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Original

Metformin reduces abortion in pregnant women with polycystic ovary syndrome

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Pages 680-684 | Received 17 Jul 2006, Accepted 11 Sep 2006, Published online: 07 Jul 2009

References

  • Asuncion M, Calvo R M, San Millan J L, Sancho J, Avila S, Escobar-Morreale H F. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 2000; 85: 2434–2438
  • Knochenhauer E S, Key T J, Kahsar-Miller M, Waggoner W, Boots L R, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 1998; 83: 3078–3082
  • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41–47
  • Balen A H, Tan S L, MacDougall J, Jacobs H S. Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993; 8: 959–964
  • Gray R H, Wu L Y. Subfertility and risk of spontaneous abortion. Am J Public Health 2000; 90: 1452–1454
  • Regan L, Owen E J, Jacobs H S. Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet 1990; 336: 1141–1144
  • Watson H, Kiddy D S, Hamilton-Fairley D, Scanlon M J, Barnard C, Collins W P, Bonney R C, Franks S. Hypersecretion of luteinizing hormone and ovarian steroids in women with recurrent early miscarriage. Hum Reprod 1993; 8: 829–833
  • Homburg R, Armar N A, Eshel A, Adams J, Jacobs H S. Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome. Br Med J 1988; 297: 1024–1026
  • Clifford K, Rai R, Watson H, Franks S, Regan L. Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. Br Med J 1996; 312: 1508–1511
  • Fedorcsak P, Storeng R, Dale P O, Tanbo T, Abyholm T. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000; 79: 43–48
  • Okon M A, Laird S M, Tuckerman E M, Li T C. Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertil Steril 1998; 69: 682–690
  • Tulppala M, Stenman U H, Cacciatore B, Ylikorkala O. Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol 1993; 100: 348–352
  • Glueck C J, Wang P, Fontaine R, Tracy T, Sieve-Smith L. Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome. Metabolism 1999; 48: 511–519
  • Glueck C J, Kupferminc M J, Fontaine R N, Wang P, Weksler B B, Eldor A. Genetic hypofibrinolysis in complicated pregnancies. Obstet Gynecol 2001; 97: 44–48
  • Jakubowicz D J, Iuorno M J, Jakubowicz S, Roberts K A, Nestler J E. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87: 524–529
  • Palomba S, Russo T, Orio F, Jr, Falbo A, Manguso F, Cascella T, Tolino A, Carmina E, Colao A, Zullo F. Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome. Hum Reprod 2006; 21: 457–465
  • Coetzee E J, Jackson W P. Oral hypoglycaemics in the first trimester and fetal outcome. S Afr Med J 1984; 65: 635–637
  • Sarlis N J, Weil S J, Nelson L M. Administration of metformin to a diabetic woman with extreme hyperandrogenemia of nontumoral origin: management of infertility and prevention of inadvertent masculinization of a female fetus. J Clin Endocrinol Metab 1999; 84: 1510–1512
  • Jakubowicz D J, Seppala M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, Koistinen R, Nestler J E. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001; 86: 1126–1133
  • Jakubowicz D J, Essah P A, Seppala M, Jakubowicz S, Baillargeon J P, Koistinen R, Nestler J E. Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. J Clin Endocrinol Metab 2004; 89: 833–839
  • Bolton A E, Pockley A G, Clough K J, Mowles E A, Stoker R J, Westwood O M, Chapman M G. Identification of placental protein 14 as an immunosuppressive factor in human reproduction. Lancet 1987; 1: 593–595
  • Okamoto N, Uchida A, Takakura K, Kariya Y, Kanzaki H, Riittinen L, Koistinen R, Seppala M, Mori T. Suppression by human placental protein 14 of natural killer cell activity. Am J Reprod Immunol 1991; 26: 137–142
  • Giudice L C, Mark S P, Irwin J C. Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual–trophoblast interface. J Reprod Immunol 1998; 39: 133–148
  • Jones J I, Gockerman A, Busby W H, Jr, Wright G, Clemmons D R. Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the α5β1 integrin by means of its Arg-Gly-Asp sequence. Proc Natl Acad Sci U S A 1993; 90: 10553–10557
  • Meenakumari K J, Agarwal S, Krishna A, Pandey L K. Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome. Braz J Med Biol Res 2004; 37: 1637–1644
  • Atiomo W U, Bates S A, Condon J E, Shaw S, West J H, Prentice A G. The plasminogen activator system in women with polycystic ovary syndrome. Fertil Steril 1998; 69: 236–241
  • Sampson M, Kong C, Patel A, Unwin R, Jacobs H S. Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI-1) activity in lean women with and without the polycystic ovary syndrome. Clin Endocrinol (Oxf) 1996; 45: 623–629
  • Glueck C J, Wang P, Fontaine R N, Sieve-Smith L, Tracy T, Moore S K. Plasminogen activator inhibitor activity: an independent risk factor for the high miscarriage rate during pregnancy in women with polycystic ovary syndrome. Metabolism 1999; 48: 1589–1595
  • Gris J C, Neveu S, Mares P, Biron C, Hedon B, Schved J F. Plasma fibrinolytic activators and their inhibitors in women suffering from early recurrent abortion of unknown etiology. J Lab Clin Med 1993; 122: 606–615
  • Velazquez E M, Mendoza S G, Wang P, Glueck C J. Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome. Metabolism 1997; 46: 454–457
  • Grant P J. Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab 2003; 29: 6S44–6S52
  • Morin-Papunen L, Rautio K, Ruokonen A, Hedberg P, Puukka M, Tapanainen J S. Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88: 4649–4654
  • Glueck C J, Wang P, Goldenberg N, Sieve L. Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin. Clin Appl Thromb Hemost 2004; 10: 323–334
  • Tarkun I, Arslan B C, Canturk Z, Turemen E, Sahin T, Duman C. Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. J Clin Endocrinol Metab 2004; 89: 5592–5596
  • Kravariti M, Naka K K, Kalantaridou S N, Kazakos N, Katsouras C S, Makrigiannakis A, Paraskevaidis E A, Chrousos G P, Tsatsoulis A, Michalis L K. Predictors of endothelial dysfunction in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005; 90: 5088–5095
  • Diamanti-Kandarakis E, Alexandraki K, Protogerou A, Piperi C, Papamichael C, Aessopos A, Lekakis J, Mavrikakis M. Metformin administration improves endothelial function in women with polycystic ovary syndrome. Eur J Endocrinol 2005; 152: 749–756
  • Diamanti-Kandarakis E, Paterakis T, Alexandraki K, Piperi C, Aessopos A, Katsikis I, Katsilambros N, Kreatsas G, Panidis D. Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. Hum Reprod 2006; 21: 1426–1431
  • Caballero A E, Delgado A, Aguilar-Salinas C A, Herrera A N, Castillo J L, Cabrera T, Gomez-Perez F J, Rull J A. The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial. J Clin Endocrinol Metab 2004; 89: 3943–3948
  • Orio F, Jr, Palomba S, Cascella T, De Simone B, Manguso F, Savastano S, Russo T, Tolino A, Zullo F, Lombardi G, et al. Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab 2005; 90: 6072–6076
  • Turner M J, Walsh J, Byrne K M, Murphy C, Langan H, Farah N. Outcome of clinical pregnancies after ovulation induction using metformin. J Obstet Gynaecol 2006; 26: 233–235
  • Glueck C J, Wang P, Goldenberg N, Sieve-Smith L. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Repord 2002; 17: 2858–2864

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