The role of iron in the pathogenesis of endometriosis

References

• Giudice L C, Tazuke S I, Swiersz L. Status of current research on endometriosis. J Reprod Med 1998; 43(Suppl 3)252–262
   PubMed Web of Science ®Google Scholar
• Nap A W, Groothuis P G, Demir A Y, Evers J L, Dunselman G A. Pathogenesis of endometriosis. Best Pract Res Clin Obstet Gynaecol 2004; 18: 233–244
   PubMed Web of Science ®Google Scholar
• Templeton D M, Liu Y. Genetic regulation of cell function in response to iron overload or chelation. Biochim Biophys Acta 2003; 1619: 113–124
   PubMed Web of Science ®Google Scholar
• Johansson S, Berg L, Hall H, Höglund P. NK cells: elusive players in autoimmunity. Trends Immunol 2005; 26: 613–618
   PubMed Web of Science ®Google Scholar
• Burney R O, Talbi S, Hamilton A E, Vo K C, Nyegaard M, Nezhat C R, Lessey B A, Giudice L C. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology 2007; 148: 3814–3826
   PubMed Web of Science ®Google Scholar
• Kao L C, Germeyer A, Tulac S, Lobo S, Yang J P, Taylor R N, Osteen K, Lessey B A, Giudice L C. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 2003; 144: 2870–2881
   PubMed Web of Science ®Google Scholar
• Dearn S, Rahman M, Lewis A, Ahmed Z, Eggo M C, Ahmed A. Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-α in HEC-1B human endometrial epithelial cell line. Mol Med 2000; 6: 37–49
   PubMed Web of Science ®Google Scholar
• Eyster K M, Boles A L, Brannian J D, Hansen K A. DNA microarray analysis of gene expression markers of endometriosis. Fertil Steril 2002; 77: 38–42
   PubMed Web of Science ®Google Scholar
• Lebovic D I, Baldocchi R A, Mueller M D, Taylor R N. Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses. Fertil Steril 2002; 78: 849–854
   PubMed Web of Science ®Google Scholar
• Arimoto T, Katagiri T, Oda K, Tsunoda T, Yasugi T, Osuga Y, Yoshikawa H, Nishii O, Yano T, Taketani Y, et al. Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. Int J Oncol 2003; 22: 551–560
   PubMed Web of Science ®Google Scholar
• Matsuzaki S, Canis M, Vaurs-Barriere C, Pouly J L, Boespflug-Tanguy O, Penault-Llorca F, Dechelotte P, Dastugue B, Okamura K, Mage G. DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection. Mol Hum Reprod 2004; 10: 719–728
   PubMed Web of Science ®Google Scholar
• Smith S K. Study of the profile of gene expression in the endometrium. J Gynecol Obstet Biol Reprod 2004; 33: 3S15–3S18
   PubMedGoogle Scholar
• Fan Y, Chen B L, Ma X D, Su M Q. Detection of expression of endometriosis-related cytokine and their receptor genes by cDNA microarray technique. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005; 21: 489–492
   PubMedGoogle Scholar
• Matsuzaki S, Canis M, Pouly J L, Dechelotte P, Okamura K, Mage G. The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis. Mol Hum Reprod 2005; 11: 345–349
   PubMed Web of Science ®Google Scholar
• Matsuzaki S, Canis M, Vaurs-Barriere C, Boespflug-Tanguy O, Dastugue B, Mage G. DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection. Fertil Steril 2005; 84(Suppl 2)1180–1190
   PubMedGoogle Scholar
• Kato N, Sasou S, Motoyama T. Expression of hepatocyte nuclear factor-1β (HNF-1β) in clear cell tumors and endometriosis of the ovary. Mod Pathol 2006; 19: 83–89
   PubMed Web of Science ®Google Scholar
• Wu Y, Kajdacsy-Balla A, Strawn E, Basir Z, Halverson G, Jailwala P, Wang Y, Wang X, Ghosh S, Guo S W. Transcriptional characterizations of differences between eutopic and ectopic endometrium. Endocrinology 2006; 147: 232–246
   PubMed Web of Science ®Google Scholar
• Gaetje R, Holtrich U, Engels K, Kourtis K, Cikrit E, Kissler S, Rody A, Karn T, Kaufmann M. Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. Gynecol Endocrinol 2007; 23: 567–573
   PubMed Web of Science ®Google Scholar
• Wren J D, Wu Y, Guo S W. A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium. Hum Reprod 2007; 22: 2093–2102
   PubMed Web of Science ®Google Scholar
• Goumenou A, Panayiotides I, Mahutte N G, Matalliotakis I, Fragouli Y, Arici A. Immunohistochemical expression of p53, MDM2, and p21Waf1 oncoproteins in endometriomas but not adenomyosis. J Soc Gynecol Investig 2005; 12: 263–266
   PubMedGoogle Scholar
• Fauvet R, Poncelet C, Hugol D, Lavaur A, Feldmann G, Daraï E. Expression of apoptosis-related proteins in endometriomas and benign and malignant ovarian tumours. Virchows Arch 2003; 443: 38–43
   PubMed Web of Science ®Google Scholar
• Matsuzaki S, Canis M, Murakami T, Dechelotte P, Bruhat M A, Okamura K. Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis. Fertil Steril 2001; 75: 956–960
   PubMed Web of Science ®Google Scholar
• Lembessis P, Milingos S, Michalas S, Milingos D, Creatsas G, Sourla A, Koutsilieris M. Urokinase-type plasminogen activator and insulin-like growth factor-binding protein 3 mRNA expression in endometriotic lesions and eutopic endometrium: implications for the pathophysiology of endometriosis. Ann N Y Acad Sci 2003; 997: 223–228
   PubMed Web of Science ®Google Scholar
• Khan K N, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Miura S, Sekine I, Ishimaru T. Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis. Acta Obstet Gynecol Scand 2006; 85: 458–466
   PubMed Web of Science ®Google Scholar
• Khan K N, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, Matsuyama T, Ishimaru T. Interleukin-6- and tumour necrosis factor α-mediated expression of hepatocyte growth factor by stromal cells and its involvement in the growth of endometriosis. Hum Reprod 2005; 20: 2715–2723
   PubMed Web of Science ®Google Scholar
• Yoshida S, Harada T, Mitsunari M, Iwabe T, Sakamoto Y, Tsukihara S, Iba Y, Horie S, Terakawa N. Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways. J Clin Endocrinol Metab 2004; 89: 823–832
   PubMed Web of Science ®Google Scholar
• Pritts E A, Zhao D, Ricke E, Waite L, Taylor R N. PPAR-γ decreases endometrial stromal cell transcription and translation of RANTES in vitro. J Clin Endocrinol Metab 2002; 87: 1841–1844
   PubMed Web of Science ®Google Scholar
• Corton C H, Anderson S P, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol 2000; 40: 491–518
   PubMed Web of Science ®Google Scholar
• Hornung D, Waite L L, Ricke E A, Bentzien F, Wallweiner D, Taylor R N. Nuclear peroxisome proliferator-activated receptors have opposing effects on monocyte chemotaxis in endometriosis. J Clin Endocrinol Metab 2001; 86: 3108–3114
   PubMed Web of Science ®Google Scholar
• Aytan H, Caliskan A C, Demirturk F, Aytan P, Koseoglu D R. Peroxisome proliferator-activated receptor-γ agonist rosiglitazone reduces the size of experimental endometriosis in the rat model. Aust N Z J Obstet Gynaecol 2007; 47: 321–325
   PubMed Web of Science ®Google Scholar
• Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 1997; 389: 349–352
   PubMed Web of Science ®Google Scholar
• Wu Y, Starzinski-Powitz A, Guo S W. Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. Reprod Sci 2007; 14: 374–382
   PubMed Web of Science ®Google Scholar
• Murphy A A, Santanam N, Parthasarathy S. Endometriosis: a disease of oxidative stress. Semin Reprod Endocrinol 1998; 16: 263–273
   PubMedGoogle Scholar
• Yoshino O, Osuga Y, Hirota Y, Koga K, Hirata T, Harada M, Morimoto C, Yano T, Nishii O, Tsutsumi O, Taketani Y. Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis. Am J Reprod Immunol 2004; 52: 306–311
   PubMed Web of Science ®Google Scholar
• Schneider H, Rudd C E. CD28 and Grb-2 (but not Gads or Grap) cooperate with Vav1 in the activation of NFAT/AP-1. Biochem Biophys Res Commun 2008; 369: 616–621
   PubMed Web of Science ®Google Scholar
• Konno R, Fujiwara H, Netsu S, Odagiri K, Shimane M, Nomura H, Suzuki M. Gene expression profiling of the rat endometriosis model. Am J Reprod Immunol 2007; 58: 330–343
   PubMed Web of Science ®Google Scholar
• Yankee T M, Solow S A, Draves K D, Clark E A. Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways. J Immunol 2003; 170: 349–355
   PubMed Web of Science ®Google Scholar
• Hever A, Roth R B, Hevezi P, Marin M E, Acosta J A, Acosta H, Rojas J, Herrera R, Grigoriadis D, White E, et al. Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator. Proc Natl Acad Sci U S A 2007; 104: 12451–12456
   PubMed Web of Science ®Google Scholar
• Ulukus M, Arici A. Immunology of endometriosis. Minerva Ginecol 2005; 57: 237–248
   PubMedGoogle Scholar
• Abe Y, Van Eden M, Gatanaga M, Wang F I, Brightbill H D, Granger G A, Gatanaga T. The role of lymphotoxin in the IL-2-driven differentiation of human lymphokine-activated T-killer (T-LAK) cells in vitro. Lymphokine Cytokine Res 1993; 12: 279–284
   PubMedGoogle Scholar
• Abe Y, Matsumoto S, Kito K, Ueda N. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J Biol Chem 2000; 275: 21525–21531
   PubMed Web of Science ®Google Scholar
• Ishii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 2000; 39: 41–82
   PubMed Web of Science ®Google Scholar
• Brown S L, Jala V R, Raghuwanshi S K, Nasser M W, Haribabu B, Richardson R M. Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. J Immunol 2006; 177: 3242–3249
   PubMed Web of Science ®Google Scholar
• Simoni J, Simoni G, Lox C D, McGunegle D E, Feola M. Cytokines and PAF release from human monocytes and macrophages: effect of hemoglobin and contaminants. Artif Cells Blood Substit Immobil Biotechnol 1994; 22: 525–534
   PubMed Web of Science ®Google Scholar
• Kato N, Sasou S, Motoyama T. Expression of hepatocyte nuclear factor-1β (HNF-1β) in clear cell tumors and endometriosis of the ovary. Mod Pathol 2006; 19: 83–89
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Tsuda H, Aida S, Shimazaki H, Tamai S, Matsubara O. Immunohistochemical detection of hepatocyte nuclear factor 1β in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium. Hum Pathol 2007; 38: 1074–1080
   PubMed Web of Science ®Google Scholar
• González-Ramos R, Donnez J, Defrère S, Leclercq I, Squifflet J, Lousse J C, Van Langendonckt A. Nuclear factor-κB is constitutively activated in peritoneal endometriosis. Mol Hum Reprod 2007; 13: 503–509
   PubMed Web of Science ®Google Scholar
• Yamauchi N, Harada T, Taniguchi F, Yoshida S, Iwabe T, Terakawa N. Tumor necrosis factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-κB and mitogen-activated protein kinase pathways. Fertil Steril 2004; 82(Suppl 3)1023–1028
   PubMed Web of Science ®Google Scholar
• Wu M H, Chen K F, Lin S C, Lgu C W, Tsai S J. Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1α. Am J Pathol 2007; 170: 590–598
   PubMed Web of Science ®Google Scholar
• Gurates B, Bulun S E. Endometriosis: the ultimate hormonal disease. Semin Reprod Med 2003; 21: 125–134
   PubMed Web of Science ®Google Scholar
• Taylor R N, Lebovic D I, Hornung D, Mueller M D. Endocrine and paracrine regulation of endometrial angiogenesis. Ann N Y Acad Sci 2001; 943: 109–121
   PubMed Web of Science ®Google Scholar
• Hayrabedyan S, Kyurkchiev S, Kehayov I. FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis. J Reprod Immunol 2005; 67: 87–101
   PubMed Web of Science ®Google Scholar
• Komiyama S, Aoki D, Komiyama M, Nozawa S. Local activation of TGF-β1 at endometriosis sites. J Reprod Med 2007; 52: 306–312
   PubMed Web of Science ®Google Scholar
• Tamburro S, Canis M, Albuisson E, Dechelotte P, Darcha C, Mage G. Expression of transforming growth factor β1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants. Fertil Steril 2003; 80: 1131–1136
   PubMed Web of Science ®Google Scholar
• Schall T J, Bacon K, Toy K J, Goeddel D V. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990; 347: 669–671
   PubMed Web of Science ®Google Scholar
• Bersinger N A, von Roten S, Wunder D M, Raio L, Dreher E, Mueller M D. PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis. Am J Obstet Gynecol 2006; 195: 103–108
   PubMed Web of Science ®Google Scholar
• Lebovic D I, Chao V A, Taylor R N. Peritoneal macrophages induce RANTES (regulated on activation, normal T cell expressed and secreted) chemokine gene transcription in endometrial stromal cells. J Clin Endocrinol Metab 2004; 89: 1397–1401
   PubMed Web of Science ®Google Scholar
• Wester L, Michaelsson E, Holmdahl R, Olofsson T, Åkerström B. Receptor for α1-microglobulin on T lymphocytes: inhibition of antigen-induced interleukin-2 production. Scand J Immunol 1998; 48: 1–7
   PubMed Web of Science ®Google Scholar
• Santin M, Cannas M. Collagen-bound α1-microglobulin in normal and healed tissues and its effect on immunocompetent cells. Scand J Immunol 1999; 50: 289–295
   PubMed Web of Science ®Google Scholar
• Subbarao K, Jala V R, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng M T, Haribabu B. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol 2004; 24: 369–375
   PubMed Web of Science ®Google Scholar
• Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B-4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders. J Exp Med 2000; 192: 421–431
   PubMed Web of Science ®Google Scholar
• Konno R, Fujiwara H, Suzuki M. Effectiveness of leukotriene receptor antagonists for dysmenorrhea of endometriosis. Fam Med 2004; 36: 8–9
   PubMed Web of Science ®Google Scholar
• Ihara T, Uchiide I, Sugamata M. Light and electron microscopic evaluation of antileukotriene therapy for experimental rat endometriosis. Fertil Steril 2004; 81(Suppl 1)819–823
   PubMed Web of Science ®Google Scholar
• Osteen K G, Yeaman G R, Bruner-Tran K L. Matrix metalloproteinases and endometriosis. Semin Reprod Med 2003; 21: 155–164
   PubMed Web of Science ®Google Scholar
• Zhou H E, Nothnick W B. The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis. Front Biosci 2005; 10: 569–575
   PubMed Web of Science ®Google Scholar
• Bruse C, Guan Y, Carlberg M, Carlström K, Bergqvist A. Basal release of urokinase plasminogen activator, plasminogen activator inhibitor-1, and soluble plasminogen activator receptor from separated and cultured endometriotic and endometrial stromal and epithelial cells. Fertil Steril 2005; 83(Suppl 1)1155–1160
   PubMedGoogle Scholar
• Froelich C J, Zhang X, Turbov J, Hudig D, Winkler U, Hanna W L. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol 1993; 151: 7161–7171
   PubMed Web of Science ®Google Scholar
• Fujimoto J, Ichigo S, Hori M, Tamaya T. Expression of E-cadherin, α- and β-catenin mRNAs in ovarian endometriosis. Eur J Obstet Gynecol Reprod Biol 1996; 67: 179–183
   PubMed Web of Science ®Google Scholar
• Clarke C J, Truong T G, Hannun Y A. Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem 2007; 282: 1384–1396
   PubMed Web of Science ®Google Scholar
• Pettersen C A, Adler K B. Airways inflammation and COPD: epithelial–neutrophil interactions. Chest 2002; 121(Suppl 5)S142–S150
   Web of Science ®Google Scholar
• Barrier B F, Sharpe-Timms K L. Expression of soluble adhesion molecules in sera of women with stage III and IV endometriosis. J Soc Gynecol Investig 2002; 9: 98–101
   PubMedGoogle Scholar
• Kyama C M, Overbergh L, Mihalyi A, Meuleman C, Mwenda J M, Mathieu C, D'Hooghe T M. Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis. Fertil Steril 2008; 89: 301–310
   PubMed Web of Science ®Google Scholar
• Meinhardt U, Mullis P E. The aromatase cytochrome P-450 and its clinical impact. Horm Res 2002; 57: 145–152
   PubMed Web of Science ®Google Scholar
• Barros R P, Machado U F, Warner M, Gustafsson J A. Muscle GLUT4 regulation by estrogen receptors ERβ and ERα. Proc Natl Acad Sci U S A 2006; 103: 1605–1608
   PubMed Web of Science ®Google Scholar
• Slater M, Quagliotto G, Cooper M, Murphy C R. Endometriotic cells exhibit metaplastic change and oxidative DNA damage as well as decreased function, compared to normal endometrium. J Mol Histol 2005; 36: 257–263
   PubMed Web of Science ®Google Scholar
• Poppenberger B, Berthiller F, Lucyshyn D, Sieberer T, Schuhmacher R, Krska R, Kuchler K, Glössl J, Luschnig C, Adam G. Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. J Biol Chem 2003; 278: 47905–47914
   PubMed Web of Science ®Google Scholar
• Gagne J F, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62: 608–617
   PubMed Web of Science ®Google Scholar
• Mann G E, Niehueser-Saran J, Watson A, Gao L, Ishii T, de Winter P, Siow R C. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao 2007; 59: 117–127
   PubMedGoogle Scholar
• Pennington J D, Jacobs K M, Sun L, Bar-Sela G, Mishra M, Gius D. Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy. Curr Pharm Des 2007; 13: 3368–3377
   PubMed Web of Science ®Google Scholar
• Thome J, Gsell W, Rösler M, Kornhuber J, Frölich L, Hashimoto E, Zielke B, Wiesbeck G A, Riederer P. Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease. Life Sci 1997; 60: 13–19
   PubMed Web of Science ®Google Scholar
• Walmer D K, Wrona M A, Hughes C L, Nelson K G. Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. Endocrinology 1992; 131: 1458–1466
   PubMed Web of Science ®Google Scholar
• Newsome A L, Johnson J P, Seipelt R L, Thompson M W. Apolactoferrin inhibits the catalytic domain of matrix metalloproteinase-2 by zinc chelation. Biochem Cell Biol 2007; 85: 563–572
   PubMed Web of Science ®Google Scholar
• Madsen M, Møller H J, Nielsen M J, Jacobsen C, Graversen J H, van den Berg T, Moestrup S K. Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem 2004; 279: 51561–51567
   PubMed Web of Science ®Google Scholar
• Zuwała-Jagiełło J. Haemoglobin scavenger receptor: function in relation to disease. Acta Biochim Pol 2006; 53: 257–268
   PubMed Web of Science ®Google Scholar
• Fornace A J, Jr. Mammalian genes induced by radiation; activation of genes associated with growth control. Annu Rev Genet 1992; 26: 507–526
   PubMed Web of Science ®Google Scholar
• Jackson L W, Schisterman E F, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Hum Reprod 2005; 20: 2014–2020
   PubMed Web of Science ®Google Scholar
• Sheikh M S, Fernandez-Salas E, Yu M, Hussain A, Dinman J D, Peltz S W, Huang Y, Fornace A J, Jr. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J Biol Chem 1999; 274: 16487–16493
   PubMed Web of Science ®Google Scholar
• Zhao Z Z, Nyholt D R, Le L, Martin N G, James M R, Treloar S A, Montgomery G W. KRAS variation and risk of endometriosis. Mol Hum Reprod 2006; 12: 671–676
   PubMed Web of Science ®Google Scholar
• Dinulescu D M, Ince T A, Quade B J, Shafer S A, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 2005; 11: 63–70
   PubMed Web of Science ®Google Scholar
• Martinez O, Goud B. Rab proteins. Biochim Biophys Acta 1998; 1404: 101–112
   PubMed Web of Science ®Google Scholar
• Echard A, Jollivet F, Martinez O, Lacapère J J, Rousselet A, Janoueix-Lerosey I, Goud B. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science 1998; 279: 580–585
   PubMed Web of Science ®Google Scholar
• Lee A S. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 2007; 67: 3496–3499
   PubMed Web of Science ®Google Scholar
• Pan M, Cederbaum A I, Zhang Y L, Ginsberg H N, Williams K J, Fisher E A. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest 2004; 113: 1277–1287
   PubMed Web of Science ®Google Scholar
• Courtois F, Suc I, Garofalo C, Ledoux M, Seidman E, Levy E. Iron-ascorbate alters the efficiency of Caco-2 cells to assemble and secrete lipoproteins. Am J Physiol Gastrointest Liver Physiol 2000; 279: G12–G19
   PubMed Web of Science ®Google Scholar
• Harada T, Iwabe T, Terakawa N. Role of cytokines in endometriosis. Fertil Steril 2001; 76: 1–10
   PubMed Web of Science ®Google Scholar
• Pol O, Alameda F, Puig M M. Inflammation enhances μ-opioid receptor transcription and expression in mice intestine. Mol Pharmacol 2001; 60: 894–899
   PubMed Web of Science ®Google Scholar
• Matsuzaki S, Canis M, Pouly J L, Botchorishvili R, Déchelotte P J, Mage G. Both GnRH agonist and continuous oral progestin treatments reduce the expression of the tyrosine kinase receptor B and μ-opioid receptor in deep infiltrating endometriosis. Hum Reprod 2007; 22: 124–128
   PubMed Web of Science ®Google Scholar
• Zurawski G, Benedik M, Kamb B, Araens J, Zurawski S, Lee F. Activation of mouse T-helper cells induces abundant proenkephalin mRNA synthesis. Science 1986; 232: 772–775
   PubMed Web of Science ®Google Scholar
• Kumar B, Koul S, Khandrika L, Meacham R B, Koul H K. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 2008; 68: 1777–1785
   PubMed Web of Science ®Google Scholar
• Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett 2005; 157: 175–188
   PubMed Web of Science ®Google Scholar
• Ferrándiz M L, Devesa I. Inducers of heme oxygenase-1. Curr Pharm Des 2008; 14: 473–486
   PubMed Web of Science ®Google Scholar
• Ryter S W, Tyrrell R M. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 2000; 28: 289–309
   PubMed Web of Science ®Google Scholar
• Kato J, Kobune M, Ohkubo S, Fujikawa K, Tanaka M, Takimoto R, Takada K, Takahari D, Kawano Y, Kohgo Y, et al. Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation. Exp Hematol 2007; 35: 879–887
   PubMed Web of Science ®Google Scholar
• Yoshiki N, Kubota T, Aso T. Identification of heme oxygenase in human endometrium. J Clin Endocrinol Metab 2001; 86: 5033–5038
   PubMed Web of Science ®Google Scholar
• Ryter S W, Si M, Lai C C, Su C Y. Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron. Am J Physiol Heart Circ Physiol 2000; 279: H2889–H2897
   PubMed Web of Science ®Google Scholar
• Inguaggiato P, Gonzalez-Michaca L, Croatt A J, Haggard J J, Alam J, Nath K A. Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney Int 2001; 60: 2181–2191
   PubMed Web of Science ®Google Scholar
• Yamaguchi K, Mandai M, Toyokuni S, Hamanishi J, Higuchi T, Takakura K, Fujii S. Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res 2008; 14: 32–40
   PubMed Web of Science ®Google Scholar
• Kim B H, Jun Y C, Jin J K, Kim J I, Kim N H, Leibold E A, Connor J R, Choi E K, Carp R I, Kim Y S. Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neurosci Lett 2007; 422: 158–163
   PubMed Web of Science ®Google Scholar
• Tacchini L, Fusar-Poli D, Bernelli-Zazzera A. Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochem Pharmacol 2002; 63: 139–148
   PubMed Web of Science ®Google Scholar
• Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci 2004; 1012: 1–13
   PubMed Web of Science ®Google Scholar
• Le N T, Richardson D R. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 2002; 1603: 31–46
   PubMed Web of Science ®Google Scholar
• Kalyanaraman B. Iron signaling and oxidant damage. Cardiovasc Toxicol 2007; 7: 92–94
   PubMed Web of Science ®Google Scholar
• Nappi A J, Vass E. Iron, metalloenzymes and cytotoxic reactions. Cell Mol Biol (Noisy-le-grand) 2000; 46: 637–647
   PubMed Web of Science ®Google Scholar
• Wagener F A, Volk H D, Willis D, Abraham N G, Soares M P, Adema G J, Figdor C G. Different faces of the heme–heme oxygenase system in inflammation. Pharmacol Rev 2003; 55: 551–571
   PubMed Web of Science ®Google Scholar
• Liu Y, Popovich Z, Templeton D M. Global genomic approaches to the iron-regulated proteome. Ann Clin Lab Sci 2005; 35: 230–239
   PubMed Web of Science ®Google Scholar
• Eisenstein R S. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr 2000; 20: 627–662
   PubMed Web of Science ®Google Scholar
• Van Langendonckt A, Casanas-Roux F, Dolmans M M, Donnez J. Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis. Fertil Steril 2002; 77: 561–570
   PubMed Web of Science ®Google Scholar
• Fisher A E, Naughton D P. Therapeutic chelators for the twenty first century: new treatments for iron and copper mediated inflammatory and neurological disorders. Curr Drug Deliv 2005; 2: 261–268
   PubMedGoogle Scholar
• Burk R F, Hill K E. Regulation of selenoproteins. Annu Rev Nutr 1993; 13: 65–81
   PubMed Web of Science ®Google Scholar
• Ursini F, Maiorino M, Brigelius F R, Aumann K D, Roveri A, Schomburg D, Flohe L. Diversity of glutathione peroxidases. Methods Enzymol 1995; 252: 38–53
   PubMed Web of Science ®Google Scholar
• Szczepańska M, Koźlik J, Skrzypczak J, Mikołajczyk M. Oxidative stress may be a piece in the endometriosis puzzle. Fertil Steril 2003; 79: 1288–1293
   PubMed Web of Science ®Google Scholar
• Alam J, Smith A. Receptor-mediated transport of heme by hemopexin regulates gene expression in mammalian cells. J Biol Chem 1989; 264: 17637–17640
   PubMed Web of Science ®Google Scholar
• Alam J, Smith A. Heme–hemopexin-mediated induction of metallothionein gene expression. J Biol Chem 1992; 267: 16379–16384
   PubMed Web of Science ®Google Scholar
• Wicherek L, Popiela T J, Galazka K, Dutsch-Wicherek M, Opławski M, Basta A, Klimek M. Metallothionein and RCAS1 expression in comparison to immunological cells activity in endometriosis, endometrial adenocarcinoma and endometrium according to menstrual cycle changes. Gynecol Oncol 2005; 99: 622–630
   PubMed Web of Science ®Google Scholar
• Srivastava S, Spite M, Trent J O, West M B, Ahmed Y, Bhatnagar A. Aldose reductase-catalyzed reduction of aldehyde phospholipids. J Biol Chem 2004; 279: 53395–53406
   PubMed Web of Science ®Google Scholar
• Rossi M, Sharkey A M, Viganò P, Fiore G, Furlong R, Florio P, Ambrosini G, Smith S K, Petraglia F. Identification of genes regulated by interleukin-1β in human endometrial stromal cells. Reproduction 2005; 130: 721–729
   PubMed Web of Science ®Google Scholar
• Marzullo L, Tosco A, Capone R, Andersen H S, Capasso A, Leone A. Identification of dietary copper- and iron-regulated genes in rat intestine. Gene 2004; 338: 225–233
   PubMed Web of Science ®Google Scholar
• Cooper C E. Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector. Trends Biochem Sci 2002; 27: 33–39
   PubMed Web of Science ®Google Scholar
• Hintze K J, Theil E C. DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression. Proc Natl Acad Sci U S A 2005; 102: 15048–15052
   PubMed Web of Science ®Google Scholar
• Balla J, Vercellotti G M, Jeney V, Yachie A, Varga Z, Eaton J W, Balla G. Heme, heme oxygenase and ferritin in vascular endothelial cell injury. Mol Nutr Food Res 2005; 49: 1030–1043
   PubMed Web of Science ®Google Scholar
• Hintze K J, Wald K A, Zeng H, Jeffery E H, Finley J W. Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. J Nutr 2003; 133: 2721–2727
   PubMed Web of Science ®Google Scholar
• Iwasaki K, Mackenzie E L, Hailemariam K, Sakamoto K, Tsuji Y. Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells. Mol Cell Biol 2006; 26: 2845–2856
   PubMed Web of Science ®Google Scholar
• Li X L, Xing Q C, Dong B, Gao Y Y, Xing S S, Pang Y Z, Jiang H F, Tang C S. Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus. Int J Cardiol 2007; 117: 411–412
   PubMed Web of Science ®Google Scholar
• Osanai T, Sasaki S, Kamada T, Fujiwara N, Nakano T, Tomita H, Matsunaga T, Magota K, Okumura K. Circulating coupling factor 6 in human hypertension: role of reactive oxygen species. J Hypertens 2003; 21: 2323–2328
   PubMed Web of Science ®Google Scholar
• Smeitink J A, van den Heuvel L W, Koopman W J, Nijtmans L G, Ugalde C, Willems P H. Cell biological consequences of mitochondrial NADH:ubiquinone oxidoreductase deficiency. Curr Neurovasc Res 2004; 1: 29–40
   PubMed Web of Science ®Google Scholar
• Cheng J, Diaz Encarnacion M M, Warner G M, Gray C E, Nath K A, Grande J P. TGF-β1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process. Am J Physiol Cell Physiol 2005; 289: C959–C970
   PubMed Web of Science ®Google Scholar
• Wynn T A. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199–210
   PubMed Web of Science ®Google Scholar
• Hsieh Y Y, Chang C C, Tsai F J, Peng C T, Yeh L S, Lin C C. Polymorphism for transforming growth factor β 1-509 (TGF-B1-509): association with endometriosis. Biochem Genet 2005; 43: 203–210
   PubMed Web of Science ®Google Scholar
• Kontoghiorghes G J, Efstathiou A, Ioannou-Loucaides S, Kolnagou A. Chelators controlling metal metabolism and toxicity pathways: applications in cancer prevention, diagnosis and treatment. Hemoglobin 2008; 32: 217–227
   PubMed Web of Science ®Google Scholar
• Sã Chaud R, Dutreix C, Balez S, Pommier F, Dumortier T, Morisson S, Brun E. Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks. Int J Clin Pharmacol Ther 2008; 46: 102–108
   PubMed Web of Science ®Google Scholar
• Yang L P, Keam S J, Keating G M. Deferasirox: a review of its use in the management of transfusional chronic iron overload. Drugs 2007; 67: 2211–2230
   PubMed Web of Science ®Google Scholar