 2002 . pH-Sensitive hydrogels as gastrointestinal tract absorption enhancers: transport mechanisms of salmon calcitonin and other model molecules using the Caco-2 cell model . Biotechnology Progress , 18 : 612
   PubMed Web of Science ®Google Scholar
• Lopez , JE and Peppas , NA . 2004 . Cellular evaluation of insulin transmucosal delivery . Journal of Biomaterials Science, Polymer Edition , 15 : 385
   PubMed Web of Science ®Google Scholar
• Torres-Lugo , M , Garcia , M , Record , R and Peppas , NA . 2002 . Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins . Journal of Controlled Release , 80 : 197
   PubMed Web of Science ®Google Scholar
• Goto , T , Morishita , M , Kavimandan , N , Takayama , K and Peppas , NA . 2006 . Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats . Journal of Pharmaceutical Sciences , 95 : 462
   PubMed Web of Science ®Google Scholar
• Verraest , DL , Peters , JA , Batelaan , JG and van Bekkum , H . 1995 . Carboxymethylation of inulin . Carbohydrate Research , 271 : 101
   PubMed Web of Science ®Google Scholar
• Blanchette , J and Peppas , NA . 2005 . Oral chemotherapeutic delivery: design and cellular response . Annals of Biomedical Engineering , 33 : 142
   PubMed Web of Science ®Google Scholar
• Wood , KM , Stone , GM and Peppas , NA . 2008 . Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery . Biomacromolecules , 9 : 1293
   PubMed Web of Science ®Google Scholar
• Carr , DA and Peppas , NA . 2010 . Assessment of poly(methacrylic acid-co-N-vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco-2 and HT29-MTX cell lines . Journal of Biomedical Materials Research. Part A , 92A : 504
   Web of Science ®Google Scholar
• Klier , J , Scranton , AB and Peppas , NA . 1990 . Self-associating networks of poly(methacrylic acid-g-ethylene glycol) . Macromolecules , 23 : 4944
   Web of Science ®Google Scholar
• Robinson , DN and Peppas , NA . 2002 . Preparation and characterization of pH-responsive poly(methacrylic acid-g-ethylene glycol) nanospheres . Macromolecules , 35 : 3668
   Web of Science ®Google Scholar
• Sporn , MB . 1996 . The war on cancer . Lancet , 347 : 1377
   PubMed Web of Science ®Google Scholar
• Phillips , MR and Peppas , NA . 2009 . Hydrogels modified with carbohydrates for oral protein delivery . Transactions of Annual Biomaterials Meeting , 33 : 267
   Google Scholar
• Howard , DH , Kauh , JK and Lipscomb , J . 2010 . The value of new chemotherapeutic agents for metastatic colorectal cancer . Archives of Internal Medicine , 170 : 537
   PubMed Web of Science ®Google Scholar
• Gilman , A . 1963 . The initial clinical trial of nitrogen mustard . American Journal of Surgery , 105 : 574
   PubMed Web of Science ®Google Scholar
• Wardman , P . 2007 . Chemical radiosensitizers for use in radiotherapy . Clinical Oncology , 19 : 397
   PubMed Web of Science ®Google Scholar
• McKinnell , RG , Parchment , RE , Perantoni , AO , Damjanov , I and Pierce , GB . 2006 . The biological basis of cancer , New York , NY : Cambridge University Press .
   Google Scholar
• Madsen , F and Peppas , NA . 1999 . Complexation graft copolymer networks: swelling properties, calcium binding and proteolytic enzyme inhibition . Biomaterials , 20 : 1701
   PubMed Web of Science ®Google Scholar
• Rappeneau , S , Baeza-Squiban , A , Jeulin , C and Marano , F . 2000 . Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human epithelial cells in vitro . Toxicological Science , 54 : 212
   PubMed Web of Science ®Google Scholar
• Dalmark , M and Storm , HH . 1981 . A fickian diffusion transport process with features of transport catalysis. Doxorubicin transport in human red blood cells . The Journal of General Physiology , 78 : 349
   PubMed Web of Science ®Google Scholar
• Gottesman , MM . 2002 . Mechanisms of cancer drug resistance . Annual Review of Medicine , 53 : 615
   PubMed Web of Science ®Google Scholar
• Dordal , MS , Winter , JN and Atkinson , AJ . 1992 . Kinetic analysis of P-glycoprotein-mediated doxorubicin efflux . Journal of Pharmacology and Experimental Therapeutics , 263 : 762
   PubMed Web of Science ®Google Scholar
• Seiwert , TY , Salama , JK and Vokes , EE . 2007 . The concurrent chemoradiation paradigm—general principles . Nature Clinical Practice Oncology , 4 : 86
   PubMedGoogle Scholar