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Platelets Volume 13, 2002 - Issue 1
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Research Article

Towards a definition of aspirin resistance: a typological approach

Artur-Aron Weber Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
,
Boris Przytulski Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
,
Andrea Schanz Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
,
Thomas Hohlfeld Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
&
Karsten Schrör Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
Pages 37-40 | Published online: 07 Jul 2009

  • Antiplatelet Trialist's Collaboration. Collaborative overview of randomized trials of antiplatelet therapy: I. Prevention of death, myocardial infarction, and stroke by prolonged anti-platelet therapy in various categories of patinets. Br Med J 1994; 308: 81-106.
  • Helgason CM, Hoff JA, Kondos GT, Brace LD. Platelet aggregation in patients with atrial fibrillation taking aspirin or warfarin. Stroke 1993; 24: 1458-91.
  • Helgason CM, Tortorice KL, Winkler SR, Penney, DW, Schuler JJ, McClelland TJ, Brace LD. Aspirin response and failure in cerebral infarction. Stroke 1993; 24: 345-50.
  • Helgason CM, Bolin KM, Hoff JA, Winkler SR, Mangat A, Tortorice KL, Brace LD. Development of aspirin resistance in persons with previous ischemic stroke. Stroke 1994; 25: 2331-6.
  • Mueller MR, Salat A, Stangl P, Murabito M, Pulaki S, Boehm D, Koppensteiner R, Ergun E, Mittlboeck M, Schreiner W, Losert U, Wolner E. Variable platelet response to low-dose ASA an the risk of limb deterioration in patients submitted to peripheral arterial angioplasty. Thromb Haemost 1997; 78: 1003-7.
  • Buchanan MR, Blister SJ. Individual variation in the effects of ASA on platelet function: implications for the use of ASA clinically. Can J Cordial 1995; 11: 221-7.
  • Zimmermann N, Kiensle P, Weber A-A, Winter J, Gams E, Schrör K, Hohlfeld T. Aspirin resistance after coronary artery bypass grafting. J Throrac Cardiovasc Surg 2001; 121: 982-4.
  • Weksler BB, Kent JL, Rudolph D, Scherer PB, Levy DE. Effects of low dose aspirin on platelet function in patients with recent cerebral ischemia. Stroke 1985; 16: 5-9.
  • Berglund U, Wallentin L. Persistent inhibition of platelet function during long-term treatment with 75 mg acetylsalicylic acid daily in men with unstable coronary artery disease. Eur Heart J 1991; 12: 428-33.
  • Patrono C, Coller B, Dalen JE, FitzGerald GA, Fuster V, Gent M, Hirsh J, Roth G. Platelet-active drugs. The relationships among dose, effectiveness, and side effects. Chest 2001; 119 (Suppl.): 39S-63S.
  • Weber A-A, Liesener S, Schanz A, Hohlfeld T, Schrör K. Habitual smoking causes an abnormality in platelet thromboxane A2 metabolism and results in an altered susceptibility to aspirin effects. Platelets 2000; 11: 177-82.
  • Weber A-A, Liesener S, Hohlfeld T, Schrör K. 40mg aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. Thromb Res 2000; 97: 365-7.
  • Benedek IH, Joshi AS, Pieniaszek HI, King S-YP, Kernhauser DM. Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers. J Clin Pharmacol 1995; 35: 1181-6.
  • Weber A-A, Zimmermann KC, Meyer-Kirchrath J, Schrör K. Cydooxygenase-2 in human platelets as a possible factor in aspirin resistance. Lancet 1999; 353: 900.
  • Patrignani P, Sciulli MG, Manarini S, Santini C, Cerletti C, Evangelista V. COX-2 is not involved in thromboxane biosynthesis by activated human platelets. J Physiol Pharmacol 1999; 63: 661-7.
  • Vejar M, Fragasso G, Hackett D, Lipkin DP, Maseri A, Born GV, Ciabattoni G, Patrono C. Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina. Thromb Haemost 1990; 63: 163-8.
  • Maclouf F, Folco G, Patrono C. Eicosanoids and iso-eicosanoids: constitutive, inducible and transcellular biosynthesis in vascular disease. Thromb Haemost 1998; 79: 691-705.
  • Muck S, Weber A-A, Schrör K. Effects of terbogrel on platelet function and prostaglandin endoperoxide transfer. Ear J Pharmacol 1998; 344: 45-8.
  • Kawasaki T, Ozeki Y, Igawa T, Kambayashi J. Increased platelet sensitivity to collagen in individuals resitant to low-dose aspirin. Stroke 2000; 31: 591-5.

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