229
Views
6
CrossRef citations to date
0
Altmetric
VITAMIN D DEFICIENCY AND ANDROGEN EXCESS EFFECT ON SMALL CEREBRAL ARTERIOLES IN FEMALE RATS

Vitamin D deficiency and androgen excess result eutrophic remodeling and reduced myogenic adaptation in small cerebral arterioles in female rats

, , , , , , , , , , & show all
Pages 529-534 | Received 13 Jun 2018, Accepted 26 Nov 2018, Published online: 09 Jan 2019

References

  • Munzker J, Hofer D, Trummer C, et al. Testosterone to dihydrotestosterone ratio as a new biomarker for an adverse metabolic phenotype in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2015;100:653–660.
  • Mishra S, Das AK, Das S. Hypovitaminosis D and associated cardiometabolic risk in women with PCOS. J Clin Diagn Res. 2016;10:BC01–BC04.
  • Shi D, Dyck MK, Uwiera RRE, et al. A unique rodent model of cardiometabolic risk associated with the metabolic syndrome and polycystic ovary syndrome. Endocrinology. 2009;150:4425–4436.
  • Cai JJ, et al. Androgen actions on endothelium functions and cardiovascular diseases. J Geriatr Cardiol. 2016;13:183–196.
  • Kim SM, Lutsey PL, Michos ED. Vitamin D and cardiovascular disease: can novel measures of vitamin D status improve risk prediction and address the vitamin D racial paradox? Curr Cardiovasc Risk Rep. 2017;11:1–15.
  • Enkhjargal B , Malaguit JH, Wing M, et al.Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats. J Cereb Blood Flow Metab. 2017;271678X17726287
  • Kotsa K, Yavropoulou MP, Anastasiou O, et al. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril. 2009;92:1053–1058.
  • Rondanelli M, Perna S, Faliva M, et al. Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Arch Gynecol Obstet. 2014;290:1079–1092.
  • Masszi G, Benko R, Csibi N, et al. Endothelial relaxation mechanisms and nitrative stress are partly restored by vitamin D3 therapy in a rat model of polycystic ovary syndrome. Life Sci. 2013;93:133–138.
  • Sara L, Nadasy GL, Antal P, et al. Pharmacological reactivity of resistance vessels in a rat PCOS model – vascular effects of parallel vitamin D(3) treatment. Gynecol Endocrinol. 2012;28:961–964.
  • Ruland S, Aiyagari V. Cerebral autoregulation and blood pressure lowering. Hypertension 2007;49:977–978.
  • Castro P, Azevedo E, Serrador J, et al. Hemorrhagic transformation and cerebral edema in acute ischemic stroke: link to cerebral autoregulation. J Neurol Sci. 2017;372:256–261.
  • Renna NF, de Las Heras N, Miatello RM. Pathophysiology of vascular remodeling in hypertension. Int J Hypertens. 2013;2013:808353.
  • Mulvany MJ. Small artery remodelling in hypertension. Basic Clin Pharmacol Toxicol. 2012;110:49–55.
  • Rizzoni D, De Ciuceis C, Porteri E, et al. Structural alterations in small resistance arteries in obesity. Basic Clin Pharmacol Toxicol. 2012;110:56–62.
  • Mulvany MJ. Abnormalities of the resistance vasculature in hypertension: correction by vasodilator therapy. Pharmacol Rep. 2005;57; 144–150.
  • Jacobsen JC, Hornbech MS, Holstein-Rathlou NH. Significance of microvascular remodelling for the vascular flow reserve in hypertension. Interface Focus. 2011;1:117–131.
  • Feihl F, Liaudet L, Waeber B. The macrocirculation and microcirculation of hypertension. Curr Hypertens Rep. 2009;11:182–189.
  • Raignault A, Bolduc V, Lesage F, et al. Pulse pressure-dependent cerebrovascular eNOS regulation in mice. J Cereb Blood Flow Metab. 2017;37:413–424.
  • Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab. 2008;7:476–484.
  • Horvath B, Lenzser G, Benyo B, et al. Hypersensitivity to thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats. PLoS One 2010;5:e14477.
  • Reinhard M, Wehrle-Wieland E, Grabiak D, et al. Oscillatory cerebral hemodynamics-the macro- vs. microvascular level. J Neurol Sci. 2006;250:103–109.
  • Hamner JW, Cohen MA, Mukai S, et al. Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations. J Physiol. 2004;559:965–973.
  • Wang L, Maldonado L, Beecham GW, et al. DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient. Neurol Genet. 2016;2:e72.
  • Zanatta L, Goulart PB, Gonçalves R, et al. 1alpha,25-dihydroxyvitamin D(3) mechanism of action: modulation of L-type calcium channels leading to calcium uptake and intermediate filament phosphorylation in cerebral cortex of young rats. Biochim Biophys Acta. 2012;1823:1708–1719.
  • Zhang X, Song Z, Guo Y, et al. The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats. Mol Cell Biochem. 2015;399:155–165.
  • Gezen-Ak D, Dursun E, Yilmazer S. The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons. PLoS One. 2011;6:e17553.
  • Ogiwara K, Ohya S, Suzuki Y, et al. Up-regulation of the voltage-gated KV2.1 K(+) channel in the renal arterial myocytes of dahl salt-sensitive hypertensive rats. Biol Pharm Bull. 2017;40:1468–1474.
  • Tharp DL, Ivey JR, Shaw RL, et al. Ovariectomy increases L-type Ca(2+) channel activity in porcine coronary smooth muscle. Menopause. 2014;21:661–668.
  • Maddali KK, Korzick DH, Tharp DL, et al. PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2. J Biol Chem. 2005;280:43024–43029.
  • Zhao X, Zhao M, Amin-Hanjani S, et al. Wall shear stress in major cerebral arteries as a function of age and gender-a study of 301 healthy volunteers. J Neuroimaging. 2015;25:403–407.
  • Palm-Meinders IH, Box FMA, de Craen AJM, et al. Diastolic wall shear stress in the internal carotid artery is associated with different cardiovascular risk factors than systolic wall shear stress. Cerebrovasc Dis. 2009;28:185–190.
  • Ferrara LA, Mancini M, Iannuzzi R, et al. Carotid diameter and blood flow velocities in cerebral circulation in hypertensive patients. Stroke. 1995;26:418–421.
  • Balden R, Selvamani A, Sohrabji F. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology. 2012;153:2420–2435.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.