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Special Review: Platelets at the Heart of Therapy

The platelets’ perspective to pathogen reduction technologies

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Pages 140-147 | Received 26 Oct 2016, Accepted 20 Jan 2017, Published online: 29 Mar 2017

References

  • Lancet. Notes of Gulliver’s researches in anatomy, physiology, pathology, and botany, 1880. In: Power, editor. Carpenter’s physiology. 9th ed. 1882. p. 916.
  • Bizzozero G. Ueber einer neuen formbestandtheil des blutes und dessen rolle bei der thrombose und der blutgerinnung. Arch Path Anat Physiol 1882.;90:261–332.
  • Wright JH. The origin and nature of the blood plates. Boston Med Surg J 1910;154:643–645.
  • Zucker MB.Platelet agglutination and vasoconstriction as factors in spontaneous hemostasis in normal, thrombocytopenic, heparinized and hypoprothrombinemic rats. Am J Physiol 1947; 148(2):275–288.
  • Spaet TH. Vascular factors in the pathogenesis of hemorrhagic syndromes. Blood 1952; 7(6):641–652.
  • Harker LA, Finch CA. Thrombokinetics in man. J Clin Invest 1969;48(6):963–974.
  • Hartwig JH. The platelet: Form and function. Semin Hematol 2006; 43S1:S94–S100.
  • Ho-Tin-Noe B, Demers M, Wagner DD. How platelets safeguard vascular integrity. J Thromb Haemost 2011;9 (Suppl 1):56–65.
  • Cox D, Kerrigan SW, Watson SP. Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation. J Thromb Haemost 2011;9(6):1097–1107.
  • Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev 2015;29(3):153–162.
  • Ypma PF, van der Meer PF, Heddle NM, van Hilten JA, Stijnen T, Middelburg RA, Hervig T, van der Bom JG, Brand A, Kerkhoffs JL et al. A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: The pathogen reduction evaluation and predictive analytical rating score (prepares) trial. BMJ Open 2016;6(1):e010156.
  • Stanworth SJ, Walsh TS, Prescott RJ, Lee RJ, Watson DM, Wyncoll DL, Intensive Care Study of Coagulopathy I. Thrombocytopenia and platelet transfusion in UK critical care: A multicenter observational study. Transfusion 2013;53(5):1050–1058.
  • Desborough M, Estcourt LJ, Doree C, Trivella M, Hopewell S, Stanworth SJ, Murphy MF. Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies undergoing intensive chemotherapy or stem cell transplantation. Cochrane Database Syst Rev 2016;(8):CD010982.
  • SaBTO WG. Pathogen inactivation of platelets: Report of the advisory committee on the safety of blood, tissues and organs (sabto) working group. Department of Health: United Kingdom (UK) Government; 2014.
  • Wandt H, Schaefer-Eckart K, Wendelin K, Pilz B, Wilhelm M, Thalheimer M, Mahlknecht U, Ho A, Schaich M, Kramer M et al. Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: An open-label, multicentre, randomised study. Lancet 2012;380(9850):1309–1316.
  • Triulzi DJ, Assmann SF, Strauss RG, Ness PM, Hess JR, Kaufman RM, Granger S, Slichter SJ. The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia. Blood 2012;119(23):5553–5562.
  • Estcourt L, Stanworth S, Doree C, Hopewell S, Murphy MF, Tinmouth A, Heddle N. Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation. The Cochrane Database Syst Reviews 2012;5:Cd004269.
  • Stroncek DF, Rebulla P. Platelet transfusions. Lancet 2007;370(9585):427–438.
  • Slichter SJ, Corson J, Jones MK, Christoffel T, Pellham E, Bailey SL, Bolgiano D. Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (pas). Blood 2014;123(2):271–280.
  • Dumont LJ, AuBuchon JP, Whitley P, Herschel LH, Johnson A, McNeil D, Sawyer S, Roger JC. Seven-day storage of single-donor platelets: Recovery and survival in an autologous transfusion study. Transfusion 2002;42(7):847–854.
  • Dunbar NM, Dumont LJ, Szczepiorkowski ZM. How do we implement day 6 and day 7 platelets at a hospital-based transfusion service? Transfusion 2016;56(6):1262–1266.
  • Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sorensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med 2009;15(11):1273–1280.
  • Kattlove HE, Alexander B. The effect of cold on platelets. I. Cold-induced platelet aggregation. Blood 1971;38(1):39–48.
  • Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell 2003;112(1):87–97.
  • Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. Glycosylation restores survival of chilled blood platelets. Science 2003;301(5639):1531–1534.
  • Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM. 2005. The macrophage alphambeta2 integrin alpham lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem 280(18):18025–18032.
  • Rumjantseva V, Hoffmeister KM. Novel and unexpected clearance mechanisms for cold platelets. Transfus Apher Sci 2010;42(1):63–70.
  • Pidcoke HF, Spinella PC, Ramasubramanian AK, Strandenes G, Hervig T, Ness PM, Cap AP. Refrigerated platelets for the treatment of acute bleeding: A review of the literature and reexamination of current standards. Shock 2014;41 Suppl 1:51–53.
  • Klein HG, Anderson D, Bernardi MJ, Cable R, Carey W, Hoch JS, Robitaille N, Sivilotti ML, Smaill F. Pathogen inactivation: Making decisions about new technologies. Report of a consensus conference. Transfusion 2007;47(12):2338–2347.
  • Connell NT. Transfusion medicine. Prim Care 2016;43(4):651–659.
  • Kerkhoffs JL, Eikenboom JC, van de Watering LM, van Wordragen-Vlaswinkel RJ, Wijermans PW, Brand A. The clinical impact of platelet refractoriness: Correlation with bleeding and survival. Transfusion 2008;48(9):1959–1965.
  • Kaufman RM, Assmann SF, Triulzi DJ, Strauss RG, Ness P, Granger S, Slichter SJ. Transfusion-related adverse events in the platelet dose study. Transfusion 2015;55(1):144–153.
  • Vamvakas EC, Blajchman MA. Blood still kills: Six strategies to further reduce allogeneic blood transfusion-related mortality. Transfus Med Rev 2010;24(2):77–124.
  • Ribault S, Harper K, Grave L, Lafontaine C, Nannini P, Raimondo A, Faure IB. Rapid screening method for detection of bacteria in platelet concentrates. J Clin Microbiol 2004;42(5):1903–1908.
  • Stormer M, Vollmer T. Diagnostic methods for platelet bacteria screening: Current status and developments. Transfus Med Hemother 2014;41(1):19–27.
  • Silliman CC, Fung YL, Ball JB, Khan SY. Transfusion-related acute lung injury (trali): Current concepts and misconceptions. Blood Rev 2009;23(6):245–255.
  • Shaz BH, Stowell SR, Hillyer CD. Transfusion-related acute lung injury: From bedside to bench and back. Blood 2011;117(5):1463–1471.
  • Morrow JF, Braine HG, Kickler TS, Ness PM, Dick JD, Fuller AK. Septic reactions to platelet transfusions. A persistent problem. JAMA 1991;266(4):555–558.
  • Kiefel V. Reactions induced by platelet transfusions. Transfus Med Hemother 2008;35(5):354–358.
  • Hong H, Xiao W, Lazarus HM, Good CE, Maitta RW, Jacobs MR. Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance. Blood 2016;127(4):496–502.
  • McDonald CP, Roy A, Mahajan P, Smith R, Charlett A, Barbara JA. Relative values of the interventions of diversion and improved donor-arm disinfection to reduce the bacterial risk from blood transfusion. Vox Sang 2004;86(3):178–182.
  • Blajchman MA, Goldman M, Baeza F. Improving the bacteriological safety of platelet transfusions. Transfus Med Rev 2004;18(1):11–24.
  • Germain M, Ghibu S, Delage G. The precautionary principle in blood safety: Not quite the same as aiming for zero risk. Transfus Med Rev 2012;26(2):181–184; reply pg 184–186.
  • Hillyer CD, Josephson CD, Blajchman MA, Vostal JG, Epstein JS, Goodman JL. Bacterial contamination of blood components: Risks, strategies, and regulation: Joint ash and aabb educational session in transfusion medicine. Hematol Am Soc Hematol Educ Program 2003;575–589.
  • Fuller AK, Uglik KM, Savage WJ, Ness PM, King KE. Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single-donor platelets. Transfusion 2009;49(12):2588–2593.
  • Vlaar AP, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJ, Tool AT, de Korte D et al. Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. Blood 2010;116(8):1360–1368.
  • Gulston M, Fulford J, Jenner T, de Lara C, O’Neill P. Clustered DNA damage induced by gamma radiation in human fibroblasts (hf19), hamster (v79-4) cells and plasmid DNA is revealed as fpg and nth sensitive sites. Nucleic Acids Res 2002;30(15):3464–3472.
  • Sokolov MV, Smilenov LB, Hall EJ, Panyutin IG, Bonner WM, Sedelnikova OA. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 2005;24(49):7257–7265.
  • Anderson KC, Weinstein HJ. Transfusion-associated graft-versus-host disease. N Engl J Med 1990;323(5):315–321.
  • Leitman SF, Holland PV. Irradiation of blood products. Indications and guidelines. Transfusion 1985;25(4):293–303.
  • Akahoshi M, Takanashi M, Masuda M, Yamashita H, Hidano A, Hasegawa K, Kasajima T, Shimizu M, Motoji T, Oshimi K et al. A case of transfusion-associated graft-versus-host disease not prevented by white cell-reduction filters. Transfusion 1992;32(2):169–172.
  • Tynngard N, Studer M, Lindahl TL, Trinks M, Berlin G. The effect of gamma irradiation on the quality of apheresis platelets during storage for 7 days. Transfusion 2008;48(8):1669–1675.
  • Osman A, Hitzler WE, Meyer CU, Landry P, Corduan A, Laffont B, Boilard E, Hellstern P, Vamvakas EC, Provost P. Effects of pathogen reduction systems on platelet microRNAs, mRNAs, activation, and function. Platelets 2015;26(2):154–163.
  • Osman A, Hitzler WE, Ameur A, Provost P. Differential expression analysis by RNA-seq reveals perturbations in the platelet mRNA transcriptome triggered by pathogen reduction systems. PLoS One 2015;10(7):e0133070.
  • Wollowitz S. Fundamentals of the psoralen-based helinx technology for inactivation of infectious pathogens and leukocytes in platelets and plasma. Semin Hematol 2001;38(4 Suppl 11):4–11.
  • Irsch J, Lin L. Pathogen inactivation of platelet and plasma blood components for transfusion using the intercept blood system. Transfus Med Hemother 2011;38(1):19–31.
  • Kaiser-Guignard J, Canellini G, Lion N, Abonnenc M, Osselaer JC, Tissot JD. The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates. Blood Reviews 2014;28(6):235–241.
  • Seghatchian J, de Sousa G. Pathogen-reduction systems for blood components: The current position and future trends. Transfus Apher Sci 2006;35(3):189–196.
  • Kumar V, Lockerbie O, Keil SD, Ruane PH, Platz MS, Martin CB, Ravanat JL, Cadet J, Goodrich RP. Riboflavin and UV-light based pathogen reduction: Extent and consequence of DNA damage at the molecular level. Photochem Photobiol 2004;80:15–21.
  • Pohler P, Muller M, Winkler C, Schaudien D, Sewald K, Muller TH, Seltsam A. Pathogen reduction by ultraviolet c light effectively inactivates human white blood cells in platelet products. Transfusion 2015;55(2):337–347.
  • Seltsam A, Muller TH. Uvc irradiation for pathogen reduction of platelet concentrates and plasma. Transfus Med Hemother 2011;38(1):43–54.
  • Douki T, Laporte G, Cadet J. Inter-strand photoproducts are produced in high yield within a-DNA exposed to UVC radiation. Nucleic Acids Res 2003;31(12):3134–3142.
  • McCullough J. Pathogen inactivation: A new paradigm for preventing transfusion-transmitted infections. Am J Clin Pathol 2007;128(6):945–955.
  • Vamvakas EC, Blajchman MA. Transfusion-related mortality: The ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood 2009;113(15):3406–3417.
  • Stramer SL. Current perspectives in transfusion-transmitted infectious diseases: Emerging and re-emerging infections. ISBT Sci Ser 2014;9(1):30–36.
  • Osman A, Hitzler WE, Provost P. Peculiarities of studying the effects of pathogen reduction technologies on platelets. Proteom Clin Appl 2016;10(8):805–815.
  • Huzly D, Umhau M, Bettinger D, Cathomen T, Emmerich F, Hasselblatt P, Hengel H, Herzog R, Kappert O, Maassen S et al. Transfusion-transmitted hepatitis e in germany, 2013. Euro Surveill 2014;19(21).
  • Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, Kennedy IT, Kitchen A, Patel P, Poh J et al. Hepatitis e virus in blood components: A prevalence and transmission study in southeast England. Lancet 2014;384(9956):1766–1773.
  • Sauleda S, Ong E, Bes M, Janssen A, Cory R, Babizki M, Shin T, Lindquist A, Hoang A, Vang L et al. Seroprevalence of hepatitis e virus (hev) and detection of hev RNA with a transcription-mediated amplification assay in blood donors from Catalonia (Spain). Transfusion 2015;55(5):972–979.
  • Hauser L, Roque-Afonso AM, Beyloune A, Simonet M, Deau Fischer B, Burin des Roziers N, Mallet V, Tiberghien P, Bierling P. Hepatitis e transmission by transfusion of intercept blood system-treated plasma. Blood 2014;123(5):796–797.
  • Weber CF, Meininger D, Byhahn C, Seifried E, Zacharowski K, Adam E, Henschler R, Müller MM. Conventional vs pathogen-inactivated platelet concentrates for the treatment of perioperative coagulopathy. Der Chirurg 2011;82(4):348–358.
  • Butler C, Doree C, Estcourt LJ, Trivella M, Hopewell S, Brunskill SJ, Stanworth S, Murphy MF. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database Syst Rev 2013;3:CD009072.
  • Kissopoulou A, Jonasson J, Lindahl TL, Osman A. Next generation sequencing analysis of human platelet polya+ mRNAs and rRNA-depleted total RNA. PLoS One 2013;8(12):e81809.
  • Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct 2014;9:3.
  • Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood 2011;118(14):e101–111.
  • Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P et al. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics 2013;14:1.
  • Landry P, Plante I, Ouellet DL, Perron MP, Rousseau G, Provost P. Existence of a microrna pathway in anucleate platelets. Nat Struct Mol Biol 2009;16(9):961–966.
  • Ple H, Landry P, Benham A, Coarfa C, Gunaratne PH, Provost P. The repertoire and features of human platelet microRNAs. PLoS One 2012;7(12):e50746.
  • Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ et al. Circular RNA enrichment in platelets is a signature of transcriptome degradation. Blood 2016;127(9):e1–e11.
  • Provost P. Platelets enrich their transcriptome circle. Blood 2016;127(9):1080–1081.
  • Edelstein LC, Bray PF. Micrornas in platelet production and activation. Blood 2011;117(20):5289–5296.
  • Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF. Micrornas in platelet production and activation. J Thromb Haemost 2013;11(Suppl 1):340–350.
  • Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O’Donnell E, Farndale RW, Ware J et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 2010;327(5965):580–583.
  • Beyer C, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol 2010;6(1):21–29.
  • Kriebardis A, Antonelou M, Stamoulis K, Papassideri I. Cell-derived microparticles in stored blood products: Innocent-bystanders or effective mediators of post-transfusion reactions? Blood Transfus 2012;10(Suppl 2):s25–38.
  • Keuren JF, Magdeleyns EJ, Govers-Riemslag JW, Lindhout T, Curvers J. Effects of storage-induced platelet microparticles on the initiation and propagation phase of blood coagulation. Br J Haematol 2006;134(3):307–313.
  • Bode AP, Knupp CL. Effect of cold storage on platelet glycoprotein ib and vesiculation. Transfusion1994; 34(8):690–696.
  • Wang C, Mody M, Herst R, Sher G, Freedman J. Flow cytometric analysis of platelet function in stored platelet concentrates. Transfus Sci 1999;20(2):129–139.
  • Maurer-Spurej E, Chipperfield K. Past and future approaches to assess the quality of platelets for transfusion. Transfus Med Rev 2007;21(4):295–306.
  • Boilard E, Blanco P, Nigrovic PA. Platelets: Active players in the pathogenesis of arthritis and SLE. Nat Rev Rheumatol 2012;8(9):534–542.
  • Projahn D, Koenen RR. Platelets: Key players in vascular inflammation. J Leukoc Biol 2012;92(6):1167–1175.
  • Clark SR, Thomas CP, Hammond VJ, Aldrovandi M, Wilkinson GW, Hart KW, Murphy RC, Collins PW, O’Donnell VB. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proc Natl Acad Sci USA 2013;110(15):5875–5880.
  • Kleinjan A, Boing AN, Sturk A, Nieuwland R. Microparticles in vascular disorders: How tissue factor-exposing vesicles contribute to pathology and physiology. Thromb Res 2012;130(Suppl 1):S71–73.
  • Laffont B, Corduan A, Ple H, Duchez AC, Cloutier N, Boilard E, Provost P. Activated platelets can deliver mrna regulatory ago2•microRNA complexes to endothelial cells via microparticles. Blood 2013;122(2):253–261.
  • Laffont B, Corduan A, Rousseau M, Duchez AC, Lee CH, Boilard E, Provost P. Platelet microparticles reprogram macrophage gene expression and function. Thromb Haemost 2016;115(2):311–323.

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