Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies

References

• Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339: 1523–6
   PubMed Web of Science ®Google Scholar
• Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 1995; 155: 381–386
   PubMed Web of Science ®Google Scholar
• Knekt P, Jarvinen R, Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: A cohort study. Br. Med. J. 1996; 312: 478–481
   PubMed Web of Science ®Google Scholar
• Truelsen T, Gronbaek M, Schnohr P, Boysen G. Intake of beer, wine, and spirits and risk of stroke: The copenhagen city heart study. Stroke 1998; 29: 2467–2472
   PubMed Web of Science ®Google Scholar
• Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. New Engl. J. Med. 1984; 310: 1137–1140
   PubMed Web of Science ®Google Scholar
• Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. New Engl. J. Med. 1992; 326: 242–250
   PubMed Web of Science ®Google Scholar
• Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 613–617
   PubMed Web of Science ®Google Scholar
• Elwood PC, Renaud S, Sharp DS, Beswick AD, O’Brien JR, Yarnell JW. Ischemic hearth disease and platelet aggregation. The Caerphilly Collaborative Hearth Disease Study. Circulation 1991; 83: 38–44
   PubMed Web of Science ®Google Scholar
• Collins CE, Rampton DS. Review article: Platelets in inflammatory bowel disease-pathogenetic role and therapeutic implications. Alim. Pharmacol. Therap. 1997; 11: 237–247
   PubMed Web of Science ®Google Scholar
• Awtry EH, Loscalzo J. Aspirin. Circulation 2000; 101: 1206–1218
   PubMed Web of Science ®Google Scholar
• Segal-Isaacson CJ, Wylie-Rosett J. The cardiovascular effects of fish oils and omega-3 fatty acids. Hearth Dis. 1999; 1: 149–154
   PubMedGoogle Scholar
• Serebruany VL, Lowry DR, Fuzailov SY, Levine DJ, O’Connor CM, Gurbel PA. Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction. J. Thromb. Thrombol. 2000; 9: 229–234
   PubMed Web of Science ®Google Scholar
• Salonen JT, Salonen R, Seppanen K, Rinta-Kiikka S, Kuukka M, Korpela H, Alfthan G, Kantola M, Schalch W. Effects of antioxidant supplementation on platelet function: A randomized pair-matched. Placebo-controlled, double-blind trial in men with low antioxidant status. Am. J. Clin. Nutr. 1991; 53: 1222–1229
   PubMed Web of Science ®Google Scholar
• Freedman JE, Farhat JH, Loscalzo J, Keaney Jr JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996; 94: 2434–2440
   PubMed Web of Science ®Google Scholar
• Calzada C, Bruckdorfer KR, Rice-Evans CA. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997; 128: 97–105
   PubMed Web of Science ®Google Scholar
• Vita JA. Polyphenols and cardiovascular disease: Effects on endothelial and platelet function. Am. J. Clin. Nutr. 2005; 81: 292S–297S
   PubMed Web of Science ®Google Scholar
• Ruf J-C. Alcohol, wine and platelet function. Biol. Res. 2004; 37: 209–215
   PubMed Web of Science ®Google Scholar
• Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000; 130: 2073S–2085S
   PubMed Web of Science ®Google Scholar
• Shahidi F, Naczk M. Food phenolics. Lancaster. Technomic Publishing Company, USA, PA 1995; 75–158
   Google Scholar
• Macheix J-J, Fleuriet A, Billot J. Fruit phenolics. Boca Raton. CRC Press, Inc, USA, FL 1990; 17–92
   Google Scholar
• Clifford MN. Chlorogenic acids and other cinnamates–nature, occurrence, dietary burden, absorption and metabolism. J. Sci. Food Agric. 2000; 80: 1033–1043
   Web of Science ®Google Scholar
• Soleas GJ, Diamandis EP, Goldberg DM. Wine as a biological fluid: History, production, and role in disease prevention. J. Clin. Lab. Anal. 1997; 11: 287–313
   PubMed Web of Science ®Google Scholar
• Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005; 81: 230S–242S
   PubMed Web of Science ®Google Scholar
• Rasmussen SE, Frederiksen H, Krogholm KS, Poulsen L. Dietary proanthocyanidins: Occurrence, dietary intake, bioavailability and protection against cardiovascular disease. Mol. Nutr. Food Res. 2005; 49: 159–174
   PubMed Web of Science ®Google Scholar
• Kris-Etherton PM, Keen CL. Evidence that antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr. Opin. Lipidol. 2002; 13: 41–49
   PubMed Web of Science ®Google Scholar
• Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoid and phenolic acids. Free Radic. Biol. Med. 1996; 20: 933–956
   PubMed Web of Science ®Google Scholar
• Natella F, Nardini M, Virgili F, Scaccini C. Role of dietary polyphenols in the platelet aggregation network–a review of the in vitro studies. Curr. Top. Nutrac. Res. 2006; 4: 1–22
   Web of Science ®Google Scholar
• Umar A, Depont F, Jacquet A, Lignot S, Segur MC, Boisseau M, Begaud B, Moore N. Effects of armagnac or vodka on platelet aggregation in healthy volunteers: A randomized controlled clinical trial. Thromb. Res. 2005; 115: 31–37
   PubMed Web of Science ®Google Scholar
• Bydlowski SP, Yunker RL, Rymaszewski Z, Subbiah MTR. Coffee extracts inhibit platelet aggregation in vivo and in vitro. Int. J. Vit. Nutr. Res. 1987; 57: 217–223
   PubMed Web of Science ®Google Scholar
• Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM. The role of polyphenolic compounds in the diet as inhibitors of platelet function. Proc. Nutr. Soc. 2003; 62: 469–478
   PubMed Web of Science ®Google Scholar
• Yao SK, Ober JC, Krishnaswami A, Ferguson JJ, Anderson HV, Golino P, Buja LM, Willerson JT. Endogeneous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium injured arteries. Circulation 1992; 86: 1302–1309
   PubMed Web of Science ®Google Scholar
• Freedman JE, Parker 3rd C, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001; 103: 2792–2798
   PubMed Web of Science ®Google Scholar
• Osman HE, Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. J. Nutr. 1998; 128: 2307–2312
   PubMed Web of Science ®Google Scholar
• Keevil JG, Osman HE, Reed JD, Folts JD. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J. Nutr. 2000; 130: 53–56
   PubMed Web of Science ®Google Scholar
• Shanmganayagam D, Beahm MR, Osman HE, Krueger CG, Reed JD, Folts JD. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. J. Nutr, 132: 3592–3598
   PubMed Web of Science ®Google Scholar
• Duttaroy AK, Jorgensen A. Effect of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets 2004; 15: 287–292
   PubMed Web of Science ®Google Scholar
• Janssen K, Mensink RP, Cox FJ, Harryvan JL, Hovenier R, Hollman PC, Katan MB. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: Results from an in vitro and a dietary supplement study. Am. J. Clin. Nutr. 1998; 67: 255–262
   PubMed Web of Science ®Google Scholar
• Briggs WH, Folts JD, Osman HE, Goldman IL. Administration of raw onion inhibits platelet-mediated thrombosis in dogs. J. Nutr. 2001; 131: 2619–2622
   PubMed Web of Science ®Google Scholar
• Chen JH, Chen HI, Tsai SJ, Jen CJ. Chronic consumption of raw but not boiled Welsh onion juice inhibits rat platelet function. J. Nutr. 2000; 130: 34–37
   PubMed Web of Science ®Google Scholar
• Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D, Fuhrman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 2000; 71: 1062–1076
   PubMed Web of Science ®Google Scholar
• Choo MK, Park EK, Yoon HK, Kim DH. Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. Biol. Pharm. Bull. 2002; 25: 1328–3132
   PubMed Web of Science ®Google Scholar
• Gooderham MH, Adlercreutz H, Ojala ST, Wahala K, Holub BJ. A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. J. Nutr. 1996; 126: 2000–2006
   PubMed Web of Science ®Google Scholar
• Wolfram RM, Oguogho A, Efthimiou Y, Budinsky AC, Sinzinger H. Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers. Prostagl., Leukotr. Essent. Fatty Acids 2002; 66: 529–533
   PubMed Web of Science ®Google Scholar
• Duffy SJ, Vita JA, Holbrook M, Swerdloff PL, Keaney Jr JF. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 2001; 21: 1084–1089
   Google Scholar
• Hodgson JM, Puddey IB, Mori TA, Burke V, Baker RI, Beilin LJ. Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. Eur. J. Clin. Nutr. 2001; 55: 881–886
   PubMed Web of Science ®Google Scholar
• Hodgson JM, Puddey IB, Burke V, Beilin J, Mori TA, Chan SY. Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects. Br. J. Nutr. 2002; 87: 141–145
   PubMed Web of Science ®Google Scholar
• Kang WS, Lim IH, Yuk Y-P, Chung KE, Park JB, Yoo HS, Yun YP. Antithrombotic activities of green tea catechins and (-)-epigallo-catechin gallate. Thromb. Res. 1999; 96: 229–237
   PubMed Web of Science ®Google Scholar
• Pace-Asciak CR, Rounova O, Hahn SE, Diamandis EP, Goldberg DM. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin. Chim. Acta 1996; 246: 163–182
   PubMed Web of Science ®Google Scholar
• Pignatelli P, Lenti L, Pulcinelli FM, Catasca R, Saccani G, Germano G, Marcoccia A, Silvestri MA, Ghiselli A, Violi F. Red and white wine differently affect collagen-induced platelet aggregation. Pathophys. Haemos. Thromb. 2002; 32(5–6)356–358
   Google Scholar
• Pellegrini N, Pareti FI, Stabile F, Brusamolino A, Simonetti A. Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers. Eur. J. Clin. Nutr. 1996; 50: 209–213
   PubMed Web of Science ®Google Scholar
• Wollny T, Aiello L, Di Tommaso D, Bellavia V, Rotilio D, Donati MB, De Gaetano G, Iacoviello L. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: A role for increased nitric oxide production. Br. J. Pharmacol. 1999; 127: 747–755
   PubMed Web of Science ®Google Scholar
• Kikura M, Levy JH, Safon RA, Lee MK, Szlam F. The influente of red wine or whitewine intake on platelet function and viscoelastic property of blood in volunteers. Platelets 2004; 15: 37–41
   PubMed Web of Science ®Google Scholar
• Lavy A, Fuhrman B, Markel A, Dankner G, Ben-Amotz A, Presser D, Aviram M. Effect of dietary supplementation of red or white wine on human blood chemistry, hematology and coagulation: Favorable effect of red wine on plasma high-density lipoprotein. Ann. Nutr. Metab. 1994; 38: 287–294
   PubMed Web of Science ®Google Scholar
• Veenstra J, van de Pol H, Schaafsma G. Moderate alcohol consumption and platelet aggregation in healthy middle-aged men. Alcohol 1990; 7: 547–549
   PubMed Web of Science ®Google Scholar
• Blache D, Durand P, Prost M, Loreau N. (+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. Free Radic. Biol. Med. 2002; 33: 1670–1680
   PubMed Web of Science ®Google Scholar
• Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, Turner AH, Mann NJ, Sinclair AJ. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am. J. Clin. Nutr. 2003; 77: 1466–1473
   PubMed Web of Science ®Google Scholar
• Conquer JA, Maiani G, Azzini E, Raguzzini A, Holub BJ. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J. Nutr. 1998; 128: 593–597
   PubMed Web of Science ®Google Scholar
• Hubbard GP, Wolffrm S, Lovegrove JA, Gibbins JM. Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet aggregation pathway in humans. J. Thromb. Haemost. 2004; 2: 2138–2145
   PubMed Web of Science ®Google Scholar
• Wang ST, Tan D, Zhao Y, Gao G, Gao X, Hu L. The effect of Pycnogenol on the microcirculation, platelet function, and ischemic myocardium in patients with coronary artery diseases. Eur. Bull. Drug Res. 1999; 7: 19–25
   Google Scholar
• Coimbra SR, Lage SH, Brandizzi L, Yoshida V, Da Luz PL. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz. J. Med. Biol. Res 2005; 38: 1339–1347
   PubMed Web of Science ®Google Scholar
• Demrow HS, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 1995; 91: 1182–1188
   PubMed Web of Science ®Google Scholar
• Blache D, Bouthillier D, Davignon J. Acute influence of smoking on platelet behaviour, endothelium and plasma lipids and normalization by aspirin. Atherosclerosis 1992; 93: 179–188
   PubMed Web of Science ®Google Scholar
• Gleerup G, Winther K. Smoking further increases platelet activity in patients with mild hypertension. Eur. J. Clin. Invest. 1996; 26: 49–52
   PubMed Web of Science ®Google Scholar
• Araghi-Niknam M, Hosseini S, Larson D, Rohdewald P, Watson RR. Pine bark extract reduces platelet aggregation. Intern. Med. 2000; 2: 73–77
   Google Scholar
• Polette A, Blache D. Effect of vitamin E on acute iron load-potentiated aggregation, secretion, calcium uptake and thromboxane biosynthesis in rat platelets. Atherosclerosis 1992; 96: 171–179
   PubMed Web of Science ®Google Scholar
• Barradas MA, Jeremy JY, Kontoghiorghes JY, Mikhailidis DP, Hoffbrand AV, Dandona P. Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity. FEBS Lett. 1989; 245: 105–109
   PubMed Web of Science ®Google Scholar
• Das NP, Griffiths LA. Studies on flavonoid metabolism. Metabolism of (+)–[14C] catechin in the rat and guinea pig. Biochem. J. 1969; 115: 831–836
   PubMed Web of Science ®Google Scholar
• Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP. Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4. Int. J. Tissue React. 1996; 18: 67–71
   PubMedGoogle Scholar
• Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H, Fujiki H. Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 1998; 19: 1771–1776
   PubMed Web of Science ®Google Scholar
• Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT. Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals. J. Agric. Food Chem. 2001; 49: 5679–5684
   PubMed Web of Science ®Google Scholar
• Buchanan CJ, Fallace G, Fry SC. In vivo release of 14C-labeled phenolic groups from intact dietary spinaci cell walls during passage through the rat intestine. J. Sci. Food Agric. 1996; 71: 459–469
   Web of Science ®Google Scholar
• Kroon PA, Faulds CB, Ryden P, Robertson JA, Williamson G. Release of covalently bound ferulic acid from fiber in human colon. J. Agric. Food Chem. 1997; 45: 661–667
   Web of Science ®Google Scholar
• Wende G, Buchanan CJ, Fry SC. Hydrolysis and fermentation by rat gut microorganisms of 2-O-b-D-xylopyranosyl-(5-O-feruloyl)-L-arabinose derived from grass cell wall arabinoxylan. J. Sci. Food Agric. 1997; 73: 296–300
   Web of Science ®Google Scholar
• Plumb GW, Garcia-Conesa MT, Kroon PA, Rhodes M, Williamson G. Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora. J. Sci. Food Agric. 1999; 79: 390–392
   Web of Science ®Google Scholar
• Couteau D, McCartney AL, Gibson GR, Williamson G, Faulds CB. Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. J. Appl. Microbiol. 2001; 90: 873–881
   PubMed Web of Science ®Google Scholar
• Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT. Intestinal release and uptake of phenolic antioxidant diferulic acids. Free Radic. Biol. Med. 2001; 31: 304–314
   PubMed Web of Science ®Google Scholar
• Rechner AR, Spencer JP, Kuhnle G, Hahn U, Rice-Evans CA. Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radic. Biol. Med. 2001; 30: 1213–1222
   PubMed Web of Science ®Google Scholar
• Nardini M, Cirillo E, Natella F, Scaccini C. Absorption of phenolic acids in humans after coffee consumption. J. Agric. Food Chem. 2002; 50: 5735–5741
   PubMed Web of Science ®Google Scholar
• Nardini M, Natella F, Scaccini C, Ghiselli A. Phenolic acids from beer are absorbed and extensively metabolized in humans. J. Nutr. Biochem. 2006; 17: 14–22
   PubMed Web of Science ®Google Scholar
• Manach C, Morand C, Texier O, Favier ML, Agullo G, Demigne C, Regerat F, Remesy C. Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J. Nutr. 1995; 125: 1911–1922
   PubMed Web of Science ®Google Scholar
• Ohta T, Nakano T, Egashira Y, Sanada H. Antioxidant activity of ferulic acid beta-glucuronide in the LDL oxidation system. Biosci. Biotechnol. Biochem. 1997; 61: 1942–1943
   PubMed Web of Science ®Google Scholar
• Cano A, Arnao MB, Williamson G, Garcia-Conesa MT. Superoxide scavenging by polyphenols: Effect of conjugation and dimerization. Redox Rep. 2002; 7: 379–383
   PubMed Web of Science ®Google Scholar
• Spencer JP, Kuhnle GG, Williams RJ, Rice-Evans C. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem. J. 2003; 372: 173–181
   PubMed Web of Science ®Google Scholar
• Watson DG, Oliveira EJ. Solid-phase extraction and gas chromatography-mass spectrometry determination of kaempferol and quercetin in human urine after consumption of Ginkgo biloba tablets. J. Chromatogr. 1999; 723: 203–210
   Web of Science ®Google Scholar
• Bourne L, Paganga G, Baxter D, Hughes P, Rice-Evans C. Absorption of ferulic acid from low-alcohol beer. Free Radic. Res. 2000; 32: 273–280
   PubMed Web of Science ®Google Scholar
• Rechner AR, Kuhnle G, Hu H, Roedig-Penman A, Van Den Braak MH, Moore KP, Rice-Evans CA. The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic. Res. 2002; 36: 1229–1241
   PubMed Web of Science ®Google Scholar
• Shelnutt SR, Cimino CO, Wiggins PA, Ronis MJ, Badger TM. Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage. Am. J. Clin. Nutr. 2002; 76: 588–594
   PubMed Web of Science ®Google Scholar
• Baba S, Osakabe N, Natsume M, Terao J. Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid. Life Sci. 2004; 75: 165–178
   PubMed Web of Science ®Google Scholar
• Wittemer SM, Ploch M, Windeck T, Muller SC, Drewelow B, Derendorf H, Veit M. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans. Phytomedicine 2005; 12: 28–38
   PubMed Web of Science ®Google Scholar
• Manach C, Morand C, Crespy V, Demigne C, Texier O, Regerat F, Remesy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 1998; 426: 331–336
   PubMed Web of Science ®Google Scholar
• Asai A, Miyazawa T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000; 67: 2785–2793
   PubMed Web of Science ®Google Scholar
• Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J. Agric. Food Chem. 2000; 48: 5496–500
   PubMed Web of Science ®Google Scholar
• Rondini L, Peyrat-Maillard MN, Marsset-Baglieri A, Berset C. Sulfated ferulic acid is the main in vivo metabolite found after short-term ingestion of free ferulic acid in rats. J. Agric. Food Chem. 2002; 50: 3037–3041
   PubMed Web of Science ®Google Scholar
• Zhao Z, Egashira Y, Sanada H. Ferulic acid sugar esters are recovered in rat plasma and urine mainly as the sulfoglucuronide of ferulic acid. J. Nutr. 2003; 133: 1355–1361
   PubMed Web of Science ®Google Scholar
• Labieniec M, Gabryelak T. Interactions of tannic acid and its derivatives (ellagic and gallic acids) with calf thymus DNA and bovine serum albumin using spectroscopic method. J. Photochem. Photobiol. B 2006; 82: 72–78
   PubMed Web of Science ®Google Scholar
• Muralidhara BK, Prakash V. Interaction of 3. Int. J. Pept. Protein Res 1995; 46: 1–8
   PubMedGoogle Scholar
• Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 2000; 130: 2243–2250
   PubMed Web of Science ®Google Scholar
• Tzeng SH, Ko WC, Ko FN, Teng CM. Inhibition of platelet aggregation by some flavonoids. Thromb. Res. 1991; 64: 91–100
   PubMed Web of Science ®Google Scholar
• Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993; 342: 1007–1011
   PubMed Web of Science ®Google Scholar
• Hollman PC, van Trijp JM, Buysman MN, van der Gaag MS, Mengelers MJ, De Vries JH, Katan MB. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett. 1997; 418: 152–156
   PubMed Web of Science ®Google Scholar
• Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem. Pharmacol. 2000; 60: 1539
   PubMed Web of Science ®Google Scholar
• Pignatelli P, Pulcinelli FM, Celestini A, Lenti L, Ghiselli A, Gazzaniga PP, Violi F. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am. J. Clin. Nutr. 2000; 72: 1150–1155
   PubMed Web of Science ®Google Scholar
• Bush LR, Shebuski RJ. In vivo models of arterial thrombosis and thrombolysis. Faseb J. 1990; 4: 3087–3098
   PubMed Web of Science ®Google Scholar
• McGregor L, Bellangeon M, Chignier E, Lerond L, Rousselle C, McGregor JL. Effect of a micronized purified flavonoid fraction on in vivo platelet functions in the rat. Thromb. Res. 1999; 94: 235–240
   PubMed Web of Science ®Google Scholar
• Gryglewski RJ, Korbut R, Robak J, Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem. Pharmacol. 1987; 36: 317–322
   PubMed Web of Science ®Google Scholar
• Umar A, Guerin V, Renard M, Boisseau M, Garreau C, Begaud B, Molimard M, Moore N. Effects of armagnac extracts on human platelet function in vitro and on rat arteriovenous shunt thrombosis in vivo. Thromb. Res. 2003; 110: 135–140
   PubMed Web of Science ®Google Scholar
• Umar A, Boisseau M, Segur MC, Begaud B, Moore N. Effect of age of Armagnac extract and duration of treatment on antithrombotic effects in a rat thrombosis model. Thromb. Res. 2003; 111: 185–189
   PubMed Web of Science ®Google Scholar
• Keller JW, Folts JD. Relative effects of cigarette smoke and ethanol on acute platelet thrombus formation in stenosed canine coronary arteries. Cardiovasc. Res. 1988; 22: 73–78
   PubMed Web of Science ®Google Scholar
• Mikhailidis DP, Barradas MA, Jeremy JY. The effect of ethanol on platelet function and vascular prostanoids. Alcohol 1990; 7: 171–180
   PubMed Web of Science ®Google Scholar
• Renaud S, McGregor JL, Martin JL. Influence of alcohol on platelet functions in relation to atherosclerosis. Diet. diabetes and atherosclerosis. Raven Press, New York 1984
   Google Scholar
• Meade TW, Vickers MV, Thompson SG, Stirling Y, Haines AP, Miller GJ. Br. Med. J. Epidemiological characteristics of platelet aggregability. 1985; 290: 428–432, (Clin. Res. Ed.)
   Google Scholar
• Ruf JC. Alcohol, wine and platelet function. Biol. Res. 2004; 37: 209–215
   PubMed Web of Science ®Google Scholar
• Hillbom ME, Kangasaho M, Hjelm-Jager M. Platelet aggregation and thromboxane B2 formation after ethanol abuse: Is there a relationship to stroke?. Acta Neurol. Scand. 1984; 70: 432–437
   PubMed Web of Science ®Google Scholar
• Renaud SC, Ruf JC. Effects of alcohol on platelet functions. Clin. Chim. Acta 1996; 246: 77–89
   PubMed Web of Science ®Google Scholar
• Ruf JC, Berger JL, Renaud S. Platelet rebound effect of alcohol withdrawal and wine drinking in rats. Relation to tannins and lipid peroxidation. Arterioscler. Thromb. Vasc. Biol. 1995; 15: 140–144
   PubMed Web of Science ®Google Scholar
• Mezzano D, Leighton F. Haemostatic cardiovascular risk factors: Differential effects of red wine and diet on healthy young. Pathophysiol. Haemost. Thromb. 2003; 33: 472–478
   PubMed Web of Science ®Google Scholar
• Seigneur M, Bonnet J, Dorian B, Benchimol D, Drouillet F, Gouverneur G, Larrue J, Crockett R, Boisseau MR, Ribereau-Gayon P. Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. J. Appl. Cardiol. 1990; 5: 215–222
   Google Scholar
• Kang WS, Chung KH, Chung JH, Lee JY, Park JB, Zhang YH, Yoo HS, Yun YP. Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase. J. Cardiovasc. Pharmacol. 2001; 38: 875–884
   PubMed Web of Science ®Google Scholar
• Sheu J-R, Hsiao G, Chou P-H, Shen M-Y, Chou D-S. Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J. Agric. Food Chem. 2004; 52: 4414–4418
   PubMed Web of Science ®Google Scholar
• Hsiao G, Chang CY, Shen MY, Chou DS, Tzeng SH, Chen TF, Sheu JR. Alpha-naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. J. Agric. Food Chem. 2005; 53: 5179–5186
   PubMed Web of Science ®Google Scholar
• Nakashima S, Koike T, Nozawa Y. Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Mol. Pharmacol. 1991; 39: 475–480
   PubMed Web of Science ®Google Scholar
• Ferrell Jr JE, Chang Sing PD, Loew G, King R, Mansour JM, Mansour TE. Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices. Mol. Pharmacol. 1979; 16: 556–568
   PubMed Web of Science ®Google Scholar
• Ruckstuhl M, Beretz A, Anton R, Landry Y. Flavonoids are selective cyclic GMP phosphodiesterase inhibitors. Biochem. Pharmacol. 1979; 28: 535–538
   PubMed Web of Science ®Google Scholar
• Beretz A, Stierle A, Anton R, Cazenave JP. Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin. Biochem. Pharmacol. 1982; 31: 3597–3600
   PubMed Web of Science ®Google Scholar
• Dobrydneva Y, Williams RL, Blackmore PF. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br. J. Pharmacol. 1999; 128: 149–157
   PubMed Web of Science ®Google Scholar
• Dobrydneva Y, Williams RL, Morris GZ, Blackmore PF. Dietary phytoestrogens and their synthetic structural analogues as calcium channel blockers in human platelets. J. Cardiovasc. Pharmacol. 2002; 40: 399–410
   PubMed Web of Science ®Google Scholar
• Ozaki Y, Satoh K, Kuroda K, Qi R, Yatomi Y, Yanagi S, Sada K, Yamamura H, Yanabu M, Nomura S. Anti-CD9 monoclonal antibody activates p72syk in human platelets. J. Biol. Chem. 1995; 270: 15119–15124
   PubMed Web of Science ®Google Scholar
• Levy-Toledano S, Gallet C, Nadal F, Bryckaert M, Maclouf J, Rosa JP. Phosphorylation and dephosphorylation mechanisms in platelet function: A tightly regulated balance. Thromb. Haemost. 1997; 78: 226–233
   PubMed Web of Science ®Google Scholar
• Schoene NW, Guidry CA. Dietary soy isoflavones inhibit activation of rat platelets. J. Nutr. Biochem. 1999; 10: 421–426
   PubMed Web of Science ®Google Scholar
• Hubbard GP, Stevens JM, Cicmil M, Sage T, Jordan PA, Williams CM, Lovegrove JA, Gibbins JM. Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J. Thromb. Haemost. 2003; 1: 1079–1088
   PubMed Web of Science ®Google Scholar
• Handin RI, Karabin R, Boxer GJ. Enhancement of platelet function by superoxide anion. J. Clin. Invest. 1977; 59: 959–965
   PubMed Web of Science ®Google Scholar
• Pratico D, Iuliano L, Ghiselli A, Alessandri C. Violi F. Hydrogen peroxide as trigger of platelet aggregation. Haemostasis 1991; 21: 169–174
   PubMedGoogle Scholar
• Iuliano L, Violi F, Pedersen JZ, Pratico D, Rotilio G, Balsano F. Free radical-mediated platelet activation by hemoglobin released from red blood cells. Arch. Biochem. Biophys. 1992; 299: 220–224
   PubMed Web of Science ®Google Scholar
• Blache D. Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity. Am. J. Physiol. 1995; 268: H679–685
   PubMed Web of Science ®Google Scholar
• Pignatelli P, Pulcinelli FM, Lenti L, Gazzaniga PP, Violi F. Hydrogen peroxide is involved in collagen-induced platelet activation. Blood 1998; 91: 484–490
   PubMed Web of Science ®Google Scholar
• Krotz F, Sohn HY, Gloe T, Zahler S, Riexinger T, Schiele TM, Becker BF, Theisen K, Klauss V, Pohl U. NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment. Blood 2002; 100: 917–924
   PubMed Web of Science ®Google Scholar
• Mansvelt EP, van Velden DP, Fourie E, Rossouw M, van Rensburg SJ, Smuts CM. The in vivo antithrombotic effect of wine consumption on human blood platelets and hemostatic factors. Ann. N Y Acad. Sci. 2002; 957: 329–332
   PubMed Web of Science ®Google Scholar
• Sharpe PC, McGrath LT, McClean E, Young IS, Archbold GP. Effect of red wine consumption on lipoprotein (a) and other risk factors for atherosclerosis. Quart. J. Med. 1995; 88: 101–108
   Google Scholar
• Fitzpatrick DF, Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol, 265: H774–778
   PubMedGoogle Scholar
• Andriambeloson E, Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br. J. Pharmacol. 1997; 20: 1053–1058
   Google Scholar
• Cuevas AM, Germain AM. Diet and endothelial function. Biol. Res. 2004; 37: 225–230
   PubMed Web of Science ®Google Scholar
• Yao SK, Ober JC, Krishnaswami A, Ferguson JJ, Anderson HV, Golino P, Buja LM, Willerson JT. Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Circulation 1992; 86: 1302–1309
   PubMed Web of Science ®Google Scholar
• Haslam E, Lilly TH. Natural astringency in foodstuffs. A molecular interpretation. Crit. Rev. Food Sci. Nutr. 1988; 27: 1–40
   PubMed Web of Science ®Google Scholar
• Spencer CM, Cai Y, Martin S, Gaffney PN, Goulding D, Magnolato D, Lilley E, Haslam E. Polyphenol complexation–some thoughts and observations. Phytochemistry 1988; 27: 2397–2409
   Web of Science ®Google Scholar
• Serafini M, Maiani G, Ferro-Luzzi A. Effect of ethanol on red wine tannin-protein (BSA) interactions. J. Agric. Food Chem. 1997; 45: 3148–3151
   Web of Science ®Google Scholar
• Reddy S, Aggarwal BB. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett. 1994; 341: 19–22
   PubMed Web of Science ®Google Scholar
• Nakachi K, Matsuyama S, Miyake S, Suganuma M, Imai K. Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention. Biofactors 2000; 13: 49–54
   PubMed Web of Science ®Google Scholar
• Nardini M, Leonardi F, Scaccini C, Virgili F. Modulation of ceramide-induced NF-kB binding activity and apoptotic response by caffeic acid in U937 cells: Comparison with other antioxidants. Free Radic. Biol. Med. 2001; 30: 722–733
   PubMed Web of Science ®Google Scholar
• McGregor L, Renaud S. Inhibitory effect of alcohol on platelet functions of rats fed saturated fats. Thromb. Res. 1981; 22: 221–225
   PubMed Web of Science ®Google Scholar
• Fenn CG, Littleton JM. Interactions between ethanol and dietary fat in determining human platelet function. Thromb. Haemost. 1984; 51: 50–53
   PubMed Web of Science ®Google Scholar
• Lahoz C, Alonso R, Ordovas JM, Lopez-Farre A, de Oya M, Mata P. Effects of dietary fat saturation on eicosanoid production, platelet aggregation, and blood pressure. Eur. J. Clin. Invest. 1997; 27: 780–787
   PubMed Web of Science ®Google Scholar
• Sanchez-Muniz FJ, Oubina P, Rodenas S, Benedi J, Cuesta C. Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein. Eur. J. Nutr. 2003; 42: 299–306
   PubMed Web of Science ®Google Scholar
• Latta EK, Packham MA, DaCosta SM, Rand ML. Effects of chronic administration of ethanol on platelets from rabbits with diet-induced hypercholesterolemia. Unchanged characteristics and responses to ADP but reduction of enhanced thrombin-induced, TxA2-independent platelet responses. Arterioscler. Thromb. 1994; 14: 1372–1377
   PubMedGoogle Scholar
• Serafini M, Ghiselli A, Ferro-Luzzi A. In vivo antioxidant effect of green and black tea in man. Eur. J. Clin. Nutr. 1996; 50: 28–32
   PubMed Web of Science ®Google Scholar
• Hollman PC, van Het Hof KH, Tijburg LB, Katan MB. Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic. Res. 2001; 34: 297–300
   PubMed Web of Science ®Google Scholar
• Varani K, Portaluppi F, Gessi S, Merighi S, Ongini E, Belardinelli L, Borea PA. Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: Functional and biochemical aspects. Circulation 2000; 102: 285–289
   PubMed Web of Science ®Google Scholar