Oral dehydroepiandrosterone restores ß-endorphin response to OGTT in early and late postmenopause

References

• Orentreich N, Brind JL, Rizer RL, et al. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 1984;59:551–555.
   PubMed Web of Science ®Google Scholar
• Liu CH, Laughlin GA, Fischer UG, et al. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20-desmolase enzymatic activity. J Clin Endocrinol Metab. 1990;71:900–906.
   PubMed Web of Science ®Google Scholar
• Couch RM, Muller J, Winter JS. Regulation of the activities of 17-hydroxylase and 17,20-desmolase in the human adrenal cortex: kinetic analysis and inhibition by endogenous steroids. J Clin Endocrinol Metab. 1986;63:613–618.
   PubMed Web of Science ®Google Scholar
• Mortola JF, Yen SS. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab. 1990;71:696–704.
   PubMed Web of Science ®Google Scholar
• Morales AJ, Nolan JJ, Nelson JC, et al. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. 1994;78:1360–1367.
   PubMed Web of Science ®Google Scholar
• Panjari M, Davis SR. DHEA for postmenopausal women: a review of the evidence. Maturitas. 2010;66:172–179.
   PubMed Web of Science ®Google Scholar
• Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004;292:2243–2248.
   PubMed Web of Science ®Google Scholar
• Dhatariya K, Bigelow ML, Nair KS. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes. 2005;54:765–769.
   PubMed Web of Science ®Google Scholar
• Berr C, Lafont S, Debuire B, et al. Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. Proc Natl Acad Sci USA. 1996;93:13410–13415.
   PubMed Web of Science ®Google Scholar
• Stomati M, Bersi C, Bernardi F, et al. Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre- and postmenopausal women. Gynecol Endocrinol. 1998;12:35–40.
   PubMed Web of Science ®Google Scholar
• Labrie F. Intracrinology. Mol Cell Endocrinol. 1991;78:C113–C118.
   PubMed Web of Science ®Google Scholar
• Flynn MA, Weaver-Osterholtz D, Sharpe-Timms KL, et al. Dehydroepiandrosterone replacement in aging humans. J Clin Endocrinol Metab. 1999;84:1527–1533.
   PubMed Web of Science ®Google Scholar
• Genazzani AD, Stomati M, Strucchi C, et al. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril. 2001;76:241–248.
   PubMed Web of Science ®Google Scholar
• Stomati M, Monteleone P, Casarosa E, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol. 2000;14:342–363.
   PubMed Web of Science ®Google Scholar
• Stomati M, Rubino S, Spinetti A, et al. Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women. Gynecol Endocrinol. 1999;13:15–25.
   PubMed Web of Science ®Google Scholar
• Giugliano D, Torella R, Lefebvre PJ, et al. Opioid peptides and metabolic regulation. Diabetologia. 1998;31:3–15.
   Google Scholar
• Genazzani AR, Petraglia F, Facchinetti F, et al. Steroid replacement treatment increases beta-endorphin and beta-lipotropin plasma levels in postmenopausal women. Gynecol Obstet Invest. 1988;26:153–159.
   PubMed Web of Science ®Google Scholar
• Genazzani AR, Stomati M, Valentino V, et al. Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Climacteric. 2011;14:661–668.
   PubMed Web of Science ®Google Scholar
• Madeira IR, Carvalho CN, Gazolla FM, et al. Cut-off point for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established from Receiver Operating Characteristic (ROC) curve in the detection of metabolic syndrome in overweight pre-pubertal children. Arq Bras Endocrinol Metabol. 2008;52:1466–1473.
   PubMedGoogle Scholar
• Pluchino N, Ninni F, Stomati M, et al. One-year therapy with 10mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu. Maturitas. 2008;59:293–303.
   PubMed Web of Science ®Google Scholar
• Genazzani AR, Pluchino N, Begliuomini S, et al. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol. 2006;22:627–635.
   PubMed Web of Science ®Google Scholar
• Advis JP, McCann SM, Negro-Vilar A. Evidence that catecholaminergic and peptidergic (luteinizing hormone-releasing hormone) neurons in suprachiasmatic-medial preoptic, medial basal hypothalamus and median eminence are involved in estrogen-negative feedback. Endocrinology. 1980;107:892–901.
   PubMed Web of Science ®Google Scholar
• Piva F, Limonta P, Dondi D, et al. Effects of steroids on the brain opioid system. J Steroid Biochem Mol Biol. 1995;53:343–348.
   PubMed Web of Science ®Google Scholar
• Labrie F, Martel C, Balser J. Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary? Menopause. 2011;18:30–43.
   PubMed Web of Science ®Google Scholar
• Lightman SL, Jacobs HS, Maguire AK, et al. Climacteric flushing: clinical and endocrine response to infusion of naloxone. Br J Obstet Gynaecol. 1981;88:919–924.
   PubMedGoogle Scholar